Abstract: A peritoneal dialysis (“PD”) system includes a cycler including an actuation surface having a peristaltic pump actuator; a manifold assembly including a rigid manifold having first and second chambers (110a, 110b), the rigid manifold configured and arranged to be abutted against the actuation surface for operation, a peristaltic pump tube (124gh) extending from the first chamber (110a) to the second chamber (110b) of the rigid manifold, a dialysis fluid container line (124b) extending from the first chamber (110a), and a branch line (124c) extending between the dialysis fluid container line (124b) and the second chamber (110b); and a control unit configured to cause the peristaltic pump actuator to actuate the peristaltic pump tube (124gh) to pump dialysis fluid from the branch line (124c) into the second chamber (110b) and from the second chamber (110b) into the first chamber (110a).

Abstract: A method of performing dialysis includes: recirculating a dialysis fluid from a patient or a dialyzer for at least two cycles, each cycle contacting the dialysis fluid first with a zirconium phosphate layer followed by at least one of a urease layer, a zirconium oxide layer, or a carbon layer; storing the recirculated dialysis fluid in a storage container; and transferring the dialysis fluid from the storage container to the patient or the dialyzer. In one example, the zirconium phosphate layer and the at least one of the urease layer, the zirconium oxide layer, or the carbon layer is provided by a sorbent cartridge.

Abstract: A device or system includes a mixer comprising a three-dimensional lattice defining a plurality of tortuous, interconnecting passages therethrough. The mixer is in communication with sources or streams of at least two separate components which, when mixed, form a combined fluid stream. The sources or streams may be, at least initially, on opposite sides of the mixer, or the sources or streams may be on the upstream side of the mixer with an outlet disposed downstream of the mixer. A related method may include providing a mixer comprising a three-dimensional lattice defining a plurality of tortuous, interconnecting passages therethrough, and selecting a material for the mixer based on physical characteristics of said material, said characteristics including a selected one or more of mean flow pore size, thickness and porosity volume.

Abstract: A reconstitution device includes a body, a first piercing member located at a first end of the body, and a receptacle located at the second end of the body. The receptacle includes a collar configured to engage a vial, and a cap extending from the collar and holding a second piercing member. The second piercing member is disposed within the collar. The reconstitution device includes a first fluid pathway formed within and extending from the first piercing member to the second piercing member. The reconstitution device includes a second fluid pathway formed within and extending from the second piercing member to a portion of the body between the first piercing member and the second piercing member.

Abstract: A virtual assistant/chatbot to improve clinical workflow for home renal replacement therapies is disclosed herein. A virtual assistant/chatbot includes a patient-facing user interface configured to enable a patient to engage in a virtual chat session by typing, speaking, or otherwise providing information regarding a patient request or issue related to their renal replacement therapy. The virtual assistant/chatbot also includes a backend server-based system configured to provide logic to respond to a patient's requests. The logic defines a sequence of questions and answers for resolving patient queries. The sequence of assistant/chatbot questions and patient answers may be configured in a node arrangement such that certain patient answers/requests lead to additional questions for additional information from a patient.

Abstract: An automated peritoneal dialysis system and machine configured to perform dextrose mixing are disclosed. An example dialysis machine includes a pump, a first solution having a first formulation stored in a first container that is placed in fluid communication with the pump, and a second solution having a second formulation stored in a second container that is also placed in fluid communication with the pump. The first container has a first unique identifier indicative of the first formulation and the second container has a second unique identifier indicative of the second formulation. The dialysis machine also includes a logic implementer programmed to receive a therapy prescription and operate the pump if the first formulation indicated by the first unique identifier is specified by the therapy prescription, or the second formulation indicated by the second unique identifier is specified by the therapy prescription.

Abstract: A method for producing sterile solution product bags includes positioning a manifold assembly onto a filling machine. The manifold assembly includes a plurality of bags, a first filter, and a connection line in fluid communication with the first filter. Each of the plurality of bags includes a bladder and a stem in fluid communication with the bladder and with the connection line. The method includes activating a pump and at least partially filling one or more of the bladders by pumping fluid through the feed line, the first filter, and the connection line. The method includes sealing the stem of each of the filled product bags at a location between the connection line and the bladder, thereby creating one or more at least partially filled and sealed product bags. The method includes separating each of the at least partially filled and sealed product bags from the connection line.

Abstract: The invention provides a neck-worn sensor (referred to herein as the ‘necklace’) that is a single, body-worn system that measures the following parameters from an ambulatory patient: heart rate, pulse rate, pulse oximetry, respiratory rate, temperature, thoracic fluid levels, stroke volume, cardiac output, and a parameter sensitive to blood pressure called pulse transit time. From stroke volume, a first algorithm employing a linear model can estimate the patient's pulse pressure. And from pulse pressure and pulse transit time, a second algorithm, also employing a linear algorithm, can estimate systolic blood pressure and diastolic blood pressure. Thus, the necklace can measure all five vital signs along with hemodynamic parameters. It also includes a motion-detecting accelerometer, from which it can determine motion-related parameters such as posture, degree of motion, activity level, respiratory-induced heaving of the chest, and falls.

Abstract: Methods, sorbent cartridges and cleaning devices are disclosed for refurbishing sorbent materials. In one implementation among multiple implementations, a medical fluid delivery method includes: providing a sorbent cartridge including H+ZP within a casing for a treatment; and after the treatment, refurbishing the H+ZP while maintained within the casing via (i) regenerating the non-disinfected H+ZP by flowing an acid solution through the casing, (ii) rinsing the regenerated H+ZP while maintained within the casing, (iii) disinfecting the regenerated and rinsed H+ZP by flowing a disinfecting agent through the casing, and (iv) rinsing the regenerated and disinfected H+ZP while maintained within the casing. Multiple batch sorbent refubishing implementations are also disclosed.

Abstract: A sterile solution product bag for lyophilizing includes a bladder, a first stem having a first stem inlet end and a first stem outlet end. The first stem outlet end is fluidly connected to the bladder and the first stem inlet end is adapted to receive a liquid. A first filter is disposed in-line with the first stem and includes a first filter membrane, a first filter open end, and a first filter closed end. The first filter closed end is disposed between the first stem inlet end and the first stem outlet end and the first filter open end is disposed in proximity to the first stem inlet end. A second stem having a second stem inlet end fluidly connected to the bladder and a second stem outlet end adapted to receive a vapor. A second filter is disposed within the second stem and includes a filter membrane.

Abstract: The present disclosure provides multi-layer articles that comprise a polyolefin component and a polymer blend attached to the polyolefin component, wherein the polymer blend includes (1) a propylene and ?-olefin copolymer in an amount from about 15% to about 70% by weight of the polymer blend, and (2) a carbon monoxide-containing polyolefin-based copolymer in an amount from about 25% to about 85% by weight of the polymer blend. The polymer blend has an extractables fraction with pH higher than 5. Also provided are methods of bonding a first layer comprising polyvinyl chloride to a second layer comprising the disclosed polymer blend.

Abstract: A renal therapy system is disclosed. In an example, the renal therapy system includes a user interface device, such as a tablet computer. The renal therapy system also includes a renal therapy machine configured to perform a renal therapy. The renal therapy machine includes a data transfer interface configured to communicatively couple to the user interface device, a dialysis fluid pump, and a processor that operates a connectivity agent having an activated mode and a deactivated mode. When in the activated mode, the connectivity agent enables the processor to send data related to a performance of the renal therapy to a system hub. In the deactivated mode, the processor is prevented from sending the data to or receiving any data from the system hub. The user interface device is configured to receive data from and send data to the processor regardless of a status of the connectivity agent.

Abstract: A medical device data back-association system, apparatuses, and methods are disclosed. In an example embodiment, a server receives first medical device data from a medical device including a device identifier and stores the first medical device data to an unassociated record in a database after determining that there is no association between the device identifier and any patient identifier or medication order identifier. While the medical device is administering the medication to a patient, the server receives an identifier message including at least two of the device identifier, the patient identifier, and the medication order identifier. The server creates an identifier association between a medical record of the patient and the medical device using the identifier message. The server uses the identifier association to store subsequent medical device data from the medical device to the medical record of the patient.

Abstract: The invention provides a sensor for measuring both impedance and ECG waveforms that is configured to be worn around a patient's neck. The sensor features 1) an ECG system that includes an analog ECG circuit, in electrical contact with at least two ECG electrodes, that generates an analog ECG waveform; and 2) an impedance system that includes an analog impedance circuit, in electrical contact with at least two (and typically four) impedance electrodes, that generates an analog impedance waveform. Also included in the neck-worn system are a digital processing system featuring a microprocessor, and an analog-to-digital converter. During a measurement, the digital processing system receives and processes the analog ECG and impedance waveforms to measure physiological information from the patient. Finally, a cable that drapes around the patient's neck connects the ECG system, impedance system, and digital processing system.

Abstract: A water purification apparatus (300) capable of being cleaned at a point of care, and methods for cleaning the water purification apparatus (300) at the point of care. The water purification apparatus (300) and the methods provide an efficient use of a heater (302) for heat disinfection the water purification apparatus (300), e.g. by recirculating heated fluid to further heat the fluid. Several different cleaning programs are provided that may be utilized for cleaning different parts of the water purification apparatus (300).

Abstract: A system for reconstituting and sterilizing a concentrate includes a mixing container, a filtration device, and a product bag. The a mixing container has an inlet port and outlet port in fluid communication with a mixing chamber disposed between the inlet port and the outlet port. The mixing chamber is adapted to contain a product concentrate. The filtration device has an inlet and an outlet, the inlet of the filtration device coupled to the outlet port of the mixing container. The filtration device includes a filter membrane with a nominal pore size in a range of approximately 0.1 ?m to approximately 0.5 ?m. The product bag has an inlet port coupled to the outlet of the filtration device, and has a bladder defining an empty sterile chamber for receiving sterilized and reconstituted product resulting from mixing a diluent with a product concentrate in the mixing chamber to obtain a mixture then introduced through the filtration device to obtain the reconstituted and sterilized product.

Abstract: A system and method are disclosed for the automated collection of dialysis data. An example method includes receiving and aggregating dialysis data comprising a fill volume amount and a drain volume amount for at least one continuous ambulatory peritoneal dialysis (“CAPD”) cycle. The method also includes calculating an amount of ultrafiltration removed for each CAPD cycle by subtracting the fill volume amount from the drain volume amount for the respective CAPD cycle, and storing ultrafiltration data that is indicative of the amount of ultrafiltration removed as part of the aggregated dialysis data. The method further includes determining or receiving an indication that a dialysis machine is connected. After the dialysis machine is connected, the method includes transmitting the aggregated dialysis data to the dialysis machine to enable the aggregated dialysis data to be combined with additional dialysis data generated by the dialysis machine for determining total dialysis data.

Abstract: A personalized chronic care system including (i) a sensor; (ii) a data receiving device separate from the sensor and configured to receive data directly or indirectly from the sensor; (iii) a data analytics device separate from the sensor and including at least one algorithm configured to analyze the sensor data and provide an analyzed data outcome; and (iv) at least one output device separate from the sensor and in communication with the data analytics device, the at least one output device configured to receive and communicate the analyzed data outcome to a health care provider.

Abstract: Methods, systems, and apparatuses for integrating medical device data are disclosed. In an example embodiment, a processor receives infusion therapy progress data that is generated by an infusion pump and renal failure therapy progress data that is generated by a renal failure therapy machine. The processor also receives physiological data that generated by at least one physiological sensor. The processor determines fluid balance data based on a difference between the infusion therapy progress data and the renal failure therapy progress data. The processor displays the fluid balance data in conjunction with hemodynamic information from the physiological data.