Patents Assigned to BioCardia, Inc.
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Publication number: 20130331881Abstract: Methods for easy, atraumatic access to areas of the vasculature that are otherwise difficult to access, using steerable guide catheters constructed with components that are selected to provide optimal navigability, torque transfer, and push ability for a variety of typical percutaneous access routes. The catheter wall thickness in the deflecting segment of the guide catheter is about 1 French (1/3 mm) or less, and includes a slotted deflection tube, and this construction allows a very tight turning radius which in turn enables guide catheter access to regions of the vasculature that are otherwise inaccessible.Type: ApplicationFiled: August 13, 2013Publication date: December 12, 2013Applicant: BioCardia, Inc.Inventors: Daniel C. Rosenman, Daniel Kayser, Michael Keleher, Nick Fravala, Richard Cook, Mark Tale, Frank Arko, Simon Stertzer, Peter A. Altman
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Publication number: 20130331819Abstract: Methods for easy, atraumatic access to areas of the vasculature that are otherwise difficult to access, using steerable guide catheters constructed with components that are selected to provide optimal navigability, torque transfer, and push ability for a variety of typical percutaneous access routes. The catheter wall thickness in the deflecting segment of the guide catheter is about 1 French (? mm) or less, and includes a slotted deflection tube, and this construction allows a very tight turning radius which in turn enables guide catheter access to regions of the vasculature that are otherwise inaccessible.Type: ApplicationFiled: August 13, 2013Publication date: December 12, 2013Applicant: BioCardia, Inc.Inventors: Daniel C. Rosenman, Daniel Kayser, Michael Keleher, Nick Fravala, Richard Cook, Mark Tale, Frank Arko, Simon Stertzer, Peter A. Altman
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Publication number: 20130323212Abstract: A method of treating chronic post-myocardial infarction including helical needle transendocardial delivery of autologous bone marrow (ABM) mononuclear cells around regions of hypo or akinesia in chronic post-myocardial infarction (MI) patients. The treatment is safe and improves ejection fraction (EF).Type: ApplicationFiled: July 30, 2013Publication date: December 5, 2013Applicant: BioCardia, Inc.Inventors: Luis M. de la Fuente, Simon H. Stertzer, Julio Argentieri, Eduardo Penaloza, Peter A. Altman
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Patent number: 8529550Abstract: Catheter systems and methods for implanting helical or dart-like implants into the myocardium or other body tissue. The catheter system includes a helix for fixing the distal end of the catheter to the myocardium, an implant held by the helix, mechanisms for driving the fixation helix into the myocardium, and mechanisms for driving the implant into the myocardium, removing the fixation helix and leaving the implant behind. The implant may be coated, filled, or made of a drug or drug eluting compound, or drug delivery matrix of any composition.Type: GrantFiled: December 6, 2005Date of Patent: September 10, 2013Assignee: BioCardia, Inc.Inventors: Daniel C. Rosenman, Peter A. Altman, Mark A. Lovich, Michael A. Schwartz, Aaron J. Miller
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Patent number: 8496926Abstract: A method of treating chronic post-myocardial infarction including helical needle transendocardial delivery of autologous bone marrow (ABM) mononuclear cells around regions of hypo or akinesia in chronic post-myocardial infarction (MI) patients. The treatment is safe and improves ejection fraction (EF).Type: GrantFiled: April 16, 2007Date of Patent: July 30, 2013Assignee: BioCardia, Inc.Inventors: Luis M. de la Fuente, Simon H. Stertzer, Julio Argentieri, Eduardo Penaloza, Peter A. Altman
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Publication number: 20130184656Abstract: A catheter system for delivery of therapeutic substances to a depth within the heart muscle via the venous side of the heart. The system includes a reservoir of potentially embolic therapeutic agent.Type: ApplicationFiled: March 5, 2013Publication date: July 18, 2013Applicant: BIOCARDIA, INC.Inventor: Biocardia, Inc.
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Patent number: 8388581Abstract: Devices and methods are described for delivery of therapeutic substances to a depth within the heart muscle via the venous side of the heart, with a primary focus on delivery through the coronary sinus. The devices and methods may be combined with percutaneous access catheters in order to provide for right heart delivery of therapeutic agents.Type: GrantFiled: June 30, 2003Date of Patent: March 5, 2013Assignee: Biocardia, Inc.Inventor: Peter A. Altman
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Patent number: 8027740Abstract: A drug delivery catheter suited for cardiac procedures. The catheter includes a distal helical coil or other fixation and penetrating element which can be operated from the proximal end of the catheter to engage and penetrate the myocardium. Once delivered to the inside of the heart, the catheter can be used to inject small doses of therapeutic agents to the myocardium. The drug delivery system of the catheter allows for precise control of the dose injected into the heart wall.Type: GrantFiled: July 5, 2002Date of Patent: September 27, 2011Assignee: BioCardia, Inc.Inventors: Peter A. Altman, John D. Altman, Simon Stertzer
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Patent number: 7998105Abstract: A method of treating the intraluminal disease in a coronary artery by injecting therapeutic agents perivascularly into the myocardium near the site of disease.Type: GrantFiled: September 24, 2003Date of Patent: August 16, 2011Assignee: BioCardia, Inc.Inventor: Peter A. Altman
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Patent number: 7840261Abstract: A catheter system suitable for implanting pacemaker leads. A guide catheter is provided with steering capability, and the necessary steering components are modified to permit the catheter to be sliced during withdrawal, so that the proximal forced applied to the pacemaker lead is minimized and the lead is less likely to be dislodged.Type: GrantFiled: June 5, 2002Date of Patent: November 23, 2010Assignee: BioCardia, Inc.Inventors: Daniel C. Rosenman, R. Hardwin Mead, Peter A. Altman
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Patent number: 7736346Abstract: Catheter-based systems are disclosed for geometrically and temporally controlled deliveries of fluid agents to the heart. Each system includes an elongate catheter shaft, a tissue penetration element at the shaft distal end, and a handle at the shaft proximal end for manipulating the penetrating element. The penetrating element and a proximate conductive coil provide bipolar sensing electrodes. One version of the system includes a fluid lumen through the penetrating element and a contrast fluid lumen open at the catheter shaft distal end. In other versions, the penetrating element contains two fluid lumens. These systems facilitate tissue mapping and therapeutic agent delivery protocols in which several agents can be simultaneously delivered at a depth within heart tissue, prevented from intermingling until they reach the tissue. Treatment and contrast agents can be delivered simultaneously or temporally spaced, directed to the same region or to different regions separated by intervening tissue.Type: GrantFiled: October 18, 2005Date of Patent: June 15, 2010Assignee: Biocardia, Inc.Inventors: Aaron Miller, Loren Bentley, Daniel C. Rosenman, Peter A. Altman
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Patent number: 7547301Abstract: Implantable cardiac drug delivery systems. The systems are installed endocardially into a chamber in the heart, and are variously capable of delivering anti-arrhythmia agents into the heart wall, and into the epicardial space outside the heart, and into other chambers in the heart through the septa of the heart.Type: GrantFiled: July 12, 2007Date of Patent: June 16, 2009Assignee: Biocardia, Inc.Inventors: Peter A. Altman, John D. Altman
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Patent number: 7500970Abstract: A catheter system for injecting therapeutic agents including large molecules into the body. The catheter includes a distensible penetrating element with a distally locating expansion coil and a distally located chamber for holding a therapeutic agent which is to be injected into the body.Type: GrantFiled: April 26, 2004Date of Patent: March 10, 2009Assignee: BioCardia, Inc.Inventor: Peter A. Altman
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Patent number: 7402151Abstract: Methods for easy, atraumatic access to areas of the vasculature that are otherwise difficult to access, using steerable guide catheters constructed with components that are selected to provide optimal navigability, torque transfer, and push ability for a variety of typical percutaneous access routes. The catheter wall thickness in the deflecting segment of the guide catheter is about 1 French (? mm) or less, and includes a slotted deflection tube, and this construction allows a very tight turning radius which in turn enables guide catheter access to regions of the vasculature that are otherwise inaccessible.Type: GrantFiled: December 17, 2004Date of Patent: July 22, 2008Assignee: BioCardia, Inc.Inventors: Daniel Rosenman, Daniel Kayser, Michael Keleher, Nick Fravala, Richard Cook, Mark Tale, Frank Arko, Simon Stertzer, Peter A. Altman
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Patent number: 7351237Abstract: Devices and methods for testing a pulmonary vein to determine whether or not ablation would be effective in terminating atrial fibrillation. The devices and methods include a catheter having an expandable balloon attached to the distal end of the catheter. The balloon has pores on the distal end of the balloon for administering a fluid into the target pulmonary vein. The fluid inhibits the electrical impulses generated by the target pulmonary vein. Once the electrical impulses of the target pulmonary vein have been inhibited it can be determined whether or not the atrial fibrillation continues to occur. If the atrial fibrillation has been eliminated, then ablation or other therapy is appropriate. Thus, the devices and methods limit unnecessary treatment of a pulmonary vein.Type: GrantFiled: August 2, 2005Date of Patent: April 1, 2008Assignee: BioCardia, Inc.Inventor: Peter A. Altman
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Publication number: 20070088244Abstract: Catheter-based systems are disclosed for geometrically and temporally controlled deliveries of fluid agents to the heart. Each system includes an elongate catheter shaft, a helical, linear or curved tissue penetration element at the distal end of the shaft, and a handle at the proximal end of the shaft for manipulating the penetrating element through the catheter shaft. The penetrating element and a conductive coil near the shaft distal end provide a pair of electrodes for bipolar sensing of tissue electrical activity. One version of the system includes a fluid lumen through the penetrating element and a contrast fluid lumen open at the catheter shaft distal end. In other versions of the catheter system, the penetrating element contains two fluid lumens. These systems facilitate a variety of tissue mapping and therapeutic agent delivery protocols in which several agents can be simultaneously delivered at a depth within heart tissue, prevented from intermingling until they reach the tissue.Type: ApplicationFiled: October 18, 2005Publication date: April 19, 2007Applicant: BioCardia, Inc.Inventors: Aaron Miller, Loren Bentley, Daniel Rosenman, Peter Altman
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Patent number: 7156824Abstract: A catheter for injecting a thermally sensitive gelation material to remote sites within a patient's body by maintaining the thermally sensitive gelation material in a liquid state until it is delivered to a target area within the body.Type: GrantFiled: April 26, 2004Date of Patent: January 2, 2007Assignee: BioCardia, Inc.Inventor: Daniel C. Rosenman
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Patent number: 7104988Abstract: A system is disclosed, for administering a therapeutic agent locally and to a depth within cardiac tissue. An elongate, flexible catheter contains a flexible electric conductor and supports at its distal end an implantable electrode incorporating a penetrating element, typically a fixation helix or a linear needle that penetrates cardiac tissue as the electrode is implanted. A therapeutic agent is delivered through the electrode, to the cardiac tissue surrounding the penetrating element. The electrode can act as a sensor, to monitor an electrical condition of the surrounding cardiac tissue, and to control delivery of the agent responsive to the sensed electrical condition. Several embodiments feature a distal reservoir adjacent the electrode for effecting transient deliveries of the therapeutic agent in minute quantities. Other embodiments are disclosed for providing sustained deliveries of the agents.Type: GrantFiled: March 19, 2002Date of Patent: September 12, 2006Assignee: Biocardia, Inc.Inventors: Peter A. Altman, John D. Altman
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Patent number: 7048711Abstract: A system and method for delivering a drug to a target site within a patient's body. The system and method include a steerable guide catheter and a drug delivery catheter. The steerable guide catheter has a first extension tube and a second extension tube that are joined together and form a shoulder. The delivery catheter has a distal docking segment and a proximal docking segment. The guide catheter is inserted into the patient's body, then the delivery catheter is inserted into the guide catheter. The distal docking segment engages the first extension tube, the proximal docking segment engages the second extension tube, and the shoulder limits the distance the delivery catheter can be inserted into the guide catheter. Also, once the delivery catheter is inserted it can be rotated to attach the helical tip to the target site. The guide catheter also includes a steering mechanism as well as a friction mechanism which controls the tension on the steering mechanism.Type: GrantFiled: January 27, 2003Date of Patent: May 23, 2006Assignee: BioCardia, Inc.Inventors: Daniel C. Rosenman, Peter A. Altman, Brian K. Hakim, Daniel J. Kayser, Robert E. Maston, Douglas McEtchin
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Patent number: 7029466Abstract: Implantable cardiac drug delivery systems. The systems are installed endocardially into a chamber in the heart, and are variously capable of delivering anti-arrhythmia agents into the heart wall, and into the epicardial space outside the heart, and into other chambers in the heart through the septa of the heart.Type: GrantFiled: October 3, 2002Date of Patent: April 18, 2006Assignee: BioCardia, Inc.Inventor: Peter A. Altman