Patents Assigned to BioControl Systems, Inc.
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Patent number: 7030403Abstract: Methods and apparatus for evaluating the quality of a sample of a product, an ingredient, an environment or process by measuring multiple parameters thereof, including light emitted from a reacting sample containing ATP, ADP, alkaline phosphatase or other parameters such as pH, temperature, conductivity, reduction potential, dissolved gases, specific ions, and microbiological count. The apparatus comprises an integrated sample testing device used to collect a sample, mix reagents, react the sample, and collect it in a measurement chamber. The apparatus also comprises an instrument having a photon detection assembly for use with the sample testing device. The instrument can also comprise one or more sensing probes and a communication port to facilitate data collection, transfer and analysis.Type: GrantFiled: December 5, 2002Date of Patent: April 18, 2006Assignee: Biocontrol Systems, Inc.Inventors: Philip T. Feldsine, Tim A. Kelly, Jim Christensen, Joseph B. Di Carlo, Mark Andersen, Anita Kressner
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Patent number: 6924498Abstract: Methods and apparatus for evaluating the quality of a sample of a product, an ingredient, an environment or a process by measuring multiple parameters thereof, including light emitted from a reacting sample containing ATP, ADP, alkaline phosphatase or other parameters such as pH, temperature, conductivity, oxidation reduction potential, dissolved gases, specific ions, and microbiological count. The apparatus comprises an integrated sample testing device used to collect a sample, mix reagents, react the sample, and collect it in a measurement chamber. The apparatus also comprises an instrument having a photon detection assembly for use with the sample testing device. The instrument can also comprise one or more sensing probes and a communication port to facilitate data collection, transfer and analysis. The method further comprises a mechanism for storing data, evaluating data, graphing data, and determining conformance to established criteria.Type: GrantFiled: June 4, 2004Date of Patent: August 2, 2005Assignee: Biocontrol Systems, Inc.Inventors: Philip T. Feldsine, Tim A. Kelly, Jim Christensen, Joseph B. Di Carlo, Mark Andersen, Anita Kressner
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Publication number: 20050123954Abstract: The present invention includes methods, kits and compositions useful for the detection of microorganisms. These agents and methods are primarily directed to a method of detecting the presence of a microorganism in a sample, involving concentrating or isolating the microorganism through the use of a binding agent, and subsequently performing nucleic acid amplification of a microorganism polynucleotide.Type: ApplicationFiled: September 13, 2004Publication date: June 9, 2005Applicant: BioControl Systems, Inc.Inventor: Philip Feldsine
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Patent number: 6863866Abstract: The present invention relates generally to self-contained devices and methods for detecting biological contaminants and, more particularly, to self-contained devices and methods for detecting biological contaminants in relevant settings including, for example, food processing plants, hospitals, medical offices, veterinary offices, and restaurants by using a device or methodology that includes a sampler component and dye component that binds to the biological material in a detectable fashion.Type: GrantFiled: June 4, 2001Date of Patent: March 8, 2005Assignee: BioControl Systems, Inc.Inventors: Tim Allen Kelly, George Michael Hass, Philip Thomas Feldsine
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Publication number: 20040220748Abstract: Methods and apparatus for evaluating the quality of a sample of a product, an ingredient, an environment or a process by measuring multiple parameters thereof, including light emitted from a reacting sample containing ATP, ADP, alkaline phosphatase or other parameters such as pH, temperature, conductivity, oxidation reduction potential, dissolved gases, specific ions, and microbiological count. The apparatus comprises an integrated sample testing device used to collect a sample, mix reagents, react the sample, and collect it in a measurement chamber. The apparatus also comprises an instrument having a photon detection assembly for use with the sample testing device. The instrument can also comprise one or more sensing probes and a communication port to facilitate data collection, transfer and analysis. The method further comprises a mechanism for storing data, evaluating data, graphing data, and determining conformance to established criteria.Type: ApplicationFiled: June 4, 2004Publication date: November 4, 2004Applicant: Biocontrol Systems, Inc.Inventors: Philip T. Feldsine, Tim A. Kelly, Jim Christensen, Joseph B. Di Carlo, Mark Andersen, Anita Kressner
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Publication number: 20030235512Abstract: A self-contained signal generating device and methods for using and making the same are provided. The device and methods may detect the presence of a number of different substances, such as proteins, and utilizes a target material binding dye, which may precipitate a target material as well as stain it, and/or undergo a detectable change, e.g., an absorption or emission frequency shift, on binding of the substance to be detected.Type: ApplicationFiled: April 9, 2003Publication date: December 25, 2003Applicant: BioControl Systems, Inc.Inventors: Charles Carpenter, Melanie Tornberg, Genevieve Clark, Brian Eckenroth, Mark W. Pierson, Elizabeth Ehrenfeld
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Publication number: 20030209653Abstract: Methods and apparatus for evaluating the quality of a sample of a product, an ingredient, an environment or a process by measuring multiple parameters thereof, including light emitted from a reacting sample containing ATP, ADP, alkaline phosphatase or other parameters such as pH, temperature, conductivity, oxidation reduction potential, dissolved gases, specific ions, and microbiological count. The apparatus comprises an integrated sample testing device used to collect a sample, mix reagents, react the sample, and collect it in a measurement chamber. The apparatus also comprises an instrument having a photon detection assembly for use with the sample testing device. The instrument can also comprise one or more sensing probes and a communication port to facilitate data collection, transfer and analysis. The method further comprises a mechanism for storing data, evaluating data, graphing data, and determining conformance to established criteria.Type: ApplicationFiled: January 30, 2003Publication date: November 13, 2003Applicant: Biocontrol Systems, Inc.Inventors: Philip T. Feldsine, Tim A. Kelly, Jim Christensen, Joseph B. Di Carlo, Mark Andersen, Anita Kressner
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Publication number: 20030143752Abstract: Methods and apparatus for evaluating the quality of a sample of a product, an ingredient, an environment or process by measuring multiple parameters thereof, including light emitted from a reacting sample containing ATP, ADP, alkaline phosphatase or other parameters such as pH, temperature, conductivity, reduction potential, dissolved gases, specific ions, and microbiological count. The apparatus comprises an integrated sample testing device used to collect a sample, mix reagents, react the sample, and collect it in a measurement chamber. The apparatus also comprises an instrument having a photon detection assembly for use with the sample testing device. The instrument can also comprise one or more sensing probes and a communication port to facilitate data collection, transfer and analysis.Type: ApplicationFiled: December 5, 2002Publication date: July 31, 2003Applicant: Biocontrol Systems, Inc.Inventors: Philip T. Feldsine, Tim A. Kelly, Jim Christensen, Joseph B. Di Carlo, Mark Andersen, Anita Kressner
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Patent number: 6551834Abstract: A self-contained signal generating device and methods for using and making the same are provided. The device and methods may detect the presence of a number of different substances, such as proteins, and utilizes a target material binding dye, which may precipitate a target material as well as stain it, and/or undergo a detectable change, e.g., an absorption or emission frequency shift, on binding of the substance to be detected.Type: GrantFiled: February 2, 2001Date of Patent: April 22, 2003Assignee: BioControl Systems, Inc.Inventors: Charles Carpenter, Melanie Tornberg, Genevieve Clark, Brian Eckenroth, Mark W. Pierson, Elizabeth Ehrenfeld
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Patent number: 6509168Abstract: Method for detection of a biological material in a sample. The method includes the steps of liquifying the sample (if necessary) and pouring the liquified sample into the incubation plate. The incubation plate has a generally flat horizontal surface and the surface is divided into a plurality of at least 20 recessed wells. Each well is adapted to hold an aliquot of liquid and is sized and shaped, and formed of a suitable material, to hold the aliquot within the well by surface tension. Any excess liquid from the liquified sample is poured from the surface of the plate. The method then involves incubating that incubation plate until the presence or absence of the biological material is determined.Type: GrantFiled: April 18, 2001Date of Patent: January 21, 2003Assignee: Biocontrol Systems, Inc.Inventors: Andrew J. Croteau, Mark W. Pierson, David E. Townsend, Ali Naqui
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Patent number: 6472167Abstract: This invention relates to a method for detecting the existence or measuring the concentration of total viable bacteria in a test sample from a food product. A medium is provided which contains three or more different enzyme substrates each having a nutrient moiety and a detectable moiety linked together. When a substrate is hydrolysed by a bacterial enzyme to create a separate detectable moiety, it causes or produces a detectable signal. These substrates produce detectable signals when any one of a phosphatase enzyme, a glycosidase enzyme or a peptidase enzyme is present in the medium.Type: GrantFiled: February 24, 1998Date of Patent: October 29, 2002Assignee: BioControl Systems, Inc.Inventors: David E. Townsend, Chun-ming Chen
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Publication number: 20020127699Abstract: Compositions, formulae, devices and methods for the detection of target microorganisms, such as by visual immunoprecipitate assay, enzyme linked immunoassay, chemiluminescence, immunoblotting, or similar detection technology, wherein detection requires the discrimination among closely related genera, species and strains of antigenically related microorganisms based on immunological reactivity of a highly conserved antigen epitopes with a reagent system comprised of an antibody linked to a detecting reagent. The invention permits a detectable event to occur by exposing inaccessible but highly conserved and specific antigen epitopes to the detecting reagent. Exposure of such antigen epitopes without inactivating microbial metabolism allows for specific detection.Type: ApplicationFiled: March 5, 2002Publication date: September 12, 2002Applicant: BioControl Systems, Inc.Inventors: Philip T. Feldsine, David E. Kerr, Ping Zhu, Linda Mui
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Publication number: 20020058298Abstract: The present invention relates generally to compositions and methods for detecting target microorganisms in a sample. In particular, the present invention relates to compositions comprising a conditionally detectable maker and an enzyme substrate that provides detection of the target microorganism as well as methods of use thereof. With the invention disclosed herein, a widely applicable approach is revealed which utilizes a presumptive indicator for the target microorganism and non-target microorganisms capable of growth and detection in a medium followed by a confirmation indicator, which is substantially only reacted upon by the non-target microorganisms.Type: ApplicationFiled: August 27, 2001Publication date: May 16, 2002Applicant: BioControl System, Inc.Inventor: David E. Townsend
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Patent number: 6387650Abstract: This invention relates to a method for detecting the existence or measuring the concentration of total viable bacteria in a test sample from a food product. A medium is provided which contains three or more different enzyme substrates each having a nutrient moiety and a detectable moiety linked together. When a substrate is hydrolyzed by a bacterial enzyme to create a separate detectable moiety, it causes or produces a detectable signal. These substrates produce detectable signals when any one of a phosphatase enzyme, a glycosidase enzyme or a peptidase enzyme is present in the medium.Type: GrantFiled: June 7, 1995Date of Patent: May 14, 2002Assignee: Biocontrol Systems, Inc.Inventors: David E. Townsend, Chun-ming Chen
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Patent number: 6379918Abstract: Compositions, formulae, devices and methods for the detection of target microorganisms, such as by visual immunoprecipitate assay, enzyme linked immunoassay, chemiluminescence, immunoblotting, or similar detection technology, wherein detection requires the discrimination among closely related genera, species and strains of antigenically related microorganisms based on immunological reactivity of a highly conserved antigen epitopes with a reagent system comprised of an antibody linked to a detecting reagent. The invention permits a detectable event to occur by exposing inaccessible but highly conserved and specific antigen epitopes to the detecting reagent. Exposure of such antigen epitopes without inactivating microbial metabolism allows for specific detection.Type: GrantFiled: August 13, 1999Date of Patent: April 30, 2002Assignee: Biocontrol Systems, Inc.Inventors: Philip T. Feldsine, David E. Kerr, Ping Zhu, Linda Mui
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Publication number: 20020031796Abstract: This invention relates to a method for detecting the existence or measuring the concentration of total viable bacteria in a test sample from a food product. A medium is provided which contains three or more different enzyme substrates each having a nutrient moiety and a detectable moiety linked together. When a substrate is hydrolysed by a bacterial enzyme to create a separate detectable moiety, it causes or produces a detectable signal. These substrates produce detectable signals when any one of a phosphatase enzyme, a glycosidase enzyme or a peptidase enzyme is present in the medium.Type: ApplicationFiled: August 6, 2001Publication date: March 14, 2002Applicant: Biocontrol Systems, Inc.Inventors: David E. Townsend, Chun-Ming Chen
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Publication number: 20020009766Abstract: Method for detection of a biological material in a sample. The method includes the steps of liquifying the sample (if necessary) and pouring the liquified sample into the incubation plate. The incubation plate has a generally flat horizontal surface and the surface is divided into a plurality of at least 20 recessed wells. Each well is adapted to hold an aliquot of liquid and is sized and shaped, and formed of a suitable material, to hold the aliquot within the well by surface tension. Any excess liquid from the liquified sample is poured from the surface of the plate. The method then involves incubating that incubation plate until the presence or absence of the biological material is determined.Type: ApplicationFiled: April 18, 2001Publication date: January 24, 2002Applicant: BioControl Systems, Inc.Inventors: Andrew J. Croteau, Mark W. Pierson, David E. Townsend, Ali Naqui
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Publication number: 20010026942Abstract: A self-contained signal generating device and methods for using and making the same are provided. The device and methods may detect the presence of a number of different substances, such as proteins, and utilizes a target material binding dye, which may precipitate a target material as well as stain it, and/or undergo a detectable change, e.g., an absorption or emission frequency shift, on binding of the substance to be detected.Type: ApplicationFiled: February 2, 2001Publication date: October 4, 2001Applicant: Biocontrol Systems, Inc.Inventors: Charles Carpenter, Melanie Tornberg, Genevieve Clark, Brian Eckenroth, Mark W. Pierson, Elizabeth Ehrenfeld
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Patent number: 6287797Abstract: Method for detection of a biological material in a sample. The method includes the steps of liquifying the sample (if necessary) and pouring the liquified sample into the incubation plate. The incubation plate has a generally flat horizontal surface and the surface is divided into a plurality of at least 20 recessed wells. Each well is adapted to hold an aliquot of liquid and is sized and shaped, and formed of a suitable material, to hold the aliquot within the well by surface tension. Any excess liquid from the liquified sample is poured from the surface of the plate. The method then involves incubating that incubation plate until the presence or absence of the biological material is determined.Type: GrantFiled: March 26, 1999Date of Patent: September 11, 2001Assignee: BioControl Systems, Inc.Inventors: Andrew J. Croteau, Mark W. Pierson, David E. Townsend, Ali Naqui
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Patent number: 5658747Abstract: Compositions, devices and methods for the detection of target microorganisms, such as by a visual immunoprecipitation assay, where the detection requires the migration of the target microorganisms (typically a target microorganism-antibody-detection reagent complex) along a lateral flow membrane of a diagnostic device. The present invention permits such detection by inhibiting the agglutination, or other aggregation, of target microorganisms (and particularly target microorganisms bound to an antibody-detection reagent) while the microorganisms are migrating along the lateral flow membrane.Type: GrantFiled: May 10, 1994Date of Patent: August 19, 1997Assignee: BioControl System, Inc.Inventors: Philip T. Feldsine, Sharon L. Brunelle, Maria T. Falbo-Nelson, Dennis M. Scully