Patents Assigned to BioDelivery Sciences International, Inc.
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Publication number: 20200155543Abstract: The present invention relates to a solid pharmaceutical dosage form for abusable drug delivery with reduced illicit abuse potential. The dosage form is presented as a bioerodable transmucosal delivery device that includes an abusable drug and an antagonist to the abusable drug associated with an abuse-resistant matrix. The devices of the invention may be in the form of a layered film or a tablet. Upon application in a non-abusive manner, the device adheres to the mucosal surface, providing transmucosal drug delivery of the drug with minimal absorption of the antagonist into systemic circulation.Type: ApplicationFiled: November 5, 2019Publication date: May 21, 2020Applicant: BioDelivery Sciences International, Inc.Inventors: Andrew Finn, Niraj Vasisht
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Publication number: 20200129503Abstract: The present invention provides abuse deterrent mucoadhesive devices for delivery of buprenorphine. Each device comprises a mucoadhesive layer and a backing layer, and the pH in each layer is selected, such that absorption of buprenorphine is maximized.Type: ApplicationFiled: October 28, 2019Publication date: April 30, 2020Applicant: BioDelivery Sciences International, Inc.Inventors: Andrew Finn, Niraj Vasisht
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Publication number: 20200069676Abstract: The present invention relates to methods and compositions for treating pain in a subject and safely transitioning a subject from a full ?-opioid receptor agonist to a partial ?-opioid receptor agonist.Type: ApplicationFiled: September 10, 2019Publication date: March 5, 2020Applicant: BioDelivery Sciences International, Inc.Inventors: Andrew Finn, Todd Kirby, Lynn R. Webster
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Publication number: 20200061052Abstract: The present invention relates to a pharmaceutical dosage form for transmucosal delivery of an active agent to two or more mucosal surfaces. The dosage form is presented as a transmucosal delivery device. The devices of the invention may include at least two mucoadhesive surfaces. The devices may further include an intermediate layer disposed between the mucoadhesive layers. The pharmaceutical can be incorporated in any one or all of the mucoadhesive layers or the intermediate layer. Upon application, the device adheres to at least two surfaces, providing transmucosal delivery of the drug to at least two surfaces.Type: ApplicationFiled: September 5, 2019Publication date: February 27, 2020Applicant: BioDelivery Sciences International, Inc.Inventors: Niraj Vasisht, Andrew Finn
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Publication number: 20200030227Abstract: Provided herein are methods for treating chronic pain by administering low doses of buprenorphine twice daily (or once daily) via a transmucosal drug delivery device. The methods and devices efficiently treat chronic pain without significant side effects.Type: ApplicationFiled: August 6, 2019Publication date: January 30, 2020Applicant: BioDelivery Sciences International, Inc.Inventors: Andrew Finn, Niraj Vasisht
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Publication number: 20190275029Abstract: The present invention relates to methods and compositions for treating pain in a subject and safely transitioning a subject from a full ?-opioid receptor agonist to a partial ?-opioid receptor agonist.Type: ApplicationFiled: March 15, 2019Publication date: September 12, 2019Applicant: BioDelivery Sciences International, Inc.Inventors: Andrew Finn, Todd Kirby, Lynn R. Webster
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Publication number: 20190262333Abstract: An autonomous mobile object is configured to transport a plurality of packages having recipients residing in a designated area. The autonomous mobile object includes an operation controller configured to control the autonomous mobile object such that the autonomous mobile object autonomously travels to a designated place associated with the designated area, a storage apparatus having a plurality of compartments, each compartment configured to be independently lockable and unlockable and store a package, and a loading unit configured to load the storage apparatus storing the package and unload the storage apparatus at the designated place.Type: ApplicationFiled: March 4, 2019Publication date: August 29, 2019Applicant: BioDelivery Sciences International, Inc.Inventors: Niraj Vasisht, Andrew Finn
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Publication number: 20190111048Abstract: The present invention provides methods for enhancing transmucosal uptake of a medicament, e.g., fentanyl or buprenorphine, to a subject and related devices. The method includes administering to a subject a transmucosal drug delivery device comprising the medicament. Also provided are devices suitable for transmucosal administration of a medicament to a subject and methods of their administration and use. The devices include a medicament disposed in a mucoadhesive polymeric diffusion environment and a barrier environment.Type: ApplicationFiled: November 1, 2017Publication date: April 18, 2019Applicant: BioDelivery Sciences International, Inc.Inventors: Andrew Finn, Niraj Vasisht
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Publication number: 20190000833Abstract: The present invention provides abuse deterrent mucoadhesive devices for delivery of buprenorphine. Each device comprises a mucoadhesive layer and a backing layer, and the pH in each layer is selected, such that absorption of buprenorphine is maximized.Type: ApplicationFiled: July 9, 2018Publication date: January 3, 2019Applicant: BioDelivery Sciences International, Inc.Inventors: Andrew Finn, Niraj Vasisht
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Publication number: 20180333407Abstract: The present invention relates to methods and compositions for treating pain in a subject and safely transitioning a subject from a full ?-opioid receptor agonist to a partial ?-opioid receptor agonist.Type: ApplicationFiled: April 17, 2018Publication date: November 22, 2018Applicant: BioDelivery Sciences International, Inc.Inventors: Andrew Finn, Todd Kirby, Lynn R. Webster
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Publication number: 20180200182Abstract: Provided herein are methods for treating chronic pain by administering low doses of buprenorphine twice daily (or once daily) via a transmucosal drug delivery device. The methods and devices efficiently treat chronic pain without significant side effects.Type: ApplicationFiled: January 14, 2018Publication date: July 19, 2018Applicant: BioDelivery Sciences International, Inc.Inventors: Andrew Finn, Niraj Vasisht
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Publication number: 20180133210Abstract: The present invention provides methods for enhancing transmucosal uptake of a medicament, e.g., fentanyl or buprenorphine, to a subject and related devices. The method includes administering to a subject a transmucosal drug delivery device comprising the medicament. Also provided are devices suitable for transmucosal administration of a medicament to a subject and methods of their administration and use. The devices include a medicament disposed in a mucoadhesive polymeric diffusion environment and a barrier environment.Type: ApplicationFiled: November 1, 2017Publication date: May 17, 2018Applicant: BioDelivery Sciences International, Inc.Inventors: Andrew Finn, Niraj Vasisht
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Publication number: 20180098986Abstract: The present invention relates to a solid pharmaceutical dosage form for abusable drug delivery with reduced illicit abuse potential. The dosage form is presented as a bioerodable transmucosal delivery device that includes an abusable drug and an antagonist to the abusable drug associated with an abuse-resistant matrix. The devices of the invention may be in the form of a layered film or a tablet. Upon application in a non-abusive manner, the device adheres to the mucosal surface, providing transmucosal drug delivery of the drug with minimal absorption of the antagonist into systemic circulation.Type: ApplicationFiled: December 13, 2017Publication date: April 12, 2018Applicant: BioDelivery Sciences International, Inc.Inventors: Andrew Finn, Niraj Vasisht
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Publication number: 20180064706Abstract: The present invention provides abuse deterrent mucoadhesive devices for delivery of buprenorphine. Each device comprises a mucoadhesive layer and a backing layer, and the pH in each layer is selected, such that absorption of buprenorphine is maximized.Type: ApplicationFiled: November 13, 2017Publication date: March 8, 2018Applicant: BioDelivery Sciences International, Inc.Inventors: Andrew Finn, Niraj Vasisht
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Patent number: 9901539Abstract: Provided herein are methods for treating chronic pain by administering low doses of buprenorphine twice daily (or once daily) via a transmucosal drug delivery device. The methods and devices efficiently treat chronic pain without significant side effects.Type: GrantFiled: December 21, 2012Date of Patent: February 27, 2018Assignee: BioDelivery Sciences International, Inc.Inventors: Andrew Finn, Niraj Vasisht
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Publication number: 20170231977Abstract: The present invention relates to a pharmaceutical dosage form for transmucosal delivery of an active agent to two or more mucosal surfaces. The dosage form is presented as a transmucosal delivery device. The devices of the invention may include at least two mucoadhesive surfaces. The devices may further include an intermediate layer disposed between the mucoadhesive layers. The pharmaceutical can be incorporated in any one or all of the mucoadhesive layers or the intermediate layer. Upon application, the device adheres to at least two surfaces, providing transmucosal delivery of the drug to at least two surfaces.Type: ApplicationFiled: May 18, 2016Publication date: August 17, 2017Applicant: BioDelivery Sciences International, Inc.Inventors: Niraj Vasisht, Andrew Finn
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Publication number: 20170216278Abstract: The present invention provides methods for enhancing transmucosal uptake of a medicament, e.g., fentanyl or buprenorphine, to a subject and related devices. The method includes administering to a subject a transmucosal drug delivery device comprising the medicament. Also provided are devices suitable for transmucosal administration of a medicament to a subject and methods of their administration and use. The devices include a medicament disposed in a mucoadhesive polymeric diffusion environment and a barrier environment.Type: ApplicationFiled: April 11, 2017Publication date: August 3, 2017Applicant: BioDelivery Sciences International, Inc.Inventors: Andrew Finn, Niraj Vasisht
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Patent number: 9655843Abstract: The present invention provides methods for enhancing transmucosal uptake of a medicament, e.g., fentanyl or buprenorphine, to a subject and related devices. The method includes administering to a subject a transmucosal drug delivery device comprising the medicament. Also provided are devices suitable for transmucosal administration of a medicament to a subject and methods of their administration and use. The devices include a medicament disposed in a mucoadhesive polymeric diffusion environment and a barrier environment.Type: GrantFiled: July 18, 2016Date of Patent: May 23, 2017Assignee: BioDelivery Sciences International, Inc.Inventors: Andrew Finn, Niraj Vasisht
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Patent number: 9597288Abstract: The present invention provides methods for enhancing transmucosal uptake of a medicament, e.g., fentanyl or buprenorphine, to a subject and related devices. The method includes administering to a subject a transmucosal drug delivery device comprising the medicament. Also provided are devices suitable for transmucosal administration of a medicament to a subject and methods of their administration and use. The devices include a medicament disposed in a mucoadhesive polymeric diffusion environment and a barrier environment.Type: GrantFiled: June 30, 2016Date of Patent: March 21, 2017Assignee: BioDelivery Sciences International, Inc.Inventors: Andrew Finn, Niraj Vasisht
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Patent number: 9522188Abstract: The present invention relates to a solid pharmaceutical dosage form for abusable drug delivery with reduced illicit abuse potential. The dosage form is presented as a bioerodable transmucosal delivery device that includes an abusable drug and an antagonist to the abusable drug associated with an abuse-resistant matrix. The devices of the invention may be in the form of a layered film or a tablet. Upon application in a non-abusive manner, the device adheres to the mucosal surface, providing transmucosal drug delivery of the drug with minimal absorption of the antagonist into systemic circulation.Type: GrantFiled: December 13, 2006Date of Patent: December 20, 2016Assignee: BioDelivery Sciences International, Inc.Inventors: Andrew Finn, Niraj Vasisht