Abstract: A process for producing a small-sized, lipid-based cochleate. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structures by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca2+ or Zn2+, forms a cochleate precipitate of a particle size less than one micron. The process may be used to produce cochleates containing biologically relevant molecules.
Type:
Application
Filed:
April 23, 2008
Publication date:
January 29, 2009
Applicant:
BioDelivery Sciences International, Inc.
Inventors:
Leila Zarif, Tuo Jin, Ignacio Segarra, Raphael J. Mannino
Abstract: The present invention is directed to cochleate composition that include a nucleotide. The nucleotide may generally be bound via a linker to a component of the cochleate, or to a lipophilic tail. Additionally or alternatively, the nucleotide may be associated with a transfection agent. The present invention also includes methods for making and using the compositions provided herein.
Type:
Application
Filed:
April 11, 2005
Publication date:
October 2, 2008
Applicant:
BioDelivery Sciences International, Inc.
Inventors:
Raphael J. Mannino, Susan Gould-Fogerite
Abstract: Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions.
Type:
Application
Filed:
January 11, 2007
Publication date:
January 10, 2008
Applicant:
BioDelivery Sciences International, Inc.
Inventors:
Susan Gould-Fogerite, Raphael Mannino, Patrick Ahl, Gaofeng Shang, Zi Chen, Sara Krause-Elsmore
Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.
Type:
Application
Filed:
January 11, 2007
Publication date:
October 11, 2007
Applicants:
BioDelivery Sciences International, Inc., University of Medicine and Dentistry of New Jersey
Inventors:
Raphael Mannino, Susan Gould-Fogerite, Sara Krause-Elsmore, David Delmarre, Ruying Lu
Abstract: The present invention relates to a solid pharmaceutical dosage form for abusable drug delivery with reduced illicit abuse potential. The dosage form is presented as a bioerodable transmucosal delivery device that includes an abusable drug and an antagonist to the abusable drug associated with an abuse-resistant matrix. The devices of the invention may be in the form of a layered film or a tablet. Upon application in a non-abusive manner, the device adheres to the mucosal surface, providing transmucosal drug delivery of the drug with minimal absorption of the antagonist into systemic circulation.
Type:
Application
Filed:
December 13, 2006
Publication date:
June 28, 2007
Applicant:
BioDelivery Sciences International, Inc.
Abstract: Disclosed are cochleates and cochleate compositions that associated with an replacement enzyme component and/or a plasmid component that encodes a replacement enzyme. Also disclosed are methods of making and using the compositions of the invention, including methods of administration. Use of the invention provides safe, effective and efficient delivery of replacement enzymes and/or plasmids encoding the same in a variety of dosage forms.
Type:
Application
Filed:
February 3, 2005
Publication date:
February 9, 2006
Applicant:
BioDelivery Sciences International, Inc.
Inventors:
Francis O'Donnell, Raphael Mannino, Susan Gould-Fogerite
Abstract: Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions.
Type:
Application
Filed:
April 9, 2004
Publication date:
January 20, 2005
Applicants:
BioDelivery Sciences International, Inc., University of Medicine and Dentistry of New Jersey
Inventors:
Susan Gould-Fogerite, Raphael Mannino, Patrick Ahl, Gaofeng Shang, Zi Chen, Sara Krause-Elsmore
Abstract: The present invention provides geodate delivery vehicles and methods of manufacture and administration. A vehicle including a lipid monolayer disposed about a hydrophobic domain is disclosed, that can be part of an emulsion or other mixture, or further disposed in a lipid strata. A vehicle including a lipid strata disposed about a hydrophobic domain is also disclosed. The vehicle can be incorporated into a variety of medicinal, food preparations, and personal care products to deliver or stabilize a cargo moiety. Packaged delivery vehicles for later addition of cargo moieties are also contemplated.
Type:
Application
Filed:
November 3, 2003
Publication date:
July 29, 2004
Applicant:
BioDelivery Sciences International, Inc.
Inventors:
Raphael J. Mannino, Sara L. Krause-Elsmore, Susan Gould-Fogerite, David Delmarre, Ruying Lu
Abstract: A process for producing a small-sized, lipid-based cochleate. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structures by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca2+ or Zn2+, forms a cochleate precipitate of a particle size less than one micron. The process may be used to produce cochleates containing biologically relevant molecules.
Type:
Application
Filed:
April 23, 2003
Publication date:
December 11, 2003
Applicants:
BioDelivery Sciences International, Inc., University of Medicine and Dentistry of New Jersey
Inventors:
Leila Zarif, Tuo Jin, Ignacio Segarra, Raphael J. Mannino
Abstract: A process for producing a small-sized, lipid-based cochleate. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structures by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca2+ or Zn2+, forms a cochleate precipitate of a particle size less than one micron. The process may be used to produce cochleates containing biologically relevant molecules.
Type:
Grant
Filed:
July 11, 2000
Date of Patent:
July 15, 2003
Assignees:
BioDelivery Sciences International, Inc., University of Medicine and Dentistry of New Jersey
Inventors:
Leila Zarif, Tuo Jin, Ignacio Segarra, Raphael J. Mannino