Abstract: A heart valve implant comprising a supporting stent, a heart valve element, and a skirt. The skirt includes or is formed of at least one molded body, wherein the molded body is made of dried treated bacterial cellulose that has a swelling capacity that is greater than untreated bacterial cellulose of the same type.

Abstract: The invention relates to a heart valve prosthesis including a heart valve a main body for supporting the heart valve. The heart valve includes a terminating material selected from material and configured to at least partially close a paravalvular leak by controlled thrombus development.

Abstract: A heart valve prosthesis (1), including: a stent framework (2), which can be transferred from a collapsed state into an expanded state, in which the stent framework (2) extends along an axis (A?), wherein the stent framework (2) has a plurality of struts (20, 24), which form a plurality of cells (21a, 21b, 25) connected to one another; and a heart valve (3), which is fixed to the stent framework (2). In accordance with the invention, the thickness (d?) of the struts varies in the peripheral direction (U) of the expanded stent framework (2).

Abstract: An adjustable diameter catheter includes a wall extending in an axial direction surrounding a lumen of the catheter, the wall having at least one outer spring and at least one inner spring arranged coaxially to the outer spring. The at least one outer spring surrounds the at least one inner spring. The at least one inner and outer springs each have a distal end which are connected to one another. The at least one inner and outer springs each have a plurality of windings. A winding direction of the at least one outer spring is opposite to a winding direction of the at least one inner spring.

Abstract: A delivery catheter includes an inner shaft having an atraumatic distal catheter tip. The inner shaft is configured to carry the implant thereon. The catheter tip includes a region that is fixed to the inner shaft and a region that is deformable and not fixed to the inner shaft. An outer shaft surrounds the inner shaft and is displaceable relative thereto. An implant capsule at a distal end of the outer shaft is configured to encase the implant and to release the implant at the target site via relative displacement of the inner and outer shafts. A plunger is axially displaceable with respect to the catheter tip in response to movement of the outer shaft to apply axial compressive force to the catheter tip and deform the region that is deformable and expand that region radially.

Abstract: A device for closing the left atrial appendage. The device has a flexible and elongate pulling element fixed to a flexible material layer connected fixed to a self-expanding stent. The closure implant can be drawn back into the lumen of a catheter by the pulling element, and in so doing the stent framework can be transferred into a compressed state. The device enables a monitored and controllable release of the closure implant.

Abstract: A method for preparing tissue, in particular pericardial tissue, in particular for use as a sealing means for a heart valve prosthesis for paravalvular leaks, characterised in that the tissue, in particular pericardial tissue, is decellularized (4), subjected to a cross-linking (6) with a glutaraldehyde-containing solution, and subjected to a shape- and a structure-stabilising step (7, 8, 9). The invention also relates to a heart valve prosthesis.

Abstract: A method for preparing tissue for medical applications, including decellularizing the tissue by means of a detergent, characterized in that the decellularizing detergent contains at least one amphiphilic lipopeptide; treating the decellularized tissue with an ?-galactosidase; and cross-linking the collagen fibers of the treated tissue by means of a suitable cross-linking agent.

Abstract: An implant with an open-worked, hollow cylindrical main structure composed of a multiplicity of crosspieces, wherein the implant adopts a compressed state and an expanded state. So as to achieve a greater level of radial rigidity and an increased collapse pressure in the expanded state compared to conventional implants, wherein the deliverability is not adversely affected at the same time, the density of the crosspieces in the expanded state is greater than the density of the crosspieces in the compressed state, at least in one portion of the implant. The invention further provides a system including a catheter with a balloon and an implant of the type disclosed above.

Abstract: Some invention embodiments relate to an implant having a base body composed of a biocorrodible magnesium alloy and a polylactide coating. The implant is characterized in that the coating contains seed crystals and/or lipophilic substances as additives.

Abstract: Packaging has an outer sleeve, which surrounds an interior space for receiving an object, such as a sterilized medical implant. A separate container is arranged in the interior space and surrounds an absorber in a gas-tight manner, such that a gas present in the interior space cannot pass to the absorber. The container is configured to be opened by the application of force when the outer sleeve is closed, such that a gas disposed in the interior space can pass to the absorber and can be absorbed thereby. In preferred embodiments, the absorber absorbs air with the reactive constituents O2 and/or H2O. Depending on the application, however, other gases can also be absorbed by the absorber. A method for packaging is also provided.

Abstract: A delivery catheter for implanting a self-expanding implant such as a cardiovascular implant. An outer catheter shaft is formed as an implant capsule for encasing the implant during delivery. A flexible distal support element having a substantially truncated cone-shaped portion, which tapers in the proximal direction, is attached, directly proximally of the implant, in a fixed position to a first, inner catheter shaft, and/or a flexible proximal support element having a substantially truncated cone-shaped portion, which tapers in the proximal direction, is inserted at the proximal end of the implant capsule into the second, outer catheter shaft in a fixed position.

Abstract: A method of preparing biological tissue for use as a component of an implant, in particular as part of a heart valve prosthesis, which can be implanted by catheter. The biological tissue is subjected to a dimensional and structural stabilization step and is dried. For the dimensional and structural stabilization, a combination of a first, polyethylene glycol-containing solution and at least one second, glycerol-containing solution is used.

Abstract: A medical valve implant comprising: an implant structure configured as a medical valve; and a base body that includes a collar extending in a circumferential direction around the implant structure, wherein the collar includes a first cell structure composed of a plurality of cells forming an inner cross section of the base body that is matched to an outer cross section of the implant structure, characterized in that the collar includes a second cell structure fastened to an inner contour of a cell of the first cell structure at two fastening points and configured to move radially outward relative to the first cell structure so that an outer contour of the base body is formed by the first cell structure and the second cell structure.

Abstract: An implant includes a biocorrodible metallic material having a coating. The coating contains at least one layer in which ionic channels are embedded.

Abstract: A magnesium alloy includes 3 to 7.0% Zn, 0.001 to 0.5% Ca, the remainder being magnesium containing impurities, which promote electrochemical potential differences and/or the formation of intermetallic phases, in a total amount of no more than 0.005 of Fe, Si, Mn, Co, Ni, Cu, Al, Zr and P, wherein the alloying elements are selected from the group of the rare earths having the ordinal numbers 21, 39, 57 to 71 and 89 to 103 in a total amount of no more than 0.001% by weight.

Abstract: A magnesium alloy includes <3% by weight of Zn, ?0.6% by weight of Ca, with the rest being formed by magnesium containing impurities, which favor electrochemical potential differences and/or promote the formation of intermetallic phases, in a total amount of no more than 0.005% by weight of Fe, Si, Mn, Co, Ni, Cu, Al, Zr and P, wherein the alloy contains elements selected from the group of rare earths with the atomic number 21, 39, 57 to 71 and 89 to 103 in a total amount of no more than 0.002% by weight.

Abstract: A method for increasing the fatigue strength of a tubular semifinished product for a medical implant, a tubular semifinished product for a medical implant having improved fatigue strength, and a medical implant produced from such a semifinished product.