Abstract: Medical systems are described, including a medical system that includes a sheath with at least one lumen configured to be coupled to a suction source, an irrigation device that includes at least one irrigation lumen configured to be coupled to an irrigation source, and a medical device that includes a handle and a shaft. The shaft may include a working channel with a distal opening, one or more illumination devices, and one or more visualization devices. The medical device may be configured to be positioned within the sheath during delivery of the sheath to a treatment site and during an application of energy to break up one or more objects to form one or more particles or dust. The irrigation device may be configured to be positioned within the sheath and deliver irrigation fluid while suction is applied to the treatment site.

Abstract: The present disclosure relates to injectable compositions sterile injectable fluid compositions comprising a polysaccharide having a color in the visible spectrum, methods of forming the same, kits containing the same, and methods for performing agent-assisted procedures in a patient using the same.

Abstract: An implantable medical device includes an expandable frame that is expandable between a collapsed configuration for delivery and an expanded configuration for deployment, the expandable frame including a periphery defined by the expandable frame. A covering spans at least part of the expandable frame. An expandable element is secured relative to the periphery, the expandable element is adapted to seal against an irregular body opening such as an irregular-shaped ostium of a patient's LAA (left atrial appendage).

Abstract: A vapor delivery needle is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, denaturate the prostate. In some embodiments, the vapor delivery needle can be advanced a predetermined distance into the prostate with a solenoid actuation mechanism. Methods associated with use of the energy delivery probe are also covered.

Abstract: Methods and systems for providing a flow of fluid to an endoscope. An illustrative container and tube set arranged and configured to couple to an endoscope may comprise, a first container configured to contain a fluid, a first water supply tube including a first lumen extending therethrough and in fluid communication with the first container, a branched connector positioned in line with first water supply tube and including a first fluid inlet, a first fluid outlet, and a second fluid outlet, a second container having a second fluid inlet in selective fluid communication with the second fluid outlet of the branched connector, a second water supply tube including a second lumen extending therethrough and in selective fluid communication with the bottom portion of the second container, and a first gas supply tube in operative fluid communication with the second container.

Abstract: An illustrative mechanical thrombectomy system may comprise an outer catheter extending from a proximal end to a distal end and defining a first lumen extending therethrough and an inner sheath extending from a proximal end to a distal end and defining a second lumen extending therethrough. The inner sheath may be slidably disposed within the first lumen of the outer catheter. An inner shaft may be slidably disposed within the second lumen of the inner sheath and an expandable anchor mechanism may be coupled to the distal end region of the inner shaft. The expandable anchor mechanism may be configured to move between a collapsed delivery configuration and an expanded configuration.

Abstract: A system includes a first tube, a sharp coil at a distal end of the first tube, a second tube displaceable within the first tube, and a sharp housing at a distal of the second tube for storing fasteners. The housing can be positioned at a first tissue, and the coil rotated to advance the coil into engagement with the first tissue. The first tube is retracted to retract the first tissue, and then a first fastener is deployed at the first tissue location. Then, without removing the system from the patient, the distal end of the system is moved adjacent a second tissue location, and the process is repeated for a second fastener at the second tissue location. A suture extends between the first and second fasteners, and tension is applied to the suture to draw the first and second tissues toward each other to reconfigure the tissue.

Abstract: A retrieval device attachable to a scope includes a handle which has an attachment portion configured to couple the handle to the scope; a shaft coupled to the handle having a wire immovably coupled to the handle; and a sheath movable relative to the handle over the wire between a distal position and a proximal position via an actuator of the handle. The actuator actuates a slider assembly of the handle. The slider assembly is coupled to the sheath and movable relative to the attachment portion to move the sheath and an expandable end effector coupled to the distal end of the wire. The end effector is movable between a collapsed configuration when the sheath is moved distally to the distal position to cover the end effector and an expanded configuration when the sheath is moved proximally to the proximal position, uncovering the end effector.

Abstract: A system includes an adapter and an insertion device. The device includes a shaft extending longitudinally from a proximal end to a distal end. The shaft includes first and second working channels extending therethrough. The adapter includes a proximal portion coupled to the distal end and a distal portion defining a chamber receiving a stone. The proximal portion includes an outlet extending through a portion thereof positioned so that, when the adapter is in desired alignment, a fluid supplied to the first channel is directed out of the adapter via the outlet to an area surrounding the adapter. The adapter further includes an inlet channel extending longitudinally through the proximal portion to a distal opening which is open to the chamber. The inlet channel is configured so that, when negative pressure is applied thereto, the fluid is drawn through the distal opening through the inlet channel to the second channel.

Abstract: Medical devices and systems for treating a stricture, for example along the biliary and/or pancreatic tract, are disclosed. An example system may include a guidewire having a distal end and defining a lumen. A stiffening rod may be slidably disposed within the lumen. The stiffening rod may have a distal end and a distal end region disposed adjacent to the distal end. The stiffening rod may be configured to shift between a first position where the distal end of the stiffening rod is disposed proximally of the distal end of the guidewire and a second position where the distal end of the stiffening rod is disposed distally of the distal end of the guidewire.

Abstract: An example medical device includes a handle, an actuation mechanism coupled to the handle, and a delivery needle, wherein a proximal end of the delivery needle is coupled to a first end of the handle. A fluid delivery device is coupled to a second end of the housing, and a retractable sensor is positioned within the handle. The retractable sensor is configured to extend distally through a lumen of the delivery needle in a non-retracted position during placement of the delivery needle within a body of a patient, wherein actuation of the actuation mechanism causes the retractable sensor to retract proximally through the lumen of the delivery needle into the handle to a retracted position.

Abstract: An alignment tool includes a body and a plurality of securement arms extending from the body, each of the plurality of securement arms adapted to releasably secure the alignment tool relative to a loader. The alignment tool includes a plurality of alignment arms extending from the body, each of the plurality of alignment arms including a first end having an alignment slot and an opposing second end including a handle portion, the plurality of alignment arms movable between a closed configuration defining a minimum distance between the first end of each of the plurality of alignment arms and an open configuration defining a maximum distance between the first end of each of the plurality of alignment arms. The plurality of alignment arms are biased into the closed configuration.

Abstract: A gastric bypass device includes an occlusion device that is adapted to be deployed relative to a patient's pyloric sphincter and a liner that extends distally from the occlusion device. A tether extends from the occlusion device. A dynamic leash may be secured relative to the occlusion device and may work in conjunction with the tether to help hold the occlusion device in place.

Abstract: A gastric bypass device includes an occlusion device that is adapted to be deployed relative to a patient's pyloric sphincter, an anastomosis anchor that is adapted to be deployed relative to an anastomosis between the patient's stomach and their small intestine, and a tether that extends through the patient's small intestine between the occlusion device and the anastomosis anchor. A dynamic leash may be secured relative to the occlusion device and may work in conjunction with the tether to help hold the occlusion device in place. The gastric bypass device may be deployed using a variety of methods including a push-pull wire method, a rail method, a garage method, a two-piece method and a comprehensive method.

Abstract: A system includes a scope device, an adapter and an outer sheath. The device includes a scope cap and a shaft extending longitudinally from a proximal end to a distal end. The shaft includes a working channel. The cap is coupled to the distal end such that cap's inlet opening is in communication with and in alignment with the channel. The adapter has a substantially tubular body mountable over the cap such that a distal chamber defined via the adapter and the cap is open to and in communication with the opening thereof so that, when a negative pressure is applied through the channel, a suction force applied is applied through the distal chamber to draw the stone one of into and against the chamber from the area. The sheath delivers a fluid to the area via a space extending between sheath's interior and shaft's exterior.

Abstract: A clipping system includes an adapter configured to be mounted over an insertion device and a clip including first and second jaws movable between an insertion configuration and an initial deployed configuration. A first extending member is releasably coupled to the clip and movably connected to the adapter to permit a movement of the clip relative to the adapter from the insertion configuration to the initial deployed configuration. The first extending member is configured to permit withdrawal of the adapter away from the clip to place the system in a review configuration to enhance a visual observation of the clip. The first extending member is operable to retract the clip over the adapter so that the clip is forced open, freeing the clip from tissue on which it has been clipped. The first extending member is configured to release the clip therefrom in a final deployed configuration.

Abstract: The disclosure relates to systems and methods for irrigated bipolar radiofrequency ablation. Some examples of the system include an elongate inner electrode assembly and an elongate outer electrode assembly. An irrigation path for irrigation fluid flow is defined between the outer surface of the inner electrode assembly and the outer surface of the outer electrode assembly.

Abstract: Aspiration medical devices and methods for making and using aspiration medical devices are disclosed. An example aspiration medical device may include a catheter shaft having a distal end region and defining an inflow orifice adjacent to the distal end region. An aspiration member may be disposed within the catheter shaft. The aspiration member may have a plurality of axially-spaced fluid jets formed therein. A collar may be disposed over the aspiration member. The collar may have a jet support region disposed adjacent to at least one of the fluid jets and a wall support region disposed adjacent to a wall of the catheter shaft.

Abstract: A medical device system may include an elongate shaft having a lumen extending from a proximal end to a distal end, a proximal release wire, and a distal release wire. The proximal release wire may extend distally from a proximal end configured to remain outside the body to a distal end and may be slidably disposed within the lumen of the elongate shaft. The proximal release wire may include a distal stopper coupled to the distal end thereof. The distal release wire may extend distally from a proximal end to a distal end and may be slidably disposed within the lumen of the elongate shaft. The proximal end of the distal release wire may be slidably coupled to the distal end of the proximal release wire. The distal release wire may be configured to releasably attach a medical device to the distal end of the elongate shaft.