Patents Assigned to Capitalbio Corporation
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Publication number: 20140010733Abstract: An interface device for bio-chip at least comprises an interface unit, said interface unit consisting of instrument interface layer, fluid channel layer and sample interface layer. The instrument interface layer has at least one instrument interface. The fluid channel layer has one hollow-out fluid channel. The sample interface layer has at least one sample interface, and both ends of said fluid channel connect to the sample interface and the instrument interface respectively. The interface device separates sample solutions from the instrument interface by gas or liquid in the fluid channel, thus to avoid direct contacts between sample solutions and instrument interface which will cause pollution, and omitting cleaning processes after using instruments. With simple structure, easy operation and low cost, it applies to chemistry field, biology field and medical analysis field.Type: ApplicationFiled: February 10, 2012Publication date: January 9, 2014Applicants: TSINGHUA UNIVERSITY, CAPITALBIO CORPORATIONInventors: Jiaming Ye, Pinhong Wang, Guoqing Wang, Wanli Xing
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Publication number: 20140011707Abstract: A hybridization system is provided, which comprises a biological chip having a substrate (1) with a probe dot matrix (3) and a cover plate (2) with at least two through-holes (4), where a hybrid chamber (5) is formed between the substrate (1) and the cover plate (2), at least two fluid channels (6) are interconnected respectively with the hybrid chamber (5) by the two through-holes (4), and a fluid control device is interconnected with the fluid channels (6). The biological chip hybridization system integrates hybridizing, cleaning and drying functions, uses power provided by the fluid control device as the drive force for promoting the liquid flow for automatically reciprocation flow in the fluid channels (6) and the chamber (5) to achieve a dynamic hybridization, thus improving the hybrid efficiency and uniformity, and achieving automatic control.Type: ApplicationFiled: February 10, 2012Publication date: January 9, 2014Applicants: TSINGHUA UNIVERSITY, CAPITALBIO CORPORATIONInventors: Jiaming Ye, Pinhong Wang, Guoqing Wang, Liqing Duan, Kaijun Zhao, Jinxiu Zhang, Xiumei Song, Dong Wang, Huafang Gao, Wanli Xing
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AUTOMATIC INJECTION DEVICE FOR MICROARRAY CHIP AND AUTOMATIC INJECTION HYBRIDIZATION MICROARRAY CHIP
Publication number: 20140011703Abstract: An automatic injection device comprises at least an injection unit (1). The said injection unit (1) is formed by sealing a cover plate layer (3) with hydrophilic surfaces and a microfluid layer (4). The said cover plate layer (3) is provided with at least two through holes (5). he said microfluid layer (4) is provided with a hollow-out hybridization chamber (7) and at least two hollow-out microfluid channels (6). One end of each channel (6) is connected with the hybridization chamber (7), and the other end is connected with a through hole (5) of the cover plate layer (3) respectively. Taking advantage of the hydrophilicity of the cover plate, the automatic injection device makes a solution automatically enter and fill the hybridization chamber (7) and the microfluid channels (6) by the driving force of liquid surface tension. The flow uniformity of sample solution in microarray chip is achieved by the structural design of the hybridization chamber (7) and the microfluid channels (6).Type: ApplicationFiled: February 10, 2012Publication date: January 9, 2014Applicants: TSINGHUA UNIVERSITY, CAPITALBIO CORPORATIONInventors: Jiaming Ye, Pinhong Wang, Guoqing Wang, Wanli Xing -
Patent number: 8603750Abstract: The present invention provides apparatus, kits and methods for assaying analytes using photoelectrochemical molecules as labels. Specifically, the present invention provides a method for assaying an analyte, comprising: a) contacting a sample suspected of containing an analyte with a reactant capable of binding and/or reacting with the analyte under suitable conditions to allow binding of analyte, if present in the sample, to the reactant; and b) assessing binding and/or reacting between the analyte and the reactant to determine presence and/or amount of analyte in the sample, wherein the reactant, analyte, or additional reactant or additional analyte or analyte analog is labeled with a photoelectrochemically active molecule.Type: GrantFiled: May 6, 2003Date of Patent: December 10, 2013Assignees: CapitalBio Corporation, Tsinghua UniversityInventors: Lianghong Guo, Dong Dong, Dong Zheng, Fuquan Wang, Xiqiang Yang, Jing Cheng
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Patent number: 8597592Abstract: An apparatus and methods for the precise, repeatable dispensing of small, sample fluid volumes, especially as related to the printing of microarrays for biological and/or chemical testing. A pressure tuning module meters fluid volumes for aspiration and dispensation and builds pressure for fluid dispensation, in conjunction with a microvalve that precisely controls the volume of the fluid dispensed under the built pressure. A pressure source can be switched in line to efficiently purge the apparatus of residual sample fluid. A working fluid can be optionally aspirated into the system, prior to aspirating the sample fluid, in order to maximize sample fluid recovery.Type: GrantFiled: January 13, 2006Date of Patent: December 3, 2013Assignees: CapitalBio Corporation, Tsinghua UniversityInventors: Dong Wang, Kun Zou, Jing Cheng
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Patent number: 8540416Abstract: The present invention provides a device for handling fluids, and more particularly a merging apparatus for fluidic and microfluidic devices utilizing passive valving in conjunction with a single sensor to uniformly blend contributory working fluid streams. Symmetric and non symmetric embodiments with and without branch channels are described. The present invention also provides methods for merging liquids using the device of the invention.Type: GrantFiled: February 6, 2007Date of Patent: September 24, 2013Assignees: Capitalbio Corporation, Tsinghua UniversityInventors: Xiaosheng Guan, Min Guo, Cheng Zhou, Yuming Hu, Jing Cheng
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Publication number: 20130244270Abstract: The present invention relates to a microfluidic device used for cell motility screening and chemotaxis testing which comprises microfluidic channels and chambers. Cells which can secret a chemoattractant or chemorepellent are selectively planted in the microfluidic device and a stable chemoattractant or chemorepellent gradient can be established in the channels.Type: ApplicationFiled: August 10, 2011Publication date: September 19, 2013Applicants: Tsinghua University, CapitalBio CorporationInventors: Lan Xie, Rui Ma, Chao Han, Wanli Xing, Jing Cheng
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Publication number: 20130217584Abstract: A microarray-based assay is provided, which is used for analyzing molecular interactions, including polynucleotides, polypeptides, antibodies, small molecule compounds, peptides and carbohydrates. Such method comprises coupling a target molecule to a particle and then binding to a probe molecule on microarray. In particular, multiplexed genetic analysis of nucleic acid fragments can be implemented. Specific genes, single nucleotide polymorphisms or gene mutations, such as deletions, insertions, and indels, can be identified. Coupled with microarray, the particles, themselves or further modified, facilitate the detection of results with non-expensive devices or even naked eyes. This technology enables the detection and interpretation of molecular interactions in an efficient and cost effective way.Type: ApplicationFiled: August 6, 2010Publication date: August 22, 2013Applicants: Tsinghua University, CapitalBio CorporationInventors: Guanbin Zhang, Guangxin Xiang, Wanli Xing, Jing Cheng
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Publication number: 20130210675Abstract: Provided are compositions for controlled release of biomolecules, which comprise conjugates of polymers and biomolecules conjugated through non-covalent interactions. Also provided are methods for controlled release of biomolecules and their use in biochips.Type: ApplicationFiled: July 13, 2011Publication date: August 15, 2013Applicant: CapitalBio CorporationInventors: Su Guo, Guoqing Wang, Guohao Zhang, Can Wang, Bei Han, Miao Liu, Jinxiu Zhang, Tao Deng, Wanli Xing, Jing Cheng
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Publication number: 20130204076Abstract: An integrated microfluidic device and its usage are provided. The microfluidic device comprises an upper layer (1) and a lower layer (2), wherein the lower layer (2) is bound to the upper layer (1). The upper layer (1) comprises a micro-channel (3) and the lower layer (2) comprises a micro-well (7) array. The micro-channel (3) is in fluidic connection with the micro-well (7) array, and the height of the micro-channel (3) is greater than the diameter of the oocyte (4) flowing through the micro-channel (3). The integrated microfluidic device has many advantages including low cost, high integration, and convenient operation, and has application prospects in reproductive medicine and the research of fertilization and embryo early development.Type: ApplicationFiled: June 17, 2011Publication date: August 8, 2013Applicants: Tsinghua University, CapitalBio CorporationInventors: Chao Han, Guoliang Huang, Jing Cheng
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Publication number: 20130203611Abstract: An automatic slide loading device for microarray scanner comprises slide holders (1), a carrier device (2) and a positioning chamber (3), wherein the slide holder (1) can hold microarray slides (6) and the slide holder (1) is placed out of the scanning platform of the microarray scanner when the microarray scanner is in off work state, wherein the carrier device (2) is connected to the positioning chamber (3) and the carrier device (2) can load the slide holder (1) into the positioning chamber (3), wherein the positioning chamber (3) is placed above the scanning platform of the microarray scanner and is used to precisely locate the working surface of the microarray slides (6) in the slide holder (1).Type: ApplicationFiled: August 5, 2011Publication date: August 8, 2013Applicants: Tsinghua University, CapitalBio CorporationInventors: Hang Li, Huihui Teng, Danyang Mei, Wenjun Wang, Gang Li, Xiaokun Qin, Zhengde Feng, Dong Wang, Jing Cheng
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Patent number: 8353685Abstract: This invention relates generally to the field of peristaltic pump. In particular, the invention provides a peristaltic pump, which peristaltic pump comprises, inter alia, an actuating part, a cartridge part comprising at least three chambers and mechanisms for controlling movement of the actuating part to and from the cartridge part to control opening or closing of the inlet and outlet to the chamber(s).Type: GrantFiled: July 14, 2003Date of Patent: January 15, 2013Assignees: Capitalbio Corporation, Tsinghua UniversityInventors: Chengxun Liu, Min Guo, Jing Cheng
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Patent number: 8293519Abstract: This invention relates generally to the field of microarray chips and uses thereof. In particular, the invention provides a microarray reaction device that can be used in assaying the interaction between various moieties, e.g., nucleic acids, immunoreactions involving proteins, interactions between a protein and a nucleic acid, a ligand-receptor interaction, and small molecule and protein or nucleic acid interactions, etc. Articles of manufacture and kits comprising the microarray reaction device and assaying methods using the microarray reaction device are also provided.Type: GrantFiled: August 13, 2003Date of Patent: October 23, 2012Assignees: Capitalbio Corporation, Tsinghua UniversityInventors: Feijun Xian, Wanli Xing, Jing Cheng, Dong Liang, Liang Zhang, Dong Wang
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Patent number: 8273309Abstract: The present invention relates to a wicking inhibitor for fluidic and microfluidic devices that reduces wicking by providing a structure that interrupts the flow of a working fluid through a fluidic channel interface having corner angles greater than ninety degrees.Type: GrantFiled: December 15, 2006Date of Patent: September 25, 2012Assignees: Capitalbio Corporation, Tsinghua UniversityInventors: Xiaosheng Guan, Min Guo, Cheng Zhou, Yuming Hu, Jing Cheng
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Patent number: 8137622Abstract: A device for biochip hybridization or washing is provided, which comprises a carousel (12), a translational movement controller, a revolving movement controller, and optionally a heating chamber (13). The revolving movement controller controls the revolving movement of the carousel and allows it to move in a wobbling fashion, allowing liquid movement of the hybridization or washing boxes (11) during hybridization and/or washing of biochips on the carousel. The translational movement controller brings the carousel back to horizontal position once the revolving movement controller stops, thereby ensures that the liquid do not spill out. The heating chamber circulates hot air within the device, thereby ensures that the hybridization and washing in a thermostatic condition.Type: GrantFiled: October 9, 2007Date of Patent: March 20, 2012Assignees: CapitalBio Corporation, Tsinghua UniversityInventors: Hang Li, Jianxin Ye, Xingling Al, Xianhua Wang, Liang Zhang, Jing Cheng
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Patent number: 8124382Abstract: The present invention provides kits and microarrays containing primer pairs for amplifying drug resistance genes and/or probes for detection of drug resistance genes. Also provided are methods of detecting drug resistance genes using kits and microarrays described herein.Type: GrantFiled: January 18, 2007Date of Patent: February 28, 2012Assignees: CapitalBio Corporation, Tsinghua UniversityInventors: Lingxiang Zhu, Zhiwei Zhang, Di Jiang, Ning Du, Can Wang, Huawei Yang, Qiong Zhang, Huafang Gao, Yuxiang Zhou, Jing Cheng
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Patent number: 8033976Abstract: The invention provides an apparatus for separating a multiphase mixture into discrete density phases, comprising a circular bowl rotatable about a central axis and having an opening through which the mixture is introduced into the bowl, whereby the rotation of the bowl separates the mixture to form annular columns of the discrete density phases; a delivery conduit inserted into the bowl through the opening for introducing the mixture into the bowl; and a collection assembly for removing the separated discrete density phases, comprising a collection conduit for collecting the annular columns, a waste collecting conduit, and a cleaning conduit. The collection assembly is movable as a single unit with respect to the bowl such that it can be positioned within the bowl to sequentially, selectively and individually remove the annular columns from the bowl while the bowl is rotating substantially without disturbing the remaining annular columns within the bowl.Type: GrantFiled: September 30, 2004Date of Patent: October 11, 2011Assignees: CapitalBio CorporationInventor: Keith Richard Mitchelson
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Patent number: 8003063Abstract: The invention is directed to microfluidic devices comprising at least two processing channels, wherein each of the processing channels comprises an inlet, an outlet, and a high-flow-resistant and hydrophilic conduit; a distributing channel, wherein the distributing channel comprises an upstream end and a downstream end, and is in fluid communication with each inlet of the processing channels via the high-flow-resistant and hydrophilic conduit; and a flushing channel, wherein the flushing channel comprises an upstream end and a downstream end, and is in fluid communication with each outlet of the processing channels. The invention also provides methods of using the microfluidic devices.Type: GrantFiled: March 9, 2007Date of Patent: August 23, 2011Assignees: CapitalBio Corporation, Tsinghua UniversityInventors: Xiaosheng Guan, Min Guo, Rong Zhang, Dong Dong, Yuming Hu, Ting Cui, Jing Cheng
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Patent number: 7939035Abstract: The present invention provides a sample preparation device for extracting drug residue. It comprises a case, in which a water bath, a vortex mixer, and a homogenizer are integrated. The case also has on it an integrated control panel for controlling heating temperature of the water bath and homogenization time of the homogenizer.Type: GrantFiled: November 22, 2004Date of Patent: May 10, 2011Assignee: Capitalbio CorporationInventors: Renyuan Chen, Guoqing Wang, Feijun Xian, Wanli Xing, Xianhua Wang, Jing Cheng
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Patent number: 7928357Abstract: The invention provides a scanning platform for high speed scanning of microarrays. The platform uses a novel flexible a metal strip/wheel linear driving system to convert rotary movement of motors into linear movement, thereby drives movement of a stage/microarray in the direction of scanning. The platform of the present invention provides high movement speed, high resolution, and low return deviation. It is also simple in structure and low in manufacturing cost.Type: GrantFiled: June 2, 2005Date of Patent: April 19, 2011Assignee: CapitalBio CorporationInventors: Xianhua Wang, Hui Zhu, Guoliang Huang, Jing Cheng