Abstract: A method of creating a reperfusion injury can include: providing a cell culture device having an internal chamber with at least one port coupled to a perfusion modulating system capable of modulating perfusion in the internal chamber, wherein the internal chamber includes a cell culture; perfusing a fluid through the internal chamber with the perfusion modulating system, wherein the perfusion modulating system includes at least one pump; reducing fluid flow through the internal chamber; reperfusing fluid flow through the internal chamber; and creating a reperfusion injury in the cell culture by the reperfusion of the fluid flow through the internal chamber. The cell culture includes at least one type of tissue cell. The cell culture can include a tissue construct formed of hydrogel and/or extracellular matrix.

Abstract: The present invention includes systems and methods for providing cybersecurity to web-enabled applications for protection of critical software and host systems. The present invention is operable to build a Hidden Markov model of an application using automated analysis of code and documentation in order to characterize potential state and state transitions. The present invention is also operable to use additional data such as timing and proximity to assess incoming data. Incoming messages are then assigned a trust score based on Bayesian calculations.

Abstract: In an aspect, the disclosure pertains to inhibitors of ANGPTL4; synthesis methods for making disclosed compounds; pharmaceutical compositions comprising disclosed compounds; methods of treating disorders of uncontrolled cellular proliferation, e.g., a cancer; and methods of treating a disease associated with an ANGPTL4 dysfunction using disclosed compounds and pharmaceutical compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: A method of producing electrical power includes: a cathode having a porphyrin precursor attached to a substrate, and having a first enzyme, wherein the first enzyme reduces oxygen; an anode having a first region of an anode substrate and having a gold nanoparticle composition located thereon, and having a second region of the anode substrate having an enzyme composition located thereon, wherein the enzyme composition includes a second enzyme, wherein the first region and second region are separate regions; and a neutral fuel liquid in contact with the anode and cathode, the neutral fuel liquid having a neutral pH and a fuel reagent; and operating the fuel cell to produce electrical power with the neutral fuel liquid having the neutral pH and the fuel reagent.

Abstract: A modular surrogate can include: a body having an external body surface with an anatomical shape, wherein the body includes an internal chamber with at least one port formed in the body extending inwardly; at least one anatomical module having an external module portion and a module stem coupled thereto, the module stem being received into a corresponding module port of the at least one port, the external module portion having an external module surface with an anatomical shape, the external body surface matches with the external module surface to provide a continuous anatomical shape; at least one sensor located in the at least one anatomical module; and at least one controller, wherein when the at least one anatomical module is coupled with the body, the at least one sensor is capable of being operably coupled with the at least one controller.

Abstract: A door breach device can include: an elongate shaft having a first end and an opposite second end; a pivot mechanism at the first end of the shaft; a spearhead rotatably coupled with the pivot mechanism and having a tip on a tip-side of the pivot mechanism and having a shaft cavity on a shaft-side, where the shaft cavity is adapted to receive the shaft therein; a restraint slidably received on the shaft-side of the spearhead and on the shaft; a handle protruding from the shaft; and a hitch at the second end of the shaft. A method of breaching a door can include: forcing the spearhead through a door until the restraint releases the spearhead and the spearhead rotates by the pivot mechanism so as to form an angle with the shaft; and pulling the spearhead against the door until the door is breached.

Abstract: A method for providing a therapy to a subject that has been exposed to an Aflatoxin B1 can include administering a compound having a structure of Formula 1 to the subject after exposure to the Aflatoxin B1: wherein: R1, R2, R3, R4, R5 and/or R6 are each individually a chemical moiety and n is 1, 2, 3, 4, or 5. The compound can be Amprenavir or a derivative thereof, prodrug thereof, salt thereof, or stereoisomer thereof, or having any chirality at any chiral center, or tautomer, polymorph, solvate, or combination thereof. The prodrug can be Amprenavir phosphate.

Abstract: A passive non-linear earplug can include: a tapered body having a channel extending from a wider distal end to a narrower proximal end, the tapered body having shape memory and size adapted for being received into an ear canal of a human subject; and a disk attached to the wider distal end of the tapered body, the disk having one or more holes aligned with the channel. A structural tube can be located in the channel. A handle can be attached to the tapered body and/or disk. An annular member can be coupled to the disk opposite of the tapered body, the annular member having an aperture that at least partially aligns with the channel. A tube member can be coupled to the disk opposite of the tapered body. The earplug can attenuate loud sounds while allowing normal sounds to be heard, which provides for the non-linearity.

Abstract: A method of selectively inhibiting pathogenic microbes includes: providing a compound that is functional as a selective antimicrobial having a structure of Formula 1, or derivative thereof, salt thereof, or stereoisomer thereof, or having any chirality at any chiral center, or tautomer, polymorph, solvate, or combination thereof; and contacting a pathogenic microbe with the compound such that the pathogenic microbe is selectively inhibited; wherein: ring A is a cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or polycycle combination thereof; X is S, SO, or SO2; Y is a linker or bond; Z is CH, CR2, or N; Z1 is C or N to form an imidazopyridine; each Z2, Z3, or Z4 is independently CH, CR2, or N; each Z5 or Z6 is C or CH; each R1, R2, R3 and/or R4 is independently a substituent; m is 0, 1, 2, 3, or 4; and n is zero or a positive integer.

Abstract: A method of calculating blast injury metrics in a weapon training/IED blast scene can include: reconstructing topological layout of the scene having at least one real subject and a blast source; obtaining anthropometric and posture data for each real subject; obtaining anatomical soldier model for each real subject; identifying real position of at least one real pressure sensor on each soldier during a blast; positioning a virtual sensor on each anatomical soldier model to correspond with real pressure sensor on the real subject; calculating weapon signature of the blast source, the weapon signature including pressure versus time for a blast from the blast source; generating simulated pressure traces on each anatomical soldier model at east virtual pressure sensor; calculating blast injury metrics for the at least one real subject; and generating a report that includes the blast injury metrics for the at least one real subject.

Abstract: An anode can include: an electrode substrate; a first region of the substrate having a catalyst composition located thereon, wherein the catalyst composition includes an inorganic or metallic catalyst; and a second region of the substrate having an enzyme composition located thereon, wherein the combination of the catalyst composition and enzyme composition converts a fuel reagent to carbon dioxide at neutral pH. The first region and second region can be separate regions. The catalyst of the catalyst composition can include gold nanoparticles. The catalyst can include an inorganic or metallic catalyst selected from vanadium oxide, titanium (III) chloride, Pd(OAc)2, MnO, zeolite, alumina, graphitic carbon, palladium, platinum, gold, ruthenium, rhodium, iridium, or combinations thereof. The catalyst can be nanoparticle, nanorod, nanodot, or combination thereof. The catalyst can have sizes that range from about 10 to 20 nm.

Abstract: A cathode can include: an electrode substrate; a porphyrin precursor attached to the substrate; and an enzyme coupled to the electrode substrate to be associated with the porphyrin precursor, the enzyme reduces oxygen. The cathode can include a conductive material associated with the porphyrin precursor and/or the enzyme. The cathode can include 1-pyrenebutanoic acid, succinimidyl ester (PBSE) associated with the porphyrin precursor and/or the enzyme and/or the conductive material. The cathode can include 2,5-dimethyl-1-phenyl-1H-pyrrole-3-carbaldehyde (DMY-Carb) associated with the 1-pyrenebutanoic acid, succinimidyl ester (PBSE) and/or the porphyrin precursor and/or the enzyme and/or the conductive material. The porphyrin precursor is attached to the substrate through covalent coupling.

Abstract: An electrolyte composition can be capable of becoming molten when heated sufficiently. The electrolyte can include at least one lithium halide salt; and at least one lithium non-halide salt combined with the at least one lithium halide salt so as to form an electrolyte composition capable of becoming molten when above a melting point about 350° C. A lithium halide salt includes a halide selected from F and Cl. A first lithium non-halide salt can be selected from the group consisting of LiVO3, Li2SO4, LiNO3, and Li2MoO4. A thermal battery can include the electrolyte composition, such as in the cathode, anode, and/or separator region therebetween. The battery can discharge electricity by having the electrolyte composition at a temperature so as to be a molten electrolyte.

Abstract: A system for reconstruction of an explosion blast loading on a subject can include at least two pressure sensors and a computing system configured to: receive sensor data from the at least two pressure sensors, the sensor data being generated in response to an explosion blast wave; compute an explosion location and explosive charge mass of an explosive that caused the explosion blast wave based on the sensor data; and compute explosion blast loading on a subject from the explosion location and explosive charge mass. The pressure sensors can be configured as wearable pressure sensors or on equipment. The computing of the explosion location and explosive charge mass includes processing the sensor data through an inverse problem solver (IPS); and/or the computing of the explosion blast loading on the subject includes simulating the explosion blast wave with a forward problem solver (FPS).

Abstract: A method of inducing ischemia includes: providing a cell culture device having a first cell culture in an internal chamber and a second cell culture in at least one fluid channel and a perfusion modulating system that causes changes in oxygen flow in the internal chamber and/or at least one fluid channel; flowing liquid media having oxygen through the internal chamber and at least one fluid channel of the cell culture device; modulating oxygen perfusion in the internal chamber with the perfusion modulating system by varying and selectively blocking the flow rate of at least one of the liquid media or oxygen through the internal chamber to induce varying levels of ischemia; and assaying for ischemia in the first cell culture.

Abstract: A method of assaying metastasis can include: providing a device of one of the embodiments; introducing the at least one cancer cell into the at least one internal chamber or at least one fluid channel; and studying metastasis of the at least one cancer cell. Optionally: introducing cancer cells into a first internal chamber; detecting escape of the cancer cell from the first internal chamber into the fluid channel; detecting migration of the cancer cell through the fluid channel; detecting adhesion of the cancer cell to a coating on the fluid channel; detecting invasion of the cancer cell into a second internal chamber from the fluid channel; or visualizing metastasis of the cancer cell with a visualization device.

Abstract: A thermal battery can include: an anode of lithium alloy; a metal-fluoride cathode having Ni; and an electrolyte composition in contact with the anode and cathode. The electrolyte composition can be a tertiary electrolyte composition of LiF—LiCl—Li2SO4. A thermal battery can also include: an anode of lithium alloy; a metal-fluoride cathode having an oxide selected from V2O5 or LiVO3; and an electrolyte composition in contact with the anode and cathode. In one aspect, a metal of the metal fluoride cathode includes Ni, Fe, V, Cr, Mn, Co, or mixture thereof. In one aspect, the metal-fluoride cathode includes NiF2, FeF3, VF3, CrF3, MnF3, CoF3, or a mixture thereof. A method of providing electricity can include: providing an electronic device having a thermal battery with a metal-fluoride cathode having Ni and/or having an oxide selected from V2O5 or LiVO3; and discharging the thermal battery to provide electricity.

Abstract: A method of testing an analyte can include using a cell culture device that includes: at least three distinct chambers between the top wall and bottom wall. The chambers can include: an internal chamber defined by at least one porous internal wall; one or more boundary layer chambers having at least an inner boundary layer chamber defined by the at least one porous internal wall and at least one porous inner boundary layer wall, the at least one porous internal wall having a plurality of pores fluidically coupling the central internal chamber to the one or more boundary layer chamber; and an outer chamber.

Abstract: Disclosed herein are media for culture of cells, tissues, and/or organs. The media formulations disclosed herein can be used to support growth, viability, and/or function of one or more than one cell type, tissue, or organ. In some embodiments, one or more cell types, tissues, organ devices, and/or organs are contacted with a disclosed culture medium under conditions sufficient to support growth, viability, and/or function of the cell types, tissues, and/or organs. The disclosed media can be used in methods of culturing multiple cell types, and in some examples, is used in a platform device including one or more organ devices, for example, by circulating the medium through the one or more organ devices in the platform.

Abstract: A thermal battery can include: an anode of lithium alloy; a metal-fluoride cathode having Ni; and an electrolyte composition in contact with the anode and cathode. A thermal battery can also include: an anode of lithium alloy; a metal-fluoride cathode having an oxide selected from V2O5 or LiVO3; and an electrolyte composition in contact with the anode and cathode. In one aspect, a metal of the metal fluoride cathode includes Ni, Fe, V, Cr, Mn, Co, or mixture thereof. In one aspect, the metal-fluoride cathode includes NiF2, FeF3, VF3, CrF3, MnF3, CoF3, or a mixture thereof. A method of providing electricity can include: providing an electronic device having a thermal battery with a metal-fluoride cathode having Ni and/or having an oxide selected from V2O5 or LiVO3; and discharging the thermal battery to provide electricity.