Patents Assigned to CFD Research Corporation
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Publication number: 20140183416Abstract: The present disclosure provides an aqueous based electrically conductive ink, which is essentially solvent free and includes a nano-scale conducting material; a binding agent; and an enzyme. In one embodiment, the ink includes at least one of a mediator, a cross-linking agent and a substrate as well. In one further embodiment, the present disclosure provides electrically conductive ink including a single walled, carboxylic acid functionalized carbon nanotube; 1-Ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride and N-hydroxy succinimide (NHS) ester; polyethyleneimine; an aqueous buffer; and glucose oxidase.Type: ApplicationFiled: March 5, 2014Publication date: July 3, 2014Applicant: CFD Research CorporationInventors: Vojtech Svoboda, Jianjun Wei, Sameer Singhal, Yevgenia Ulyanova
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Patent number: 8703022Abstract: The present disclosure provides an aqueous based electrically conductive ink, which is essentially solvent free and includes a nano-scale conducting material; a binding agent; and an enzyme. In one embodiment, the ink includes at least one of a mediator, a cross-linking agent and a substrate as well. In one further embodiment, the present disclosure provides electrically conductive ink including a single walled, carboxylic acid functionalized carbon nanotube; 1-Ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride and N-hydroxy succinimide (NHS) ester; polyethyleneimine; an aqueous buffer; and glucose oxidase.Type: GrantFiled: June 8, 2011Date of Patent: April 22, 2014Assignee: CFD Research CorporationInventors: Vojtech Svoboda, Jianjun Wei, Sameer Singhal
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Patent number: 8685286Abstract: The present disclosure provides an electrode including an electrically conductive ink deposited thereon comprising: a nano-scale conducting material; a binding agent; and an enzyme; wherein said ink is essentially solvent free. In one embodiment, the ink includes at least one of a mediator, a cross-linking agent and a substrate as well. In one further embodiment, the electrode provided herein is used in a battery, fuel cell or sensor.Type: GrantFiled: June 8, 2011Date of Patent: April 1, 2014Assignee: CFD Research CorporationInventors: Vojtech Svoboda, Jianjun Wei, Sameer Singhal
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Patent number: 8685186Abstract: A group of tertiary amine azides are useful as hypergolic fuels for hypergolic bipropellant mixtures. The fuels provide higher density impulses than monomethyl hydrazine (MMH) but are less toxic and have lower vapor pressures that MMH. In addition, the fuels have shorter ignition delay times than dimethylaminoethylazide (DMAZ) and other potential reduced toxicity replacements for MMH.Type: GrantFiled: January 23, 2013Date of Patent: April 1, 2014Assignee: CFD Research CorporationInventor: Debasis Sengupta
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Patent number: 8663374Abstract: An apparatus for concentrating aerosol particles can include: a sample air inlet; an enriched aerosol outlet; an aerosol lean outlet; a flow path connecting the air inlet and aerosol rich and aerosol lean outlets; and a plurality of alternately energized and grounded electrode pairs along the flow path. The aerosol rich outlet can be in fluid communication with an aerosol particle capture device. The apparatus can include a sheath air inlet providing a flow of aerosol free air over surfaces of the alternately energized and grounded electrode pairs. The apparatus can include an elongate focusing chamber having a cylindrical shape containing the alternately energized and grounded electrode pairs that are configured as circular rings. The apparatus can include one or more structures configured to impart tangential, spiral or helical flow to a stream entering through the sample air inlet.Type: GrantFiled: August 3, 2012Date of Patent: March 4, 2014Assignee: CFD Research CorporationInventors: Kapil Pant, Shivshankar Sundaram, Yi Wang
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Publication number: 20130192462Abstract: Disclosed is an electrostatic aerosol concentrator for the concentration of aerosol particles and their collection for subsequent analysis. The concentrator comprises an airflow chamber that includes alternately energized and grounded electrode elements that work in concert to impart radial inward motion to charged aerosol particles and focusing them toward an enriched aerosol outlet. If desired, filtered air inlets may be used to provide a sheath of aerosol-free air along the chamber periphery and prevent deposition of particles onto electrode surfaces. Aerosol particles entering the airflow chamber may carry a positive or negative charge naturally, or a charge may be induced on the particles using a charging section located upstream of the aerosol inlet. Natural or induced charges on the aerosol particles may be used to selectively concentrate subpopulations of aerosol particles from a mixture of particles.Type: ApplicationFiled: August 3, 2012Publication date: August 1, 2013Applicant: CFD RESEARCH CORPORATIONInventors: Kapil Pant, Shivshankar Sundaram, Yi Wang
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Publication number: 20130149735Abstract: Methods of assaying the leukocyte adhesion cascade (LAC) and monitoring leukocyte rolling, adhesion, and/or migration can be implemented with an apparatus that includes an idealized microvascular network (IMN) of one or more interconnected idealized flow channels in fluid communication through a porous wall with a tissue space (e.g., idealized tissue space). The methods of assaying the LAC can be implemented with means for quantifying modulation of the leukocyte adhesion cascade. Methods of assaying the LAC can be implemented with the device and one or more active agents to monitor leukocyte rolling, adhesion, and/or migration in the presence of absence of the active agent. Migration can be through the idealized flow channels, through the porous wall, and/or into the tissue space.Type: ApplicationFiled: January 16, 2013Publication date: June 13, 2013Applicant: CFD RESEARCH CORPORATIONInventor: CFD Research Corporation
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Publication number: 20130133242Abstract: A group of tertiary amine azides are useful as hypergolic fuels for hypergolic bipropellant mixtures. The fuels provide higher density impulses than monomethyl hydrazine (MMH) but are less toxic and have lower vapor pressures that MMH. In addition, the fuels have shorter ignition delay times than dimethylaminoethylazide (DMAZ) and other potential reduced toxicity replacements for MMH.Type: ApplicationFiled: January 23, 2013Publication date: May 30, 2013Applicant: CFD RESEARCH CORPORATIONInventor: CFD Research Corporation
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Patent number: 8435465Abstract: A microfluidic cartridge for isolating biological molecules having a capture chamber containing functionalized solid supports maintained in a fluidized state provides reduced pressure drops and bubble formation during microfluidic extraction. The cartridge may include an electric field lysis chamber and/or a chemical lysis chamber. The electric-field lysis chamber may comprise an electrically insulating structure arranged between two opposing planar electrodes.Type: GrantFiled: November 3, 2008Date of Patent: May 7, 2013Assignee: CFD Research CorporationInventors: Shivshankar Sundaram, Balabhaskar Prabhakarpandian, Kapil Pant, Yi Wang
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Publication number: 20130101991Abstract: An apparatus for assaying a tumor drug delivery vehicle and or drug can include an idealized microvascular network (IMN) of one or more interconnected idealized flow channels in fluid communication through a porous wall with a tissue space (e.g., idealized tissue space) containing animal cells and means for quantifying drug delivery through the IMN to the animal cells.Type: ApplicationFiled: December 14, 2012Publication date: April 25, 2013Applicant: CFD Research CorporationInventor: CFD Research Corporation
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Patent number: 8425700Abstract: A method for preparing a gelled liquid propane (GLP) composition comprises the introduction of liquid propane into an evacuated mixing vessel containing a gellant and mixing the liquid propane with the gellant. A bi-propellant system comprising GLP is particularly well-suited for outer planet missions greater than 3 AU from the sun and also functions in earth and near earth environments. Additives such as powders of boron, carbon, lithium, and/or aluminum can be added improve performance or enhance hypergolicity. The gelling agent can be silicon dioxide, clay, carbon, or organic or inorganic polymers. The bi-propellant system may be, but need not be, hypergolic.Type: GrantFiled: January 25, 2011Date of Patent: April 23, 2013Assignee: CFD Research CorporationInventor: Roberto DiSalvo
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Patent number: 8417465Abstract: An apparatus and method for assaying blood-brain barrier properties for drug and drug delivery vehicle screening comprising of a microfluidic apparatus with gaps separating lumen and tissue space enabling formation of tight junctions similar to in vivo conditions using endothelial cells and brain cells.Type: GrantFiled: March 17, 2010Date of Patent: April 9, 2013Assignee: CFD Research CorporationInventors: Balabhaskar Prabhakarpandian, Kapil Pant, Shivshankar Sundaram, Ketan Harendrakumar Bhatt
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Patent number: 8382922Abstract: A group of tertiary amine azides are useful as hypergolic fuels for hypergolic bipropellant mixtures. The fuels provide higher density impulses than monomethyl hydrazine (MMH) but are less toxic and have lower vapor pressures that MMH. In addition, the fuels have shorter ignition delay times than dimethylaminoethylazide (DMAZ) and other potential reduced toxicity replacements for MMH.Type: GrantFiled: May 18, 2010Date of Patent: February 26, 2013Assignee: CFD Research CorporationInventor: Debasis Sengupta
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Patent number: 8380443Abstract: An apparatus and method for identifying and screening for agents affecting the leukocyte adhesion cascade (LAC) encompassing rolling, adhesion and migration comprises an optically clear, plastic microfluidic chip comprising flow channels with diameters in the range of 10-500 ?m. The flow channels are coated with endothelial cells and at least a portion of the flow channels contains 1-30 ?m sized openings, optionally filled with a native or synthetic extracellular matrix, that allow leukocyte migration into one or more tissue spaces.Type: GrantFiled: November 4, 2009Date of Patent: February 19, 2013Assignee: CFD Research CorporationInventors: Balabhaskar Prabhakarpandian, Kapil Pant, Shivshankar Sundaram
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Patent number: 8355876Abstract: An apparatus and method for assaying a tumor drug delivery vehicle comprises a synthetic microvascular network of interconnected flow channels in fluid communication through a porous wall with a tissue space containing animal cells and means for quantifying drug delivery from the microvascular network to the animal cells.Type: GrantFiled: December 28, 2009Date of Patent: January 15, 2013Assignee: CFD Research CorporationInventors: Balabhaskar Prabhakarpandian, Kapil Pant, Shivshankar Sundaram
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Patent number: 8246720Abstract: An electrostatic aerosol concentrator includes an airflow chamber with alternately energized and grounded electrode elements that work in concert to impart radial inward motion to charged aerosol particles and focusing them toward an enriched aerosol outlet. Aerosol particles entering the airflow chamber may carry a positive or negative charge naturally, or a charge may be induced on the particles using a charging section located upstream of the aerosol inlet. Natural or induced charges on the aerosol particles may be used to selectively concentrate subpopulations of aerosol particles from a mixture of particles. For example, bacterial spores or aerosolized viruses may be selectively enriched without concentrating other aerosol particles.Type: GrantFiled: July 31, 2007Date of Patent: August 21, 2012Assignee: CFD Research CorporationInventors: Kapil Pant, Shivshankar Sundaram, Yi Wang
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Publication number: 20120168046Abstract: A group of tertiary amine azides are useful as hypergolic fuels for hypergolic bipropellant mixtures. The fuels provide higher density impulses than monomethyl hydrazine (MMH) but are less toxic and have lower vapor pressures that MMH. In addition, the fuels have shorter ignition delay times than dimethylaminoethylazide (DMAZ) and other potential reduced toxicity replacements for MMH.Type: ApplicationFiled: May 18, 2010Publication date: July 5, 2012Applicant: CFD RESEARCH CORPORATIONInventor: Debasis Sengupta
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Patent number: 8191552Abstract: A method and apparatus for nasal drug delivery comprises a first tube in fluid communication with a means for generating a negative pressure and a second tube in fluid communication with an aerosol. The first tube is contacted with one nostril, the said second tube is contacted with the other nostril, and a negative pressure is applied to the first tube, producing a negative pressure within a nasal cavity and causing the aerosol to be drawn into the nasal passages and to deposit on an internal nasal surface.Type: GrantFiled: November 13, 2009Date of Patent: June 5, 2012Assignees: CFD Research Corporation, Centers For Disease Control and PreventionInventors: Andrzej Przekwas, Vincent Harrand, Mark Papania
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Patent number: 8175814Abstract: A synthetic microfluidic microvasculature network and associated methods mimic the structure, fluid flow characteristics, and physiological behavior of physiological microvasculature networks. Computational methods for simulating flow and particle adherence in synthetic and physiological microvascular systems and methods for determining parameters influencing particle adhesion and drug delivery are described with applications in the optimization of drug delivery and microvascular treatments and in describing disease mechanisms that affect the microvasculature.Type: GrantFiled: April 22, 2009Date of Patent: May 8, 2012Assignee: CFD Research CorporationInventors: Balabhaskar Prabhakarpandian, Shivshankar Sundaram, Kapil Pant
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Patent number: 8158409Abstract: A microfluidically-controlled transmission mode nanoscal surface plasmonics sensor device comprises one or more arrays of aligned nanochannels in fluid communication with inflowing and outflowing fluid handling manifolds that control the flow of fluid through the array(s). Fluid comprising a sample for analysis is moved from an inlet manifold, through the nanochannel array, and out through an exit manifold. The fluid may also contain a reagent used to modify the interior surfaces of the nanochannels, and/or a reagent required for the detection of an analyte.Type: GrantFiled: January 11, 2010Date of Patent: April 17, 2012Assignees: CFD Research Corporation, University of PittsburghInventors: Jianjun Wei, Sameer Singhal, David Hennessey Waldeck, Matthew Joseph Kofke