Patents Assigned to Chang Gung University
  • Patent number: 11969739
    Abstract: A method for performing contactless ODEP for separation of CTCs is provided with the steps of obtaining patients' blood with rare cell suspected CTCs; adding at least one fluorescent antibody binding to CTCs into the blood; staining the blood; injecting the stained blood with fluorescent dye into an ODEP device and then performing fluorescent image identification; trapping the CTCs with at least one fluorescent antibody in the ODEP device by creating an image pattern and then generating an ODEP force; Separating the trapped CTCs from other non-CTCs cells; absorbing the trapped CTCs; and obtaining a high purity of CTCs. An apparatus for performing contactless ODEP for separation of CTCs is also provided.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: April 30, 2024
    Assignee: Chang Gung University
    Inventor: Min-Hsien Wu
  • Publication number: 20240123017
    Abstract: A method for promoting chronic wound healing is provided, including administering an effective amount of Bletilla formosana (Hayata) Schltr. extract to a subject in need thereof, wherein the effective amount of Bletilla formosana (Hayata) Schltr. extract is 0.01 mg/kg-body weight to 100 mg/kg-body weight, and wherein the chronic wound including diabetic wound and Diabetic Foot Ulcer.
    Type: Application
    Filed: October 5, 2023
    Publication date: April 18, 2024
    Applicant: Chang Gung University of Science and Technology
    Inventors: Tsong-Long Hwang, Yu-Chia Chang
  • Publication number: 20240091191
    Abstract: Disclosed herein is related to a method for treating a symptom associated with senescence in a subject by administering to the subject with an effective amount of corylin and/or neobavaisoflavone, wherein the symptom associated with senescence is loss of muscle strength, muscle weakness, loss of motor coordination, loss of balance, skin wrinkle, or a poor blood biochemical parameter.
    Type: Application
    Filed: September 2, 2022
    Publication date: March 21, 2024
    Applicant: Chang Gung University
    Inventors: Chin-Chuan CHEN, Yann-Lii LEU, Shu-Huei WANG, Tong-Hong WANG, Shu-Fang CHENG
  • Patent number: 11931187
    Abstract: A method for predicting clinical severity of a neurological disorder includes steps of: a) identifying, according to a magnetic resonance imaging (MRI) image of a brain, brain image regions each of which contains a respective portion of diffusion index values of a diffusion index, which results from image processing performed on the MRI image; b) for one of the brain image regions, calculating a characteristic parameter based on the respective portion of the diffusion index values; and c) calculating a severity score that represents the clinical severity of the neurological disorder of the brain based on the characteristic parameter of the one of the brain image regions via a prediction model associated with the neurological disorder.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: March 19, 2024
    Assignees: Chang Gung Medical Foundation Chang Gung Memorial Hospital at Keelung, Chang Gung Memorial Hospital, Linkou, Chang Gung University
    Inventors: Jiun-Jie Wang, Yi-Hsin Weng, Shu-Hang Ng, Jur-Shan Cheng, Yi-Ming Wu, Yao-Liang Chen, Wey-Yil Lin, Chin-Song Lu, Wen-Chuin Hsu, Chia-Ling Chen, Yi-Chun Chen, Sung-Han Lin, Chih-Chien Tsai
  • Patent number: 11911663
    Abstract: A training device and a training method for reducing hypertonic are disclosed. The training device includes a base, a driving circuit, two pedals, a control circuit, and a switch circuit. The driving circuit is fixed on the base. Each of the two pedals is coupled to the base. The driving circuit drives each of the two pedals to swing repeatedly between a first position and a second position relative to the base. When the control circuit executes a training program, the control circuit actuates the driving circuit.
    Type: Grant
    Filed: March 23, 2022
    Date of Patent: February 27, 2024
    Assignee: CHANG GUNG UNIVERSITY
    Inventors: Ya-Ju Chang, Hsiao-Lung Chan, Jiunn-Woei Liaw, Cheng-Chung Kuo
  • Patent number: 11903735
    Abstract: An apparatus and method for examining an organism surface includes a pliable member including a contact layer, a plurality of channels, and a reaction layer, wherein the plurality of channels are disposed between the contact layer and the reaction layer; each of the channels having a size in the range of micrometers and formed of biocompatibility materials, and the contact layer including a plurality of spherical projections having a size in the range of micrometers and formed of biocompatible materials, and the reaction layer including examining molecules and a reaction unit.
    Type: Grant
    Filed: April 30, 2021
    Date of Patent: February 20, 2024
    Assignees: CHANG GUNG UNIVERSITY, CHANG GUNG MEMORIAL HOSPITAL, LINKOU
    Inventors: Hsin-Yao Wang, Ting-Wei Lin, Jang-Jih Lu
  • Patent number: 11839610
    Abstract: A method for inhibiting infection of SARS-CoV-2 in a subject is provided, comprising administering an effective amount of plant extract, wherein the plant extract comprises an alcohol extract of the herbal of Menispermaceae, wherein the herbal of Menispermaceae is Stephania cepharantha or Stephania tetrandra.
    Type: Grant
    Filed: June 10, 2022
    Date of Patent: December 12, 2023
    Assignees: CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY, CHANG GUNG UNIVERSITY
    Inventors: Tsong-Long Hwang, Yu-Li Chen, Yu-Chia Chang
  • Publication number: 20230390351
    Abstract: A method for inhibiting infection of SARS-CoV-2 in a subject is provided, including administering to the subject a compound, wherein the compound comprises Aromoline, Obamegine, Berbamine or Bersavine.
    Type: Application
    Filed: January 16, 2023
    Publication date: December 7, 2023
    Applicant: Chang Gung University of Science and Technology
    Inventors: Tsong-Long Hwang, Yu-Li Chen, Michal Korinek, Marcela Safratova, Anna Hostalkova
  • Publication number: 20230364011
    Abstract: Disclosed herein is a method for alleviating dry eye syndrome using a composition containing a polylysine nanoparticle. The polylysine nanoparticle is produced by subjecting lysine hydrochloride to a pyrolysis treatment at a temperature ranging from 240° C. to 280° C.
    Type: Application
    Filed: September 19, 2022
    Publication date: November 16, 2023
    Applicant: Chang Gung University
    Inventors: Jui-Yang Lai, Chih-Ching Huang, Han-Jia Lin, Hong-Jyuan Jian
  • Patent number: 11806088
    Abstract: A method includes providing medical images of a subject for selecting a target image from thereamong, building a 3D image model based on the medical images and the target image with a surgical target site assigned, performing image registration to superimpose the 3D image model on a real-time image of the subject so as to result in a combined image, determining a virtual entry site located on the combined image, connecting the surgical target site and the virtual entry site with a straight line, generating a guiding path extending from the virtual entry site, in a direction away from the surgical target site and along the straight line, and displaying the guiding path for guiding a surgical instrument.
    Type: Grant
    Filed: March 30, 2021
    Date of Patent: November 7, 2023
    Assignees: CHANG GUNG UNIVERSITY, CHANG GUNG MEMORIAL HOSPITAL, KEELUNG
    Inventors: Shin-Yan Chiou, Pin-Yuan Chen, Hao-Li Liu, Kuo-Chen Wei
  • Publication number: 20230321078
    Abstract: A method for inhibiting infection of SARS-CoV-2 in a subject is provided, comprising administering an effective amount of plant extract, wherein the plant extract comprises an alcohol extract of the herbal of Menispermaceae, wherein the herbal of Menispermaceae is Stephania cepharantha or Stephania tetrandra.
    Type: Application
    Filed: June 10, 2022
    Publication date: October 12, 2023
    Applicant: Chang Gung University of Science and Technology
    Inventors: Tsong-Long Hwang, Yu-Li Chen, Yu-Chia Chang
  • Patent number: 11744765
    Abstract: A standing training mobile device for carrying a patient to perform active-assisted upright locomotion is provided. The standing training mobile device includes a base, a mobile module, a lifting module, a control module, and a support module. The mobile module and the lifting module are disposed on the base. The control module is disposed on the lifting module and is coupled to the mobile module. The control module includes a manipulation platform and two control assemblies disposed on the manipulation platform for use of the patient. The support module includes a support frame, a first support assembly, a second support assembly, and a third support assembly. The first support assembly, the second support assembly, and the third support assembly are slidably disposed on the support frame respectively. The second support assembly is disposed between the first support assembly and the third support assembly.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: September 5, 2023
    Assignees: CHANG GUNG UNIVERSITY, NATIONAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Wen-Yu Liu, Hen-Yu Lien, Chung-Hsien Kuo, Yang-Hua Lin
  • Patent number: 11712178
    Abstract: A plantar pressure sensing system is located at a sole of shoe. The plantar pressure sensing system includes a first layer, a second layer a plurality of sensor, a plurality of convex portions, a plurality of connection portions, a processor and a storage. The processor is coupled with the storage and configured to be connected with the plurality of sensors. The plurality of sensors are configured to form the first layer. The plurality of convex portions and the plurality of connection portions are configured to form the second layer. Overall, the plantar pressure sensing system is able to detect pressure with the sensors by setting the alignment of the convex portions, thereby obtaining a more accurate pressure(s) reading from the sole of shoe. The data validity of the plantar pressure sensing system is improved.
    Type: Grant
    Filed: April 1, 2021
    Date of Patent: August 1, 2023
    Assignee: CHANG GUNG UNIVERSITY
    Inventors: Hsiao-Lung Chan, Jiunn-Woei Liaw, Ya-Ju Chang, Cheng-Chung Kuo
  • Patent number: 11698357
    Abstract: The present disclosure provides a method for screening, isolating and purifying analytes.
    Type: Grant
    Filed: July 5, 2019
    Date of Patent: July 11, 2023
    Assignee: CHANG GUNG UNIVERSITY
    Inventors: Min-Hsien Wu, Po-Yu Chu, Wen-Pin Chou, Chia-Jung Liao
  • Patent number: 11679102
    Abstract: Disclosed herein is a method for inhibiting virus infection, including administering to a subject in need thereof an effective amount of a ferroptosis inhibitor or a pharmaceutically acceptable salt thereof. Also disclosed is a method for inhibiting viral replication, including contacting a virus with a ferroptosis inhibitor or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: June 20, 2023
    Assignee: Chang Gung University
    Inventors: Shin-Ru Shih, Yu-An Kung, Huan-Jung Chiang, Chuan-Tien Hung, Yu-Nong Gong, Hsin-Ping Chiu, Chiung-Guei Huang, Peng-Nien Huang, Sheng-Yu Huang
  • Patent number: 11653903
    Abstract: The invention relates to an automatic reflection hammer system, which comprises the following components: a reflective hammer chassis, an outer side having a detachable reflection hammer head, and a pulley, a universal joint, a vertical height adjustment mechanism, and a fixing bracket. Wherein, the reflection hammer chassis links with the universal joint, the universal joint links to the vertical height adjustment mechanism, and the vertical height adjustment mechanism links with the fixing bracket.
    Type: Grant
    Filed: September 10, 2019
    Date of Patent: May 23, 2023
    Assignee: CHANG GUNG UNIVERSITY
    Inventors: Jer-Chyi Wang, Yi Fu, Kuo-Hsuan Chang
  • Patent number: 11634464
    Abstract: Disclosed herein are recombinant polypeptides derived from FBP1 and FBP2. Also disclosed herein are recombinant expression vectors and recombinant host cells for producing the aforesaid recombinant polypeptides. The recombinant polypeptides are proven to be useful and effective in producing a picornavirus with a type I internal ribosome entry site (IRES), so as to facilitate the preparation of a viral vaccine.
    Type: Grant
    Filed: June 22, 2020
    Date of Patent: April 25, 2023
    Assignee: CHANG GUNG UNIVERSITY
    Inventors: Shin-Ru Shih, Yu-An Kung, Chuan-Tien Hung
  • Patent number: 11583848
    Abstract: The present invention discloses a nanoparticle control and detection system and operating method thereof. The present invention controls and detects the nanoparticles in the same device. The device comprises a first transparent electrode, a photoconductive layer, a spacer which is deposed on the edge of the photoconductive layer and a second transparent electrode. The aforementioned device controls and detects the nanoparticles by applying AC/DC bias and AC/DC light source to the transparent electrode.
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: February 21, 2023
    Assignee: CHANG GUNG UNIVERSITY
    Inventors: Chia-Ming Yang, Chao-Sung Lai, Yu-Ping Chen, Min-Hsien Wu
  • Publication number: 20230030454
    Abstract: Disclosed herein is a method for identifying and treating a Streptococcus pyogenes (group A Streptococcus, GAS) infection in a subject. The method mainly includes determining the presence of endopeptidase O (PepO) protein in the biological sample; and administering an effective amount of an anti-infective agent to the subject to ameliorate symptoms associated with the GAS infection if the PepO protein is present in the biological sample.
    Type: Application
    Filed: July 27, 2021
    Publication date: February 2, 2023
    Applicant: Chang Gung University
    Inventor: Chuan CHIANG-NI
  • Publication number: 20220339122
    Abstract: Disclosed herein is a method of treating diseases and/or disorders associated with the dysregulated activation and recruitment of neutrophils. The method includes administering to a subject in need thereof an effective amount of 3,3?-dihydroxy-2?,6?-bis(p-hydroxybenzyl)-5-methoxybibenzyl (or bletinib), a salt, a solvate or an ester thereof.
    Type: Application
    Filed: April 27, 2021
    Publication date: October 27, 2022
    Applicant: Chang Gung University
    Inventors: Tsong-Long HWANG, Ting-I KAO, Tian-Shung WU