Patents Assigned to Chang Gung University
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Patent number: 11969739Abstract: A method for performing contactless ODEP for separation of CTCs is provided with the steps of obtaining patients' blood with rare cell suspected CTCs; adding at least one fluorescent antibody binding to CTCs into the blood; staining the blood; injecting the stained blood with fluorescent dye into an ODEP device and then performing fluorescent image identification; trapping the CTCs with at least one fluorescent antibody in the ODEP device by creating an image pattern and then generating an ODEP force; Separating the trapped CTCs from other non-CTCs cells; absorbing the trapped CTCs; and obtaining a high purity of CTCs. An apparatus for performing contactless ODEP for separation of CTCs is also provided.Type: GrantFiled: September 20, 2019Date of Patent: April 30, 2024Assignee: Chang Gung UniversityInventor: Min-Hsien Wu
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Publication number: 20240123017Abstract: A method for promoting chronic wound healing is provided, including administering an effective amount of Bletilla formosana (Hayata) Schltr. extract to a subject in need thereof, wherein the effective amount of Bletilla formosana (Hayata) Schltr. extract is 0.01 mg/kg-body weight to 100 mg/kg-body weight, and wherein the chronic wound including diabetic wound and Diabetic Foot Ulcer.Type: ApplicationFiled: October 5, 2023Publication date: April 18, 2024Applicant: Chang Gung University of Science and TechnologyInventors: Tsong-Long Hwang, Yu-Chia Chang
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Publication number: 20240091191Abstract: Disclosed herein is related to a method for treating a symptom associated with senescence in a subject by administering to the subject with an effective amount of corylin and/or neobavaisoflavone, wherein the symptom associated with senescence is loss of muscle strength, muscle weakness, loss of motor coordination, loss of balance, skin wrinkle, or a poor blood biochemical parameter.Type: ApplicationFiled: September 2, 2022Publication date: March 21, 2024Applicant: Chang Gung UniversityInventors: Chin-Chuan CHEN, Yann-Lii LEU, Shu-Huei WANG, Tong-Hong WANG, Shu-Fang CHENG
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Patent number: 11931187Abstract: A method for predicting clinical severity of a neurological disorder includes steps of: a) identifying, according to a magnetic resonance imaging (MRI) image of a brain, brain image regions each of which contains a respective portion of diffusion index values of a diffusion index, which results from image processing performed on the MRI image; b) for one of the brain image regions, calculating a characteristic parameter based on the respective portion of the diffusion index values; and c) calculating a severity score that represents the clinical severity of the neurological disorder of the brain based on the characteristic parameter of the one of the brain image regions via a prediction model associated with the neurological disorder.Type: GrantFiled: March 16, 2018Date of Patent: March 19, 2024Assignees: Chang Gung Medical Foundation Chang Gung Memorial Hospital at Keelung, Chang Gung Memorial Hospital, Linkou, Chang Gung UniversityInventors: Jiun-Jie Wang, Yi-Hsin Weng, Shu-Hang Ng, Jur-Shan Cheng, Yi-Ming Wu, Yao-Liang Chen, Wey-Yil Lin, Chin-Song Lu, Wen-Chuin Hsu, Chia-Ling Chen, Yi-Chun Chen, Sung-Han Lin, Chih-Chien Tsai
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Patent number: 11911663Abstract: A training device and a training method for reducing hypertonic are disclosed. The training device includes a base, a driving circuit, two pedals, a control circuit, and a switch circuit. The driving circuit is fixed on the base. Each of the two pedals is coupled to the base. The driving circuit drives each of the two pedals to swing repeatedly between a first position and a second position relative to the base. When the control circuit executes a training program, the control circuit actuates the driving circuit.Type: GrantFiled: March 23, 2022Date of Patent: February 27, 2024Assignee: CHANG GUNG UNIVERSITYInventors: Ya-Ju Chang, Hsiao-Lung Chan, Jiunn-Woei Liaw, Cheng-Chung Kuo
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Patent number: 11903735Abstract: An apparatus and method for examining an organism surface includes a pliable member including a contact layer, a plurality of channels, and a reaction layer, wherein the plurality of channels are disposed between the contact layer and the reaction layer; each of the channels having a size in the range of micrometers and formed of biocompatibility materials, and the contact layer including a plurality of spherical projections having a size in the range of micrometers and formed of biocompatible materials, and the reaction layer including examining molecules and a reaction unit.Type: GrantFiled: April 30, 2021Date of Patent: February 20, 2024Assignees: CHANG GUNG UNIVERSITY, CHANG GUNG MEMORIAL HOSPITAL, LINKOUInventors: Hsin-Yao Wang, Ting-Wei Lin, Jang-Jih Lu
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Patent number: 11839610Abstract: A method for inhibiting infection of SARS-CoV-2 in a subject is provided, comprising administering an effective amount of plant extract, wherein the plant extract comprises an alcohol extract of the herbal of Menispermaceae, wherein the herbal of Menispermaceae is Stephania cepharantha or Stephania tetrandra.Type: GrantFiled: June 10, 2022Date of Patent: December 12, 2023Assignees: CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY, CHANG GUNG UNIVERSITYInventors: Tsong-Long Hwang, Yu-Li Chen, Yu-Chia Chang
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Publication number: 20230390351Abstract: A method for inhibiting infection of SARS-CoV-2 in a subject is provided, including administering to the subject a compound, wherein the compound comprises Aromoline, Obamegine, Berbamine or Bersavine.Type: ApplicationFiled: January 16, 2023Publication date: December 7, 2023Applicant: Chang Gung University of Science and TechnologyInventors: Tsong-Long Hwang, Yu-Li Chen, Michal Korinek, Marcela Safratova, Anna Hostalkova
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Publication number: 20230364011Abstract: Disclosed herein is a method for alleviating dry eye syndrome using a composition containing a polylysine nanoparticle. The polylysine nanoparticle is produced by subjecting lysine hydrochloride to a pyrolysis treatment at a temperature ranging from 240° C. to 280° C.Type: ApplicationFiled: September 19, 2022Publication date: November 16, 2023Applicant: Chang Gung UniversityInventors: Jui-Yang Lai, Chih-Ching Huang, Han-Jia Lin, Hong-Jyuan Jian
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Patent number: 11806088Abstract: A method includes providing medical images of a subject for selecting a target image from thereamong, building a 3D image model based on the medical images and the target image with a surgical target site assigned, performing image registration to superimpose the 3D image model on a real-time image of the subject so as to result in a combined image, determining a virtual entry site located on the combined image, connecting the surgical target site and the virtual entry site with a straight line, generating a guiding path extending from the virtual entry site, in a direction away from the surgical target site and along the straight line, and displaying the guiding path for guiding a surgical instrument.Type: GrantFiled: March 30, 2021Date of Patent: November 7, 2023Assignees: CHANG GUNG UNIVERSITY, CHANG GUNG MEMORIAL HOSPITAL, KEELUNGInventors: Shin-Yan Chiou, Pin-Yuan Chen, Hao-Li Liu, Kuo-Chen Wei
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Publication number: 20230321078Abstract: A method for inhibiting infection of SARS-CoV-2 in a subject is provided, comprising administering an effective amount of plant extract, wherein the plant extract comprises an alcohol extract of the herbal of Menispermaceae, wherein the herbal of Menispermaceae is Stephania cepharantha or Stephania tetrandra.Type: ApplicationFiled: June 10, 2022Publication date: October 12, 2023Applicant: Chang Gung University of Science and TechnologyInventors: Tsong-Long Hwang, Yu-Li Chen, Yu-Chia Chang
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Patent number: 11744765Abstract: A standing training mobile device for carrying a patient to perform active-assisted upright locomotion is provided. The standing training mobile device includes a base, a mobile module, a lifting module, a control module, and a support module. The mobile module and the lifting module are disposed on the base. The control module is disposed on the lifting module and is coupled to the mobile module. The control module includes a manipulation platform and two control assemblies disposed on the manipulation platform for use of the patient. The support module includes a support frame, a first support assembly, a second support assembly, and a third support assembly. The first support assembly, the second support assembly, and the third support assembly are slidably disposed on the support frame respectively. The second support assembly is disposed between the first support assembly and the third support assembly.Type: GrantFiled: December 19, 2019Date of Patent: September 5, 2023Assignees: CHANG GUNG UNIVERSITY, NATIONAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Wen-Yu Liu, Hen-Yu Lien, Chung-Hsien Kuo, Yang-Hua Lin
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Patent number: 11712178Abstract: A plantar pressure sensing system is located at a sole of shoe. The plantar pressure sensing system includes a first layer, a second layer a plurality of sensor, a plurality of convex portions, a plurality of connection portions, a processor and a storage. The processor is coupled with the storage and configured to be connected with the plurality of sensors. The plurality of sensors are configured to form the first layer. The plurality of convex portions and the plurality of connection portions are configured to form the second layer. Overall, the plantar pressure sensing system is able to detect pressure with the sensors by setting the alignment of the convex portions, thereby obtaining a more accurate pressure(s) reading from the sole of shoe. The data validity of the plantar pressure sensing system is improved.Type: GrantFiled: April 1, 2021Date of Patent: August 1, 2023Assignee: CHANG GUNG UNIVERSITYInventors: Hsiao-Lung Chan, Jiunn-Woei Liaw, Ya-Ju Chang, Cheng-Chung Kuo
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Patent number: 11698357Abstract: The present disclosure provides a method for screening, isolating and purifying analytes.Type: GrantFiled: July 5, 2019Date of Patent: July 11, 2023Assignee: CHANG GUNG UNIVERSITYInventors: Min-Hsien Wu, Po-Yu Chu, Wen-Pin Chou, Chia-Jung Liao
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Patent number: 11679102Abstract: Disclosed herein is a method for inhibiting virus infection, including administering to a subject in need thereof an effective amount of a ferroptosis inhibitor or a pharmaceutically acceptable salt thereof. Also disclosed is a method for inhibiting viral replication, including contacting a virus with a ferroptosis inhibitor or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 28, 2021Date of Patent: June 20, 2023Assignee: Chang Gung UniversityInventors: Shin-Ru Shih, Yu-An Kung, Huan-Jung Chiang, Chuan-Tien Hung, Yu-Nong Gong, Hsin-Ping Chiu, Chiung-Guei Huang, Peng-Nien Huang, Sheng-Yu Huang
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Patent number: 11653903Abstract: The invention relates to an automatic reflection hammer system, which comprises the following components: a reflective hammer chassis, an outer side having a detachable reflection hammer head, and a pulley, a universal joint, a vertical height adjustment mechanism, and a fixing bracket. Wherein, the reflection hammer chassis links with the universal joint, the universal joint links to the vertical height adjustment mechanism, and the vertical height adjustment mechanism links with the fixing bracket.Type: GrantFiled: September 10, 2019Date of Patent: May 23, 2023Assignee: CHANG GUNG UNIVERSITYInventors: Jer-Chyi Wang, Yi Fu, Kuo-Hsuan Chang
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Patent number: 11634464Abstract: Disclosed herein are recombinant polypeptides derived from FBP1 and FBP2. Also disclosed herein are recombinant expression vectors and recombinant host cells for producing the aforesaid recombinant polypeptides. The recombinant polypeptides are proven to be useful and effective in producing a picornavirus with a type I internal ribosome entry site (IRES), so as to facilitate the preparation of a viral vaccine.Type: GrantFiled: June 22, 2020Date of Patent: April 25, 2023Assignee: CHANG GUNG UNIVERSITYInventors: Shin-Ru Shih, Yu-An Kung, Chuan-Tien Hung
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Patent number: 11583848Abstract: The present invention discloses a nanoparticle control and detection system and operating method thereof. The present invention controls and detects the nanoparticles in the same device. The device comprises a first transparent electrode, a photoconductive layer, a spacer which is deposed on the edge of the photoconductive layer and a second transparent electrode. The aforementioned device controls and detects the nanoparticles by applying AC/DC bias and AC/DC light source to the transparent electrode.Type: GrantFiled: September 4, 2019Date of Patent: February 21, 2023Assignee: CHANG GUNG UNIVERSITYInventors: Chia-Ming Yang, Chao-Sung Lai, Yu-Ping Chen, Min-Hsien Wu
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Publication number: 20230030454Abstract: Disclosed herein is a method for identifying and treating a Streptococcus pyogenes (group A Streptococcus, GAS) infection in a subject. The method mainly includes determining the presence of endopeptidase O (PepO) protein in the biological sample; and administering an effective amount of an anti-infective agent to the subject to ameliorate symptoms associated with the GAS infection if the PepO protein is present in the biological sample.Type: ApplicationFiled: July 27, 2021Publication date: February 2, 2023Applicant: Chang Gung UniversityInventor: Chuan CHIANG-NI
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Publication number: 20220339122Abstract: Disclosed herein is a method of treating diseases and/or disorders associated with the dysregulated activation and recruitment of neutrophils. The method includes administering to a subject in need thereof an effective amount of 3,3?-dihydroxy-2?,6?-bis(p-hydroxybenzyl)-5-methoxybibenzyl (or bletinib), a salt, a solvate or an ester thereof.Type: ApplicationFiled: April 27, 2021Publication date: October 27, 2022Applicant: Chang Gung UniversityInventors: Tsong-Long HWANG, Ting-I KAO, Tian-Shung WU