Abstract: Disclosed herein are recombinant polypeptides derived from FBP1 and FBP2. Also disclosed herein are recombinant expression vectors and recombinant host cells for producing the aforesaid recombinant polypeptides. The recombinant polypeptides are proven to be useful and effective in producing a picornavirus with a type I internal ribosome entry site (IRES), so as to facilitate the preparation of a viral vaccine.

Abstract: Disclosed herein are compounds of formula (I), and pharmaceutical compositions comprising the same. The compounds of formula (I) are neutrophilic inflammation inhibitors, thus, they are useful for treatment and/or prophylaxis of inflammatory diseases and/or disorders associated with abnormal activation of neutrophils, such as ARDS, ALI, COPD, lung fibrosis, chronic bronchitis, pulmonary emphysema, ?-1 anti-trypsin deficiency, cystic fibrosis, idiopathic pulmonary fibrosis, liver injury, steatohepatitis, liver fibrosis, damages caused by ischemia and reperfusion, myocardial infarction, shock, stroke, and organ transplantation, ulcerative cholitis, vasculitis, SLE, sepsis, SIRS, arthritis, psoriasis, atopic dermatitis, and inflammatory skin diseases.

Abstract: Disclosed herein are compounds of formula (I), and pharmaceutical compositions comprising the same. The compounds of formula (I) are neutrophilic inflammation inhibitors, thus, they are useful for treatment and/or prophylaxis of inflammatory diseases and/or disorders associated with abnormal activation of neutrophils, such as ARDS, ALI, COPD, lung fibrosis, chronic bronchitis, pulmonary emphysema, ?-1 anti-trypsin deficiency, cystic fibrosis, idiopathic pulmonary fibrosis, liver injury, steatohepatitis, liver fibrosis, damages caused by ischemia and reperfusion, myocardial infarction, shock, stroke, and organ transplantation, ulcerative cholitis, vasculitis, SLE, sepsis, SIRS, arthritis, psoriasis, atopic dermatitis, and inflammatory skin diseases.

Abstract: An immunoassay includes forming first mixtures by reacting a combination reagent with serum of a subject; simultaneously forming second mixtures by reacting randomly selected platelet samples with the serum wherein in each mixture there are immunity compounds formed by combining the platelet antigens with predetermined antibodies in the serum, and other platelet antigens and other antibodies in the serum not forming the immunity compounds; preparing an interception device including receptacles and a filter net; placing each mixture in one receptacle; washing the mixtures wherein the mixtures forming the immunity compounds are intercepted by the filter net with others passing through; adding a signal sensing reagent to each receptacle; reacting the signal sensing reagent with the intercepted mixtures forming the immunity compounds to form final products; and performing a signal sensing to determine whether the final products contain anti-platelet antibodies and determine compatibility of cross matching of resp

Abstract: A reduced graphene oxide-based biosensor includes a nano-structure field-effect transistor including a channel region which includes a reduced graphene oxide having a linking moiety to be bonded to a receptor specific to an analyte, and which is represented by a formula of —(C?O)—X—COOH, wherein X represents a C1-C3 alkenylene group or a C1-C3 alkylene group.

Abstract: A method of screening, isolating and purifying rare cells includes obtaining cell groups with rare cells from a sample, removing cells not to be screened from the cell groups, and drawing the remaining cells as a cell suspension sample. An introduction device is activated to load the cell suspension sample onto an optically-induced dielectrophoresis chip including a cell isolation zone having a division arrangement wherein at least one optical pattern is configured on the cell isolation zone for screening, isolating and purifying the rare cells. The at least one optical pattern is configured to migrate, rotate or both. The at least one optical pattern is activated to attract the rare cells into a collection tank on the chip, and a liquid drawing device is activated to draw the rare cells out of the collection tank, thereby obtaining purified rare cells from the sample.

Abstract: The present invention provides capacitor-based fluid sensing units. The capacitor-based fluid sensing unit comprises a substrate, a first electrode configured on the substrate, a sensing layer configured on the first electrode, a second electrode configured on the sensing layer. More particularly, the second electrode is a porous electrode, while the sensing layer is made of a porous dielectric material and has a thickness between 50 nm and 5 mm. Permittivity of the sensing layer changes as fluid permeates from the second electrode to the sensing layer. The subsequent change in capacitance of the capacitor-based fluid sensing unit is used to determine the volume of the fluid.

Abstract: A method for establishing a computer-aided data interpretation model for immune diseases by immunomarkers and visualization is revealed. First combine a plurality of immunomarkers into an immunomarker panel. Then collect test data of a plurality of subjects measured by the immunomarker panel, and disease diagnosis information of the subjects for establishment of an immunomarker-panel testing database. Next new subjects are tested by the immunomarker panel. The data obtained and the corresponding information in the immunomarker-panel testing database are processed by unsupervised machine learning algorithm to get a computer-aided data interpretation model showing comparison of case distribution patterns. The method provides real-time analysis of multiple data to medical professionals for their reference. Thereby the correctness, the timeliness and the reproducibility of the interpretation result for the diagnosis and treatment of immune diseases are all improved.

Abstract: A method for performing an assessment of vision is provided, and comprises: determining a current difficulty level for the assessment; displaying a question of the assessment, the question including a visual element that has a movable pattern, the movable pattern having at least one variable attribute that is related to the current difficulty level; in response to receipt of an inputted answer, determining whether the inputted answer is correct; and determining whether the assessment is to be concluded, and in the affirmative, generating a result of the assessment based on the current difficulty level.

Abstract: Light-addressable potentiometric sensing units are provided. A light-addressable potentiometric sensing unit comprises a conductive substrate, a metal oxide semiconductor layer, and a sensing layer. The metal oxide semiconductor layer is made of indium gallium zinc oxide, indium gallium oxide, indium zinc oxide, indium oxide co-doped with tin and zinc, tin oxide, or zinc oxide. The wide-band gap characteristic of the metal oxide semiconductor layer enables the light-addressable potentiometric sensing unit to resist the interference from visible light. The light-addressable potentiometric sensing unit therefore exhibits a more stable performance.

Abstract: The present invention provides methods for treating cancer, by administering a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof. Also provided are methods for reducing cancer cell metastasis, by administering a therapeutically effective amount of a compound of formula (I) described herein or a pharmaceutically acceptable salt thereof.

Abstract: A semiconductor structure having a multiple-porous graphene layer includes a sapphire substrate, a single or multiple layer porous graphene film, and a gallium nitride layer. A fabrication method for forming the semiconductor structure having a single or multiple layer porous graphene film, includes: firstly, growing up the graphene on the copper foil; then, using the acetone and isopropyl alcohol to wash the sapphire substrate, and then using the nitrogen flow to dry up; transferring the graphene onto the semiconductor substrate, using the Poly(methyl methacrylate) to fix the single or multiple layer porous graphene film, and using the acetone to wash up; using the photolithography process to etch the whole surface of the multiple-porous graphene layer; and, using the metalorganic chemical vapor deposition to deposit gallium nitride on the single or multiple layer porous graphene film and the sapphire substrate.

Abstract: A coronary artery disease (CAD) screening method includes 1) collecting clinical information of asymptomatic individuals and testing a plurality of samples of the individuals by using a cardiovascular markers panel including a plurality of cardiovascular markers; 2) entering the clinical information and the test results and the corresponding CAD states of the individuals into a machine learning platform; 3) selecting a plurality of roust variables from the clinical information and the cardiovascular markers of the cardiovascular markers panel by using feature selection methods; 4) using a machine learning algorithm embedded in the machine learning platform to establish a CAD prediction model; and 5) entering clinical information and sample data obtained by using the cardiovascular markers panel for an individual being screened into the CAD prediction model for calculation and analysis, thereby determining whether the individual being screened has CAD or not.

Abstract: A method of predicting daily living activities performance of a person with disabilities includes establishing a rehabilitation assessments panel based on a plurality of rehabilitation evaluation scales and laboratory data; evaluating a plurality of persons with disabilities by the rehabilitation assessments panel; entering assessment results and the corresponding activities of daily living (ADL) performance into a machine learning platform; utilizing variable selection methods to select a plurality of variables having optimal classification performance from the rehabilitation assessments panel; executing a machine learning algorithm to create an ADL prediction model based on the selected variables; evaluating a participant in terms of the rehabilitation assessments panel; and entering assessment results into the ADL prediction model for calculation, thereby obtaining a prediction result of future ADL performance for the participant.

Abstract: An apparatus, for reinforcing bone and tools for mounting the same, has an implant including a barrel and a device. The implant can be expanded by an expanding apparatus including an outer tube, a base, a hollow body and a handle. The expanding apparatus can be bound to the implant to place the implant into a bone to be treated and adjust the expansion degree. The expanding apparatus can be replaced by an injector apparatus including a container for bone cement and an injecting handle. The injector apparatus can inject a mixture for reinforcing bone (e.g., bone cement) into the bone through an exit, the device, the aperture, the barrel and the window of the barrel, and into the to-be treated area.

Abstract: A method of screening breast cancer includes collecting serum samples from breast cancer patient; measuring WISP1 level in the serum sample; and comparing the serum WISP1 level of the healthy persons with the WISP1 level in the serum sample of the breast cancer patients. The mean serum WISP1 level is 631.5 pg/ml for healthy persons and the mean serum WISP1 level is 934.5 pg/ml for patients having breast cancer so that WISP1 level of 934.5 pg/ml is configured to be a biomarker in determining whether a subject has high risk of breast cancer occurrence or not.

Abstract: A method of screening, isolating and purifying rare cells includes obtaining cell groups with rare cells in from a sample, removing cells not to be screened from the cell groups, and drawing the remaining cells as cell suspension sample; activating an introduction device to load the cell suspension sample onto an optically-induced dielectrophoresis chip including a cell isolation zone having a division arrangement wherein at least one optical pattern is configured on the cell isolation zone for screening, isolating and purifying the rare cells, and the at least one optical pattern is configured to migrate, rotate or both; and activating the at least one optical pattern to attract the rare cells into a collection tank on the chip, and activating a liquid drawing device to draw the rare cells out of the collection tank, thereby obtaining purified rare cells from the sample.

Abstract: A floating gate non-volatile memory device includes at least one floating gate non-volatile memory cell including a semiconductor substrate, a gate stack unit, and a drain and source unit. The gate stack unit includes a tunnel oxide layer having a negative capacitance, a floating gate layer disposed on the tunnel oxide layer, a blocking oxide layer disposed on the floating gate layer and opposite to the tunnel oxide layer, and a control gate layer disposed on the blocking oxide layer and opposite to the floating gate layer. The drain and source unit is disposed in the semiconductor substrate and includes source and drain regions that are respectively disposed on two opposite sides of the gate stack unit.

Abstract: A method of using machine learning algorithms in analyzing laboratory test results of body fluid to detect microbes in the body fluid includes using a body fluid detection module for analytic measurements in body fluid of a person to create biological samples; sending the biological samples of a plurality of persons and corresponding microbes infection statuses to perform machine learning algorithms to establish a microbes in body fluid prediction model; and sending data obtained from the body fluid detection of a patient for testing to the microbes in body fluid prediction model for operation and analysis in order to determine whether the microbes is present in body fluid.

Abstract: Disclosed herein is a method of preventing and/or treating abnormal bone resorption and/or osteoporosis in a subject in need thereof. The method comprises administering to the subject an effective amount of an inhibitor on inhibiting neddylation. According to some embodiments of the present disclosure, the inhibitor on inhibiting neddylation is a NAE inhibitor, which includes but is not limited to, MLN4924.