Patents Assigned to Ciba-Geigy Corp.
-
Device and method for combined bioaffinity assay and electrophoretic separation of multiple analytes
Patent number: 5741639Abstract: A device for combined bioaffinity assay and electrophoretic separation is provided, which comprises a capillary system having two stages, a first stage in which bioaffinity interactions of analyte molecules and molecular recognition elements are performed, and a second stage, in which electrophoretic separation of the analyte molecules and subsequent detection of the separated species is accomplished. Within the first capillary stage the molecular recognition elements are attached and immobilized to the inside capillary wall, for example, by adsorption or by covalent binding to the capillary material. The method for combined bioaffinity assay and electrophoretic separation comprises flowing an analyte through a capillary system having two stages. In a first capillary stage the analyte molecules are captured by respective molecular recognition elements present in that stage.Type: GrantFiled: February 28, 1995Date of Patent: April 21, 1998Assignee: Ciba-Geigy Corp.Inventors: Kees Ensing, Peter Oroszlan, Aran Paulus, Carlo S. Effenhauser -
Patent number: 5576276Abstract: A pH controlled protein removal system and method in the substantial absence of (a) enzyme and (b) a surfactantly effective amount of a surfactant is disclosed. The method comprises contacting a substrate with a cleaning composition therefor, which compostion is substantially free of (a) enzyme and (b) surfactantly effective amount of a surfactant, for a period of time at an alkaline pH and removing said substrate from said composition.Type: GrantFiled: April 3, 1995Date of Patent: November 19, 1996Assignee: Ciba Geigy Corp.Inventors: Fu-Pao Tsao, Rosalind Dandridge
-
Patent number: 5569597Abstract: The present invention relates to a novel method of inserting viral DNA, which optionally may contain cargo-DNA, into plants or viable parts thereof, but preferably into plants of the monocotyledon class, and most preferably into plants of the family Gramineae, using suitable transfer microorganisms. Further comprised by the invention are recombinant DNA, plasmid and vector molecules suitably adapted to the specific conditions of the process according to the invention and the transgenic plant products obtainable in accordance with the said process.Type: GrantFiled: July 11, 1994Date of Patent: October 29, 1996Assignees: Ciba Geigy Corp., Mycogen Plant Sciences, Inc.Inventors: Nigel H. Grimsley, Barbara Hohn, Thomas Hohn, Jeffrey W. Davies, Margaret I. Boulton
-
Patent number: 5489503Abstract: Novel UV absorbers of the bis- or tris-2'-hydroxyphenyltriazine type and their use in photographic materials, inks or recording materials for ink-jet printing, and surface coatings are described which conform to the formula ##STR1## in which the radicals R.sub.1 and R.sub.9 are as defined in claim 1.Type: GrantFiled: December 6, 1994Date of Patent: February 6, 1996Assignee: Ciba-Geigy Corp.Inventor: Vien V. Toan
-
Patent number: 5481039Abstract: Compositions comprisinga) a functional liquid or an internal combustion engine fuel andb) at least one compound of the general formula I ##STR1## wherein R.sub.1 is --(CH.sub.2 --X).sub.n R, where X=--S-- or --O--, n=0 or 1 to 18 carbon atoms, a phenyl group, a phenyl group which is substituted by at least one C.sub.1 -C.sub.18 alkyl group, a phenyl-C.sub.1 -C.sub.4 alkyl group or a phenyl-C.sub.1 -C.sub.4 alkyl group which is substituted by at least one C.sub.1 -C.sub.4 alkyl group, or R.sub.1 is an alkyl group of 1 to 18 carbon atoms which is substituted by at least one OH group, or R.sub.1 is a ##STR2## group in which the alkyl moiety contains 1 to 18 carbon atoms, and R.sub.2 and R.sub.3 are the same or different and are --H or, independently of R.sub.1, have the same meanings as R.sub.1, and M is B, Al, Fe, Cr, Sb or Bi, or M is a group M'--R' or a group M'--OR", where M' is Ti, Zr or Sn, and R' and R" is C.sub.1 -C.sub.18 alkyl or R' is ##STR3## wherein M' is defined above, and R.sub.1 ', R.sub.Type: GrantFiled: October 21, 1994Date of Patent: January 2, 1996Assignee: Ciba-Geigy Corp.Inventors: Hermann O. Wirth, Hans-Helmut Friedrich
-
Patent number: 5426158Abstract: A contact lens is described which is synthesized by reaction in a mold of a isocyanate capped poly(dialkylsiloxane) prepolymer with a poly(dialkylsiloxane) di- or polyalkanol. The clear polyurethane rubber contact lens is readily made completely wettable by a transfer-grafting process or post-treatment and has a high oxygen permeability.Type: GrantFiled: April 14, 1994Date of Patent: June 20, 1995Assignee: Ciba-Geigy Corp.Inventors: Karl F. Mueller, Paul Harisiades
-
Patent number: 5424057Abstract: Compounds of the formula ##STR1## in which R is alkyl having up to 4 carbon atoms, n has an average value of at least 9, X is a radical of the formula --C(.dbd.O)--(NH--SO.sub.2).sub.m -- in which m is 0 or 1 and, if m is 1, the carbonyl group may be bonded to the oxygen atom or to the nitrogen atom, and each of the radicals A.sub.1, A.sub.2 and A.sub.3, independently of the others, is hydrogen or an acyl radical, and salts of salt-forming compounds of formula I, as well as metal complexes of compounds of formula I, in which A.sub.1, A.sub.2 and A.sub.3 are hydrogen can be used as metal chelators and as auxiliaries in diagnosis.Type: GrantFiled: April 8, 1994Date of Patent: June 13, 1995Assignee: Ciba-Geigy Corp.Inventors: Heinrich Peter, Theophile Moerker
-
Patent number: 5399578Abstract: Compounds of the formula ##STR1## in which R.sub.1 is an aliphatic hydrocarbon radical which is unsubstituted or substituted by halogen or hydroxyl, or a cycloaliphatic or araliphatic hydrocarbon radical; X.sub.1 is CO, SO.sub.2, or --O--C(.dbd.O)-- with the carbon atom of the carbonyl group being attached to the nitrogen atom shown in formula I; X.sub.2 is a divalent aliphatic hydrocarbon radical which is unsubstituted or substituted by hydroxyl, carboxyl, amino, guanidino or a cycloaliphatic or aromatic radical, or is a divalent cycloaliphatic hydrocarbon radical, it being possible for a carbon atom of the aliphatic hydrocarbon radical to be additionally bridged by a divalent aliphatic hydrocarbon radical; R.sub.2 is carboxyl which, if desired, is esterified or amidated, substituted or unsubstituted amino, formyl which, if desired, is acetalized, 1H-tetrazol-5-yl, pyridyl, hydroxyl which, if desired, is etherified, S(O).sub.Type: GrantFiled: December 29, 1992Date of Patent: March 21, 1995Assignee: Ciba-Geigy CorpInventors: Peter Buhlmayer, Franz Ostermayer, Tibur Schmidlin
-
Patent number: 5382659Abstract: The invention relates to novel aromatic acids, especially to compounds of formula ##STR1## wherein R.sub.1 is lower alkyl, R.sub.2 is lower alkyl, R.sub.3 is hydrogen, carboxy or sulfo, R.sub.4 is carboxy or sulfo, G is an unsubstituted or substituted 1,4-phenylene group or an unsubstituted or substituted 1,4-naphthylene group, and wherein either R.sub.5 and R.sub.6 together are an additional bond and L is an oxygen or sulfur atom or wherein R.sub.5 is hydrogen, R.sub.6 is halomethyl and L is an oxygen atom, and salts thereof, to the use of compounds I and their salts, to a process for the preparation of compounds I and their salts, to starting materials used in that preparation process, and salts thereof, to a process for the preparation of those starting materials and their salts, to a device in which the compounds I and their salts are used, and to a process in which that device is used.Type: GrantFiled: June 7, 1994Date of Patent: January 17, 1995Assignee: Ciba-Geigy Corp.Inventor: Jui Y. Chang
-
Patent number: 5378710Abstract: Compounds of the formula ##STR1## wherein carbon atoms 1 and 2 are linked by a single bond or a double bond, R.sub.1 is hydrogen, methyl or ethyl, and A is a group of the formula --N(--R.sub.2)--X-- wherein R.sub.2 is hydrogen or C.sub.1 -C.sub.4 alkyl and X is C.sub.1 -C.sub.12 alkylene or C.sub.3 -C.sub.6 cycloalkylidene; a group of the formula --N(--R.sub.2)--Y--Phe-- wherein R.sub.2 is as defined above, Y is a direct bond or C.sub.1 -C.sub.6 -alkylene and Phe is an unsubstituted or substituted phenylene radical; a group of the formula --O--X-- wherein X is as defined above, or a group --O--Y--Phe-- wherein Y and Phe are as defined above, are inhibitors of 5.alpha.-reductase and can be used for the therapeutic treatment of the human and animal body.Type: GrantFiled: October 6, 1993Date of Patent: January 3, 1995Assignee: Ciba-Geigy Corp.Inventor: Michel Biollaz
-
Patent number: 5376669Abstract: Compounds of formula I ##STR1## wherein Z, R, R.sub.1, R.sub.2 and X are as defined in the description, have valuable pharmaceutical properties and are effective especially against tumors. They are prepared in a manner known per se.Type: GrantFiled: March 17, 1993Date of Patent: December 27, 1994Assignee: Ciba-Geigy Corp.Inventors: Marc Lang, Edmond Differding, Jaroslav Stanek
-
Patent number: 5376378Abstract: A new polymer, the feed monomers and molar percents of which, exclusive of a polymerization initiator and crosslinker, are:A. (I) 42 mole % to 58 mole % of a siloxy silane of formula I,(II) 42 mole % to 58 mole % of an unsubstituted alkyl (meth)acrylate of formula II,(III) 0 to 5 mole % of a Group A monomer, and(IV) 0 to 16 mole % of an additional vinylic copolymerizable monomer;B. (I) 42 mole % to 58 mole % of a siloxy silane of formula I,(II) 21 mole % up to less than 42 mole % of an unsubstituted alkyl (meth)acrylate of formula II,(III) 0 to 5 mole % of a Group A monomer, and(IV) 0 to 29 mole % of an additional vinylic copolymerizable monomer; orC. (I) 16 mole % up to less than 42 mole % of a siloxy silane of formula I,(II) 42 mole % to 58 mole % of an unsubstituted alkyl (meth)acrylate of formula II,(III) 0 to 5 mole % of a Group A monomer, and(IV) 0 to 36 mole % of an additional vinylic copolymerizable monomer;where formula I is ##STR1## where formula II is ##STR2## in which R.sub.Type: GrantFiled: November 4, 1993Date of Patent: December 27, 1994Assignee: Ciba-Geigy Corp.Inventors: Xiaoling Li, Bret Berner
-
Patent number: 5354761Abstract: Compounds of formula I ##STR1## wherein Y, Z, S, S', m, n and R.sub.1 -R.sub.4 are as defined in the description, have valuable pharmaceutical properties and are effective especially against protozoal infections. They are prepared in a manner known per se.Type: GrantFiled: June 1, 1993Date of Patent: October 11, 1994Assignee: Ciba-Geigy Corp.Inventors: Jaroslav Stanek, Giorgio Caravatti, Hans-Georg Capraro, Jorg Frei
-
Patent number: 5344825Abstract: The invention relates to a novel advantageous oral dosage form for methanediphosphonates, especially the active ingredient disodium pamidronate. A preferred dosage form comprises:a) disodium-3-amino-1-hydroxypropane-1,1-diphosphonate (disodium pamidronate),b) a cationic macroporous ion exchange resin based on a styrene/divinylbenzene copolymer having an exchangeable aminophosphonate group and, where appropriate,c) further pharmaceutically acceptable excipients.The ingredients can be processed to form tablets, dragees, capsules etc.Type: GrantFiled: April 14, 1993Date of Patent: September 6, 1994Assignee: Ciba-Geigy Corp.Inventors: Satish C. Khanna, Jonathan Green
-
Patent number: 5342977Abstract: Salts of aminosulfonic acid derivatives of formula I ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are each independently of the others an aliphatic hydrocarbon radical having from 7 to 21 carbon atoms,n is 0 or 1,As is the amidically bonded residue of a (D)- or (L)-amino acid or of a (D)- or (L)-amino acid derivative from the group consisting of Gly, Ala, Ser, Thr, Asp, Asp(R.sup.5), Glu, Glu(R.sup.5), Gla, Gla(R.sup.5) and Gla(R.sup.5).sub.2, andR.sup.4 and R.sup.5 are each independently of the other the amidically bonded radical of an unsubstituted or carboxy-substituted .omega.-amino-C.sub.2 -C.sub.3 alkanesulfonic acid, are described.Those salts have an immunostimulating action and can be used as medicaments.Type: GrantFiled: December 17, 1992Date of Patent: August 30, 1994Assignee: Ciba-Geigy Corp.Inventors: Gerhard Baschang, Albert Hartmann
-
Patent number: 5334583Abstract: Described are the use of hexopyranose compounds of the formula I ##STR1## for the prophylaxis and treatment of virus infections, and novel pharmaceutical preparations especially suitable for the use in accordance with the invention.The substituents in formula I have the meanings given in the claims.Type: GrantFiled: December 2, 1992Date of Patent: August 2, 1994Assignee: Ciba-Geigy Corp.Inventors: Bohumir Lukas, Karl H. S. Ruppin
-
Patent number: 5328992Abstract: Compounds of the formula ##STR1## in which R is alkyl having up to 4 carbon atoms, n has an average value of at least 9, X is a radical of the formula --C(.dbd.O)--(NH--SO.sub.2).sub.m -- in which m is 0 or 1 and, if m is 1, the carhonyl group may be bonded to the oxygen atom or to the nitrogen atom, and each of the radicals A.sub.1, A.sub.2 and A.sub.3, independently of the others, is hydrogen or an acyl radical, and salts of salt-forming compounds of formula I, as well as metal complexes of compounds of formula I, in which A.sub.1, A.sub.2 and A.sub.3 are hydrogen can be used as metal chelators and as auxiliaries in diagnosis.Type: GrantFiled: October 27, 1992Date of Patent: July 12, 1994Assignee: Ciba-Geigy Corp.Inventors: Heinrich Peter, Theophile Moerker
-
Patent number: 5322852Abstract: The invention relates to compounds of formula I ##STR1## wherein either R.sub.1 is a radical of formula Ia,--(CH.sub.2).sub.n --O--NH.sub.2 (Ia)in which n is 0 or 1, is hydrogen and R.sub.2 is a radical of formula Ib,--(CH.sub.2).sub.p --O--NH.sub.2 (Ib)in which p is 1 or 2, and wherein R is C.sub.1 -C.sub.2 alkyl which is attached to one carbon atom of the central piperidine ring system, but not to the same carbon atom as R.sub.1 of formula Ia or as R.sub.2 of formula Ib; and m is 1 or 2, and salts thereof. The invention further relates to the preparation of these compounds, to intermediates obtained during their synthesis, to pharmaceutical compositions which contain them, and to the use of said compounds for the therapeutic treatment of the human or animal body and for the preparation of pharmaceutical compositions.The compounds of formula I are inhibitors of ornithin decarboxylase.Type: GrantFiled: February 11, 1993Date of Patent: June 21, 1994Assignee: Ciba-Geigy Corp.Inventors: Jorg Frei, Jaroslav Stanek
-
Patent number: 5317100Abstract: Compounds of the formula ##STR1## in which R.sub.1 is hydrogen or lower alkyl, R.sub.2 is hydrogen or a hydroxyl protective group R.sub.2 ' and R.sub.3 is substituted or unsubstituted phenyl or lower alkyl can be prepared in a three-stage process from readily accessible .beta.-lactam starting materials.Type: GrantFiled: October 22, 1992Date of Patent: May 31, 1994Assignee: Ciba-Geigy Corp.Inventors: Jaroslav Kalvoda, Martin Kessler, Rene Lattmann, Gerardo Ramos
-
Patent number: D395600Type: GrantFiled: January 19, 1996Date of Patent: June 30, 1998Assignee: CIBA Geigy Corp.Inventors: Sharla Borghorst, Erich Bauman, Peter Herbrechtsmeier, David Pietrobon, Michele De Lucchi, Torsten Fritze, Masahiko Kubo