Patents Assigned to Corbion Biotech, Inc.
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Patent number: 11618890Abstract: Provided are non-natural or variant beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS) II enzymes (KASII), polynucleotides encoding such variant KASII, host cells expressing such variant KASII, oils and oil products produced by such cells, and methods of making and using such variant KASII.Type: GrantFiled: August 21, 2019Date of Patent: April 4, 2023Assignee: Corbion Biotech, Inc.Inventors: Nien-Hsi Ko, Joshua Ferreira, Janice Lau Wee, William E. Maffe, Douglas A. Hattendorf
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Publication number: 20230037413Abstract: The present disclosure provides sucrose invertase variants having an enhanced ability to hydrolyze sucrose into glucose and fructose and related methods and compositions.Type: ApplicationFiled: November 19, 2020Publication date: February 9, 2023Applicant: Corbion Biotech, Inc.Inventors: Nien-Hsi KO, Janice Lau WEE, Douglas A. HATTENDORF
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Patent number: 11559074Abstract: A microalgal flour having a particle size of between 30 and 150 ?m and compressibility, measured by way of POWDER TESTER HOSOKAWA, of between 45 and 55%, has a flow value, determined according to a test A, of between 55 and 60% by weight for residue at 2,000 ?m, dispersibility and wettability, expressed according to a test B, by the height of the product decanted in a beaker, of a value of between 0 and 2 mm; and a degree of humidification of a value of more than 70%, and preferably of more than 80%, of the total powder.Type: GrantFiled: July 17, 2014Date of Patent: January 24, 2023Assignee: Corbion Biotech, Inc.Inventor: Damien Passe
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Patent number: 11542456Abstract: Lipids can be extracted from a microbial biomass that constitutes at least 20% lipids by weight and has a moisture content of less than 4% by weight by applying pressure to the biomass so as to release lipids therefrom, thereby leaving a biomass of reduced lipid content; and collecting the lipids.Type: GrantFiled: December 21, 2017Date of Patent: January 3, 2023Assignee: Corbion Biotech, Inc.Inventors: Jon Wittenberg, Felipe Arana Rodriguez
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Publication number: 20220361530Abstract: The present disclosure relate to feed ingredients and formulated feed, methods for their manufacture, and uses thereof in nutritional applications such as in aquaculture, terrestrial animal feed, and human nutrition. The feed ingredient compositions comprise lysed microbial cells with a small aspect ratio and triglyceride oil.Type: ApplicationFiled: July 14, 2022Publication date: November 17, 2022Applicant: CORBION BIOTECH, INC.Inventors: Walter RAKITSKY, John PIECHOCKI, Wenhua LU
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Patent number: 11473050Abstract: The invention relates to a method for the protein enrichment of a heterotrophically cultured microalga, the microalga being of the genus Chlorella, even more particularly Chlorella protothecoides, characterized in that it comprises: a first step directed toward limiting the ammonium supply so as to obtain a microalgal biomass with a protein content of less than 50% expressed as N.6.25, preferably less than 30%, more preferentially between 20 and 25%; a second step in which the ammonium supply in the fermentation medium is increased so as to obtain a protein content of greater than 50%, preferably greater than 60%, more preferentially greater than 65%.Type: GrantFiled: February 8, 2016Date of Patent: October 18, 2022Assignee: Corbion Biotech, Inc.Inventors: Marie Le Ruyet, Laurent Segueilha, Mélanie Cappe, Sylvain Delaroche
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Patent number: 11419350Abstract: The present disclosure relate to feed ingredients and formulated feed, methods for their manufacture, and uses thereof in nutritional applications such as in aquaculture, terrestrial animal feed, and human nutrition. The feed ingredient compositions comprise lysed microbial cells with a small aspect ratio and triglyceride oil.Type: GrantFiled: June 28, 2017Date of Patent: August 23, 2022Assignee: CORBION BIOTECH, INC.Inventors: Walter Rakitsky, John Piechocki, Wenhua Lu, Janice Wee, Jorge Galazzo
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Patent number: 11401538Abstract: Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desaturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced oxidative or thermal stability, or can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsaturated-saturated type.Type: GrantFiled: May 5, 2020Date of Patent: August 2, 2022Assignee: Corbion Biotech, Inc.Inventors: Scott Franklin, Aravind Somanchi, George Rudenko, Riyaz Bhat, Xinhua Zhao, Risha Bond, Walter Rakitsky, Alejandro Marangoni, Diza Braksmayer
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Patent number: 11352602Abstract: The present invention provides methods for making microalgal strains with improved properties relative to the strains from which they are derived. In illustrative embodiments, the methods are performed to produce microalgal strains adapted for use in the industrial production of microalgae-derived biomass products, including but not limited to triglycerides and fatty acids. Also provided are microalgal strains, which can be obtained using the methods described herein, as wells microalgal-derived biomass products, which can be produced from such microalgal strains.Type: GrantFiled: March 30, 2016Date of Patent: June 7, 2022Assignee: Corbion Biotech, Inc.Inventors: Janice Lau Wee, Dawei Yuan, Wenhua Lu, Rika Regentin, Jeffrey Villari
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Publication number: 20220081673Abstract: A process for manufacturing a lysed cell in oil suspension and methods of applying thereof, the lysed cell in oil suspension including a solids content of at least 10 wt. % and a particle size Dv90 of 100 to 300 microns, including steps a) adding a first portion of microbial cell matter to an oil, b) subjecting the mixture of microbial cell matter and oil to one or more shear steps to effect lysis of at least part of the cells and produce a suspension including lysed cells in oil, c) adding a further portion of microbial cell matter to the suspension including lysed cells in oil, d) subjecting the mixture of microbial cell matter and the suspension including lysed cells in oil to one or more shear steps to effect lysis of at least part of the cells and produce a further suspension including lysed cells in oil.Type: ApplicationFiled: January 3, 2020Publication date: March 17, 2022Applicant: CORBION BIOTECH INC.Inventors: John PIECHOCKI, Cornelis Johannes Govardus VAN STRIEN, Linda Wilhelmina Antonetta CLAASSEN, Peter Johannes Marie BAETS, Jorge GALAZZO
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Patent number: 11193105Abstract: The invention relates to a method for protein enrichment of a microalga grown under heterotrophic conditions, said microalga being of the Chlorella genus, characterized in that the heterotrophic culture comprises a step aimed at limiting the growth of said microalga by means of a deficiency of the fermentation medium in terms of a non-nitrogenous nutritional source.Type: GrantFiled: January 22, 2019Date of Patent: December 7, 2021Assignee: Corbion Biotech, Inc.Inventors: Gabriel Macquart, Sylvain Delaroche, Marie Le Ruyet, Laurent Segueilha
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Publication number: 20210244064Abstract: The invention provides novel microalgal food compositions comprising microalgal biomass that have been processed into flakes, powders and flours. The microalgal biomass of the invention is low in saturated fats, high in monounsaturated triglyceride oil and can be a good source of fiber. The invention also comprises microalgal biomass that is suitable as a vegetarian protein source and also as a good source of fiber. Novel methods of formulating food compositions with the microalgal biomass of the invention are also disclosed herein including beverages, baked goods, egg products, reduced fat foods and gluten-free foods. The provision of food compositions incorporating the microalgal biomass of the invention to ahuman have the further benefit of providing healthful ingredients while achieving levels of satiety sufficient to reduce further caloric intake.Type: ApplicationFiled: April 21, 2021Publication date: August 12, 2021Applicant: Corbion Biotech, Inc.Inventors: Geoffrey Brooks, Scott Franklin, Jeff Avila, Stephen M. Decker, Enrique Baliu, Walter Rakitsky, John Piechocki, Dana Zdanis, Leslie M. Norris
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Patent number: 11016071Abstract: Thus, the present invention relates to a method for determining the organoleptic quality of a microalgal flour composition, comprising determining the total content of 13 volatile organic compounds, the 13 volatile organic compounds being heptanal, 3-octen-2-one, 2,4-heptadienal, 3,5-octadien-2-one, 2,4-nonadienal, 2,4-decadienal, hexanoic acid, 2-ethylhexanoic acid, heptanoic acid, myristate-1, laurate-1, myristate-2 and geranyl acetone.Type: GrantFiled: March 20, 2018Date of Patent: May 25, 2021Assignee: Corbion Biotech, Inc.Inventors: Amandine Druon, Heike Jerosch, Marilynne Guillemant, Samuel Patinier
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Patent number: 10815281Abstract: The invention relates to a method for preparing a protein isolate of the biomass of microalgae of the genus Chlorella, characterised in that it comprises the following steps: supplying a microalgal biomass produced by fermentation, washing the biomass so as to eliminate the soluble interstitial compounds and concentrating the biomass, mechanically grinding the washed and concentrated biomass in a horizontal ball grinder-type system in order to produce an emulsion, destructuring the emulsion thus produced, triple-phase separation so as to separate the soluble fraction from the fractions containing the lipids and the cell debris, recovery of the soluble fraction thus produced in order to produce the soluble protein isolate, then evaporation, pasteurisation and atomisation of said protein isolate.Type: GrantFiled: November 26, 2019Date of Patent: October 27, 2020Assignee: CORBION BIOTECH, INC.Inventor: Samuel Patinier
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Patent number: 10760106Abstract: The present invention relates to variant thioesterases and their use in plants, e.g., to increase enzymatic activity and to promote increased production of mid-chain length fatty acids (e.g., 8 to 14 carbons) and at desired ratios. Further disclosed herein are methods of manufacturing renewable chemicals through the manufacture of novel triglyceride oils followed by chemical modification of the oils. Oils containing fatty acid chain lengths of C8, C10, C12 or C14 are also disclosed and are useful as feedstocks in the methods described herein.Type: GrantFiled: January 10, 2020Date of Patent: September 1, 2020Assignee: CORBION BIOTECH, INC.Inventors: David Davis, Scott Franklin, Jeffrey L. Moseley, Riyaz Bhat
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Patent number: 10683522Abstract: Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desaturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced oxidative or thermal stability, or can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsaturated-saturated type.Type: GrantFiled: April 2, 2019Date of Patent: June 16, 2020Assignee: CORBION BIOTECH, INC.Inventors: Scott Franklin, Aravind Somanchi, George Rudenko, Riyaz Bhat, Xinhua Zhao, Risha Bond, Walter Rakitsky, Alejandro Marangoni, Diza Braksmayer
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Patent number: 10570428Abstract: The present invention relates to variant thioesterases and their use in plants, e.g., to increase enzymatic activity and to promote increased production of mid-chain length fatty acids (e.g., 8 to 14 carbons) and at desired ratios. Further disclosed herein are methods of manufacturing renewable chemicals through the manufacture of novel triglyceride oils followed by chemical modification of the oils. Oils containing fatty acid chain lengths of C8, C10, C12 or C14 are also disclosed and are useful as feedstocks in the methods described herein.Type: GrantFiled: February 22, 2019Date of Patent: February 25, 2020Assignee: CORBION BIOTECH, INC.Inventors: David Davis, Scott Franklin, Jeffrey L. Moseley, Riyaz Bhat
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Publication number: 20200046002Abstract: The present invention relates to a method for preparing, by fermentation, lipid-rich compositions of microalga flour having optimised organoleptic properties, characterised in that the microalgae are cultured in a minimal culture medium.Type: ApplicationFiled: August 14, 2019Publication date: February 13, 2020Applicant: Corbion Biotech, Inc.Inventors: Amandine Druon, Marie Le Ruyet, Laurent Segueilha
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Patent number: 10557114Abstract: The invention features plant acyl-ACP thioesterase genes of the FatB class and proteins encoded by these genes. The genes are useful for constructing recombinant host cells having altered fatty acid profiles. Oleaginous microalga host cells with the new genes or previously identified FatB genes are disclosed. The microalgae cells produce triglycerides with useful fatty acid profiles.Type: GrantFiled: October 8, 2017Date of Patent: February 11, 2020Assignee: CORBION BIOTECH, INC.Inventors: George N. Rudenko, Jason Casolari, Scott Franklin
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Publication number: 20200015490Abstract: Algal flour and algal biomass are disclosed. Food compositions comprising algal biomass or algal flour with a high lipid content are disclosed.Type: ApplicationFiled: June 13, 2019Publication date: January 16, 2020Applicant: Corbion Biotech, Inc.Inventors: John Piechocki, Dana Zdanis, Leslie M. Norris, Walter Rakitsky, Beata Klamczynska