Patents Assigned to Delsys Pharmaceuticals Corporation
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Publication number: 20040115276Abstract: A liquid pharmaceutical for oral delivery wherein at the time of use, a solid unit dosage form is added to the liquid wherein the unit dosage form is comprised of a substrate soluble in the liquid and a particulate pharmaceutically active material in a pharmaceutically effective amount. At the time of use, the unit dosage form is added to the liquid, without requiring measurement of the liquid, and the entire liquid is consumed to provide for oral delivery of the pharmaceutically effective amount of material.Type: ApplicationFiled: March 28, 2003Publication date: June 17, 2004Applicant: Delsys Pharmaceutical CorporationInventors: Suggy S. Chrai, Ramaswamy Murari
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Patent number: 6724609Abstract: Provided is an electrostatic sensing chuck for attracting particles to a portion of a particle contact surface near a deposition electrode, the electrostatic sensing chuck comprising a pixel comprising: a deposition electrode (DE) for selectively establishing an attraction field (Ea) at the particle contact surface; a shield electrode (SE) oppositely biased with respect to the deposition electrode; a charge sensing circuit to measure charge accumulated on each of the deposition electrode and the shield electrode, wherein the charge sensing circuit subtracts a second charge it senses at the shield electrode from a first charge it senses at the deposition electrode, thereby determining accumulated charge at the deposition electrode balanced by accumulated charge at the shield electrode.Type: GrantFiled: January 4, 2002Date of Patent: April 20, 2004Assignee: Delsys Pharmaceutical CorporationInventors: Hoi Cheong Sun, Nitin V. Desai, William R. Roach, David Norman Ludington, Timothy Allen Pletcher, David Keller, Frank B. Lang, Peter D. Southgate, Joseph T. McGinn
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Patent number: 6720024Abstract: Provided is, among other things, a dry deposition apparatus for depositing grains on a substrate comprising: an electrostatic chuck having one or more collection zones, wherein the substrate is layered on the chuck for processing; a charged grain delivery apparatus for directing charged grains for electrostatic deposition on the substrate at the locations of the collection zones; and an optical detection device for quantifying the amount of grains deposited.Type: GrantFiled: November 27, 2002Date of Patent: April 13, 2004Assignee: Delsys Pharmaceutical CorporationInventors: Eugene Samuel Poliniak, Hoi Cheong Steve Sun, Nitin Vithalbhai Desai, Nalin Kumar, William Ronald Roach, Lawrence Harrison Hammer, Peter David Southgate, Bawa Singh, Howard Christopher Rivenburg, Peter Zanzucchi, David Keller, Dominic Stephen Rosati
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Patent number: 6702803Abstract: Controlled release, multi-step drug dosage forms comprising a plurality of dose units and a plurality of separators that control release of drug from the dose units. In one embodiment, a dose unit is a single dosage amount of a drug that is electrostatically deposited onto a substrate. The dosage forms are designed to deliver a drug to exhibit a desired pharmacokinetic profile.Type: GrantFiled: January 22, 2001Date of Patent: March 9, 2004Assignee: Delsys Pharmaceutical CorporationInventors: Gary Kupperblatt, Marc S. Karetny, Ramaswamy Murari, Suggy S. Chrai
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Publication number: 20030200922Abstract: Provided, among other things, is a re-circulating particle feed apparatus comprising: a circular conduit of dimensions suitable for circulating gas with suspended particles; a deposition station comprising an opening onto the conduit, into which opening an electrostatic chuck fits, with a deposition surface of the chuck available to the interior of the conduit; and a propulsion device for maintaining fluid and particle circulation through the conduit, wherein the propulsion device is adapted to maintain fluid and particle circulation at a rate that brings a deposition effective amount of particles within a range of electro-attractive influence at the deposition station.Type: ApplicationFiled: April 29, 2003Publication date: October 30, 2003Applicant: Delsys Pharmaceutical CorporationInventors: George R. Pawlo, Gary Santonastaso, David Keller, Ramaswamy Murari, Suggy S. Chrai
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Publication number: 20030196599Abstract: The disclosure relates to an apparatus for electrostatically adhering grains to a planar substrate comprising:Type: ApplicationFiled: April 25, 2003Publication date: October 23, 2003Applicant: Delsys Pharmaceutical CorporationInventors: Hoi Cheong Steve Sun, Bogdan Brycki
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Patent number: 6630027Abstract: Provided, among other things, is a re-circulating particle feed apparatus comprising: a circular conduit of dimensions suitable for circulating gas with suspended particles; a deposition station comprising an opening onto the conduit, into which opening an electrostatic chuck fits, with a deposition surface of the chuck available to the interior of the conduit; and a propulsion device for maintaining fluid and particle circulation through the conduit, wherein the propulsion device is adapted to maintain fluid and particle circulation at a rate that brings a deposition effective amount of particles within a range of electro-attractive influence at the deposition station.Type: GrantFiled: July 11, 2001Date of Patent: October 7, 2003Assignee: Delsys Pharmaceutical CorporationInventor: George R. Pawlo
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Patent number: 6616932Abstract: A liquid pharmaceutical for oral delivery wherein at the time of use, a solid unit dosage form is added to the liquid wherein the unit dosage form is comprised of a substrate soluble in the liquid and a particulate pharmaceutically active material in a pharmaceutically effective amount. At the time of use, the unit dosage form is added to the liquid, without requiring measurement of the liquid, and the entire liquid is consumed to provide for oral delivery of the pharmaceutically effective amount of material.Type: GrantFiled: September 23, 1999Date of Patent: September 9, 2003Assignee: Delsys Pharmaceutical CorporationInventors: Suggy S. Chrai, Ramaswamy Murari
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Patent number: 6592671Abstract: The disclosure relates to an apparatus for electrostatically adhering grains to a planar substrate comprising: a. an electrostatic chuck having a collection surface with at least one grain collection zone for, when the planar substrate is layered on the collection surface, electrostatically directing charged grains to a corresponding surface on the planar substrate; and b. a pattern of holes through the electrostatic chuck allowing a source of low pressure to act through the electrostatic chuck to adhere the planar substrate.Type: GrantFiled: January 25, 2001Date of Patent: July 15, 2003Assignee: Delsys Pharmaceutical CorporationInventors: Hoi Cheong Steve Sun, Bogdan Brycki
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Publication number: 20030087023Abstract: The present invention is directed to electrostatic chucks, methods for their use, the electrostatic deposition of objects, such as particles in a dry powder, onto recipient substrates, and the recipient substrates themselves that have been subjected to electrostatic deposition. In one aspect, the present invention provides an electrostatic chuck for electrostatically attracting an object or objects wherein the object is used in chemical or pharmaceutical assaying or manufacturing. The objects can be pharmaceutical substrates, for example, such as a pharmaceutical tablet. Additional embodiments of the invention provide chucks and their use to electrostatically attract particles, such as a pharmaceutically active ingredient, to a substrate, such as a tablet. In one aspect, the electrostatic chuck comprises a floating electrode, and is used to selectively attract particles to a substrate above the floating electrode, thereby providing for charge imaging for the deposition of particles in a selected image.Type: ApplicationFiled: June 17, 2002Publication date: May 8, 2003Applicant: Delsys Pharmaceutical CorporationInventors: Hoi Cheong Steve Sun, Timothy Allen Pletcher
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Patent number: 6491241Abstract: Provided is, among other things, and together with associated methods, a powder feed comprising: a venturi comprising an external gas inlet, a gas outlet through which gas flows at a rate amplified over a gas flow rate into the external gas inlet, and an internal gas inlet; and a cyclone with an intake port connected to the venturi gas outlet, a recycle outlet port, and a product port, wherein a gas flow rate FS into the venturi external gas inlet results in an enhanced flow rate into the cyclone intake port.Type: GrantFiled: October 14, 1999Date of Patent: December 10, 2002Assignee: Delsys Pharmaceutical CorporationInventor: Hoi Cheong Sun
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Patent number: 6475351Abstract: AC waveforms biasing of bead transporter chucks and their accumulated charge sensing circuits tailored for low resistivity substrates and beads where if traditional DC quasi-static biasing potentials were used, the bead attraction potentials of the chuck would undergo rapid RC decay and cause the bead transporter chuck to stop working. Methods for selecting AC waveforms are given, including those that maximize the time average of the bead attraction potential at the bead collection zone of the bead contact surface.Type: GrantFiled: January 30, 2001Date of Patent: November 5, 2002Assignee: Delsys Pharmaceutical CorporationInventors: Hoi Cheong Sun, Dominic Stephen Rosati, Eugene Samuel Puliniak, Bawa Singh, Nitin Vithalbhai Desai
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Patent number: 6415790Abstract: Provided is a powder delivery system which uses mechanical or electrical means to individually release covers that cover powder at a variety of powder aliquot locations on a rigid substrate.Type: GrantFiled: December 7, 1999Date of Patent: July 9, 2002Assignee: Delsys Pharmaceutical CorporationInventors: Marvin Allan Leedom, Allan Eugene White
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Patent number: 6399143Abstract: The disclosure relates to an apparatus for electrostatically adhering grains to a planar substrate comprising: a. an electrostatic chuck having a collection surface with at least one grain collection zone for, when the planar substrate is layered on the collection surface, electrostatically directing charged grains to a corresponding surface on the planar substrate; and b. a pattern of holes through the electrostatic chuck allowing a source of low pressure to act through the electrostatic chuck to adhere the planar substrate.Type: GrantFiled: June 10, 1998Date of Patent: June 4, 2002Assignee: Delsys Pharmaceutical CorporationInventors: Hoi Cheong Steve Sun, Bogdan Brycki
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Patent number: 6397840Abstract: A dry powder, for example, a medicament for an inhaler, comprises elongated particles with an aspect ratio sufficient to cause the particles to be bound to a preferably metal or non-metallic sheet material substrate at the particle tips by electrostatic deposition and for aligning a plurality of particles with their major axes aligned normal to the, substrate and oriented tip-to-tip. Particles deposited form a low density, high relative void deposition to minimize attractive forces between the particles. This minimizes agglomeration and bonding forces to the substrate facilitating the release of a powdered medicament in an inhaler. Medicament dosages in a substrate pocket are covered by a sealing layer. An embodiment of a drug dosage inhaler substrate and inhaler is disclosed.Type: GrantFiled: June 6, 2000Date of Patent: June 4, 2002Assignee: Delsys Pharmaceutical CorporationInventors: Suggy S. Chrai, Joseph Thomas McGinn, Bawa Singh
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Patent number: 6370005Abstract: Provided is an electrostatic sensing chuck for attracting particles to a portion of a particle contact surface near a deposition electrode, the electrostatic sensing chuck comprising a pixel comprising: a deposition electrode (DE) for selectively establishing an attraction field (Ea) at the particle contact surface; a shield electrode (SE) oppositely biased with respect to the deposition electrode; a charge sensing circuit to measure charge accumulated on each of the deposition electrode and the shield electrode, wherein the charge sensing circuit subtracts a second charge it senses at the shield electrode from a first charge it senses at the deposition electrode, thereby determining accumulated charge at the deposition electrode balanced by accumulated charge at the shield electrode.Type: GrantFiled: October 14, 1999Date of Patent: April 9, 2002Assignee: Delsys Pharmaceutical CorporationInventors: Hoi Cheong Sun, Nitin V. Desai, William R. Roach, David Norman Ludington, Timothy Allen Pletcher, David Keller, Frank B. Lang, Peter D. Southgate, Joseph T. McGinn
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Publication number: 20020031477Abstract: The present invention provides an integrated structural unit that includes a diagnostic form that includes at least one active ingredient that is present in an amount that advantageously does not vary by more than about five percent from a predetermined target amount. In one embodiment, the unit form comprises a substrate, a deposit that is disposed on the substrate, and a spreading layer that overlies the deposit and is used to retain and spread a sample of liquid which is to be assayed. The deposit comprises a powder, including the active ingredient(s). The diagnostic form is created via a dry powder deposition apparatus that electrostatically deposits the powder on the substrate utilizing an electrostatic chuck and charged powder delivery apparatus.Type: ApplicationFiled: July 3, 2001Publication date: March 14, 2002Applicant: Delsys Pharmaceutical CorporationInventors: Zvi Loewy, Dennis Lee Matthies
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Patent number: 6319541Abstract: A method for electrostatically depositing select doses of medicament powder at select locations on a substrate. Specifically, an apparatus contains a charged particle emitter for generating charged particles that charge a predefined region of a substrate and a charge accumulation control circuit for computing the amount of charge accumulated upon the substrate and deactivating the emitter when a selected quantity of charge has accumulated. Additionally, a triboelectric charging apparatus charges the medicament powder and forms a charged medicament cloud proximate the charged region of the substrate. The medicament particles within the medicament cloud electrostatically adhere to the charged region. The quantity of charge accumulated on the substrate at the predefined region and the charge-to-mass ratio of the medicament powder in the cloud control the amount (dose) of medicament deposited and retained by the substrate.Type: GrantFiled: December 30, 1999Date of Patent: November 20, 2001Assignee: Delsys Pharmaceutical CorporationInventors: Timothy Allen Pletcher, Pabitra Datta, Christopher Just Poux, Randall Eugene McCoy
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Publication number: 20010033863Abstract: A substrate is robotically picked up at a station and transported to a measuring station to measure the distance to a reference. The substrate is aligned to a robot before measurement. The measured substrate is then transported to a pharmaceutical or diagnostic powder/grain deposition station where the powder/grains are controllably deposited on the substrate to predetermined thicknesses over a plurality of powder/grain collection zones. The deposited powder/grains are then measured to determine the thickness and area covered by the deposited powder/grains at each collection zone. The substrate is then transported to a lamination station and each collection zone of powder/grains is welded to a cover substrate. The system remembers which collection zones are out of specification so that they can be later selectively discarded.Type: ApplicationFiled: January 31, 2001Publication date: October 25, 2001Applicant: Delsys Pharmaceutical CorporationInventors: Suggy S. Chrai, Ramaswamy Murari, Eugene Samuel Poliniak, Hoi Cheong Steve Sun, Nitin Vithalbhai Desai, Dominic Stephen Rosati, Nalin Kumar, William Ronald Roach, Lawrence Harrison Hammer, Peter David Southgate, Bawa Singh, Howard Christopher Rivenburg, David Keller, Peter John Zanzucchi, Aaron William Levine, Prince Lal
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Patent number: 6303143Abstract: A substrate is roboticaly picked up at a station and transported to a measuring station to measure the distance to a reference. The substrate is aligned to a robot before measurement. The measured substrate is then transported to a pharmaceutical or diagnostic powder/grain deposition station where the powder/grains are controllably deposited on the substrate to predetermined thicknesses over a plurality of powder/grain collection zones. The deposited powder/grains are then measured to determine the thickness and area covered by the deposited powder/grains at each collection zone. The substrate is then transported to a lamination station and each collection zone of powder/grains is welded to a cover substrate. The system remembers which collection zones are out of specification so that they can be later selectively discarded.Type: GrantFiled: June 10, 1998Date of Patent: October 16, 2001Assignees: Sarnoff Corporation, Delsys Pharmaceutical CorporationInventors: Suggy S. Chrai, Ramaswamy Murari, Eugene Samuel Poliniak, Hoi Cheong (Steve) Sun, Nitin Vithalbhai Desai, Dominic Stephen Rosati, Nalin Kumar, William Ronald Roach, Lawrence Harrison Hammer, Peter David Southgate, Bawa Singh, Howard Christopher Rivenburg, David Keller, Peter John Zanzucchi, Aaron William Levine, Prince Lal