Patents Assigned to Delsys Pharmaceuticals Corporation
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Patent number: 6294024Abstract: The present invention is directed to electrostatic chucks, methods for their use, the electrostatic deposition of objects, such as particles in a dry powder, onto recipient substrates, and the recipient substrates themselves that have been subjected to electrostatic deposition. In one aspect, the present invention provides an electrostatic chuck for electrostatically attracting an object or objects wherein the object is used in chemical or pharmaceutical assaying or manufacturing. The objects can be pharmaceutical substrates, for example, such as a pharmaceutical tablet. Additional embodiments of the invention provide chucks and their use to electrostatically attract particles, such as a pharmaceutically active ingredient, to a substrate, such as a tablet. In one aspect, the electrostatic chuck comprises a floating electrode, and is used to selectively attract particles to a substrate above the floating electrode, thereby providing for charge imaging for the deposition of particles in a selected image.Type: GrantFiled: October 20, 1998Date of Patent: September 25, 2001Assignee: Delsys Pharmaceutical CorporationInventors: Hoi Cheong Steve Sun, Timothy Allen Pletcher
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Patent number: 6295194Abstract: Provided is a method of moving a charged particle from a first position at which it is retained by a first electrode to a second position at which it is retained by a second electrode, the method comprising: applying a potential to the second electrode to attract the particle; and applying a potential to a guide electrode offset from the particle at the first position, wherein the applied potential is effective to reduce the attraction of the particle to the first position sufficiently to allow the potential applied at the second electrode to be effective to move the particle from the first position to the second position.Type: GrantFiled: September 10, 1999Date of Patent: September 25, 2001Assignee: Delsys Pharmaceutical CorporationInventors: Hoi Cheong Sun, Bawa Singh, Howard Christopher Rivenburg
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Patent number: 6287595Abstract: The present invention provides an integrated structural unit that includes a diagnostic form that includes at least one active ingredient that is present in an amount that advantageously does not vary by more than about five percent from a predetermined target amount. In one embodiment, the unit form comprises a substrate, a deposit that is disposed on the substrate, and a spreading layer that overlies the deposit and is used to retain and spread a sample of liquid which is to be assayed. The deposit comprises a powder, including the active ingredient(s). The diagnostic form is created via a dry powder deposition apparatus that electrostatically deposits the powder on the substrate utilizing an electrostatic chuck and charged powder delivery apparatus.Type: GrantFiled: March 24, 2000Date of Patent: September 11, 2001Assignee: Delsys Pharmaceuticals CorporationInventors: Zvi Loewy, Dennis Lee Matthies
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Patent number: 6237590Abstract: Provided is a powder delivery system which uses mechanical or electrical means to individually release covers that cover powder at a variety of powder aliquot locations on a rigid substrate.Type: GrantFiled: September 18, 1997Date of Patent: May 29, 2001Assignee: Delsys Pharmaceutical CorporationInventors: Marvin Allan Leedom, Allan Eugene White
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Patent number: 6187149Abstract: AC waveforms biasing of bead transporter chucks and their accumulated charge sensing circuits tailored for low resistivity substrates and beads where if traditional DC quasi-static biasing potentials were used, the bead attraction potentials of the chuck would undergo rapid RC decay and cause the bead transporter chuck to stop working. Methods for selecting AC waveforms are given, including those that maximize the time average of the bead attraction potential at the bead collection zone of the bead contact surface.Type: GrantFiled: December 7, 1999Date of Patent: February 13, 2001Assignee: Delsys Pharmaceutical CorporationInventors: Hoi Cheong Sun, Dominic Stephen Rosati, Eugene Samuel Poliniak, Bawa Singh, Nitin Vithalbhai Desai
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Patent number: 6149774Abstract: AC waveforms biasing of bead transporter chucks and their accumulated charge sensing circuits tailored for low resistivity substrates and beads where if traditional DC quasi-static biasing potentials were used, the bead attraction potentials of the chuck would undergo rapid RC decay and cause the bead transporter chuck to stop working. Methods for selecting AC waveforms are given, including those that maximize the time average of the bead attraction potential at the bead collection zone of the bead contact surface.Type: GrantFiled: June 10, 1998Date of Patent: November 21, 2000Assignee: Delsys Pharmaceutical CorporationInventors: Hoi Cheong Steve Sun, Eugene Samuel Poliniak, Dominic Stephen Rosati, Bawa Singh, Nitin Vithalbhai Desai
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Patent number: 6146685Abstract: A dry powder, for example, a medicament for an inhaler, comprises elongated particles with an aspect ratio sufficient to cause the particles to be bound to a preferably metal or non-metallic sheet material substrate at the particle tips by electrostatic deposition and for aligning a plurality of particles with their major axes aligned normal to the substrate and oriented tip-to-tip. Particles deposited form a low density, high relative void deposition to minimize attractive forces between the particles. This minimizes agglomeration and bonding forces to the substrate facilitating the release of a powdered medicament in an inhaler. Medicament dosages in a substrate pocket are covered by a sealing layer. An embodiment of a drug dosage inhaler substrate and inhaler is disclosed.Type: GrantFiled: November 5, 1998Date of Patent: November 14, 2000Assignee: Delsys Pharmaceutical CorporationInventors: Suggy S. Chrai, Joseph Thomas McGinn, Bawa Singh
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Patent number: 6096368Abstract: Bead transporter chucks for selective pick up and discharging of polymer beads for chemical synthesis or analysis, whereby repulsive field conductors are arranged around bead electrodes used for selectively attracting and retaining beads. Problems of bead control are addressed by adding repulsive fields to help guide and direct beads to desired or designated bead collection zones. The repulsive electrodes create non-uniform electric fields that control, focus, and deflect charged beads in the vicinity of the bead collection zone, helping prevent multiple bead retention at intended bead collection zones. For better bead control, and allowing manipulation of beads with higher charge/mass ratios, dielectric material may be positioned around the bead electrode and between the bead electrode and the repulsive field conductor. Multiple bead electrodes may be provided to form two or more bead collection zones, and these may selectively addressed and controlled (e.Type: GrantFiled: February 19, 1998Date of Patent: August 1, 2000Assignee: Delsys Pharmaceutical CorporationInventor: Hoi Cheong Sun
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Patent number: 6063194Abstract: Provided is, among other things, a dry deposition apparatus for depositing grains on a substrate comprising:an electrostatic chuck having one or more collection zones, wherein the substrate is layered on the chuck for processing;a charged grain delivery apparatus for directing charged grains for electrostatic deposition on the substrate at the locations of the collection zones; andan optical detection device for quantifying the amount of grains deposited.Type: GrantFiled: June 10, 1998Date of Patent: May 16, 2000Assignee: Delsys Pharmaceutical CorporationInventors: Eugene Samuel Poliniak, Hoi Cheong Steve Sun, Nitin Vithalbhai Desai, Nalin Kumar, William Ronald Roach, Lawrence Harrison Hammer, Peter David Southgate, Bawa Singh, Howard Christopher Rivenburg, Peter Zanzucchi, David Keller, Dominic Stephen Rosati, Aaron W. Levine, Bogdan Brycki