Patents Assigned to Dipharma Francis S.r.l.
  • SYNTHESIS OF AN AZASUGAR AND THE INTERMEDIATES THEREOF
    Publication number: 20160304458
    Abstract: Process for the preparation of intermediates useful in the synthesis of miglustat and their use in its manufacture.
    Type: Application
    Filed: April 14, 2016
    Publication date: October 20, 2016
    Applicant: DIPHARMA FRANCIS s.r.l.
    Inventors: Andrea MALVESTITI, Enrico BRUNOLDI, Emanuele ATTOLINO
  • PROCESS FOR THE PREPARATION OF AN ANTIDEPRESSANT AND THE INTERMEDIATES THEREOF
    Publication number: 20160145224
    Abstract: The present invention relates to a process for the preparation of 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine of formula (I), also known as vortioxetine, salts thereof, and intermediates useful for its synthesis.
    Type: Application
    Filed: November 19, 2015
    Publication date: May 26, 2016
    Applicant: DIPHARMA FRANCIS s.r.l.
    Inventors: Luca GIANNOTTI, Renzo GRAZIOSI, Emanuele ATTOLINO, Pietro ALLEGRINI
  • Process for the purification of 2-phenyl-2-methyl-propanoic acid derivatives
    Patent number: 9334223
    Abstract: Process for the preparation of 2-phenyl-2-methyl propanoic acid derivatives, useful as intermediates in the preparation of fexofenadine hydrochloride.
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: May 10, 2016
    Assignee: Dipharma Francis S.r.l.
    Inventors: Pietro Allegrini, Vittorio Lucchini, Davide Rossi, Mauro Mittino, Gabriele Razzetti
  • ANTIMUSCARINIC COMPOUND HAVING A LOW CONTENT OF IMPURITIES
    Publication number: 20160031796
    Abstract: Substantially stable to degradation Fesoterodine fumarate, a process for its preparation and a process for the synthesis of specific degradation impurities of Fesoterodine fumarate are disclosed.
    Type: Application
    Filed: June 23, 2015
    Publication date: February 4, 2016
    Applicant: Dipharma Francis S.r.l.
    Inventors: Pietro ALLEGRINI, Emanuele ATTOLINO, Renzo GRAZIOSI
  • CRYSTALLINE FORMS OF AN ANTIDEPRESSANT COMPOUND
    Publication number: 20160015706
    Abstract: The present invention relates to novel crystalline forms of vortioxetine hydrobromide, in particular three crystalline forms, a process for their preparation, a pharmaceutical composition containing said novel crystalline forms, and a process for the purification of vortioxetine or a salt thereof, comprising the formation of one or more of the novel crystalline forms of vortioxetine hydrobromide described herein.
    Type: Application
    Filed: July 6, 2015
    Publication date: January 21, 2016
    Applicant: DIPHARMA FRANCIS S.r.l.
    Inventors: Stefano Luca GIAFFREDA, Marco CURZI, Elena DICHIARANTE, Pietro ALLEGRINI, Renzo GRAZIOSI, Chiara VLADISKOVIC
  • PHARMACEUTICAL COMPOSITION
    Publication number: 20150272919
    Abstract: Pharmaceutical compositions useful in the treatment of sexual and urogenital dysfunctions such as dyspareunia, vulvodynia, vaginismus, vestibulitis and anal fistulas.
    Type: Application
    Filed: September 19, 2013
    Publication date: October 1, 2015
    Applicant: Dipharma Francis S.r.l.
    Inventors: Franca Ferrari, Silvia Rossi, Maria Cristina Bonferoni, Giuseppina Sandri, Carla Caramella, Pietro Allegrini
  • Synthesis of a glycosyltransferase inhibitor
    Patent number: 9079856
    Abstract: Process for the preparation of an iminosugar, and the intermediates thereof, having known activity as a glycosyltransferase inhibitor and used, for example, in the treatment of Gaucher's disease.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: July 14, 2015
    Assignee: Dipharma Francis S.r.l.
    Inventors: Emanuele Attolino, Andrea Malvestiti
  • Process for the preparation of sulfonamide compounds
    Patent number: 9079831
    Abstract: Process for the preparation of known sulfonamides having antibacterial activity applicable on industrial scale, which allows their production in high yields and purity, comprising in particular the step of nucleophile aromatic substitution and oxidation in suitable conditions.
    Type: Grant
    Filed: April 2, 2014
    Date of Patent: July 14, 2015
    Assignee: Dipharma Francis S.r.l.
    Inventors: Pietro Allegrini, Simone Mantegazza
  • CO-CRYSTAL OF AN ANTIDEPRESSANT COMPOUND
    Publication number: 20150126526
    Abstract: Co-crystal of a serotonin reuptake inhibitor, in stable form.
    Type: Application
    Filed: November 4, 2014
    Publication date: May 7, 2015
    Applicant: DIPHARMA FRANCIS S.R.L.
    Inventors: Nicolas TESSON, Jordi de Mier VINUÉ
  • CRYSTALLINE FORMS OF AN ADRENERGIC AGONIST
    Publication number: 20150111934
    Abstract: The present invention relates to the acetate salt of Mirabegron, in particular in two novel crystalline forms, a process for their preparation and the use of said salt and its crystalline forms in the synthesis of Mirabegron with high yields and chemical purity.
    Type: Application
    Filed: October 3, 2014
    Publication date: April 23, 2015
    Applicant: DIPHARMA FRANCIS S.R.L.
    Inventors: Alessio BOVE, Pietro ALLEGRINI, Emanuele ATTOLINO
  • PROCESS FOR THE PURIFICATION OF 2-PHENYL-2-METHYL-PROPANOIC ACID DERIVATIVES
    Publication number: 20150099899
    Abstract: Process for the preparation of 2-phenyl-2-methyl propanoic acid derivatives, useful as intermediates in the preparation of fexofenadine hydrochloride.
    Type: Application
    Filed: October 3, 2014
    Publication date: April 9, 2015
    Applicant: DIPHARMA FRANCIS S.R.L.
    Inventors: Pietro ALLEGRINI, Vittorio LUCCHINI, Davide ROSSI, Mauro MITTINO, Gabriele RAZZETTI
  • Apixaban preparation process
    Patent number: 8969561
    Abstract: Process for the preparation of apixaban and intermediates useful for the preparation thereof.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: March 3, 2015
    Assignee: Dipharma Francis S.r.l.
    Inventors: Emanuele Attolino, Alessandro Lombardo, Simone Tambini
  • APIXABAN PREPARATION PROCESS
    Publication number: 20150025242
    Abstract: Process for the preparation of apixaban and intermediates useful for the preparation thereof.
    Type: Application
    Filed: October 10, 2014
    Publication date: January 22, 2015
    Applicant: DIPHARMA FRANCIS S.r.l.
    Inventors: Emanuele ATTOLINO, Alessandro LOMBARDO, Simone TAMBINI
  • Apixaban preparation process
    Patent number: 8884016
    Abstract: Process for the preparation of apixaban and intermediates useful for the preparation thereof.
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: November 11, 2014
    Assignee: Dipharma Francis S.r.l.
    Inventor: Chiara Vladiskovic
  • PROCESS FOR THE PREPARATION OF PHARMACEUTICAL INTERMEDIATES
    Publication number: 20140309437
    Abstract: Process for the preparation of intermediates that are useful in the synthesis of active pharmaceutical ingredients (API), in particular active in the central nervous system.
    Type: Application
    Filed: April 8, 2014
    Publication date: October 16, 2014
    Applicant: DIPHARMA FRANCIS S.R.L.
    Inventors: Marco ARTICO, Emanuele ATTOLINO
  • PROCESS FOR THE PREPARATION OF SULFONAMIDE COMPOUNDS
    Publication number: 20140303402
    Abstract: Process for the preparation of known sulfonamides having antibacterial activity applicable on industrial scale, which allows their production in high yields and purity, comprising in particular the step of nucleophile aromatic substitution and oxidation in suitable conditions.
    Type: Application
    Filed: April 2, 2014
    Publication date: October 9, 2014
    Applicant: DIPHARMA FRANCIS S.r.l.
    Inventors: Pietro ALLEGRINI, Simone MANTEGAZZA
  • SYNTHESIS OF A SEROTONIN REUPTAKE INHIBITOR
    Publication number: 20140275542
    Abstract: Process for the preparation of a piperazinyl derivative, and its intermediates, which has known activity as a serotonin reuptake inhibitor and is used in therapy for treating serious symptoms of depression in adults.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Applicant: DIPHARMA FRANCIS S.R.L.
    Inventors: Maurizio TADDEI, Luca GIANNOTTI, Emanuele ATTOLINO, Pietro ALLEGRINI
  • PROCESS FOR THE PREPARATION OF FESOTERODINE OR A SALT THEREOF
    Publication number: 20140275610
    Abstract: A process for the preparation of (R)-2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)-phenol isobutyrate (Fesoterodine) or a pharmaceutically acceptable salt thereof having low content in impurities.
    Type: Application
    Filed: June 2, 2014
    Publication date: September 18, 2014
    Applicant: DIPHARMA FRANCIS S.R.L.
    Inventors: Marco ARTICO, Emanuele ATTOLINO, Pietro ALLEGRINI, Gabriele RAZZETTI
  • SYNTHESIS OF A GLYCOSYLTRANSFERASE INHIBITOR
    Publication number: 20140243369
    Abstract: Process for the preparation of animinosugar, and the intermediates thereof, having known activity as a glycosyltransferase inhibitor and used, for example, in the treatment of Gaucher's disease.
    Type: Application
    Filed: December 5, 2013
    Publication date: August 28, 2014
    Applicant: DIPHARMA FRANCIS S.R.L.
    Inventors: Emanuele ATTOLINO, Andrea MALVESTITI
  • Process for the preparation of pteridine derivatives
    Patent number: 8809553
    Abstract: The application discloses a process for the preparation of 5-deoxy-L-arabinose of formula (VI); comprising the conversion of a compound of formula (XII); wherein n is 0, 1 or 2; which can be used as intermediate for the synthesis of sapropterin.
    Type: Grant
    Filed: June 13, 2011
    Date of Patent: August 19, 2014
    Assignee: Dipharma Francis S.r.l.
    Inventors: Emanuele Attolino, Mario Michieletti, Davide Rossi, Pietro Allegrini