Abstract: Iminosugar, which possesses known activity as a glycosyltransferase inhibitor, and is used, for example, in the treatment of Gaucher's disease, in crystalline form, a process for its preparation and a pharmaceutical composition thereof.
Abstract: A process for the preparation of (R)-2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)-phenol isobutyrate (Fesoterodine) or a pharmaceutically acceptable salt thereof having low content in impurities.
Type:
Grant
Filed:
November 14, 2011
Date of Patent:
July 8, 2014
Assignee:
Dipharma Francis S.r.l.
Inventors:
Marco Artico, Emanuele Attolino, Pietro Allegrini, Gabriele Razzetti
Abstract: Process for the preparation of a cyclopropylamide compound which is useful as a structural unit in a process for the preparation of a viral protease inhibitor.
Type:
Application
Filed:
November 22, 2013
Publication date:
May 29, 2014
Applicant:
DIPHARMA FRANCIS S.R.L.
Inventors:
Pietro ALLEGRINI, Enrico BRUNOLDI, Emanuele ATTOLINO, Alessio BOVE
Abstract: A process for the preparation of (R)-2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)-phenol isobutyrate (Fesoterodine), its (S)-enantiomer, and novel intermediates useful in the synthesis.
Type:
Grant
Filed:
October 28, 2010
Date of Patent:
September 10, 2013
Assignee:
Dipharma Francis s.r.l.
Inventors:
Simone Mantegazza, Pietro Allegrini, Emanuele Attolino
Abstract: A process for purifying Rufinamide, comprising: a) providing a dispersion of crude 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide in a solvent mixture containing at least a carboxylic acid, and dissolving it; b) slowly cooling the solution to precipitate Rufinamide crystalline form A; and c) recovering the solid.
Type:
Grant
Filed:
April 20, 2012
Date of Patent:
June 11, 2013
Assignee:
Dipharma Francis S.r.L.
Inventors:
Pietro Allegrini, Dario Pastorello, Gabriele Razzetti
Abstract: Disclosed is a process for the preparation of (R)-2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)-phenol isobutyrate (Fesoterodine) or a pharmaceutically acceptable salt thereof having a low content of impurities such as tolterodine and tolterodine isobutyrate.
Type:
Grant
Filed:
December 20, 2010
Date of Patent:
June 4, 2013
Assignee:
Dipharma Francis s.r.l.
Inventors:
Marco Artico, Emanuele Attolino, Pietro Allegrini
Abstract: The application discloses a process for the preparation of 5-deoxy-L-arabinose of formula (VI); comprising the conversion of a compound of formula (XII); wherein n is 0, 1 or 2; which can be used as intermediate for the synthesis of sapropterin.
Type:
Application
Filed:
June 13, 2011
Publication date:
April 11, 2013
Applicant:
DIPHARMA FRANCIS S.R.L.
Inventors:
Emanuele Attolino, Mario Michieletti, Davide Rossi, Pietro Allegrini
Abstract: It is disclosed a process for the preparation of a compound of formula (I) or a salt thereof, comprising: nitrating a compound of formula (II) or a salt thereof, to obtain a compound of formula (IV) or a salt thereof, reducing it, to obtain a compound of formula (V) or a salt thereof, and subsequently cyclizing it to obtain a compound of formula (I) or a salt thereof and, if desired, converting a compound of formula (I) to a salt thereof, or vice versa, characterized in that: the nitration of a compound of formula (II) or a salt thereof is carried out with concentrated nitric acid in the presence of a strong inorganic acid and that the amino group in the compound of formula (II) is not protected.
Type:
Application
Filed:
July 25, 2012
Publication date:
January 31, 2013
Applicant:
DIPHARMA FRANCIS S.r.l.
Inventors:
Emanuele ATTOLINO, Roberto ROSSI, Pietro ALLEGRINI
Abstract: Process for the preparation of crystalline anhydrous (R)-2-[[[3-methyl-4-(2,2,2-trifluoroetoxy)-2-piridyl]methyl]sulphinyl]benzimidazole (dexlansoprazole).
Abstract: A process for purifying Rufinamide, comprising: a) providing a dispersion of crude 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide in a solvent mixture containing at least a carboxylic acid, and dissolving it; b) slowly cooling the solution to precipitate Rufinamide crystalline form A; and c) recovering the solid.
Type:
Application
Filed:
April 20, 2012
Publication date:
November 1, 2012
Applicant:
DIPHARMA FRANCIS S.R. L.
Inventors:
Pietro ALLEGRINI, Dario PASTORELLO, Gabriele RAZZETTI
Abstract: A process for the preparation of 4-[1-oxo-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-?,?-dimethylbenzeneacetic acid, useful as an intermediate for the preparation of fexofenadine, is provided.
Type:
Grant
Filed:
May 15, 2008
Date of Patent:
August 7, 2012
Assignee:
Dipharma Francis s.r.l.
Inventors:
Tiziano Scubla, Pietro Allegrini, Eliana Rocchini, Caterina Napoletano
Abstract: The present invention relates to processes for the preparation of 8-(3R)-3-aminopiperidinyl)-7-butyn-2-yl-3 -methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione and novel intermediates useful in its synthesis.
Type:
Application
Filed:
December 14, 2011
Publication date:
June 28, 2012
Applicant:
DIPHARMA FRANCIS S.R.L.
Inventors:
Pietro ALLEGRINI, Emanuele ATTOLINO, Marco ARTICO
Abstract: Process for the preparation of (R)-2-[[[3-methyl-4(2,2,2-trifluoroethoxy)-2-piridyl]methyl]sulfinyl]benzimidazole (Dexlansoprazole) and new intermediates useful in its preparation.
Abstract: The present invention relates to a process for the preparation of intermediates useful in the synthesis of [1[S(R)],2?,4?]-4-cyclohexyl-1-[[[2-methyl-1-oxypropoxy)propoxy](4-phenylbutyl phosphinyl]acetyl]L-proline, and the synthesis thereof, in particular as sodium salt (fosinopril sodium).
Type:
Application
Filed:
November 1, 2011
Publication date:
June 7, 2012
Applicant:
DIPHARMA FRANCIS S.r.l.
Inventors:
Pietro ALLEGRINI, Emanuele ATTOLINO, Alessandro DE MARCO, Fausto GORASSINI, Mario MICHIELETTI
Abstract: Novel crystalline hydrate form of (S)-1-phenylethylammonium (R)-diphenyl-methanesulphinyl-acetate and its use in a process for the preparation of (R)-benzhydrylsulphinylacetamide.
Type:
Grant
Filed:
November 4, 2008
Date of Patent:
June 5, 2012
Assignee:
Dipharma Francis S.R.L.
Inventors:
Giuseppe Barreca, Pietro Allegrini, Gabriele Razzetti
Abstract: Rabeprazole sodium in the monohydrate crystalline form, pharmaceutical compositions thereof, the use thereof in therapy, a process for its preparation, and the use thereof for the purification of rabeprazole sodium.
Type:
Grant
Filed:
December 18, 2007
Date of Patent:
March 27, 2012
Assignee:
Dipharma Francis S.R.L.
Inventors:
Giuseppe Barreca, Alessandro Restelli, Pietro Allegrini
Abstract: A process for the preparation of a compound of formula (I) such as 2(R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]-7(8H)-pyrazinyl]-1-(2,4,5-trifluorophenyl)-2-butanamine, or a salt thereof, in the anhydrous or hydrated form, either as a mixture of enantiomers, or as a single (R) or (S) enantiomer, comprising the conversion of a compound of formula (II), or a salt thereof, either as a single (R) or (S) enantiomer or as a mixture thereof wherein X is hydrogen, hydroxy, C1-C8 alkyl, C1-C4 alkoxy, aryl, amino, N3 or halogen; into a compound of formula (I), and if desired, the separation of a single enantiomer of formula (I) from the racemic mixture, and/or, if desired, the conversion of a compound of formula (I) into a salt thereof, or vice versa.
Type:
Grant
Filed:
March 19, 2010
Date of Patent:
January 17, 2012
Assignee:
Dipharma Francis S.r.l.
Inventors:
Pietro Allegrini, Emanuele Attolino, Gianmaria Dell'Anna, Mario Michieletti