Abstract: The invention relates to an enzyme composition, a process for the preparation thereof and the use of the enzyme composition in enzymatic hydrolysis.
Type:
Grant
Filed:
March 27, 2019
Date of Patent:
December 7, 2021
Assignee:
DSM IP ASSETS B.V.
Inventors:
Maaike Appeldoorn, Loes Elizabeth Bevers
Abstract: The present invention describes a recombinant yeast cell functionally expressing one or more heterologous nucleic acid sequences encoding for ribulose-1,5-phosphate carboxylase/oxygenase (EC4.1.1.39; Rubisco), and optionally one or more molecular chaperones for Rubisco, and one or more phosphoribulokinase (EC2.7.1.19; PRK), wherein the phosphoribulokinase is under control of a promoter (the “PRK promoter”) that enables higher expression under anaerobic conditions than under aerobic conditions.
Type:
Grant
Filed:
April 24, 2020
Date of Patent:
November 30, 2021
Assignee:
DSM IP ASSETS B.V.
Inventors:
Ioannis Papapetridis, Antonius Jeroen Adriaan Van Maris, Jacobus Thomas Pronk, Paulus Petrus De Waal, Niels Lauret, Maarten Dirk Verhoeven, Jozef Petrus Johannes Schmitz
Abstract: A chain is provided which includes a plurality of interconnected chain-links. At least one chain-link of the chain has a braided core which includes a first primary strand having polymeric elongated elements having a tenacity of at least 1.0 N/tex. The braided core is braided from at least 2 consecutive turns of the primary strand. Also disclosed is a braided endless shaped element suitable as chain-link for the chain as well as a chain which has a tenacity (Ten) in N/Tex and a combined titer of the 2 legs of the chain-link having polymeric elongated elements (T) in MTex satisfying the relationship of Ten?0.50*T?0.05.
Type:
Grant
Filed:
March 6, 2017
Date of Patent:
November 23, 2021
Assignee:
DSM IP ASSETS B.V.
Inventors:
Karel Jozef Wetzels, Dietrich Wienke, Jozef Siegfried Johannes Homminga, Roelof Marissen, Rigobert Bosman
Abstract: A recombinant host capable of producing a steviol glycoside which overexpresses a polypeptide which mediates steviol glycoside transport and which polypeptide comprises the amino acid sequence set forth in SEQ ID NO: 29 or an amino acid sequence having at least about 50% sequence identity thereto. A recombinant host capable of producing a steviol glycoside which has been modified, preferably in its genome, to result in a deficiency in the production of a polypeptide which mediates steviol glycoside transport and which polypeptide comprises the amino acid sequence set forth in SEQ ID NO: 29 or an amino acid sequence having at least about 50% sequence identity thereto.
Type:
Grant
Filed:
August 15, 2016
Date of Patent:
November 23, 2021
Assignee:
DSM IP ASSETS B.V.
Inventors:
Viktor Marius Boer, Priscilla Zwartjens, Eric Van Den Berg
Abstract: The present invention relates to a yeast cell, in particular a recombinant yeast cell, the cell lacking enzymatic activity needed for the NADH-dependent glycerol synthesis or the cell having a reduced enzymatic activity with respect to the NADH-dependent glycerol synthesis compared to its corresponding wild-type yeast cell, the cell comprising one or more heterologous nucleic acid sequences encoding an NAD+-dependent acetylating acetaldehyde dehydrogenase (EC 1.2.1.10) activity. The invention further relates to the use of a cell according to the invention in the preparation of ethanol.
Type:
Grant
Filed:
February 15, 2021
Date of Patent:
November 16, 2021
Assignee:
DSM IP ASSETS B.V.
Inventors:
Jacobus Thomas Pronk, Antonius Jeroen Adriaan Van Maris, Victor Gabriel Guadalupe Medina
Abstract: This invention relates to a method for preparing a composition having a melt viscosity of between 160 Pas and 400 Pas, as determined according to ISO-11443-2014 at 270° C. and a shear rate of 265 l/s, and a volume resistivity of at most 105 Ohm·cm, measured according to ASTM D257 on an injection molded test sample of 3 mm thickness and a diameter of 50 mm and coated with a gold layer on an upper and lower surface and, as well as the composition itself and painted parts comprising the composition.
Type:
Grant
Filed:
February 8, 2018
Date of Patent:
November 16, 2021
Assignee:
DSM IP ASSETS B.V.
Inventors:
Ronald Michaël Alexander Maria Schellekens, Michelle Elizabeth Seitz
Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.
Type:
Grant
Filed:
March 30, 2020
Date of Patent:
November 9, 2021
Assignee:
DSM IP Assets B.V.
Inventors:
John E. Nash, William T. Fisher, Douglas G. Evans
Abstract: Novel biaromatic compounds, which are vitamin D analogs, processes for their preparation and cosmetic, dermatological and pharmaceutical preparations containing one or more of these compounds.
Type:
Grant
Filed:
December 14, 2016
Date of Patent:
November 9, 2021
Assignee:
DSM IP ASSETS B.V.
Inventors:
Igor Bendik, Piero Geotti-Bianchini, Marc Heidl, Eileen Jackson, Alexander Schlifke-Poschalko
Abstract: The invention relates to an improved process for the manufacture of nano-sized organic UV absorbers having a mean particle size distribution (Dv50) determined by light scattering of less than 200 nm.
Abstract: The present invention is directed to isolated microorganisms as well as strains and mutants thereof, biomasses, microbial oils, compositions, and cultures; methods of producing the microbial oils, biomasses, and mutants; and methods of using the isolated microorganisms, biomasses, and microbial oils.
Type:
Grant
Filed:
February 6, 2018
Date of Patent:
October 26, 2021
Assignee:
DSM IP Assets B.V.
Inventors:
Kirk E. Apt, Paul Warren Behrens, Jon Milton Hansen, Joseph W. Pfeifer, III, Tracey Lynn Stahl, Ross Zirkle
Abstract: The present invention relates to the field of molecular biology and cell biology. More specifically, the present invention relates to a CRISPR-CAS system for a lipolytic yeast host cell.
Type:
Grant
Filed:
February 3, 2020
Date of Patent:
October 19, 2021
Assignee:
DSM IP ASSETS B.V.
Inventors:
Bernard Meijrink, René Verwaal, Bianca Elisabeth Maria Gielesen, Johannes Andries Roubos
Abstract: The present invention is based on the advantageous use of single-stranded oligonucleotides in the in vivo (within a cell) assembly of double-stranded oligonucleotides into a single double-stranded nucleic acid construct. The present invention relates to the use of at least a first and a second single-stranded oligonucleotide in the assembly within a cell of at least two double-stranded nucleic acid molecules into a single double-stranded nucleic acid construct of pre-determined sequence, wherein the first and second single-stranded oligonucleotide are essentially complementary to each other.
Type:
Grant
Filed:
December 15, 2016
Date of Patent:
October 19, 2021
Assignee:
DSM IP ASSETS B.V.
Inventors:
Johannes Andries Roubos, René Verwaal, Bianca Elisabeth Maria Gielesen, Brenda Vonk
Abstract: This invention provides a fermentation method of producing gellan gum, wherein a certain amount of fermentation broth is retained in the fermentor as a seed for next batch fermentation or transferred to another fermentor as a seed for next batch fermentation in that fermentor. The fermentation method of this invention reduces fermentation cost of gellan gum and lowers contamination risk during seed cultivation.
Abstract: The invention relates to a method for manufacturing a composite sheet comprising high performance polyethylene fibres and a polymeric resin comprising the steps of assembling HPPE fibres to a sheet, applying an aqueous suspension of a polymeric resin to the HPPE fibres, partially drying the aqueous suspension, optionally applying a temperature and/or a pressure treatment to the composite sheet wherein the polymeric resin is a homopolymer or copolymer of ethylene and/or propylene. The invention further relates to composite sheets obtainable by said method and articles comprising the composite sheet such as helmets, radomes or a tarpaulins.
Type:
Grant
Filed:
October 7, 2016
Date of Patent:
October 19, 2021
Assignee:
DSM IP ASSETS B.V.
Inventors:
Roelof Marissen, Johannes Wilms, Leonard Nielaba
Abstract: The present invention relates to a process for the production of ?-springene of formula (I) wherein a compound of formula (II) is heated in the presence of a catalyst.
Type:
Grant
Filed:
September 13, 2018
Date of Patent:
October 5, 2021
Assignee:
DSM IP ASSETS B.V.
Inventors:
Raphael Beumer, Werner Bonrath, Marc-André Mueller, Bettina Wüestenberg
Abstract: The present invention relates to a eukaryotic cell that is genetically modified comprising one or more heterologous gene encoding: a) D-glucose-6-phosphate dehydrogenase and/or b) 6-phosphogluconate dehydrogenase; and/or c) glucose dehydrogenase, gluconolactonase and gluconate kinase, wherein a), b) and glucose dehydrogenase in c) are NAD+ dependent.
Type:
Grant
Filed:
October 3, 2016
Date of Patent:
October 5, 2021
Assignee:
DSM IP Assets B.V.
Inventors:
Ioannis Papapetridis, Jacobus Thomas Pronk, Antonius Jeroen Adriaan Van Maris, Paul Klaassen
Abstract: A computer-based method for determining a sunscreen composition comprising a plurality of UV filter substances, comprises the steps of selecting at least one constraint for at least one characteristic of the composition to be determined (step 30), the at least one constraint comprising a sunscreen performance target; selecting an optimization objective from a plurality of optimization objectives (step 50); and automatically determining the sunscreen composition as a composition of filter substances from a set of filter substances (step 100), the composition meeting the at least one constraint and being optimized with respect to the selected optimization objective. The automatic determination comprises the steps of generating a plurality of candidate compositions, determining a sunscreen performance of the candidate compositions using a performance simulation tool and comparing the determined sunscreen performance of the candidate compositions with the sunscreen performance target.