Abstract: The disclosure relates to an organic-inorganic hybrid (OIH) polymeric composition and related methods for forming the same. The disclosure also relates to a polymeric composition as disclosed herein and related methods for forming the same. The OIH polymeric composition and the polymeric composition can be formed by UV-irradiating a corresponding composition including a Michael-addition (MA) acceptor compound, a Michael-addition (MA) donor compound, a silane compound, when present, and a photo-latent base initiator to form a corresponding base catalyst and catalyze the reactions forming the networked polymer. The OIH polymeric composition and the polymeric composition can be used as a coating on any of a variety of substrates or as an interlayer in an additive manufacturing process.

Abstract: Provided herein are plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or disorder associated with elevated PAI-1. The disclosure includes, but is not limited to, the use of such compounds to prevent or reduce thrombosis and fibrosis, to promote thrombolysis, and to modulate lipid metabolism and treat diseases or disorders associated with elevated PAI-1, cholesterol, or lipid levels.

Abstract: The disclosure relates to an organic-inorganic hybrid (OIH) polymeric composition and related methods for forming the same. The disclosure also relates to a polymeric composition as disclosed herein and related methods for forming the same. The OIH polymeric composition and the polymeric composition can be formed by UV-irradiating a corresponding composition including a Michael-addition (MA) acceptor compound, a Michael-addition (MA) donor compound, a silane compound, when present, and a photo-latent base initiator to form a corresponding base catalyst and catalyze the reactions forming the networked polymer. The OIH polymeric composition and the polymeric composition can be used as a coating on any of a variety of substrates or as an interlayer in an additive manufacturing process.

Abstract: The disclosure relates to curable polyepoxysilane compounds and compositions, methods related to curing of such compounds via hydrolysis and/or condensation to form coatings on a substrate, and coated articles formed from the curable polyepoxysilane compounds. The polyepoxysilane compounds are silane-functional precursors and can be used as coatings (or pretreatments) on various substrates (e.g., metals such as aluminum) and provide a substantial improvement in corrosion resistance relative to other anti-corrosion coatings. The silane-functional precursors can be prepared by reaction of functional silanes (e.g., amino-functional silanes or other epoxide-reactive functionalized silanes) with epoxide-containing organic or hydrocarbon compounds and oligomers/polymers thereof (e.g., glycidyl-type ethers or other epoxide-/oxirane-functionalized hydrocarbon compounds), for example including hydrocarbons with one or more aromatic hydrocarbon groups (e.g., in an aromatic polyether).

Abstract: The disclosure relates to curable polysilyl phosphate compounds and compositions as well as related methods and flame-retardant textiles incorporating the same. Curable polysilyl phosphate compounds according to the disclosure include a hydrocarbon moiety comprising at least one phosphate group and more than two hydrolysable silyl groups linked to the hydrocarbon moiety. In some embodiments, the hydrocarbon moiety is derived from spirocyclic pentaerythritol diphosphoryl chloride. The curable polysilyl phosphate compound can applied to a textile substrate and then cured to provide a flame-retardant textile with the cured polysilyl phosphate compound as a coating bonded to the textile substrate.

Abstract: The disclosure relates to curable polyureasil compounds, methods related to curing of such compounds via hydrolysis and/or condensation to form coatings on a substrate, and coated articles formed from the curable polyureasil compounds. The polyureasil compounds are generally hydrocarbon-based, including multiple urea groups and multiple hydrolysable silyl groups per molecule. The hydrolysable silyl groups can be hydrolyzed and subsequently condensed to provide a networked polymeric structure with siloxane/urea linkages between polyureasil compound precursors to form a cured polyureasil composition useful as a coating for a substrate, in particular an anti-corrosion coating for a metallic substrate.

Abstract: The disclosure generally relates to a dispersion of nanoparticles in a liquid medium. The liquid medium is suitably water-based and further includes an ionic liquid-based stabilizer in the liquid medium to stabilize the dispersion of nanoparticles therein. The stabilizer can be polymeric or monomeric and generally includes a moiety with at least one quaternary ammonium cation from a corresponding ionic liquid. The dispersion suitably can be formed by shearing or otherwise mixing a mixture/combination of its components. The dispersions can be used to form nanoparticle composite films upon drying or otherwise removing the liquid medium carrier, with the stabilizer providing a nanoparticle binder in the composite film. The films can be formed on essentially any desired substrate and can impart improved electrical conductivity and/or thermal conductivity properties to the substrate.

Abstract: The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or disorder associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to prevent or reduce thrombosis and fibrosis, to promote thrombolysis, and to modulate lipid metabolism and treat diseases or disorders associated with elevated PAI-1, cholesterol, or lipid levels.

Abstract: The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.

Abstract: The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.

Abstract: The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or disorder associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to prevent or reduce thrombosis and fibrosis, to promote thrombolysis, and to modulate lipid metabolism and treat diseases or disorders associated with elevated PAI-1, cholesterol, or lipid levels.

Abstract: The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.

Abstract: The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.

Abstract: The disclosure relates to water-dispersible polyurethane polymers as well as related polyurethane dispersion (PUD) compositions including the same, methods of making the same, methods of using the same, and articles coated with the same. The water-dispersible polyurethane polymer includes hydrophobic oligomeric polyether soft segments that include 1,2-di-substituted oxyethylene repeating units. The 1,2-di-substituted oxyethylene repeating units are derived from unsaturated fatty acid esters, such as from a distribution of epoxidized vegetable oil fatty acid esters subjected to a ring-opening polymerization process for oligomeric polyether polyol formation. The water-dispersible polyurethane polymer further includes hard segments common to other PUD compositions.

Abstract: The disclosure generally relates to a dispersion of nanoparticles in a liquid medium. The liquid medium is suitably water-based and further includes an ionic liquid-based stabilizer in the liquid medium to stabilize the dispersion of nanoparticles therein. The stabilizer can be polymeric or monomeric and generally includes a moiety with at least one quaternary ammonium cation from a corresponding ionic liquid. The dispersion suitably can be formed by shearing or otherwise mixing a mixture/combination of its components. The dispersions can be used to form nanoparticle composite films upon drying or otherwise removing the liquid medium carrier, with the stabilizer providing a nanoparticle binder in the composite film. The films can be formed on essentially any desired substrate and can impart improved electrical conductivity and/or thermal conductivity properties to the substrate.

Abstract: Nanolatexes comprising functional monomers and methods for making nanolatexes. Compositions comprising between about 3:97 and 90:10 (w/w) nanolatex particles to conventional latex particles. Because of the particle size differences between the conventional and nanolatexes, the nanolatexes may distribute themselves advantageously amongst the conventional latexes during coalescence, resulting in films having unexpected properties. In particular, when the average particle size of the conventional latex is about six times larger than the average particle size of the nanolatex, a composition comprising a ratio of 1 conventional latex particle for every 25 nanolatex particles results in unexpectedly strong (large Young's modulus) and smooth (high specular gloss) films.

Abstract: The disclosure relates to curable polyureasil compounds, methods related to curing of such compounds via hydrolysis and/or condensation to form coatings on a substrate, and coated articles formed from the curable polyureasil compounds. The polyureasil compounds are generally hydrocarbon-based, including multiple urea groups and multiple hydrolysable silyl groups per molecule. The hydrolysable silyl groups can be hydrolyzed and subsequently condensed to provide a networked polymeric structure with siloxane/urea linkages between polyureasil compound precursors to form a cured polyureasil composition useful as a coating for a substrate, in particular an anti-corrosion coating for a metallic substrate.

Abstract: The disclosure relates to curable polyepoxysilane compounds and compositions, methods related to curing of such compounds via hydrolysis and/or condensation to form coatings on a substrate, and coated articles formed from the curable polyepoxysilane compounds. The polyepoxysilane compounds are silane-functional precursors and can be used as coatings (or pretreatments) on various substrates (e.g., metals such as aluminum) and provide a substantial improvement in corrosion resistance relative to other anti-corrosion coatings. The silane-functional precursors can be prepared by reaction of functional silanes (e.g., amino-functional silanes or other epoxide-reactive functionalized silanes) with epoxide-containing organic or hydrocarbon compounds and oligomers/polymers thereof (e.g., glycidyl-type ethers or other epoxide-/oxirane-functionalized hydrocarbon compounds), for example including hydrocarbons with one or more aromatic hydrocarbon groups (e.g., in an aromatic polyether).

Abstract: The disclosure relates to curable polysilyl phosphate compounds and compositions as well as related methods and flame-retardant textiles incorporating the same. Curable polysilyl phosphate compounds according to the disclosure include a hydrocarbon moiety comprising at least one phosphate group and more than two hydrolysable silyl groups linked to the hydrocarbon moiety. In some embodiments, the hydrocarbon moiety is derived from spirocyclic pentaerythritol diphosphoryl chloride. The curable polysilyl phosphate compound can applied to a textile substrate and then cured to provide a flame-retardant textile with the cured polysilyl phosphate compound as a coating bonded to the textile substrate.

Abstract: Methods of treating fabrics using sol-gel halamine chemistry to impart antimicrobial properties thereto are described, as well as fabrics produced by the described methods. In one embodiment, the antimicrobial fabrics may be used to fabricate antimicrobial divider curtains for use in hospitals and medical facilities.