Abstract: The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.

Abstract: A self curing, two component penetrating densifying sealant and coating composition that imparts protection and reinforcement to porous substrates, such as wood and concrete, as well as non porous substrates, such a metal surfaces, whether or not corroded, and concrete surfaces.

Abstract: Disclosed are surfactant compounds and compositions that are antimicrobial. Also provided are polymeric compositions incorporating the surfactant compounds. The polymeric compositions may be used to form antibacterial coatings on surfaces.

Abstract: The present invention discloses a reactivity-based self-stratifying coating composition. The coating composition can include a polyol, silsesquioxane, a polyester polyol, and a crosslinker that form a mixture within a solvent. The polyol can be selected from a fluorinated polyether, a fluoroethylene-alkyl vinyl ether and/or a combination thereof. The silsesquioxane can be an epoxy functional silsesquioxane having a formula of (R)6(C6H11O2)2(SiO1.5)8 where R can be selected from hydrogen, methyl, ethyl, propyl, butyl, pentyl, hexyl, cyclopentyl, cyclohexyl, benzyl, phenyl, and isomers thereof. In some instances, the epoxy functional silsesquioxane can be a di-epoxy silsesquioxane.

Abstract: The disclosure relates to curable polyureasil compounds, methods related to curing of such compounds via hydrolysis and/or condensation to form coatings on a substrate, and coated articles formed from the curable polyureasil compounds. The polyureasil compounds are generally hydrocarbon-based, including multiple urea groups and multiple hydrolysable silyl groups per molecule. The hydrolysable silyl groups can be hydrolyzed and subsequently condensed to provide a networked polymeric structure with siloxane/urea linkages between polyureasil compound precursors to form a cured polyureasil composition useful as a coating for a substrate, in particular an anti-corrosion coating for a metallic substrate.

Abstract: Methods of treating fabrics using sol-gel halamine chemistry to impart antimicrobial properties thereto are described, as well as fabrics produced by the described methods. In one embodiment, the antimicrobial fabrics may be used to fabricate antimicrobial divider curtains for use in hospitals and medical facilities.

Abstract: Disclosed are surfactant compounds and compositions that are antimicrobial. Also provided are polymeric compositions incorporating the surfactant compounds. The polymeric compositions may be used to form antibacterial coatings on surfaces.

Abstract: The disclosure relates to water-dispersible polyurethane polymers as well as related polyurethane dispersion (PUD) compositions including the same, methods of making the same, methods of using the same, and articles coated with the same. The water-dispersible polyurethane polymer includes hydrophobic oligomeric polyether soft segments that include 1,2-di-substituted oxyethylene repeating units. The 1,2-di-substituted oxyethylene repeating units are derived from unsaturated fatty acid esters, such as from a distribution of epoxidized vegetable oil fatty acid esters subjected to a ring-opening polymerization process for oligomeric polyether polyol formation. The water-dispersible polyurethane polymer further includes hard segments common to other PUD compositions.

Abstract: A coating composition may include a polyol, a silsesquioxane, a polyurethane dendrimer, a crosslinker, and a pigment in contact with a dispersing agent. A process for preparing a coating composition is further disclosed including the step of contacting a polyol, a silsesquioxane, a polyurethane dendrimer, and a crosslinker to form a coating mixture dispersed within a solvent. The process further includes adding a pigment in contact with a dispersing agent to the coating mixture, and forming a self-stratifying coating having at least one layer, wherein the pigment resides substantially within one of the at least one layer.

Abstract: The disclosure generally relates to a dispersion of nanoparticles in a liquid medium. The liquid medium is suitably water-based and further includes an ionic liquid-based stabilizer in the liquid medium to stabilize the dispersion of nanoparticles therein. The stabilizer can be polymeric or monomeric and generally includes a moiety with at least one quaternary ammonium cation from a corresponding ionic liquid. The dispersion suitably can be formed by shearing or otherwise mixing a mixture/combination of its components. The dispersions can be used to form nanoparticle composite films upon drying or otherwise removing the liquid medium carrier, with the stabilizer providing a nanoparticle binder in the composite film. The films can be formed on essentially any desired substrate and can impart improved electrical conductivity and/or thermal conductivity properties to the substrate.

Abstract: The present invention discloses a reactivity-based self-stratifying coating composition. The coating composition can include a polyol, silsesquioxane, a polyester polyol, and a crosslinker that form a mixture within a solvent. The polyol can be selected from a fluorinated polyether, a fluoroethylene-alkyl vinyl ether and/or a combination thereof. The silsesquioxane can be an epoxy functional silsesquioxane having a formula of (R)6(C6H11O2)2(SiO1.5)8 where R can be selected from hydrogen, methyl, ethyl, propyl, butyl, pentyl, hexyl, cyclopentyl, cyclohexyl, benzyl, phenyl, and isomers thereof. In some instances, the epoxy functional silsesquioxane can be a di-epoxy silsesquioxane.

Abstract: The present invention relates to microemulsions of immiscible fluids stabilized by reactive ionic liquid surfactant wherein the ionic liquid surfactant has a melting point less than 80° C. The invention also relates to composite materials comprising a copolymer of ethylenically reactive species, wherein one of the species is a reactive ionic liquid surfactant having a melting point less than 80° C., and wherein the material also comprises non-reactive Class I fluid. The invention further relates to methods for synthesizing the composite materials comprising preparing a microemulsion of immiscible Class I fluid and Class II fluid stabilized by reactive ionic liquid surfactant wherein the ionic liquid surfactant has a melting point less than 80° C., and polymerizing the microemulsion to form a composite material.

Abstract: The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.

Abstract: Clearcoat compositions using a phenolic ester compound are described. The phenolic ester compound is selected from the group consisting of a phenolic ester alcohol, a phenolic urethane, a phenolic blocked isocyanate, and mixtures thereof.

Abstract: This invention relates to a polymeric vehicle which reduces or eliminates VOCs in coating compositions by providing a formulated coating composition which does not require an organic solvent for application to a substrate. The polymeric vehicle of the invention comprises at least one linear oligoester diol effective for crosslinking with a crosslinker, and having a number average molecular weight within controlled limits of a polydispersity index effective for controlling the viscosity of the polymeric vehicle.

Abstract: This invention relates to a polymeric vehicle which is effective for providing a high solids formulated coating composition. The polymeric vehicle comprises a blend of at least one nonmesogenic substantially linear oligoester diol and at least one hardener which is a mesogenic polyol or crystalline polyol, which blend is effective for reaction with a crosslinker which is reactive with the nonmesogenic oligoester and hardener.

Abstract: This invention provides a polymeric vehicle and formulated coating composition which are high in solids and use water to effect viscosities to permit application of such polymeric vehicles and formulated coating compositions with existing commercial application equipment. The polymeric vehicles and formulated coatings include at least one oligoester diol, a carbamate hardener, and in some instances, an additional crosslinking agent. The combination of oligoester diol with carbamate hardener provides a low viscosity coating composition with low to zero VOC content, and provides a coating binder with extremely good film properties.

Abstract: This invention relates to a polymeric vehicle which reduces or eliminates VOCs in coating compositions by providing a formulated coating composition which does not require an organic solvent for application to a substrate. The polymeric vehicle of the invention comprises at least one linear oligoester diol effective for crosslinking with a crosslinker, and having a number average molecular weight within controlled limits of a polydispersity index effective for controlling the viscosity of the polymeric vehicle.

Abstract: This invention is directed to a fast curing polymer composition which does not require baking or thermosetting to provide a cross-linked coating binder. The composition comprises a polymer which is a homopolymer or copolymer of alpha, beta unsaturated monomers having pendent acetylenic groups which cross-link upon air drying to provide a coating binder.