Patents Assigned to Ecole Normale Superieure
  • Patent number: 11607166
    Abstract: A method for quantifying the balance of an individual recording, on a memory, at least one statokinesigram of the individual obtained from a platform comprising pressure and/or force sensors; extracting, by a processor and from the at least one statokinesigram of the individual recorded on the memory, values of at least one position trajectory parameter of the pressure center and values of at least one stability trajectory parameter of the pressure center; determining, by the processor, the value of a plurality of quantifiers, from the values of the trajectory parameters extracted; comparing, by the processor, said values of the plurality of quantifiers with the values of the same quantifiers obtained from reference statokinesigrams; and determining, by the processor, said value representative of the balance of the individual at the end of the comparison.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: March 21, 2023
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE PARIS-SACLAY, UNIVERSITE PARIS DESCARTES, ETAT FRANCAIS—MINISTERE DE LA DEFENSE—DIRECTION CENTRALE DU SERVICE DE SANTE DES ARMEES
    Inventors: Nicolas Vayatis, Pierre Paul Vidal, Nikolaos Promponas Kefalas, Julien Audiffren, Alain Yelnik, Catherine De Waele Vidal, Damien Ricard
  • Publication number: 20230054300
    Abstract: The present application relates to a double-stranded DNA molecule comprising a first double-stranded DNA molecule (1) connected to a second double-stranded DNA molecule (2) by at least one covalent bond which is not a phosphodiester, phosphorothioate, phosphoramidate or phosphorodiamidate bond, preferably by a tether, said tether preferably being a double-stranded DNA molecule.
    Type: Application
    Filed: December 21, 2018
    Publication date: February 23, 2023
    Applicants: PARIS SCIENCES ET LETTRES - QUARTIER LATIN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEURE, UNIVERSITÉ DE PARIS
    Inventors: Térence STRICK, Charlie GOSSE, Dorota KOSTRZ, Jinglong WANG, Marc NADAL
  • Publication number: 20230057033
    Abstract: Probes for the detection of ?-lactamase-type enzymatic activity. In particular, novel fluorogenic substrates for detecting the presence of a catalytically active ?-lactamase and a detection method using such substrates.
    Type: Application
    Filed: November 30, 2020
    Publication date: February 23, 2023
    Applicants: MOLSID, ECOLE NORMALE SUPERIEURE DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Jens HASSERODT, Mathieu BORDY, Quentin GLENADEL, Charlie VERRIER
  • Publication number: 20230045428
    Abstract: A system for the treatment of microorganisms includes: a textile web having optical fibers in warp and/or weft woven with binding threads in warp and/or weft, each of the optical fibers having invasive alterations along the fiber and allowing the emission of light propagating in the fiber at these alterations; a light source arranged opposite one or both free ends of the optical fibers. The textile web includes metallic warp and/or weft threads woven with the binding threads, the metallic threads being based on a metal having a negative effect on the growth of microorganisms. The light source generates a light beam having at least one wavelength in the visible or ultraviolet spectrum.
    Type: Application
    Filed: December 20, 2020
    Publication date: February 9, 2023
    Applicants: Brochier Technologies, Centre National de la Recherche Scientifique, Universite Claude Bernard Lyon 1, Institut National De La Sante Et De La Recherche Medicale, Ecole Normale Superieure De Lyon
    Inventors: Chantal GUILLARD, Christophe GILBERT, Cédric BROCHIER, Laure PERUCHON, Lina LAMAA, Davide LORITO
  • Patent number: 11517029
    Abstract: The probiotic composition comprises at least one lactic acid bacteria strain, preferably Lactobacillus with intestinal tropism, for use in promoting juvenile growth in livestock, with stimulation of linear growth and/or of IGF-1 level. Exemplary lactic acid bacteria include Lactobacillus plantarum, Lactobacillus fermentum, Lactobacillus casei, Lactobacillus paracasei and Lactobacillus rhamnosus. The strains can be selected in a mouse model. The invention also relates to a probiotic treatment method using this composition.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: December 6, 2022
    Assignees: ECOLE NORMALE SUPERIEURE DE LYON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventors: Francois Leulier, Martin Schwarzer
  • Patent number: 11504424
    Abstract: The present invention relates to an attenuated virus strain derived from a human metapneumovirus strain comprising the genome sequence represented by sequence SEQ ID NO. 1, said attenuated strain comprising one or more genetic modifications of said sequence SEQ ID NO. 1 attenuating the virulence of said strain.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: November 22, 2022
    Assignees: UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEURE DE LYON, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE LAVAL
    Inventors: Manuel Rosa-Calatrava, Guy Boivin, Julia Dubois, Mario Andres Pizzorno, Olivier Terrier, Marie-Eve Hamelin, Marie-Helene Cavanagh
  • Patent number: 11497779
    Abstract: The present invention concerns novel Lactobacillus plantarum strains capable of promoting the growth of a subject, and more particularly the juvenile or prenatal growth of farm animals, and their uses as probiotics.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: November 15, 2022
    Assignees: ECOLE NORMALE SUPERIEURE DE LYON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE CLAUDE BERNARD LYON 1
    Inventors: François Leulier, Maria Elena Martino
  • Patent number: 11451722
    Abstract: The invention relates to a method for acquiring an image by an imager (20) comprising a matrix of pixels configured to generate an electric response when exposed to an incident light flux travelling through an optical path (21) in which is arranged a wavefront correction element (22), comprising the following steps: 1) initiating the exposure of the pixels to the incident light flux; 2) for a plurality of iterations during the exposure: 2.1) non-destructive reading of the electric responses of pixels of a region of interest; 2.2) determining an evolution of the spatial distribution of pixels in logarithmic mode previous iteration with respect to the previous iteration; 2.3) based on said evolution, establishing a command for the wavefront correction element (22) in order to correct the wavefront; 2.4) configuring the wavefront correction element, 3) reading the electric responses of the pixels resulting in an image.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: September 20, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITE, ECOLE NORMALE SUPERIEURE, UNIVERSITE DE PARIS, UNIVERSITE DE BOURGOGNE, OBSERVATOIRE DE PARIS
    Inventors: David Darson, Julien Dubois, Francois Colas
  • Patent number: 11426704
    Abstract: The use of porous crystalline solids constituted of a metal-organic framework (MOF) for the capture of polar volatile organic compounds (VOCs). In particular, the MOF of interest are material having an average pores sizes of 0.4 to 0.6 nm and an hydrophobic core formed by a metal oxide and/or hydroxide network connected by linkers, the linkers being selected from the group including (i) C6-C24 aromatic polycarboxylate linkers, such as benzyl or naphtyl di-, tri- or tetracarboxylate, and (ii) C6-C16 polycarboxylate aliphatic linkers; the linkers bearing or not apolar fluorinated groups, e.g. —(CF2)n—CF3 groups, n being a integer from 0 to 5, preferably 0 ou 3, and/or apolar C1-C20 preferably C1-C4 alkyl groups, e.g. —CH3 or —CH2—CH3, grafted directly to the linkers and pointing within the pores of the MOF.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: August 30, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE DE PARIS, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, UNIVERSITÉ DE VERSAILLES—SAINT-QUENTIN-EN-YVELINES, INSTITUTO SUPERIOR TÉCNICO
    Inventors: Christian Serre, Moisés L. Pinto
  • Patent number: 11389793
    Abstract: The present invention relates to a method for producing a microfluidic device, in particular, a sol-gel method for producing a microfluidic device in hybrid silica glass. The invention also relates to a microfluidic device obtainable by the method as described above and to microfluidic device in hybrid silica glass comprising at least one microchannel having a depth of at least 1 ?m, preferably between 1 ?m and 1 mm, and more preferably between 10 and 100 ?m.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: July 19, 2022
    Assignees: TOTAL SA, ECOLE NORMALE SUPERIEURE DE LYON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS-, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventors: Michael Levant, Denis Bartolo, Stéphane Parola, Denis Chateau
  • Patent number: 11384018
    Abstract: A slag-based binder has at least one slag, optionally at least one CO3-containing mineral powder, optionally at least one co-binder different from the slag and mineral powder, at least one activator of the water/slag reaction, optionally at least one co-activator different from the one activator, at least one chelatant and/or at least one source of chelatant, said chelatant being preferably a scale inhibitor, and, optionally, at least one superplasticizer different from the chelatant. A kit is provided to make the binder. The binder is combined with an aggregate to make a dry concrete or mortar. A method for the preparation of a wet formulation (binder/water or concrete-mortar/water) is disclosed as is method of manufacturing buildings or civil engineering works or elements thereof, coatings, fillers, screeds, tiles, adhesives and/or internal or external insulation systems from the wet formulation. The binder is a substitute to OPC-based compositions and is environmentally friendly.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: July 12, 2022
    Assignees: ECOCEM MATERIALS LIMITED, ECOCEM FRANCE, ECOLE NORMALE SUPÉRIEURE DE CACHAN
    Inventors: Laurent Frouin, Mohend Chaouche, Artur Kiiashko, Nicolas Musikas
  • Patent number: 11357816
    Abstract: The invention relates to new compounds that mimic Glycosaminoglycans and are able to control interaction between Glycosaminoglycans with their effector molecules. The compounds of the invention are peptides and are able to prevent or reduce the binding of at least one effector molecule with at least one glycosaminoglycan. The compounds according to the invention can be used as drug, in particular for the stimulation of the neurogenesis and more generally to treat nervous system related pathologies.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: June 14, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), SORBONNE UNIVERSITE, ECOLE NORMALE SUPERIEURE, COLLEGE DE FRANCE
    Inventors: Jean-Maurice Mallet, Solange Lavielle, Rodrigue Marquant, Alain Prochiantz, Ariel Di Nardo, Damien Testa
  • Patent number: 11302856
    Abstract: The present invention relates to an inductive dipole element for a superconducting microwave quantum circuit. The dipole element comprises a DC-SQUID formed by a pair of Josephson junctions shunted by an inductance, wherein the Josephson junctions have equal energy, and the Josephson junctions and the inductance are arranged such that each of the junctions forms a loop with the inductance. The two loops are asymmetrically threaded with external magnetic DC fluxes ?ext1 and ?ext2, respectively, such that ?ext1=? and ?ext2=0, wherein parametric pumping is enabled by modulating the total flux ??=?ext,1+?ext,2 threading the dipole element, thereby allowing even-wave mixing between modes that participate in the dipole element with no Kerr-like interactions.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: April 12, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NATIONALE SUPERIEURE DES MINES DE PARIS, ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS-ARMINES, ECOLE NORMALE SUPERIEURE, SORBONNE UNIVERSITE, UNIVERSITE DE PARIS
    Inventors: Raphaël Lescanne, Zaki Leghtas
  • Patent number: 11246525
    Abstract: A method for quantifying the balance of an individual includes segmenting, as a function of time, a statokinesigram(s) of an individual so as to generate several statokinesigram portions; extracting, from the statokinesigram portions, values of at least one trajectory parameter; determining the value of at least two quantifiers, from the values of trajectory parameters extracted in the extraction step, for each of the statokinesigram portions generated in the segmentation step; and determining said value representative of the balance of the individual from the values of the quantifiers of each of the statokinesigram portions. The method may be implemented by a processor and memory.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: February 15, 2022
    Assignees: ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ETAT FRANCAIS—MINISTERE DE LA DEFENSE—DIRECTION CENTRALE DU SERVICE DE SANTE DES ARMEES, ECOLE NORMALE SUPERIEURE PARIS-SACLAY, UNIV PARIS XIII PARIS-NORD VILLETANEUSE, UNIVERSITE DE PARIS
    Inventors: Nicolas Vayatis, Pierre Paul Vidal, Julien Audiffren, Alain Yelnik, Damien Ricard, Ioannis Bargiotas, Laurent Oudre, Stéphane Buffat
  • Patent number: 11215446
    Abstract: A computer-implemented method for identifying mechanical parameters of an object subjected to mechanical stress is provided. The method comprises a step of acquiring, by an imaging means, images of the object taken before and during the application of the mechanical stress, three steps of calculating the effects due to the stress carried out either on the basis of the modeling of the recorded images or on the basis of a theoretical mechanical modeling of the stress, a step of defining a functional equal to the difference between the two models and a last step of minimizing said functional so that the experimental model is as close as possible to the theoretical mechanical model. Additional measurements make it possible to refine the method.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: January 4, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE DE CACHAN
    Inventors: François Hild, Hugo Leclerc, Stéphane Roux
  • Patent number: 11172885
    Abstract: A medical device including an electric measurement circuit, in which are connected at least two sensors the impedance of which varies as a function of a sensed physical parameter, a source of electrical power for powering the electric measurement circuit, an antenna for emitting an electromagnetic field as a function of the impedance of the electric measurement circuit, each of the sensors being associated with a switch for short circuiting the sensor in the measurement circuit, the medical device further including a system for controlling the switches in order successively to command the opening or closing of the switches in determined configurations. The medical device may notably be able to be applied to the human body or implanted in the human body.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: November 16, 2021
    Assignees: Centre National de la Recherche Scientifique, Ecole Polytechnique, Ecole Normale Superieure de Cachan
    Inventors: Abdul Barakat, Franz Bozsak, Yvan Eric Bonnassieux, Bruno Le Pioufle, Olivier Francais, Bruno Carreel
  • Patent number: 11078226
    Abstract: The invention relates to novel glycosidase substrates of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R?9, V, X, Y and Z are as defined in claim 1, and a method for detecting the presence of a catalytically active glycosidase by means of one of said substrates.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: August 3, 2021
    Assignees: ECOLE NORMALE SUPERIEURE DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Jens Hasserodt, Corentin Gondrand, Maxime Prost, Gaël Yvert, Gérard Triqueneaux
  • Patent number: 11001593
    Abstract: The present invention relates to a dinitroxide biradical compound of general formula (I): In formula (I), A is a carbon, an ammonium, or a phosphonium; each of A1 to A6 is a single bond, O, N, N(O), S, S(O), SO2, C(O), or a (C1-C4) alkyl chain; and Z1 and Z2 are selected from R1 and R2 in combination, so that there is always at least one R2 group that is substituted with R3 group. In Z1 and Z2, R1 is an H, an aryl, or a heteroaryl; R2 is an alkyl chain, an alkenyl chain, an alkynyl chain, a cycloalkyl, a heterocycloalkyl, an aryl, or a heteroaryl; and R3 is an alkyl chain, an alkenyl chain, an alkynyl chain, a cycloalkyl, a heterocycloalkyl, an aryl, a heteroaryl, an ether, an ester, or an azide. When Z1 and Z2 are combined together with the same carbon atom of the nitroxide ring to which they are bonded, they form a spirocycloalkyl or a spiroheterocycloalkyl, the spirocycloalkyl or the spiroheterocycloalkyl being substituted with R3.
    Type: Grant
    Filed: April 15, 2014
    Date of Patent: May 11, 2021
    Assignees: Universite D'aix-Marseille, Centre National De La Recherche Scientifique, Bruker Biospin, Ecole Normale Superieure De Lyon, Eth Zurich, Universite Claude Bernard Lvon 1
    Inventors: Olivier Ouari, Paul Tordo, Gilles Casano, Melanie Rosay, Fabien Aussenac, Christophe Coperet, Anne Lesage, Aaron Rossini, Lyndon Emsley, Alexandre Zagdoun
  • Patent number: 10968253
    Abstract: The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a target nucleic acid.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: April 6, 2021
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEURE DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventors: Théophile Ohlmann, Philippe Mangeot, Emiliano Ricci
  • Patent number: 10924687
    Abstract: High dynamic range (HDR) images are generated on the basis of a plurality of images obtained by non-destructive reading of an image sensor, called NDRO images. An HDR image generation method includes: the determination of a criterion of desired quality for the HDR image; at least two non-destructive readings of the sensor delivering at least two successive NDRO images; the selection, as a function of the criterion of desired quality, of the first and of the last NDRO image to be used to generate the HDR image; the generation of the HDR image on the basis of information extracted from a series of successive NDRO images starting with the first and terminating with the last NDRO image to be used; the storage of a single image at one and the same time throughout the entire HDR generation phase.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: February 16, 2021
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITE, UNIVERSITE PARIS DIDEROT—PARIS 7, ECOLE NORMALE SUPERIEURE, UNIVERSITE DE BOURGOGNE
    Inventors: David Darson, Julien Dubois, Barthélémy Heyrman, Dominique Ginhac, Mustapha Bouderbane