Patents Assigned to Ecole Normale Superieure
  • Patent number: 10914690
    Abstract: A method of characterizing a part including obtaining an X-ray tomography image of the part and then a step of correlating the image with a reference wherein the correlation step includes searching among a predefined set of X-ray tomography image transformations for a transformation that minimizes the difference between the image and the reference in order to characterize the inside of the part.
    Type: Grant
    Filed: December 9, 2014
    Date of Patent: February 9, 2021
    Assignees: SAFRAN AIRCRAFT ENGINES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE DE CACHAN
    Inventors: Julien Schneider, Francois Hild, Hugo Leclerc, Stephane Roux
  • Publication number: 20210030297
    Abstract: According to one aspect, the present description relates to a portable device (10) for acquiring electroencephalographic (EEG) signals emitted by a user. The portable device comprises a flexible support (11) intended to fit a localized region of the skull of the user and a set of sensors (13) of electrical signals generated by the neuronal activity of the user, arranged on said support (11) so as to form contacts with the scalp when the device is worn by the user. For each sensor, an electronic circuit for filtering and amplifying electrical signals detected by said sensor is incorporated in the flexible support (11) and forms, with said sensor, an active electrode. The portable device also comprises a housing (12) comprising an electronic system for processing signals from said electronic filtering and amplification circuits, said housing being linked mechanically to the flexible support to form, with said support, a means of attachment to a garment or accessory (101) intended to be worn by the user.
    Type: Application
    Filed: February 12, 2019
    Publication date: February 4, 2021
    Applicants: Centre National de la Recherche Scientifique, ECOLE NORMALE SUPERIEURE DE PARIS, PARIS SCIENCES ET LETTRES - QUARTIER LATIN, Ecole des Hautes Etudes en Sciences Sociales, ECOLE NATIONALE SUPERIEURE DES ARTS DECORATIFS
    Inventors: Sid Kouider, Hao Zhang, Antoine Goupille, Jeanne Vicerial, Guillaume Ployart, Arthur Biancarelli, Gaelle Gervais
  • Publication number: 20210022638
    Abstract: This method for generating an indicator of the state of a patient in coma includes: generating at least one auditory stimulation by generating a sequence of auditory stimuli, the sequence producing evoked potentials in the patient; acquiring a first electroencephalographic signal produced by patient from at least one electrode; estimating at least one pair of values corresponding to a first parameter and a second parameter extracted from the first acquired signal, including estimating a first pair of values such that calculating the first parameter includes an estimation of the amplitude variance of the first signal within a predefined time window and the calculation of the second parameter includes an estimation of the correlation of two segments of the first signal; generating a state indicator for the or each pair of values of the first and second parameters, the values defining coordinates of a point in a reference base.
    Type: Application
    Filed: March 22, 2019
    Publication date: January 28, 2021
    Applicants: PARIS SCIENCES ET LETTRES - QUARTIER LATIN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ASSISTANCE PUBLIQUE HOPITAUX DE PARIS, ÉCOLE NORMALE SUPÉRIEURE, UNIVERSITÉ DE PARIS, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
    Inventors: David HOLCMAN, Adrien DOUMERGUE, Nathalie KUBIS, Alexandra RICHARD, Aymeric FLOYRAC
  • Publication number: 20210017180
    Abstract: A ligand of Formula (A): or a carboxylate salt thereof; wherein Y1, Y2 and Y3 each independently represents —COOH or a picolinate of Formula (i): wherein each R1 independently represents a chromophore group; L1, L2 and L3 each independently represents a single bond or a linker; and X1, X2 and X3 each independently represents a hydrogen atom, a coupling function or a bio-vectorizing group. Also, a process for manufacturing the ligand and to a process for manufacturing a chelate by complexation by the ligand of a rare-earth cation, preferably a lanthanide cation. Further, a use of the ligand and/or the chelate in biological imaging and/or photoluminescence imaging.
    Type: Application
    Filed: March 29, 2019
    Publication date: January 21, 2021
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ÉCOLE NORMALE SUPÉRIEURE DE LYON, UNIVERSITÉ CLAUDE BERNARD LYON 1 (UCBL1), UNIVERSITÉ DE BRETAGNE OCCIDENTALE
    Inventors: Nadège HAMON, Maryline BEYLER, Raphaël TRIPIER, Olivier MAURY, Janah SHAYA
  • Patent number: 10886698
    Abstract: A laser source for emitting radiation in a given emission spectral band, centered on a given emission angular frequency, the central emission angular frequency is provided. The laser source comprises a laser cavity comprising a gain section having a known frequency dependent Group Delay Dispersion, and a GTI mirror arranged at one end of the gain section, having a known frequency dependent Group Delay Dispersion. The gain section and the GTI mirror are formed into a same laser medium, the laser medium having a known frequency dependent Group Delay Dispersion, and the gain section and the GTI mirror are separated by a gap of predetermined width filled with a dielectric medium thus forming a two parts laser cavity. Further, the GTI GDD at least partly compensates the sum of the Gain GDD and the material GDD in the emission spectral band.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: January 5, 2021
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITÉ, UNIVERSITE PARIS DIDEROT—PARIS 7, ECOLE NORMALE SUPERIEURE
    Inventors: Sukhdeep Dhillon, Hanond Nong, Feihu Wang, Tobias Fobbe, Nathan Jukam
  • Patent number: 10871151
    Abstract: The invention relates to a device for detecting icing and de-icing of a wind turbine blade, characterized in that it comprises: a sensor, placed on the surface of a blade, and comprising a first so-called “receiving” antenna, a second so-called “emitting” antenna, and a frequency divider inserted between said first and second antennas; and an interrogator, configured to emit an electromagnetic wave towards the receiving antenna of said sensor, and to receive an electromagnetic wave from the emitting antenna of said sensor.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: December 22, 2020
    Assignees: Electricite de France, Centre National de la Recherche Scientifique (CNRS), Ecole Normale Superieure De Cachan
    Inventors: Frédéric Taillade, Franck Daout, Francoise Schmitt
  • Patent number: 10842852
    Abstract: The disclosure provides a method of delivering a polypeptide molecule to an Otx2 target cell, including contacting the target cell with a chimeric polypeptide having (i) a targeting peptide consisting of SEQ ID NO: 2 and (ii) the polypeptide molecule.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: November 24, 2020
    Assignees: Centre National de la Recherche Scientifique, Ecole Normale Superieure
    Inventors: Alain Prochiantz, Ariel Di Nardo, Marine Beurdeley, Takao Hensch
  • Publication number: 20200349690
    Abstract: The invention relates to a method for processing images obtained by a diffraction detector, of a crystalline or polycrystalline material, in which a first image of the material is acquired in a state of reference as well as a second image of the material in a deformed state. The invention is characterised in that, in a calculator, during a first step (E6, E12), a current elastic deformation gradient tensor Fe is given a value determined by calculation, during a second step (E7), the current displacement field induced by the tensor Fe is calculated, during a third step (E8), third digital values of a deformed image {hacek over (g)}(x)=g(x+u(x)) corrected by the current displacement field are calculated, and during an iterative algorithm, iterations of the second and third steps (E12, E7, E8) are carried out on modified values of the tensor r Fe until a convergence criterion is met in relation to the correction to the current value of Fe.
    Type: Application
    Filed: December 7, 2018
    Publication date: November 5, 2020
    Applicants: Electricite de France, Centre National de la Recherche Scientifique (CNRS), Ecole Normale Superieure De Cachan
    Inventors: Félix Latourte, Qiwei Shi, François Hild, Stéphane Roux
  • Publication number: 20200297263
    Abstract: A method for determining the focus of the visual attention of an individual from electroencephalographic signals. At least one visual stimulus to be displayed is generated from at least one graphical object, a visual stimulus being an animated graphical object obtained by applying to a graphical object a temporal succession of elementary transformations that is temporally parameterized by a corresponding modulation signal. From a plurality of electroencephalographic signals produced by the individual focusing his visual attention to one of the visual stimuli, a modulation signal is reconstructed. A visual stimulus corresponding to the modulation signal for which the degree of statistical dependence with the reconstructed modulation signal is higher than a first threshold is identified.
    Type: Application
    Filed: September 6, 2018
    Publication date: September 24, 2020
    Applicants: Centre National de la Recherche Scientifique, ECOLE NORMALE SUPERIEURE DE PARIS, Ecole des Hautes Etudes en Sciences Sociales
    Inventors: Sid KOUIDER, Jean-Maurice LEONETTI, Nicolas BARASCUD, Robin ZERAFA
  • Publication number: 20200289049
    Abstract: The present invention relates to a non-implantable medical device (1, 1?) intended to cover wounds and skin lesions, comprising a biosensor (3E, 3E?), characterised in that said biosensor (3E, 3E?) comprises a piece made of absorbent, hydrophilic material fixing, on the surface and/or within the thickness thereof, a composition of agglomerated powders comprising particles of ethylene vinyl acetate (EVA) having a surface in part covered with at least one orthophosphoric acid salt and a visual indicator of microbiological growth. In particular, the medical device (1, 1?) may comprise several layers in order to enable the guiding of a liquid. The present invention relates to a method for preparing such a medical device (1, 1?).
    Type: Application
    Filed: November 29, 2018
    Publication date: September 17, 2020
    Applicants: Biomerieux, Elkem Silicones France SAS, F.D.S., Fibroline, Hospices Civils De Lyon, Universite Claude Bernard Lyon 1, Institut National de la Sante et de la Recherche Medicale (INSERM), Ecole Normale Superieure De Lyon, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Christine Rozand, Aline Dardy, Fanny Berrat, Caroline Moine, Philippe Serre
  • Patent number: 10739281
    Abstract: A tomography scanner includes at least one first emission source (GX1), one first matrix detector (D1), and a computer (C) arranged to produce an initial tomography of an object (E) based on radiographs arising from the first matrix detector, taken from various angles. The tomography scanner further includes a second emission source (GX2) and a second matrix detector (D2) arranged so that, when the object is subjected to a loading that is known at a given instant in time, the computer determines the changes in the object subjected to said loading based only on the information from the first radiograph of the object under loading arising from the first matrix detector, from the second radiograph of the object under loading arising from the second matrix detector and the initial tomograph, the first radiograph and the second radiograph being taken simultaneously at the same given instant in time.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: August 11, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE DE CACHAN
    Inventors: François Hild, Hugo Leclerc, Stéphane Roux
  • Publication number: 20200246400
    Abstract: The present invention concerns novel Lactobacillus plantarum strains capable of promoting the growth of a subject, and more particularly the juvenile or prenatal growth of farm animals, and their uses as probiotics.
    Type: Application
    Filed: August 17, 2018
    Publication date: August 6, 2020
    Applicants: Ecole Normale Superieure de Lyon, Centre National de la Recherche Scientifique (CNRS), Universite Claude Bernard Lyon 1
    Inventors: François Leulier, Maria Elena Martino
  • Patent number: 10722554
    Abstract: The invention relates to the use of a homeoprotein of the bicoid family, in particular of the Otx family, for enhancing the survival of cultivated retinal ganglion neurones, and for preventing or treating ganglion neuron degeneration particularly occurring in glaucoma.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: July 28, 2020
    Assignees: Centre National de la Recherche Scientifique, Ecole Normale Superieure
    Inventors: Alain Prochiantz, Kenneth Lee Moya
  • Patent number: 10723999
    Abstract: The present invention relates to a process for in vitro spermatogenesis from male germinal tissue comprising conducting maturation of testicular tissue comprising germ cells in a bioreactor which is made of a biomaterial and comprises at least one cavity wherein the germinal tissue is placed, and recovering elongated spermatids and/or spermatozoa.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: July 28, 2020
    Assignees: KALLISTEM, UNIVERSITÉ CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), ECOLE NORMALE SUPERIEURE DE LYON
    Inventors: Marie-Hélène Perrard, Philippe Durand, Laurent David
  • Patent number: 10718712
    Abstract: A method is provided for detecting a fluorescent species that is reversibly photoswitchable at high frequency, and more precisely to a method for detecting at least one reversibly photoswitchable fluorescent species, including a step consisting in illuminating a sample containing a reversibly photoswitchable fluorescent species with a first illuminating light beam, of wavelength ?1, and periodically modulated at an angular frequency ?, and with a second illuminating light beam of wavelength ?2 different from ?1, which is periodically modulated at the angular frequency ?, the second illuminating light beam being modulated in antiphase with respect to the first illuminating light beam.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: July 21, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITE, ECOLE NORMALE SUPERIEURE
    Inventors: Jérôme Querard, Thomas Le Saux, Ludovic Jullien
  • Patent number: 10718697
    Abstract: A method for estimating a stiffness of a deformable part of a system including a four-photodiode detector for analyzing at least one characteristic of a sample. The method includes receiving the signals recorded by the four photodiodes, calculating the resultant signals from the recorded signals, calculating a cross-correlation of the resultant signals calculated for obtaining an intercorrelated signal, estimating the stiffness of the deformable part depending on the intercorrelated signal.
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: July 21, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventor: Ludovic Bellon
  • Patent number: 10696694
    Abstract: The invention relates to cationic complexes made up of a lanthanide ion Ln3+ and a ligand of formula (I): with X, Y and R1 as defined in claim 1, and to the salts thereof with an anion, the solvates and hydrates thereof; with the exception of cationic complexes made up of a lanthanide ion Ln3+ and a ligand of one of formulae (I.1) or (I.4) as defined in claim 1, and the salts, solvates and hydrates thereof. The invention also relates to the use of such a complex or of a cationic complex made up of a lanthanide ion Ln3+ and a ligand of formula (I.1) or (I.4) as defined in claim 1, or of one of the salts thereof with an anion, the solvates or hydrates thereof, as an aid to the crystallisation of a biological macromolecule, as well as to crystallisation methods and methods for analysing or determining the structure of a biological macromolecule.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: June 30, 2020
    Assignees: ECOLE NORMALE SUPERIEURE LE LYON, UNIVERSITE CLAUDE BERNARD LYON I, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Oliver Maury, Eric Girard, Sylvain Engilberge, François Riobe
  • Patent number: 10684190
    Abstract: A device measures at least a first physical quantity of fluid flow in a three-dimensional space having at least one predetermined interface, between at least two media. The device comprises a computer prescribing first and second conditions at the different boundaries concerning the first physical quantity, associated respectively with a first source and a second source, different to one another, the first and second sources being point sources of mass flow of fluid and/or of force. The computer calculates, by distributed point source calculation, a first value of the first physical quantity from the first condition and from the first source and a second value of the first physical quantity from the second condition and from the second source, at at least one second point, different from the first test point, then combines the values to calculate for the first physical quantity respectively from the different boundary conditions and sources.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: June 16, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE DE CACHAN
    Inventors: Dominique Placko, Alain Rivollet, Thierry Bore
  • Patent number: 10673538
    Abstract: The disclosure relates to a method for transmitting an item of information in a communication channel linking a transmitter to a recipient, the method including the following successive steps: the determination, by the transmitter, of a first intelligible sound signal representative of the item of information to be transmitted, the acoustic processing, by the transmitter, of the first sound signal so as to produce a second sound signal unintelligible to the recipient, the transmission of the second sound signal from the transmitter to the recipient, the transmission of the first sound signal from the transmitter to the recipient, the transmission of the first sound signal being triggered by the transmission of the second sound signal, the second transmission of the second sound signal from the transmitter to the recipient, the second transmission of the second sound signal being triggered by the transmission of the first signal.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: June 2, 2020
    Assignees: URGO RECHERCHE INNOVATION ET DEVELOPPEMENT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEURE, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, UNIVERSITE PARIS DIDEROT—PARIS 7
    Inventors: Daniel Pressnitzer, Laure Cornu, Hervé Le Lous
  • Patent number: 10588986
    Abstract: The present invention relates to biofunctionalized nanoparticles and uses thereof in adoptive cell therapy. In particular, the present invention relates to a nanoparticle comprising an amount of at least one antigen and an amount of at least one antibody having specificity for a B cell receptor wherein the antigen and antibody are attached to the surface of the nanoparticle.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: March 17, 2020
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), ENS-ECOLE NORMALE SUPERIEURE DE LYON, UNIVERSITE CLAUDE BERNARD-LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), HOSPICE CIVILS DE LYON
    Inventors: Antoine Sicard, Olivier Thaunat