Abstract: Required are: a compound having high affinity for an emopamil binding protein; and a method for activating or inhibiting the emopamil binding protein, using such a compound. According to the present invention, provided is an emopamil binding protein binding agent comprising an alkyl ether derivative represented by the following formula [1] or a salt thereof: wherein R1 and R2, which are the same or different, each represent a hydrogen atom, a halogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted aryl group, etc.; R3 represents an optionally protected hydroxyl group, etc.; and m and n, which are the same or different, each represent an integer of 1 to 6.

Abstract: An object of the present invention is to provide a dispensing audit support apparatus and a dispensing audit support method with a high collation accuracy robustness. According to a dispensing audit support apparatus according to one aspect of the present invention, since a position, shape and size of a region of interest are set according to a position of a collation-target medicine in a captured image, and a position, shape and size of a master image are set according to the set region of interest, it is possible to avoid or reduce distortion of the medicine shape, blur, inclusion of an end part into the image, and the like due to the position and orientation of the collation-target medicine. Therefore, influence on collation accuracy is small, and it is possible to enhance the robustness of the collation accuracy.

Abstract: An object of the present invention is to provide a drug which prevents progress of Alzheimer's disease and a method of preventing progress of Alzheimer's disease. Alzheimer's disease can be effectively prevented or treated by initiating administration of a pharmaceutical composition comprising 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof as an active ingredient to a patient within a certain period from clinical diagnosis of Alzheimer's disease.

Abstract: To provide a drug identification device and a drug identification method capable of eliminating an overlap of drugs in dose packaging bags. A drug identification device includes: an inlet configured to receive dose packaging bags in each of which drugs are packaged; a conveying path configured to convey the dose packaging bags received by the inlet; an imaging element configured to capture images of the drugs on the conveying path; a processor configured to identify the drugs based on the images of the drugs captured by the imaging element; a storing case arranged at an upstream side of the inlet and configured to store the dose packaging bags; and a vibration device configured to vibrate the storing case.

Abstract: An image acquiring unit of acquires a captured image in which two or more medicines of a plurality of objects (medicines) are in point-contact or line-contact with one another. A first recognizer receives the captured image and generates an edge image indicating only a part where medicines are in point-contact or line-contact with one another, in the captured image. A second recognizer receives the captured image and the edge image, recognizes each of the plurality of medicines from the captured image, and outputs a recognition result. Since the second recognizer receives edge image indicating only the part where medicines are in point-contact or line-contact useful for separating the areas of the medicines, even if two or more medicines of the plurality of medicines are in point-contact or line-contact with one another, it is possible to accurately separate and recognize the areas of the plurality of medicines from the captured image.

Abstract: In the present invention, an image of a verification target medicine disposed on an arrangement unit is captured, prescription condition information indicating a prescription condition is acquired, an external force application unit is caused to execute an external force applying operation of applying an external force to the medicine disposed on the arrangement unit to move the medicine when an operation execution condition is satisfied, wherein the operation execution condition includes at least one of: a first operation execution condition that the number of the verification target medicines appearing in the image differs from the quantity of the medicines specified from the prescription condition information; and a second operation execution condition that a shape of the verification target medicine appearing in the image differs from a shape corresponding to a type of the medicine specified from the prescription condition information.

Abstract: It is an object of the present invention to provide an object collating device and an object collating method that enable matching of images of a dividable medical article with desirable accuracy and easy confirmation of matching results. In the object collating device according to the first aspect, when the object is determined to be divided, the first image for matching is collated with the image for matching (the second matching image) for the objects in the undivided state, so that the region to be matched is not narrowed, and matching of the images of the dividable medical article is achieved with desirable accuracy. In addition, since the first and second display processing is performed on the images for display determined to contain the objects of the same type, matching results can easily be confirmed.

Abstract: An image processing apparatus and method that can enhance visibility of medicines are provided. An image obtained by imaging medicines is acquired, the medicines are detected from the acquired image, and images of the detected medicines are cropped to generate individual medicine images. It is determined whether visibility of each generated individual medicine image is good or poor, and an individual medicine image with poor visibility is subjected to processing to enhance visibility and displayed on a display device.

Abstract: Required are: a compound having high affinity for an emopamil binding protein; and a method for activating or inhibiting the emopamil binding protein, using such a compound. According to the present invention, provided is an emopamil binding protein binding agent comprising an alkyl ether derivative represented by the following formula [1] or a salt thereof: wherein R1 and R2, which are the same or different, each represent a hydrogen atom, a halogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted aryl group, etc.; R3 represents an optionally protected hydroxyl group, etc.; and m and n, which are the same or different, each represent an integer of 1 to 6.

Abstract: A medicine inspection assistance device, an image processing device and an image processing method are provided that appropriately recognize identification information irrespective of whether the identification information is an engraved mark or a printed character. The image processing device that obtains a plurality of taken images of a medicine, performs a process of enhancing an engraved mark portion of the medicine based on at least one taken image among the taken images and generates a first enhanced image, performs a process of enhancing a printed character portion of the medicine based on at least one taken image among the taken images and generates a second enhanced image, collates an integrated image obtained by integrating the first enhanced image and the second enhanced image with each other, with a master image, and determines whether the medicine to be dispensed and the dispensed medicine are identical to each other or not.

Abstract: According to an aspect of the present invention, a listing table is created for each kind of drug, and a single kind of drug among the drugs listed in the prescription is displayed on the display screen of the monitor. Therefore, mistakenly collated drugs can be found easily, and the pharmacist (user) can perform the drug inspection efficiently. In the present invention, the listing table for the drug similar to the single kind of drug may also be displayed on the display screen. The drug whose similarity to the single kind of drug is equal to or more than a threshold value may be determined as a similar drug, and the similar drug may be included in the listing table.

Abstract: An object of the present invention is to provide an excellent drug for preventing or treating spinocerebellar ataxia. 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof has an effect of suppressing brain atrophy, especially cerebellar atrophy, and is useful as an agent for preventing or treating spinocerebellar ataxia. Cerebellar atrophy observed in spinocerebellar ataxia can be prevented or treated by administering 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof.

Abstract: A medicine inspection device, an image processing device, an image processing method, and a program are provided that appropriately extract identification information even when the positional relationship between a printed character and an engraved mark added to a medicine is not constant. The above problem is solved by an image processing device that performs a process of enhancing a printed character portion of a medicine based on at least one image taken with a surface of the medicine being irradiated with light to generate a printed-character-enhanced image, performs a process of extracting only an engraved mark portion from a three-dimensional shape of the medicine based on at least three images taken with illumination directions of the light to the surface of the medicine different from each other to generate an engraved-mark-extracted image, and generates a difference image between the printed-character-enhanced image and the engraved-mark-extracted image.

Abstract: A conveyor capable of detecting a cut line of portion packaging bags, and a medicine inspection support system are provided. The conveyor conveys the portion packaging bags to an inspecting machine, the portion packaging bags being divided one by one with use of a heat seal portion and perforations by a portion packaging machine and being continuously discharged in a longitudinal posture from the portion packaging machine. The conveyor includes a posture changing device configured to change the longitudinal posture of the portion packaging bags to a lateral posture; and a detector configured to detect a cut line of the portion packaging bags.

Abstract: The generation device includes: an illuminating unit including light-emitting units simultaneously illuminate a surface of a medicine from irradiation directions different from each other; an imaging unit acquires a plurality of first images of the medicine corresponding to the respective wavelength bands from an imaging element; an image generating unit generates, based on the first images acquired by the imaging unit, a second image to which emphasis processing for emphasizing the engraved mark or the print has been applied; and a processing control unit controls the image generating unit to generate the second image when two or more of output values of the respective first images are equal to or more than a threshold, and controls the image generating unit not to generate the second image when less than two of the output values of the respective first images are equal to or more than the threshold.

Abstract: The present invention aims to provide an identification assistance system, an identification assistance client, and an identification assistance method that enable the user to identify drugs accurately and easily. In the identification assistance system according to an aspect of the present invention, first text which is the result of voice recognition is corrected, and thus errors of the voice recognition can be corrected. In addition, the first text is corrected with reference to a drug search dictionary having learned expressions used for drug identification, and thus expressions unique to drug identification can be taken into consideration. The user can perform a search not only by using the code and/or the name of the drug but also by speaking aloud the external appearance information on the drug. Thus, even if the code and the name are unknown, the user can perform a search by using the external appearance information.

Abstract: A tablet which comprises (1) 1-(3-(2-(1-benzothiophen-5- yl)ethoxy)propyl)azetidin-3-ol or a salt thereof and (2) ethyl cellulose, said tablet having excellent elution properties and good moldability, remaining stable during prolonged storage, and exhibiting high impact resistance.

Abstract: It is an object of the present invention to provide a therapeutic agent for RNA viral infection, comprising a novel combination of a pyrazine derivative and a specific compound, which exhibits effects against an RNA virus, and also to provide a therapeutic agent for RNA viral infection, comprising a combination of a pyrazine derivative and a specific compound, which is capable of simultaneously reinforcing antiviral activities against a plurality of RNA viruses. According to the present invention, provided is a therapeutic agent for RNA viral infection, which comprises a combination of a pyrazine derivative or a salt thereof and a compound which increases the amount of a pyrazine derivative ribose triphosphate in a cell.

Abstract: A medical information registration support device according to a first aspect of the present invention includes an input accepting unit configured to accept input of medical information, a determining unit configured to determine whether the accepted medical information and registration information match each other, a candidate generating unit configured to generate a candidate for the registration information for the accepted medical information by using a trained model that is constructed through machine learning, standardizes input medical information according to a type of the medical information and outputs the standardized medical information when the accepted medical information and the registration information do not match each other, and a registering unit for registering, as the registration information, medical information selected from the candidate or medical information obtained by correcting the candidate in association with the accepted medical information.

Abstract: There is provided a medicine management system capable of checking a receipt status and a dosage stage of delivered medicines even at a delivery source. The medicine management system includes a management server for managing a receipt status and a dosage status of medicines to be delivered, a first terminal having a function of notifying the management server of information indicating receipt of medicines when the medicines have been received, a second terminal having a function of notifying the management server of information indicating dosage of medicines when the medicines have been taken, and a third terminal having a function of acquiring from the management server and displaying information on a receipt status and a dosage status of medicines.