Abstract: An object of the present invention is to provide a pharmaceutical composition comprising 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof at a high concentration, with a characteristic bitter taste masked, and a manufacturing method thereof. The present invention provides a pharmaceutical composition comprising fine granules having a core comprising 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof, and a binder; and a polymer layer with which a surface of the core is coated, wherein the fine granules have a roundness of 0.8 or more and a content of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or the salt thereof in the fine granules is 30 to 90% by mass.

Abstract: Provided is a method for industrially producing 5-(bromomethyl)-1-benzothiophene. The production method according to the present invention comprises: (1) a step for introducing 5-methyl-1-benzothiophene, a brominating agent, and a solvent into a reactor; (2) a step for emitting light having a wavelength range of 200-780 nm inside the reactor; and (3) a step for recovering 5-(bromomethyl)-1-benzothiophene from the reactor.

Abstract: A image processing device which can reduce information such as a pattern, a scar and the like on a surface of a drug which are other than an engraved mark, to accurately extract the engraved mark. The image processing device includes: an obtaining unit configured to obtain a plurality of images of a drug having an engraved mark on a surface of the drug, with emitting directions of light to the surface different from each other; an edge image generating unit configured to apply respectively to the plurality of images, edge extracting filters in directions in conformity with the emitting directions, the edge extracting filters having a size in conformity with a width of a groove of the engraved mark, and generate a plurality of edge images; and an image composing unit configured to compose the plurality of edge images and generate a composite image.

Abstract: Provided is a transport device which can perform easily thermal storage temperature controlling treatment of the thermal storage material even at a cell transport destination. The transport device of the present invention includes: a thermally insulated container that has a cylindrical shape and a bottom, a thermal storage material disposed along the inner circumferential surface of the thermally insulated container, and a temperature control unit that is detachably fitted on the thermally insulated container and is for performing thermal storage temperature controlling treatment on the thermal storage material, wherein the temperature controlling unit comprises a heat transferring body for performing the thermal storage temperature control processing on the thermal storage material when the unit is fitted on the thermally insulated container, and a storage space formed inside the heat-transferring body for storing a stored object so that the object can be freely put in and taken out.

Abstract: A medical drug verification device includes: an exterior information acquiring unit configured to acquire exterior information on a medical drug; a matching unit configured to perform matching between matching target information based on the exterior information and a reference information group of medical drugs stored in a storage device; a display control configured to cause a display device to display, based on the degree of the matching, candidates of reference information for a medical drug which is contained in the reference information group and corresponds to the exterior information; an accepting configured to accept selection of the reference information contained in the candidates; and a reflecting unit configured to reflect the exterior information and/or the matching target information corresponding to the selected reference information in the stored reference information group, wherein the reflecting unit performs the reflection when the degree of the matching for the selected reference informat

Abstract: A medicine identification system and a medicine identification method can favorable identification of a medicine using a camera-equipped mobile terminal. A smartphone including a camera changes a light-emitting region on a display, changes an illuminating direction with respect to a medicine placed on a tray having an indicator used for standardizing size and shape of the medicine, and images the medicine with different illuminating directions with the camera. The medicine identification device standardizes the size and shape of first images acquired by imaging based on the indicators captured in the first images, and extracts a medicine region image from each of the standardized first images. The medicine identification device then generates, based on the extracted medicine region images, a second image having undergone an emphasis process for emphasizing an embossed mark or a printed mark provided on the medicine, and identifies the medicine based on the generated second image.

Abstract: There are provided a dispensing inspection device and a dispensing inspection method that inspect drugs packaged in a packaging bag. The dispensing inspection device includes a transport passage that transports a packaging bag in which drugs are packaged, an imaging unit that images the drugs packaged in the packaging bag on the transport passage, a dispersion mechanism that disperses the drugs packaged in the packaging bag on the transport passage, and an inspection unit that inspects the drugs on the basis of an image of the drugs taken by the imaging unit.

Abstract: Required are: a compound having high affinity for an emopamil binding protein; and a method for activating or inhibiting the emopamil binding protein, using such a compound. According to the present invention, provided is an emopamil binding protein binding agent comprising an alkyl ether derivative represented by the following formula [1] or a salt thereof: wherein R1 and R2, which are the same or different, each represent a hydrogen atom, a halogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted aryl group, etc.; R3 represents an optionally protected hydroxyl group, etc.; and m and n, which are the same or different, each represent an integer of 1 to 6.

Abstract: An object of the present invention is to provide a drug and a method which suppress progress of disease in which the amount of amyloid ? protein in the brain is increased, such as Alzheimer's disease. 1-(3-(2-(1-Benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof has an effect of reducing the amount of amyloid ? protein in the brain parenchyma, and thus is effective as an agent for reducing the amount of amyloid ? protein in the brain. Disease in which the amount of amyloid ? protein in the brain is increased, such as Alzheimer's disease, can be prevented or treated by administering 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof.

Abstract: It is an object of the present invention to provide an antitumor agent, which is further excellent as a treatment agent used in the prevention and/or therapy of tumor associated with a bromodomain, and also to provide a bromodomain inhibitor, which is useful as a treatment agent for diseases or states associated with a bromodomain. An antitumor agent and a bromodomain inhibitor, comprising a compound represented by the following formula, have an excellent bromodomain inhibitory activity and are useful as treatment agents in the prevention and/or therapy of tumor associated with a bromodomain, and the like: wherein R1 represents a C1-6 alkyl group, etc.; R2 represents a hydrogen atom, etc.; R3 represents a halogen atom, etc.; Z1, Z2 and Z3 each represent CH, etc.; X1 represents CONH, etc.; Ring A represents a phenyl group, etc.; R4 represents a halogen atom, etc.; and m represents an integer from 0 to 5.

Abstract: It is an object of the present invention to provide an object collating device and an object collating method that enable matching of images of a dividable medical article with desirable accuracy and easy confirmation of matching results. In the object collating device according to the first aspect, when the object is determined to be divided, the first image for matching is collated with the image for matching (the second matching image) for the objects in the undivided state, so that the region to be matched is not narrowed, and matching of the images of the dividable medical article is achieved with desirable accuracy. In addition, since the first and second display processing is performed on the images for display determined to contain the objects of the same type, matching results can easily be confirmed.

Abstract: A drug inspection apparatus inspects drugs that are prepared based on prescription information and are packaged in a prescription bag. A drug database includes drug images of drugs that can be prepared. A comparison target selection section acquires drug images of drugs, which are prepared according to the prescription, and drugs similar thereto from the drug database. A first drug determination section compares captured images of prepared drugs with the drug images acquired from the drug database, and determines drugs present in the captured images and the number thereof. An inspection result determination section determines whether or not the prepared drugs and the number thereof match the prescription information based on the prescription information.

Abstract: This method for producing a freeze-dried formulation including an amorphous form of 6-fluoro-3-hydroxy-2-pyrazinecarboxamide sodium salt is useful as a method for producing a freeze-dried formulation having uniform quality.

Abstract: An object of the present invention is to provide an inspection support method and an inspection support device capable of easily inspecting packaged medicines. In accordance with the inspection support method and the inspection support device according to an aspect of the present invention, since images of packaged medicines and identification information items and quantities of medicines extracted from a prescription are displayed on a display device (display unit), a user can easily check whether or not the packaged medicines match those written in the prescription. Since master images are registered in a case where the determination of “whether or not identification information items and quantities of the packaged medicines match the identification information items and quantities which are extracted from the prescription and are displayed” is positive for all the medicines written in the prescription, it is possible to reduce a concern that inappropriate images will be registered as the master images.

Abstract: The type of a verification target medicine is verified using a master image and a captured image of the verification target medicine packed in a packaging material having light transmissivity, and then the characteristic information indicating an optical characteristic that influences the sharpness of the captured image is acquired for the packaging material packing the verification target medicine having the type verified to match the type of the medicine appearing in the master image. Subsequently, in a case where it is verified that the type of the verification target medicine matches the type of the medicine appearing in the master image, determination is made as to whether the optical characteristic indicated by the characteristic information satisfies a standard. When the optical characteristic satisfies the standard, the update processing for updating the registered master image to the image of the verification target medicine is executed.

Abstract: Provided are a medicine verification device and a method capable of performing accurate verification of the type of medicines even in a case where the sharpness of the image differs between a master image and a captured image of the verification target medicine. The type of the verification target medicine packed in a packaging material is verified by using the master image and the captured image of the verification target medicine, and then characteristic information indicating an optical characteristic of the packaging material is acquired. When the optical characteristic indicated by the characteristic information is an optical characteristic that decreases the sharpness of the captured image of the verification target medicine to be lower than that of the master image, correction processing is executed and the type of the verification target medicine is verified using the master image in which the sharpness has been corrected by the correction processing.

Abstract: A drug inspection apparatus inspects drugs that are prepared based on prescription information and are packaged in a prescription bag. A drug database includes drug images of drugs that can be prepared. A comparison target selection section acquires drug images of drugs, which are prepared according to the prescription, and drugs similar thereto from the drug database. A first drug determination section compares captured images of prepared drugs with the drug images acquired from the drug database, and determines drugs present in the captured images and the number thereof. An inspection result determination section determines whether or not the prepared drugs and the number thereof match the prescription information based on the prescription information.

Abstract: In the present invention, an image of a verification target medicine disposed on an arrangement unit is captured, prescription condition information indicating a prescription condition is acquired, an external force application unit is caused to execute an external force applying operation of applying an external force to the medicine disposed on the arrangement unit to move the medicine when an operation execution condition is satisfied, wherein the operation execution condition includes at least one of: a first operation execution condition that the number of the verification target medicines appearing in the image differs from the quantity of the medicines specified from the prescription condition information; and a second operation execution condition that a shape of the verification target medicine appearing in the image differs from a shape corresponding to a type of the medicine specified from the prescription condition information.

Abstract: A medicine verification device of the present invention includes: a detection unit that detects a boundary recess formed at a boundary position between a plurality of packaging bags each of which packs a medicine and is connected to form a continuous packaging bag having a strip-like shape; and an image capturing unit that captures an image of a surface of an imaging target portion on which at least the boundary recess is located a plurality of times while imaging conditions are changed in a state where light is emitted toward the surface of the imaging target portion in the continuous packaging bag, wherein the detection unit detects the boundary recess in the imaging target portion on the basis of the plurality of images captured while changing the imaging conditions by the image capturing unit.

Abstract: An object of the present invention is to provide a solid pharmaceutical composition which suppresses the characteristic bitter taste of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof and has a good storage stability of the-aforementioned compound or a salt thereof. The present invention provides a solid pharmaceutical composition comprising 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof and a carboxylic acid whose solubility in water at 25° C. is 50 g/100 g H2O or less, wherein pH of a solution obtained when the solid pharmaceutical composition is dissolved or suspended in a 10 mmol/L KCl solution such that 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or the salt thereof is 1 mg/mL or 8.96 mg/mL is 4.8 or less.