Abstract: A spout member including a base portion which is fixed to a bag body, a cylindrical portion which protrudes upward from the base portion, and a sealing portion which seals a front end of the cylindrical portion through a breakable thin portion is disposed between two sheets of film forming the bag body. A sealing chamber accommodating the cylindrical portion and the sealing portion is opened by tearing the two sheets of film along an opening assisting line. An opening assisting plate protruding to at least one of a left side and a right side of the sealing portion is disposed above the opening assisting line. A sandwiching reinforcement seal portion for reinforcing the two sheets of film by sealing inner surfaces thereof is provided between the opening assisting plate and the opening assisting line.

Abstract: A method of monitoring thrombus formation is described, which comprises flowing anticoagulated blood into a thrombus formation chamber, in at least a part of which a thrombus formation inducer inducing thrombus formation is provided, while releasing the anticoagulant treatment or promoting blood coagulation to thereby monitor thrombus formation in the thrombus formation chamber.

Abstract: An apparatus for monitoring thrombus formation wherein anticoagulated blood is flown through a channel simulating a blood vessel while releasing the anticoagulant treatment or promoting blood coagulation to thereby monitor thrombus formation. This apparatus for monitoring thrombus formation comprises: a thrombus formation chamber in at least a part of which a thrombus formation inducer inducing thrombus formation is provided; an inlet tube which is connected to the thrombus formation chamber and through which blood is flown into the thrombus formation chamber; and a drug tube which is connected to the inlet tube and through which a drug releasing the anticoagulant treatment or a drug promoting blood coagulation is supplied.

Abstract: A microchip comprising therein a first channel which allows inflow of a first liquid selected from whole blood, platelet-rich plasma and a drug-treated liquid thereof, a second channel connected to the first channel, which allows inflow of a second liquid containing an agent that is reactive with the first liquid, and a merged channel extended from the connection portion of the first channel with the second channel, wherein, in the merged channel, a stirring section having a stirring bar for mixing the first liquid with the second liquid is provided; and a blood monitoring device using the same.

Abstract: An apparatus for monitoring thrombus formation wherein anticoagulated blood is flown through a channel simulating a blood vessel while releasing the anticoagulant treatment or promoting blood coagulation to thereby monitor thrombus formation. This apparatus for monitoring thrombus formation comprises: a thrombus formation chamber in at least a part of which a thrombus formation inducer inducing thrombus formation is provided; an inlet tube which is connected to the thrombus formation chamber and through which blood is flown into the thrombus formation chamber; and a drug tube which is connected to the inlet tube and through which a drug releasing the anticoagulant treatment or a drug promoting blood coagulation is supplied.

Abstract: A microchip for measuring platelet function by allowing blood to flow through a channel to induce platelet aggregation, wherein the microchip comprises a channel provided inside thereof, wherein at least a part of the channel is coated with collagen for allowing adhesion of platelets; a plurality of walls extend along the direction of the flow of blood in the channel and divide the width of the channel to form a channel dividing section; and the walls are treated to have a surface roughness (Ra) of 10 to 200 nm.

Abstract: A multilayered liquid container having a discharge port welded under specified conditions to a sealant, which is constituted of a resin comprising a cycloolefin resin as a main component. The discharge port is composed of: an innermost layer constituted of a resin comprising a cycloolefin as a main component; and a surface layer whose main part is constituted of a resin comprising a specific type of polyethylene as a main component. According to the present invention, there can be provided a multilayered liquid container, which can prevent an effective component of a content fluid from being adsorbed onto or penetrating through not only the container body, but also the resin constituting the discharge port, and enables high temperature sterilization treatment, coupled with the discharge port having high welded strength and drop strength.

Abstract: A thrombin mutant in which at least serine at position 205 among amino acids in the active center of the thrombin B chain has been replaced with another amino acid, and further at least one of the following replacements have been introduced: (I) replacement of arginine at position 89 in the B-chain with another amino acid; (II) replacement of threonine at position 69 or serine at position 22 in the B-chain with another amino acid; (III) replacement of alanine at position 200 in the B-chain with another amino acid; and (IV) replacement of lysine at position 65 in the B-chain with threonine.

Abstract: It is aimed to provide a spout member and a packaging bag using the spout member which have excellent handling property and hygiene management performance at the time of supplying water or the like from the outside before and during use such as administration of water and medicine, in which a closure means for freely opening and closing an aperture formed by cutting off parts of peripheral portions of sealed film pieces is protected from a contained content at the time of storage or transportation and which have excellent protecting property even when an inner pressure acts in the packaging bag, excellent contamination preventing property until a spout is opened and excellent contamination preventing property and handling property after opening.

Abstract: A pouring port of a container for liquid at one end of which a rubber stopper allowing the penetration of an injection needle therethrough is embedded, wherein: the pouring port is formed by welding a port part, at least the innermost layer of which forming the discharge channel thereof comprises a resin containing a COP-based resin as the main component, with a stopper body part, which holds the rubber stopper and comprises a resin containing a COP-based resin as the main component, via the resin layers containing the respective COP-based resins as the main component; and at least the resin constituting the stopper body part contains a rubber component in an amount of not more than 30% by mass, or has, in the main chain, a molecular structure represented by general formula (1) [wherein R represents a hydrogen atom or an organic group having 1 to 20 carbon atoms; and n represents an integer equal to or greater than 1] and contains a PE-based resin in an amount of 30% by mass or less, and/or contains an an

Abstract: A medical container comprising a body for containing a medicament, the body of the medical container being formed of a multilayered film comprising (i) a layer formed of a linear polyolefin and (ii) a layer formed of a cyclic polyolefin adjacent to the layer (i), and the layer (i) formed of the linear polyolefin satisfying the following conditions (a) and/or (b): Condition (a): an amount of a liquid component, which remains after Soxhlet's extraction with organic solvents followed by evaporation of the solvents, is 0.2% by weight or less, and Condition (b): a branching degree of a component, which remains after Soxhlet's extraction with n-hexane followed by evaporation of n-hexane, is 50 or less per 1,000 carbon atoms.

Abstract: Multi-chamber container (1) having its interior partitioned by weak seal portions (3) provided through detachable heat sealing so that multiple contents are accommodated separately from each other, wherein use is made of heat seal layers consisting of a composition comprising two types of propylene copolymers components (component A and component B) from propylene and ethylene and/or a C4-C8 ?-olefin which have the following elution properties. Thus, a region wherein a change of seal strength by a change of heat seal temperature is small has a wide temperature range to thereby facilitate controlling of the seal strength at the weak seal portions. The proportion (mass %) of, to total solution, elution according to the TREF method (temperature: 0 to 140° C. and solvent: ODCB) is as follows. With respect to component A: 15 to 50 at 0° C., and 5 to less than 15 at 60 to 90° C. With respect to component B: 0 to 25 at 0° C., and 15 to 70 at 60 to 90° C.

Abstract: A microchip comprising therein a first channel which allows inflow of a first liquid selected from whole blood, platelet-rich plasma and a drug-treated liquid thereof, a second channel connected to the first channel, which allows inflow of a second liquid containing an agent that is reactive with the first liquid, and a merged channel extended from the connection portion of the first channel with the second channel, wherein, in the merged channel, a stirring section having a stirring bar for mixing the first liquid with the second liquid is provided; and a blood monitoring device using the same.

Abstract: The present invention is to provide an electromagnetic wave shielding material which comprises a transparent substrate and a fine line pattern formed thereon, wherein the fine line pattern comprises a metal plating film using a physically developed metal silver as a catalytic nucleus and a process for preparing an electromagnetic wave shielding material which comprises exposing a light-sensitive material having a physical development nuclei layer and a silver halide emulsion layer on a transparent substrate in this order, precipitating metal silver with an optional fine line pattern onto the physical development nuclei layer by physical development, then, removing a layer provided on the physical development nuclei layer, and subjecting to plating a metal with the use of the physically developed metal silver as a catalytic nucleus.

Abstract: To provide a liquid container, which exhibits excellent storage stability and impact resistance and which can be used for producing a soft bag pharmaceutical product of an injection liquid containing nitroglycerin, a protein, hyaluronic acid, a vitamin, a trace element, a radical scavenger, and the like. The liquid container of the invention formed of a multilayer film and/or multilayer sheet, characterized in that the multilayer film and/or multilayer sheet has a barrier layer containing, as a predominant component, a polycycloolefin-based resin having a glass transition temperature higher by 5° C. or more than the temperature at which the container is subjected to thermal treatment or high-pressure steam sterilization, and a seal layer containing, as a predominant component, a polyethylene-based resin or a polypropylene-based resin, and the barrier layer being provided adjacent to the seal layer.

Abstract: A thrombin mutant in which at least serine at position 205 among amino acids in the active center of the thrombin B chain has been replaced with another amino acid, and further at least one of the following replacements have been introduced: (I) replacement of arginine at position 89 in the B-chain with another amino acid; (II) replacement of threonine at position 69 or serine at position 22 in the B-chain with another amino acid; (III) replacement of alanine at position 200 in the B-chain with another amino acid; and (IV) replacement of lysine at position 65 in the B-chain with threonine.

Abstract: This invention provides a duplex-chamber package that has a high level of water vapor barrier properties, can realize mixing of plural contents in a hermetically sealed state, and can reduce the elution of a material contained in the sheet of a duplex-chamber package material into the contents of the package. The duplex-chamber package comprises a package comprising a first sheet superimposed onto a second sheet, the peripheral part of the assembly having been sealed, a weakly sealed part for partitioning the inside of the package into two or more chambers having been provided in a part of the package. The first sheet (I) is a laminated sheet comprising a heat seal layer, a mass transfer layer and a mass transfer blocking layer, and the mass transfer blocking layer being interposed between the heat seal layer and the mass transfer layer.

Abstract: The present invention relates to a sterilization indicator using a chemical indicator that is useful for hydrogen peroxide plasma sterilization treatment and a sterilization packaging material for storing an article to be sterilized by plasma sterilization treatment that has an indicator area formed from the sterilization indicator provided thereon. The plasma-sterilization indicator according to the invention, which includes one or more compounds (A) selected from the group consisting of adsorption indicators and metal chelate-titration indicators, and an organic metal compound (B) and is irreversible in discoloration and higher in discoloration speed, allows definite judgment of whether or not an article in a sterilization packaging material was previously subjected to plasma sterilization treatment and thus is useful as a plasma-sterilization indicator.

Abstract: A sterilization bag that is favorable for storing medical implements having sharp tips such as scalpels and forceps and can effectively suppress the occurrence of unwanted opening or damage due to contact with sharp tips is provided. The sterilization bag is formed by adhering the side edges and lower ends of a gas-permeable material and a synthetic resin film. The sterilization bag has, in its lower end portion or vicinity thereof, a damage-prevention means that prevents damage of at least one selected from the gas-permeable material, the synthetic resin film, and the adhered portion of a gas-permeable material and synthetic resin film by catching or receiving the tips of stored articles. Specific embodiments include a bag having a bulging portion obtained by mountain folding and valley folding a side surface film of synthetic resin in the lower end portion of the sterilization bag or vicinity thereof, and a bag with a laminated protective component made of synthetic resin film.

Abstract: A thrombin derivative having a lowered fibrinogen activity, a process for producing thereof, an anhydrothrombin derivative having a lowered fibrinogen activity, and a process for producing thereof are provided. This invention is to provide a thrombin derivative formed by modifying carboxyl group(s) of the thrombin and an anhydrothrombin derivative formed by modifying carboxyl group(s) of the anhydrothrombin. The thrombin derivative can be utilized as a composition for inducing platelet aggregation and further as a reagent of specific aggregation for clinical testing and the like. By affinity chromatography using carboxyl group(s) bound with anhydrothrombin as a ligand, it is made possible to carry out necessary purification with high selectivity relative to the blood coagulation factor VIII.