Patents Assigned to GALVANI BIOELECTRONICS LIMITED
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Patent number: 11672972Abstract: A nerve interface device including at least one cuff portion having an assembled position in which the cuff portion forms at least part of a passageway for receiving a nerve along a longitudinal axis passing through the passageway; and first and second rings of electrodes mounted on the at least one cuff portion, each ring of electrodes including a plurality of electrodes. Each electrode in the first ring has a corresponding longitudinally-aligned electrode in the second ring so as to form a plurality of pairs of electrodes spaced apart from each other along the longitudinal axis. The plurality of pairs of electrodes includes at least a first pair of electrodes, the first pair of electrodes mounted on the at least one cuff portion. The at least one cuff portion includes an asymmetric configuration about a central axis perpendicular to the longitudinal cuff axis.Type: GrantFiled: December 11, 2018Date of Patent: June 13, 2023Assignees: Galvani Bioelectronics Limited, UCL Business PLCInventors: Rizwan Bashirullah, Gerald Edwin Hunsberger, Matteo Donega, Daniel Chew, David Holder, Kirill Aristovich
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Publication number: 20230125962Abstract: An extravascular neural interface is disclosed containing electrodes for neurostimulation of the vessel. The devices are housed in flexible substrates, each substrate having a spinal portion for routing leads/conductors into the device for connection to the electrodes. Extending from opposite sides of the spinal portion is a self-sizing inner flap that supports and positions the electrodes to be inward facing, i.e., extravascular designs, and one more rigid outer flap. The electrodes may be flexible multifilar coil electrodes.Type: ApplicationFiled: December 22, 2022Publication date: April 27, 2023Applicant: Galvani Bioelectronics LimitedInventors: Faisal ZAIDI, Sebastien OUCHOUCHE
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Patent number: 11633601Abstract: Modulation of the neural activity of a nerve adjacent to the left gastro epiploic artery (LGEA) and/or a nerve adjacent to a short gastric artery (SGA) can modulate the neural activity of the sympathetic nerves that impact splenic function. This is useful for reducing inflammation and providing ways of treating inflammatory disorders.Type: GrantFiled: December 20, 2018Date of Patent: April 25, 2023Assignee: Galvani Bioelectronics LimitedInventors: Margarita J. Vervoordeldonk, Robert Coatney, Cindy Cleypool
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Patent number: 11623098Abstract: There is provided a neural interface device for unidirectional stimulation of a nerve including at least one A-type nerve fiber or at least one at least partially myelinated nerve fiber. The device includes an electrode arrangement for placing on or around the nerve. The electrode arrangement includes a first electrode configured to be positively charged and a second electrode configured to be negatively charged, where the surface area of the second electrode is larger than the surface area of first electrode.Type: GrantFiled: December 11, 2018Date of Patent: April 11, 2023Assignee: Galvani Bioelectronics LimitedInventor: Gerald Edwin Hunsberger
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Patent number: 11589827Abstract: There is provided a nerve activity monitoring method that includes receiving an input signal indicative of activity in a nerve of a subject; receiving physiological data indicative of physiological activity in the subject; establishing a relationship between the physiological data and the input signal; identifying a plurality of periodic portions in the input signal based on the relationship between the physiological data and the input signal; and outputting the periodic portions identified.Type: GrantFiled: June 22, 2018Date of Patent: February 28, 2023Assignees: UCL Business PLC, Galvani Bioelectronics LimitedInventors: Kirill Aristovich, David Holder, Daniel Chew, Matteo Donega
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Patent number: 11583685Abstract: An implantation system and methods of inserting an implant are disclosed. The method includes the step of making an incision in an abdominal wall with an instrument positioned within an abdominal cavity. The method further includes the steps of forming a pocket between a first surface of the abdominal wall and a second surface of the abdominal wall, such that the incision defines an opening into the pocket, inserting an implant through the opening and into the pocket, and closing the opening such that the implant is captured within the pocket.Type: GrantFiled: December 21, 2018Date of Patent: February 21, 2023Assignee: Galvani Bioelectronics LimitedInventors: Eric Irwin, Andrew Hindmarsh, John Bennett
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Patent number: 11577082Abstract: Devices and methods for the stimulation of neural signaling of an apical splenic nerve, the device having a transducer for placement on or around the apical splenic nerve, and a signal generator to generate a signal that stimulates or inhibits the neural activity of the apical splenic nerve to produce a physiological response. The transducer has at least one electrode, and the signal generator is a voltage or current source. The stimulation electrical signal has a frequency of between 1 Hz and 50 Hz.Type: GrantFiled: November 8, 2017Date of Patent: February 14, 2023Assignees: Galvani Bioelectronics Limited, GlaxoSmithKline Intellectual Property Development Limited, Université de Nice Sophia-Antipolis, Centre Nationale de La Recherche ScientifiqueInventors: Philippe Blancou, Nicolas Glaichenhaus, Arun Sridhar
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Patent number: 11571574Abstract: Modulation of neural activity in the superior laryngeal nerve (SLN) or cervical sympathetic trunk (CST) is effective in treating diseases and conditions mediated by thyroid and parathyroid hormones, in particular diseases associated with calcitonin secretion (e.g. osteoporosis) or diseases associated with thyroxine secretion (e.g. hypothyroid syndrome).Type: GrantFiled: November 10, 2017Date of Patent: February 7, 2023Assignees: GALVANI BIOELECTRONICS LIMITED, TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGYInventors: Hans Jakob Kristoffer Famm, Harumi Hotta, Arun Sridhar
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Patent number: 11559692Abstract: An extravascular neural interface is disclosed containing electrodes for neurostimulation of the vessel. The devices are housed in flexible substrates, each substrate having a spinal portion for routing leads/conductors into the device for connection to the electrodes. Extending from opposite sides of the spinal portion is a self-sizing inner flap that supports and positions the electrodes to be inward facing, i.e., extravascular designs, and one more rigid outer flap. The electrodes may be flexible multifilar coil electrodes.Type: GrantFiled: July 23, 2018Date of Patent: January 24, 2023Assignee: Galvani Bioelectronics LimitedInventors: Faisal Zaidi, Sebastien Ouchouche
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Patent number: 11517754Abstract: Modulation of neural signaling of a pancreas-related sympathetic nerve is capable of improving glycaemic control by inhibiting T cell activation or migration to the pancreas, and hence providing a way of treating or preventing type 1 diabetes.Type: GrantFiled: May 4, 2018Date of Patent: December 6, 2022Assignees: Galvani Bioelectronics Limited, Centre Nationale de La Recherche Scientifique, Université Côte d'AzurInventors: Arun Sridhar, Philippe Blancou, Nicolas Glaichenhaus
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Patent number: 11464976Abstract: Modulation of neural activity of a ganglion, by applying a signal to a sympathetic nerve adjacent to the ganglion, results in preferential reduction of sympathetic signals to an effector, thereby providing ways of treating and preventing conditions associated with exacerbated sympatho-excitation.Type: GrantFiled: December 11, 2018Date of Patent: October 11, 2022Assignee: Galvani Bioelectronics LimitedInventors: Gerald Edwin Hunsberger, Arun Sridhar
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Patent number: 11464978Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.Type: GrantFiled: December 20, 2018Date of Patent: October 11, 2022Assignee: Galvani Bioelectronics LimitedInventors: Daniel John Chew, Matteo Donega, Isha Gupta
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Patent number: 11452867Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.Type: GrantFiled: December 20, 2018Date of Patent: September 27, 2022Assignee: Galvani Bioelectronics LimitedInventors: Matteo Donega, Daniel John Chew, Margarita J. Vervoordeldonk, Isha Gupta
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Patent number: 11452872Abstract: This disclosure provides an apparatus or system for the modulation of neural activity in the cervical sympathetic chain (CSC) or superior cervical ganglion (SCG) or SCG post-ganglionic branch(es) and for the treatment of sleep apnoea, as well as methods for their use.Type: GrantFiled: February 27, 2017Date of Patent: September 27, 2022Assignees: Galvani Bioelectronics Limited, Case Western Reserve UniversityInventors: Alessandra Giarola, Yee-Hsee Hsieh, Stephen J. Lewis, Arun Sridhar
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Patent number: 11446496Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.Type: GrantFiled: December 20, 2018Date of Patent: September 20, 2022Assignee: Galvani Bioelectronics LimitedInventors: Margarita J. Vervoordeldonk, Eric Irwin, Daniel John Chew, Matteo Donega, Cindy Cleypool, Isha Gupta
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Patent number: 11446502Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is associated with a neurovascular bundle, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating inflammatory disorders. The invention provides improved ways of treating inflammatory disorders which minimize off-target effects.Type: GrantFiled: December 20, 2018Date of Patent: September 20, 2022Assignee: Galvani Bioelectronics LimitedInventors: Matteo Donega, Daniel John Chew, Isha Gupta
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Patent number: 11395915Abstract: An extravascular or intravascular neural interface is disclosed containing electrodes for neurostimulation of the vessel. The devices are housed in flexible substrates formed from a multilumen tubing housing conductors for electrodes positioned in a distal serpentine shaped end of the device. The distal serpentine shaped end includes rows or strips of electrodes or coil electrodes.Type: GrantFiled: July 23, 2018Date of Patent: July 26, 2022Assignee: Galvani Bioelectronics LimitedInventors: Faisal Zaidi, Sebastien Ouchouche
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Patent number: 11357976Abstract: An extravascular neural interface is disclosed including a device containing electrodes for neurostimulation of a vessel. The devices are housed in flexible substrates forming two flaps, an inner flap having a spinal portion for routing leads/conductors into the device for connection to the electrodes and an outer flap that overlaps the inner flap. The inner flap supports and positions the electrodes to be inward facing, i.e., extravascular designs. The electrodes may be circular or elliptical and include a plurality of wings for securing the electrodes within a flap.Type: GrantFiled: July 23, 2018Date of Patent: June 14, 2022Assignee: Galvani Bioelectronics LimitedInventors: Faisal Zaidi, Sebastien Ouchouche
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Patent number: 11331501Abstract: A device that is implantable in body tissue of a human or animal. The device is comprised of a header comprising at least one terminal adapted for removable connection to a lead and an open ended case closed by a plate to form a housing. The housing is comprised of a surrounding edge wall joined to a first side wall and a second side wall opposed to the first side wall. At least a first suture port extends through the edge wall and the second side wall but not the first side wall at an upper edge region of the housing. A second suture port may extend through the surrounding edge wall and the second side wall but not the first side wall in a similar manner. A third suture port may extend through the header. The three suture ports may define a triangular attachment configuration.Type: GrantFiled: June 20, 2019Date of Patent: May 17, 2022Assignees: Greatbatch Ltd., Galvani Bioelectronics LimitedInventors: Ignacio A. Armesto, Luis Daniel Villamil, Refet Firat Yazicioglu, Kristina Schlegel, Kent Leyde
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Patent number: D989050Type: GrantFiled: March 15, 2022Date of Patent: June 13, 2023Assignee: Galvani Bioelectronics LimitedInventors: Peng Cong, Damiano Patron, Stephen O'Driscoll