Patents Assigned to GALVANI BIOELECTRONICS LIMITED
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Patent number: 11298544Abstract: Systems and methods are provided for stimulating one or more nerves with an implantable device. The implantable device may comprise an antenna circuit including a loop antenna and a control circuit including a rectifying diode for rectifying an alternating voltage induced in the antenna circuit by an external electromagnetic field. The implantable device may also include a chargeable storage element for storing energy from the rectified voltage without using a battery. The device may also include an electrode array containing a set of electrodes for emitting an electric field using the stored energy in response to a control signal received from the control circuit. The components of the device may be affixed onto a soft polymer substrate including a linkable peripheral tab on at least two edges of a substantially rectangular body section of the substrate for forming a cuff about the one or more nerves to be stimulated.Type: GrantFiled: February 17, 2017Date of Patent: April 12, 2022Assignee: GALVANI BIOELECTRONICS LIMITEDInventors: Brian Marc Pepin, Brian Otis
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Publication number: 20210393949Abstract: The invention provides devices, apparatuses, systems and methods for treating and ameliorating inflammation of the gut. In particular, the invention provides devices, apparatuses and methods in which a neuromodulatory signal is delivered a splenic nerve and/or superior mesenteric plexus (SMP). The signal is able to treat inflammatory disorders, e.g., colitis, for example in Inflammatory Bowel Disease.Type: ApplicationFiled: February 26, 2021Publication date: December 23, 2021Applicants: GALVANI BIOELECTRONICS LIMITED, ACADEMISCH MEDISCH CENTRUMInventors: Daniel John CHEW, Wouter Jacob DE JONGE, Hans Jakob Kristoffer FAMM, Sonal PATEL, Olaf WELTING
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Patent number: 11167143Abstract: This disclosure relates to implantable neuromodulation systems and methods, and in particular to systems and methods for sensing blood-based parameter changes triggered by neural stimulation and subsequently optimizing the stimulation parameters based on feedback from the sensed blood-based parameter changes. Embodiments are directed to a method that includes delivering neural stimulation to a nerve or artery/nerve plexus based on a first set of stimulation parameters, monitoring a response to the neural stimulation that includes monitoring responses of the nerve or artery/nerve plexus and blood-based parameters of the artery, modifying the first set of the stimulation parameters based on the blood-based parameters to create a second set of stimulation parameters, and delivering the neural stimulation based on the second set of the stimulation parameters.Type: GrantFiled: February 12, 2018Date of Patent: November 9, 2021Assignee: Galvani Bioelectronics LimitedInventors: Brian Marc Pepin, Shiv Sabesan
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Publication number: 20210290949Abstract: Implantable nerve cuffs and methods for constructing or manufacturing the same are provided. Also provided is a method for installing a nerve into a nerve passage in the nerve cuff and a system using the nerve cuff. The nerve cuff is configured to retain one or more signal carrying elements such as electrodes proximal to a peripheral nerve in a human or animal subject. The nerve cuff may be constructed using a 3D printing method.Type: ApplicationFiled: July 27, 2017Publication date: September 23, 2021Applicants: GALVANI BIOELECTRONICS LIMITED, TRUSTEES OF BOSTON UNIVERSITYInventors: Bradley J. HOLINSKI, Timothy GARDNER, Charles A. LISSANDRELLO, Alice E. WHITE, Winthrop GILLIS, Jun SHEN, Timothy OTCHY, Christos MICHAS
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Patent number: 11097115Abstract: An implantable pulse generator is provided that includes a power source, a wireless communication component configured to facilitate wireless communication with a non-implanted device and pulse-generating circuitry connected to the power source. The pulse-generating circuitry can be configured to identify, based on wireless communication with the non-implanted device, temporal and amplitude characteristics for electrical pulse stimuli and to trigger electrical output stimuli having the temporal and amplitude characteristics. The implantable pulse generation can further include one or more lead connections—each being shaped to engage a lead and electrically connected to the pulse-generating circuitry to enable the lead to deliver at least part of the electrical output stimuli triggered by the pulse-generating circuitry. The implantable pulse generator can further include one or more suture-engagement components, each including one or more holes each having a diameter that is at least 0.1 mm and less than 5 mm.Type: GrantFiled: September 24, 2018Date of Patent: August 24, 2021Assignee: Galvani Bioelectronics LimitedInventor: Peng Cong
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Patent number: 10974041Abstract: The invention provides devices, apparatuses, systems and methods for treating and ameliorating inflammation of the gut. In particular, the invention provides devices, apparatuses and methods in which a neuromodulatory signal is delivered a splenic nerve and/or superior mesenteric plexus (SMP). The signal is able to treat inflammatory disorders, e.g., colitis, for example in Inflammatory Bowel Disease.Type: GrantFiled: April 22, 2016Date of Patent: April 13, 2021Assignees: GALVANI BIOELECTRONICS LIMITED, ACADEMISCH MEDISCH CENTRUMInventors: Daniel John Chew, Wouter Jacob De Jonge, Hans Jakob Kristoffer Famm, Sonal Patel, Olaf Welting
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Patent number: 10960209Abstract: Modulation of neural signaling of a branch of the GSN supplying the adrenal gland can regulate the secretion of signaling molecules from the adrenal medulla. In particular, epinephrine, norepinephrine and enkephalin release can be independently regulated.Type: GrantFiled: July 25, 2017Date of Patent: March 30, 2021Assignees: Galvani Bioelectronics Limited, Case Western Reserve UniversityInventors: Arun Sridhar, Corey Smith, Kyle Wolf, Georgy Zarkua, Shyue-An Chan
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Patent number: 10946189Abstract: An extravascular or intravascular neural interface is disclosed and can include three C-ring portions, with at least two including an electrode, an electrode pair or an electrode array. The portions are formed of a flexible material that is configured to enable the portions to self-size to fit around or against a surface of a target vessel when the neural interface is released at a position along the target vessel. A spinal portion configured to house electrical conductors for the electrodes is connected to one or more portions. The portions may be spaced sufficient apart to permit radial expansion and contraction of a target vessel around or within which the neural interface is placed, to reduce nerve compression, open trench low-pressure unrestricted blood-flow, and to enhance fluid exchange with the target vessel. The portions may be arranged in a low helix angle forming at least two full turns.Type: GrantFiled: July 23, 2018Date of Patent: March 16, 2021Assignee: Galvani Bioelectronics LimitedInventors: Faisal Zaidi, Sabastien Ouchouche, Paul Matteucci, Jr.
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Publication number: 20210069504Abstract: Modulation of neural activity of a ganglion, by applying a signal to a sympathetic nerve adjacent to the ganglion, results in preferential reduction of sympathetic signals to an effector, thereby providing ways of treating and preventing conditions associated with exacerbated sympatho-excitation.Type: ApplicationFiled: December 11, 2018Publication date: March 11, 2021Applicant: Galvani Bioelectronics LimitedInventors: Gerald Edwin HUNSBERGER, Arun SRIDHAR
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Publication number: 20210069511Abstract: Modulation of neural activity of a cardiac-related nerve at an interganglionic nerve branch in the sympathetic chain results in preferential reduction of sympathetic signals to the heart, thereby providing ways of treating and preventing cardiac dysfunction such as arrhythmias.Type: ApplicationFiled: December 11, 2018Publication date: March 11, 2021Applicant: Galvani Bioelectronics LimitedInventors: Gerald Edwin HUNSBERGER, Arun SRIDHAR
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Patent number: 10933248Abstract: Implantable systems are described that include a stimulation device positionable in vivo and configured to communicatively couple to electrodes configured to stimulate or block body tissue and an auxiliary device positionable in vivo and including one or more coils configured to wirelessly couple, in vivo, to the stimulation device and to wirelessly couple to an ex vivo device. The auxiliary device may include a coil driver and a power source controlled by a processor and memory for storing data instructions for the coil driver and for storing data received from the stimulation device. The auxiliary device may also include a radio transceiver and an antenna. The stimulation device may include a housing, a coil, a power source and an integrated circuit for controlling the electrodes. The stimulation device may be coupled to a cuff via a lead and physically coupled to the auxiliary device.Type: GrantFiled: November 3, 2017Date of Patent: March 2, 2021Assignee: GALVANI BIOELECTRONICS LIMITEDInventor: Rizwan Bashirullah
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Publication number: 20200368531Abstract: Modulation of neural signaling of an eye-related sympathetic nerve can decrease the levels of pro-inflammatory cytokines in the eye, and this provides a way of treating eye disorders, such as ocular neovascular diseases.Type: ApplicationFiled: July 27, 2018Publication date: November 26, 2020Applicants: Galvani Bioelectronics Limited, University of Southern CaliforniaInventors: Arun SRIDHAR, Andrew C WEITZ, Victor Eugene PIKOV, Alessandra GIAROLA, Mark HUMAYUN
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Publication number: 20200368528Abstract: Modulation of neural signaling of an eye-related sympathetic nerve can mitigate choroidal neovascularization (CNV) in the eye, and this provides a way of treating eye disorders, such as ocular neovascular diseases.Type: ApplicationFiled: July 27, 2018Publication date: November 26, 2020Applicants: Galvani Bioelectronics Limited, University of Southern CaliforniaInventors: Arun SRIDHAR, Andrew C WEITZ, Victor Eugene PIKOV, Alessandra GIAROLA, Mark HUMAYUN
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Publication number: 20200246622Abstract: Modulation of neural activity of a subject's aortic depressor nerve (ADN) and/or carotid sinus nerve (CSN) can modulate baroreceptor reflex function, thereby providing ways of treating or preventing disorders associated with malfunction or loss of the baroreceptor reflex.Type: ApplicationFiled: September 14, 2018Publication date: August 6, 2020Applicants: CASE WESTERN RESERVE UNIVERSITY, Galvani Bioelectronics LimitedInventors: Arun SRIDHAR, Stephen J. LEWIS, Ibrahim SALMAN
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Patent number: 10603486Abstract: Methods for fabricating implantable cuff electrodes for contacting or at least partially surrounding internal body tissue such as, e.g., nerves, smooth muscles, striated muscles, arteries, veins, ligamental tissues, connective tissues, cartilage tissues, bones, or other similar body tissues, structures and organs are disclosed. An example method includes preparing a substrate including an implantable cuff electrode shape, applying a mold material to the substrate, curing the mold material to form a mold, releasing the mold from the substrate, inserting at least one conductor into the mold that penetrates through the channel of the mold, pressing a formable material into the channel of the mold to form a body of an implantable cuff electrode about the at least one conductor, curing the body of the implantable cuff electrode, and releasing the body of the implantable cuff electrode from the mold.Type: GrantFiled: June 12, 2017Date of Patent: March 31, 2020Assignee: GALVANI BIOELECTRONICS LIMITEDInventors: Dwight Sherod Walker, Daniel John Chew
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Patent number: 10576172Abstract: An implantable system is disclosed that includes an encapsulated housing including a radioactive source. The encapsulated housing is internally coated with a light-generating coating that converts the radioactive energy to light, that is then output in vivo to a photodiode positioned proximate to at least part of the encapsulated housing in vivo. The photodiode is configured to generate electrical current from the light, which electrical current is output to a power conditioning circuit that is configured to use the electrical current as an input electrical current and to output power to a load in vivo. The encapsulated may also be internally coated, at least in part, with a light directing coating that causes light to be directed toward an optical lens that focuses the light on the photodiode. The radioactive source may be a gas having a low half-life and which poses no health risk to a patient if released.Type: GrantFiled: November 3, 2017Date of Patent: March 3, 2020Assignee: GALVANI BIOELECTRONICS LIMITEDInventor: Rizwan Bashirullah
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Patent number: D916688Type: GrantFiled: September 24, 2018Date of Patent: April 20, 2021Assignee: Galvani Bioelectronics LimitedInventors: Peng Cong, Damiano Patron, Stephen O'Driscoll
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Patent number: D926316Type: GrantFiled: September 24, 2018Date of Patent: July 27, 2021Assignee: Galvani Bioelectronics LimitedInventors: Peng Cong, Benjamin K. Yaffe, Morten Hansen
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Patent number: D947119Type: GrantFiled: June 6, 2019Date of Patent: March 29, 2022Assignee: Galvani Bioelectronics LimitedInventors: Jay Canham, David Lari, Cindy Au, Melissa Lara, Daniel Nobre, Ryan Jongwoo Choi
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Patent number: D949132Type: GrantFiled: March 9, 2021Date of Patent: April 19, 2022Assignee: Galvani Bioelectronics LimitedInventors: Peng Cong, Damiano Patron, Stephen O'Driscoll