Patents Assigned to GE Healthcare AS
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Patent number: 11964020Abstract: A method for removing or controlling or quantifying the presence of aldehydes, in particular acetaldehyde, is described. Such a method is useful in prolonging the shelf life of a pharmaceutical product.Type: GrantFiled: June 13, 2022Date of Patent: April 23, 2024Assignee: GE Healthcare LimitedInventors: Torgrim Engell, Julian Grigg, Dimitrios Mantzilas, Dag M. Evje
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Patent number: 11884686Abstract: The invention provides compounds suitable for use as contrast agents in magnetic resonance imaging (MRI). The compounds of the present invention are manganese (II) complexes having advantageous properties as compared with similar known compounds.Type: GrantFiled: June 20, 2017Date of Patent: January 30, 2024Assignee: GE HEALTHCARE ASInventors: Andreas Richard Meijer, Mikkel Jacob Thaning, Brian Christopher Bales, Michael James Rishel
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Patent number: 11730832Abstract: The present invention provides a method for the commercial presentation of a solution of gadolinium-DOTA that provides certain advantages over the known methods.Type: GrantFiled: October 26, 2020Date of Patent: August 22, 2023Assignee: GE HEALTHCARE ASInventors: Karina Martha Langseth-Manrique, Arne Wang Aabye, Harald Laugen, Eva Krog Tamnes, Borge Mathisen
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Patent number: 11724022Abstract: Disclosed herein are novel procedures, systems and excipient solutions for in situ provision of a contrast media at a user defined concentrations. An automated procedure according to embodiments of the current invention provides increased user safety, flexibility and user friendliness.Type: GrantFiled: December 20, 2018Date of Patent: August 15, 2023Assignee: GE HEALTHCARE ASInventors: Karina Martha Langseth-Manrique, Duncan Wynn
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Patent number: 11615882Abstract: Systems and methods for tracking and management of a distributed ledger including information for a batch of radiopharmaceutical material are disclosed. Certain examples provide a computer-implemented method of managing radiopharmaceutical material including tracking, using at least one processor, a status of a batch of radiopharmaceutical material, the status to include a type, a quantity, and a timestamp associated with the batch of radiopharmaceutical material; generating a record in a first copy of a distributed ledger using the type, quantity, and timestamp associated with the batch of radiopharmaceutical material; updating the record based on at least one of usage of the batch of radiopharmaceutical material, resale of at least a portion of the batch of radiopharmaceutical material, and decay of the batch of radiopharmaceutical material; and sharing the record with a second copy of the distributed ledger.Type: GrantFiled: November 7, 2018Date of Patent: March 28, 2023Assignee: GE HEALTHCARE LIMITEDInventors: Jan Wolber, Scott Lagona
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Patent number: 11565257Abstract: The present invention provides a method for the synthesis of an injectable composition comprising a [18F]-labelled pyridaben derivative that is advantageous over prior methods. In particular, the method of the present invention comprises a method of radiosynthesis that permits a more facile purification using solid phase extraction (SPE).Type: GrantFiled: March 29, 2019Date of Patent: January 31, 2023Assignee: GE HEALTHCARE LIMITEDInventors: Torgrim Engell, Alexander Jackson, Imtiaz Ahmed Khan, Alan Peter Clarke, Graeme McRobbie, Julian Grigg
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Publication number: 20230022430Abstract: The present invention provides a cassette for determining optimised solid phase extraction (SPE) purification conditions, wherein said cassette comprises: (i) a flowpath comprising a first end and a second end; and (ii) a plurality of valves oriented along said flowpath, wherein each of said plurality of valves is selectively fluidly connected to one of a number of components, wherein said components comprise: (a) 1-5 composition vials; (b) 1-3 SPE cartridges; (c) 4-10 solvent vials; (d) a water vial; and (e) a transfer line.Type: ApplicationFiled: December 17, 2020Publication date: January 26, 2023Applicant: GE HEALTHCARE LIMITEDInventors: Graeme Walter MCROBBIE, Imtiaz Ahmed Khan, Jonathan Robert SHALES
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Patent number: 11534494Abstract: The present invention provides a novel method for the preparation of 18F-fluoride (18F) for use in radiofluorination reactions. The method of the invention finds use especially in the preparation of 18F-labelled positron emission tomography (PET) tracers. The method of the invention is particularly advantageous where bulk solutions are prepared and stored in prefilled vials rather than being freshly prepared on the day of synthesis. Also provided by the present invention is a radiofluorination reaction which comprises the method of the invention, as well as a cassette for use in carrying out the method of the invention and/or the radiofluorination method of the invention on an automated radiosynthesis apparatus.Type: GrantFiled: August 19, 2020Date of Patent: December 27, 2022Assignee: GE HEALTHCARE LIMITEDInventors: Knut Richard Dyrstad, Torild Wickstrom, Thanushan Rajanayagam, Kristine Romoren, Olav Ryan
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Patent number: 11504430Abstract: The present invention provides a novel method for the preparation of 18F-fluoride (18F) for use in radiofluorination reactions. The method of the invention finds use especially in the preparation of 18F-labelled positron emission tomography (PET) tracers. The method of the invention is particularly advantageous where bulk solutions are prepared and stored in prefilled vials rather than being freshly prepared on the day of synthesis. Also provided by the present invention is a radiofluorination reaction which comprises the method of the invention, as well as a cassette for use in carrying out the method of the invention and/or the radiofluorination method of the invention on an automated radiosynthesis apparatus.Type: GrantFiled: December 21, 2011Date of Patent: November 22, 2022Assignee: GE HEALTHCARE LIMITEDInventors: Torild Wickstrom, Anders Svadberg, Ole Kristian Hjelstuen, Dag M Evje, Liane Ochsenfeld
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Patent number: 11497457Abstract: The present invention relates to a method for the evaluation of tissue gadolinium deposition that offers advantages compared with known methods. Comparison of different gadolinium-based contrast agents (GBCAs) based on retention, organ distribution, washout and safety is facilitated using the methods of the present invention.Type: GrantFiled: April 25, 2019Date of Patent: November 15, 2022Assignee: GE HEALTHCARE ASInventors: Anand Bherwani, Bob Senzig, Scott D. Slavic
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Patent number: 11488282Abstract: An adaptive template image for registering a PET or a SPECT image includes a template image model including variability of values for each voxel in a template image according to one or more control parameters.Type: GrantFiled: April 6, 2020Date of Patent: November 1, 2022Assignee: GE HEALTHCARE LIMITEDInventors: Roger Lundqvist, Nils Lennart Thurfjell, Johan Lilja
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Patent number: 11400172Abstract: The present invention relates to a method of removal of metal ion impurities, such as calcium, from lanthanide metal complexes of macrocyclic chelators. The method uses a scavenger resin to remove metal ions, displaced from chelator, by an excess of lanthanide ions. Also provided is a method of preparation of MRI contrast agents, from the purified lanthanide metal complex, by the addition of a defined excess chelator.Type: GrantFiled: January 24, 2020Date of Patent: August 2, 2022Assignee: GE HEALTHCARE ASInventors: Mikkel Jacob Thaning, Andreas Richard Meijer
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Patent number: 11389538Abstract: A method for removing or controlling or quantifying the presence of aldehydes, in particular acetaldehyde, is described. Such a method is useful in prolonging the shelf life of a pharmaceutical product.Type: GrantFiled: April 15, 2020Date of Patent: July 19, 2022Assignee: GE HEALTHCARE LIMITEDInventors: Torgrim Engell, Julian Grigg, Dimitrios Mantzilas, Dag M. Evje
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Patent number: 11311636Abstract: The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to radiotracer compositions which comprises 18F-labelled c-Met binding peptides. The invention provides said compositions, as well as associated automated methods of preparation and cassettes.Type: GrantFiled: April 4, 2019Date of Patent: April 26, 2022Assignee: GE HEALTHCARE LIMITEDInventors: Torgrim Engell, Gareth Simon Getvoldsen, Andreas Richard Meijer, Imtiaz Ahmed Khan, Graeme McRobbie, Robert James Nairne
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Patent number: 11185598Abstract: The invention relates to a process for the preparation of a diagnostic X-ray composition. The composition comprises a non-ionic X-ray contrast agent in a pharmaceutically acceptable carrier. More particularly, the invention relates to a process for secondary production of X-ray compositions comprising X-ray contrast agents with a high dissolution temperature. When using the process of the invention, precipitation is avoided and degradation of the contrast agent is reduced. The process of the invention includes heat treatment of iodinated X-ray contrast agents at low pH.Type: GrantFiled: March 22, 2011Date of Patent: November 30, 2021Assignee: GE HEALTHCARE ASInventors: Christian Glogard, Dirk-Jan in't Veld
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Patent number: 11186553Abstract: The present invention relates to a method of preparation of formulations of lanthanide metal complexes of macrocyclic chelators which further comprise a small excess of free chelator. The method uses a solid phase-bound scavenger chelator to remove excess lanthanide metal ions, prior to the addition of a defined excess chelator. Also provided is a method of preparation of MRI contrast agents, together with solid-phase bound chelator meglumine salts useful in the methods.Type: GrantFiled: November 27, 2015Date of Patent: November 30, 2021Assignee: GE HEALTHCARE ASInventors: Mikkel Jacob Thaning, Andreas Richard Meijer
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Patent number: 11135322Abstract: The present invention relates to a method of labelling biological molecules with 18F, via attachment to fluorine to a macrocyclic metal complex of a non-radioactive metal, where the metal complex is conjugated to the biological molecule. Also provided are pharmaceutical compositions, kits and methods of in vivo imaging.Type: GrantFiled: January 22, 2013Date of Patent: October 5, 2021Assignees: GE Healthcare Limited, University of SouthamptonInventors: Rajiv Bhalla, Sajinder Kaur Luthra, Gill Reid, I, William Levason
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Patent number: 11110185Abstract: The present invention relates to in vivo imaging and in particular to magnetic resonance imaging (MRI). Provided by the present invention is a pharmaceutical formulation suitable for use in an MRI procedure and which offers advantages over known such formulations. A particular dose of the pharmaceutical formulation of the invention is also envisioned as well as the use of said dose in a method of in vivo imaging. This present invention provides for simultaneous administration of a liver specific agent and a second MR contrast agent that is capable of better/further enhancing the dynamic vascular phase in a patient. The method of the invention has the advantage of simplicity and patient comfort, compared to sequential injections. Furthermore, the method of the invention provides the advantage that it can enable a lower cumulative dose of contrast agents.Type: GrantFiled: November 30, 2016Date of Patent: September 7, 2021Assignee: GE HEALTHCARE ASInventors: Andreas Richard Meijer, Mikkel Jacob Thaning, Paritosh Jayant Dhawale, Salvatore Desena, Paul Alexander Jones, Deirdre Cassidy, Concetta Valeria Gringeri
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Patent number: 11103604Abstract: A method of labelling biological molecules with 18F, via attachment of fluorine to a metal complex, where the metal complex is conjugated to the biological molecule. The invention highlights the incorporation of hydrogen bonding (H-bonding) into the metal complex scaffold, and how this can be utilised to improve the kinetics of fluoride incorporation. Also provided are pharmaceutical compositions, kits and methods of in vivo imaging.Type: GrantFiled: May 2, 2014Date of Patent: August 31, 2021Assignees: GE HEALTHCARE UK LIMITED, University of SouthamptonInventors: Rajiv Bhalla, Gill Reid, William Levason
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Patent number: 11094424Abstract: The present invention provides a system for evaporating a radioactive fluid, a method for the synthesis of a radiolabelled compound including this system, and a cassette for the synthesis of a radiolabelled compound comprising this system. The present invention provides advantages over known methods for evaporation of a radioactive fluid as it reduces drastically the amount of radioactive gaseous chemicals that are released in the hot cell. It is gentler and more secure compared to the known process and provides access to radiosyntheic processes that may not been acceptable for safety reasons related to release of volatile radioactive gases during evaporation. In addition, the process yields are higher because the radioactive volatiles are labelled intermediate species.Type: GrantFiled: August 29, 2019Date of Patent: August 17, 2021Assignee: GE HEALTHCARE LIMITEDInventors: Xavier Franci, Steve Lignon, Audrey Lange