Patents Assigned to GE Healthcare AS
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Patent number: 11077216Abstract: The present invention provides a composition comprising anti-1-amino-3-18F-fluorocyclobutyl-1-carboxylic acid (18F-FACBC) having an improved impurity profile compared with previous such compositions. Also provided is a method to obtain said composition.Type: GrantFiled: June 30, 2015Date of Patent: August 3, 2021Assignee: GE HEALTHCARE LIMITEDInventors: Knut Richard Dyrstad, Torild Wickstrom, Thanushan Rajanayagam
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Publication number: 20210222115Abstract: Disclosed herein is a cell harvesting instrument suitable for concentrating cells from a source suspension of cells and/or washing said cells, the instrument comprising: a housing for accommodating mechanical elements including at least one fluid pump, at least one valve; and a processing kit removably insertable into the housing, said kit including a generally flat frame having or supporting plural sealed fluid paths arranged in a generally flat plane and such that fluids in the paths do not contact said mechanical elements, wherein at least portions of the fluid paths comprise flexible tubes, the outer surfaces of which are manipulateable by the or each fluid pump, to provide fluid flow in one or more of the paths and/or by the or each valve to restrict fluid flow in one or more of the paths. In an embodiment, the kit comprises also a fluid processing reservoir and a filter suitable for separating cells from fluid in said paths.Type: ApplicationFiled: December 22, 2016Publication date: July 22, 2021Applicant: GE Healthcare Bio-Sciences Corp.Inventors: Weston Blaine Griffin, Dan Harris, Jim Dowling, Dan O'Sullivan
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Patent number: 11051777Abstract: A method of imaging to permit calculation of left:right striatum uptake ratios is provided, and the degree of asymmetry used to assist in the diagnosis of neurological diseases. Also provided are a method of diagnosis, method of patient selection, and method of therapy monitoring using the imaging method, and software tools for use in the method.Type: GrantFiled: July 25, 2014Date of Patent: July 6, 2021Assignee: GE HEALTHCARE LIMITEDInventors: Mark Rosser, Jan Wolber
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Patent number: 11045748Abstract: The present invention relates to a process for preparation of a composition comprising gas microbubbles. More particularly the invention relates to a process for filling of such composition into a container. The composition prepared is preferably an ultrasound contrast media composition made available in a container wherein the headspace of the container comprises the same gas as the gas of the microbubbles.Type: GrantFiled: April 26, 2013Date of Patent: June 29, 2021Assignee: GE Healthcare ASInventors: Svein Kvaale, Carl Peter Tonseth, Ole Johannes Tokerud
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Patent number: 11022609Abstract: The invention relates to a method for determining interaction kinetics for an analyte. The method comprises first contacting a solution containing the analyte with immobilized ligand, or analogue thereof, immobilized on an optical sensor surface; monitoring the binding of the analyte to the immobilized ligand or analogue, wherein the binding is measured as a resulting change in a property of the surface; and automatically determining the interaction kinetics, which determining step includes first defining parts of the dissociation phase that contains kinetic information for fitting. The invention further relates to an analytical system for studying molecular interactions, which system is capable of performing the novel method, as well as a computer program product for performing the steps of the method.Type: GrantFiled: November 12, 2014Date of Patent: June 1, 2021Assignee: GE HEALTHCARE BIO-SCIENCES ABInventor: Olof Karlsson
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Publication number: 20210123010Abstract: A device and method for detecting the level of foam in a reactor vessel monitors the intensity of the light or the movement of the light detected by a camera which monitors at least one light source positioned inside the reactor vessel or viewable through the reactor vessel.Type: ApplicationFiled: August 28, 2017Publication date: April 29, 2021Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: KLAUS GEBAUER, PIERRE LE GREVES, ANDREW DAVID PRIS, JOZSEF VASI, SAM PETROCELLI, HANNO EHRING, ESMAEIL HEIDARI, ALI CAN
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Patent number: 10984894Abstract: An image quality control system is disclosed. The example system includes an artificial intelligence modeler to process image data and metadata from patient data to generate first feature(s) from the image data and to parse the metadata to identify study information. The example system includes a computer vision processor to identify second feature(s) in the image data. The example system includes a results evaluator to compare the first feature(s) and second feature(s) to generate a comparison and to evaluate the comparison, first feature(s), and second feature(s) with respect to the study information to generate an evaluation. The example system includes a quality controller to compare the evaluation to quality criterion(-ia) to produce an approval or rejection of the patient data, the approval to trigger release of the patient data and the rejection to deny release of the patient data.Type: GrantFiled: December 27, 2018Date of Patent: April 20, 2021Assignee: GE HEALTHCARE LIMITEDInventors: Christopher Foley, Pal Tezges, Laszlo Rusko
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Patent number: 10980899Abstract: The present application provides a means for differential diagnosis of Parkinson's disease and the clinically similar Parkinsonian disorders multiple system atrophy with predominantly Parkinsonian features (MSA-P) and progressive supranuclear palsy (PSP).Type: GrantFiled: December 20, 2017Date of Patent: April 20, 2021Assignees: GE HEALTHCARE LIMITED, ACADEMIC MEDICAL CENTER, VU UNIVERSITY MEDICAL CENTERInventors: Paul Alexander Jones, Jan Booij, Chris Vriend
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Patent number: 10941124Abstract: The present invention provides methods for the preparation of compounds useful in in vivo therapeutic and diagnostic applications. In particular, the present invention provides a method for the synthesis of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and also methods for the preparation of metal chelates of DOTA.Type: GrantFiled: December 19, 2016Date of Patent: March 9, 2021Assignee: GE HEALTHCARE ASInventors: Andreas Richard Meijer, Arne Wang Aabye, Khalid Hussain, Sondre Nilsen, Mikkel Jacob Thaning, Jarle Andre Haugan, Ingvil Gausemel, Nikolai Enes, Silalahi Sumihar
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Patent number: 10913580Abstract: A container cap assembly provides a tamper-evident component for detecting cap integrity on a container includes one or more elongate bridges connecting a tamper-evident ring to a cap. The cap assembly also provides radially-extending links on the cap and the tamper-evident ring to help protect the integrity of the bridges as the cap assembly is applied to a container.Type: GrantFiled: December 27, 2013Date of Patent: February 9, 2021Assignee: GE HEALTHCARE ASInventor: Martin M. Browne
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Patent number: 10894779Abstract: The present invention provides a process to enhance the productivity such as yield of radioactive fluorine labeled flutemetamol. Provided is a process for producing a radioactive fluorine labeled flutemetamol, which comprises: (a) a step of allowing a labeling precursor represented by the predetermined general formula to react with a radioactive fluoride ion in a presence of a solvent to obtain a radioactive fluorine labeled intermediate represented by the predetermined general formula, and (b) a step of removing the protecting groups from the radioactive fluorine labeled intermediate to obtain a radioactive fluorine labeled flutemetamol, in which the above step (a) is carried out at an internal temperature of reaction solution of 140° C. or higher.Type: GrantFiled: February 22, 2018Date of Patent: January 19, 2021Assignee: GE HEALTHCARE LIMITEDInventors: Yuki Okumura, Gota Tonoya, Tomoyuki Matsunami, Kei Akama
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Patent number: 10888631Abstract: The present invention relates to a method for sterilisation of phospholipid suspensions, useful in the preparation of ultrasound contrast agent precursors comprising phospholipid-stabilised perfluorobutane microbubbles. The method provides sterility assurance, without undue thermal degradation of the phospholipid. The method is also amenable to commercial scale manufacture. Also provided are methods of preparing kits and ultrasound contrast agents incorporating the sterilisation method of the invention.Type: GrantFiled: June 26, 2015Date of Patent: January 12, 2021Assignee: GE HEALTHCARE ASInventors: Svein Kvale, Ingrid Henriksen, Ole Johannes Tokerud, Per Sontum
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Publication number: 20200377841Abstract: An apparatus for draining a bioreactor vessel includes a tubular body portion having an interior passageway, and at least one aperture in the tubular body portion providing for fluid communication with the interior passageway, the tubular body portion being configured for positioning at a bottom of a vessel, and a suction tube having a first end configured for fluid coupling with the tubular body portion, and a second end configured for fluid coupling with a port in a sidewall of the vessel.Type: ApplicationFiled: May 30, 2019Publication date: December 3, 2020Applicant: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: RICHARD DAMREN, COLIN TUOHEY, RALPH STANKOWSKI
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Patent number: 10842888Abstract: The present invention provides a method for the commercial presentation of a solution of gadolinium-DOTA that provides certain advantages over the known methods.Type: GrantFiled: January 22, 2018Date of Patent: November 24, 2020Assignee: GE Healthcare ASInventors: Karina Martha Langseth-Manrique, Arne Wang Aabye, Harald Laugen, Eva Krog Tamnes, Borge Mathisen
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Patent number: 10823677Abstract: A method of determining the concentration of at least one analyte in a plurality of samples by sequentially subjecting each sample to an analysis cycle comprises contacting the sample or a sample-derived solution with a sensor surface supporting a species capable of specifically binding the analyte or an analyte-binding species, detecting the amount of binding to the sensor surface, and regenerating the sensor surface to prepare it for the next analytical cycle, and based on the detected binding to the sensor surface determining the concentration of analyte in each sample using virtual calibration data calculated for each analysis cycle from real calibration data obtained by contacting the solid phase with samples containing known concentrations of analyte.Type: GrantFiled: June 1, 2009Date of Patent: November 3, 2020Assignee: GE HEALTHCARE BIO-SCIENCES ABInventors: Peter Borg, Asa Frostell-Karlsson, Markku Hamalainen
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Patent number: 10815269Abstract: The invention discloses a separation matrix which comprises a plurality of separation ligands, defined by the formula R1-L1-N(R3)-L2-R, immobilized on a support, wherein R1 is a five- or six-membered, substituted or non-substituted ring structure or a hydroxyethyl or hydroxypropyl group; L1 is either a methylene group or a covalent bond; R2 is a five-or six-membered, substituted or non-substituted ring structure; L2 is either a methylene group or a covalent bond; R3 is a methyl group; and wherein if R1 is a hydroxyethyl group and L1 is a covalent bond, R2 is a substituted aromatic ring structure or a substituted or non-substituted aliphatic ring structure.Type: GrantFiled: August 29, 2018Date of Patent: October 27, 2020Assignee: GE Healthcare BioProcess R&D ABInventors: Jean-Luc Maloisel, Gustav Rodrigo, Bjorn Noren, Virendra Kumbhar
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Publication number: 20200318120Abstract: A recombinant protein comprising a functional polypeptide and, linked to the N-terminus of said functional polypeptide, an N-terminal spacer having a length such that the number of amino acid residues between a signal peptide cleaving site and an N-terminus proximal structural unit of said functional polypeptide is 14-24.Type: ApplicationFiled: May 23, 2018Publication date: October 8, 2020Applicant: GE Healthcare BioProcess R&D ABInventors: Mats ANDER, Magnus BERGMAN, Tomas BJORKMAN, Joakim GALLI, Gustav RODRIGO
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Patent number: 10773185Abstract: A system for blending solutions and a buffer solution is disclosed. In this system a switch valve is present capable of flowing one or more solutions, a low pressure pump for pumping the one or more solutions through the switch valve and a T-joint capable of receiving the one or more solutions through the low pressure pump and blending the one or more solutions with a buffer solution. A high pressure pump is present for collecting a blended solution.Type: GrantFiled: December 17, 2015Date of Patent: September 15, 2020Assignee: GE Healthcare Bio-Sciences ABInventor: Bjorn Markus Olovsson
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Patent number: 10768108Abstract: A Surface Plasmon Resonance (SPR) biosensor system comprising: a SPR sensor surface, an illumination unit arranged to direct a wedge shaped beam of light at a line shaped detection area on the SPR sensor surface transverse to the direction of propagation of light, and a detection unit with detection optics for directing light reflected from the SPR sensor surface onto a two-dimensional optical detector unit such that the angle of reflection is imaged along one dimension and the width of the detection area along the other, wherein the illumination unit is arranged to selectively direct the wedge shaped beam of light at two or more spaced apart line shaped detection areas on the SPR sensor surface transverse to the direction of propagation of light.Type: GrantFiled: September 27, 2012Date of Patent: September 8, 2020Assignee: GE HEALTHCARE BIO-SCIENCES ABInventors: Bengt Ivarsson, Stefan Sjolander
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Patent number: 10760041Abstract: The invention discloses a flexible bag for cell cultivation, comprising a cultivation compartment and at least one dialysis compartment, wherein the dialysis compartment(s) is/are delimited from the cultivation compartment by one or more dialysis membranes and is/are fluidically connected to a first and a second port in the bag.Type: GrantFiled: August 27, 2014Date of Patent: September 1, 2020Assignee: GE Healthcare Bio-Sciences ABInventors: Karl Liderfelt, Eric Faldt, Andreas Castan