Patents Assigned to Genetech, Inc.
  • Nucleic acid molecules encoding a humanized antibody
    Patent number: 8796439
    Abstract: The present invention is related to chimeric and humanized antibody and to methods and compositions for the therapeutic and diagnostic use in the treatment of amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease.
    Type: Grant
    Filed: August 7, 2012
    Date of Patent: August 5, 2014
    Assignees: AC Immune S.A., Genetech, Inc.
    Inventors: Andrea Pfeifer, Maria Pihlgren, Andreas Muhs, Ryan Watts
  • Methods for the treatment of tumors expressing TAT123 or naturally occurring variants thereof
    Patent number: 8728480
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: November 10, 2011
    Date of Patent: May 20, 2014
    Assignee: Genetech, Inc.
    Inventors: Belinda Cairns, Ruihuan Chen, Gretchen Frantz, Kenneth J. Hillan, Hartmut Koeppen, Heidi S. Phillips, Paul Polakis, Susan D. Spencer, Victoria Smith, P. Mickey Williams, Thomas D. Wu, Zemin Zhang
  • HEDGEHOG ANTAGONISTS HAVING ZINC BINDING MOIETIES
    Publication number: 20140018368
    Abstract: The present invention provides compounds which antagonize hedgehog signaling and inhibit HDAC activity. The compounds can be used in methods of treating proliferative diseases and disorders such as cancer.
    Type: Application
    Filed: July 1, 2013
    Publication date: January 16, 2014
    Applicants: Genetech, Inc., Curis, Inc.
    Inventors: Xiong Cai, Changgeng Qian, Haixiao Zhai
  • Anti-FcRH5 antibodies and immunoconjugates and methods of use
    Patent number: 8617559
    Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: November 20, 2012
    Date of Patent: December 31, 2013
    Assignee: Genetech, Inc.
    Inventors: Kristi Elkins, Andrew Polson, Allen Ebens, Camelia Adams, Bing Zheng, Jagath R. Junutula, Jo-Anne Hongo, Yan Wu
  • SERINE/THREONINE KINASE INHIBITORS
    Publication number: 20130338140
    Abstract: Compounds having the formula I wherein Z, Z1 Z2 Z, R3a, R3b and Rb and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
    Type: Application
    Filed: February 28, 2012
    Publication date: December 19, 2013
    Applicants: Genetech, Inc., Array BioPharma Inc.
    Inventors: James F. Blake, Huifen Chen, Mark Joseph Chcarelli, Jason Demeese, Rustam Garrey, John J. Gaudino, Robert J. Kaus, Gabrielle R. Kolakowski, Allison L. Marlow, Peter J. Mohr, Li Ren, Jacob Schwartz, Christopher S. Siedem, Allen A. Thomas, Eli Wallace, Steven Mark Wenglowsky
  • Pyridazinones, method of making, and method of use thereof
    Patent number: 8598174
    Abstract: Compounds of Formula I that inhibit Btk are described herein. Pharmaceutical compositions comprising at least one compound of Formula I, together with at least one pharmaceutically acceptable vehicle chosen from carriers, adjuvants, and excipients, are described. Methods of treating patients suffering from certain diseases responsive to inhibition of Btk activity and/or B-cell activity are described. Methods for determining the presence of Btk in a sample are described.
    Type: Grant
    Filed: November 12, 2009
    Date of Patent: December 3, 2013
    Assignees: Genetech, Inc., Gilead Connecticut, Inc.
    Inventors: Antonio J. M. Barbosa, Jr., Peter A. Blomgren, Kevin S. Currie, Seung Lee, Jeffrey E. Kropf, Scott A. Mitchell, Daniel Ortwine, William M. Rennells, Aaron C. Schmitt, Jianjun Xu, Wendy B. Young, Zhongdong Zhao, Pavel E. Zhichkin
  • CDR-repaired antibodies
    Patent number: 8580928
    Abstract: The present application concerns restoring antigen binding during humanization of antibodies through the selection of repaired hypervariable regions rather than through framework changes.
    Type: Grant
    Filed: November 16, 2010
    Date of Patent: November 12, 2013
    Assignee: Genetech, Inc.
    Inventor: Mark S. Dennis
  • Antibodies to lymphotoxin-?
    Patent number: 8541552
    Abstract: The invention provides various antibodies that bind to lymphotoxin-?, methods for making such antibodies, compositions and articles incorporating such antibodies, and their uses in treating, for example, an autoimmune disorder. The antibodies include murine, chimeric, and humanized antibodies.
    Type: Grant
    Filed: February 11, 2011
    Date of Patent: September 24, 2013
    Assignee: Genetech, Inc.
    Inventors: Camellia W. Adams, Jane L. Grogan, Austin L. Gurney, Krista McCutcheon
  • Compositions and Methods for Stabilizing Protein-Containing Formulations
    Publication number: 20130224213
    Abstract: The present invention relates to use of certain alkylglycoside compositions for the prevention of aggregation and oxidation of antibodies and other proteins in therapeutically useful formulations thereof.
    Type: Application
    Filed: December 20, 2012
    Publication date: August 29, 2013
    Applicant: Genetech, Inc.
    Inventor: Genetech, Inc.
  • Method of diagnosing the presence of a tumor in a mammal by assessing CDO expression levels
    Patent number: 8435754
    Abstract: The present invention provides for a method of using BOC/CDO hedgehog antagonists to inhibit hedgehog signaling, as well as treating and diagnosing disorders relating to hedgehog signaling or overexpression of hedgehog, including cancer, cell proliferative disorders, and angiogenesis, neurological disorders, as well as other conditions affected by hedgehog signaling such as hair growth, neural stem cell differentiation, chondrogenesis and osteogenesis, lung surfactant production, formation of lamellated bodies in lung cells.
    Type: Grant
    Filed: November 1, 2011
    Date of Patent: May 7, 2013
    Assignees: Genetech, Inc., Curis, Inc.
    Inventors: Frederic J. de Sauvage, Hua Tian
  • Antibody formulations
    Patent number: 8372396
    Abstract: The present application describes antibody formulations, including monoclonal antibodies formulated in histidine-acetate buffer, as well as a formulation comprising an antibody that binds to domain II of HER2 (for example, Pertuzumab), and a formulation comprising an antibody that binds to DR5 (for example, Apomab).
    Type: Grant
    Filed: September 4, 2009
    Date of Patent: February 12, 2013
    Assignee: Genetech, Inc.
    Inventors: James Andya, Shiang C. Gwee, Jun Liu, Ye Shen
  • Antibodies that bind to PRO286
    Patent number: 8349329
    Abstract: The invention relates to the identification and isolation of novel DNAs encoding the human Toll proteins PRO285, PRO286, and PRO358, and to methods and means for the recombinant production of these proteins. The invention also concerns antibodies specifically binding the PRO285, or PRO286, or PRO358 Toll protein.
    Type: Grant
    Filed: March 3, 2010
    Date of Patent: January 8, 2013
    Assignee: Genetech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Melanie R. Mark, Ruey-Bing Yang
  • Methods for detecting inflammatory bowel disease
    Patent number: 8257923
    Abstract: The present invention provides for a method of detecting the presence of inflammatory bowel disease in gastrointestinal tissues or cells of a mammal by detecting increased expression of LY6 genes in the tissues or cells of the mammal relative to a control.
    Type: Grant
    Filed: January 4, 2011
    Date of Patent: September 4, 2012
    Assignee: Genetech, Inc.
    Inventors: Lauri Diehl, Kenneth Flanagan, Lian Mo
  • EGFR mutations
    Patent number: 8232062
    Abstract: The present invention relates to mutations in Epidermal Growth Factor Receptor (EGFR) and methods of detecting such mutations as well as prognostic methods method for identifying a tumors that are susceptible to anticancer therapy such as chemotherapy and/or kinase inhibitor treatment. The methods involve determining the presence of a mutated EGFR gene or mutated EGFR protein in a tumor sample whereby the presence of a mutated EGFR gene or protein indicates the tumor is susceptible to treatment.
    Type: Grant
    Filed: April 27, 2011
    Date of Patent: July 31, 2012
    Assignee: Genetech, Inc.
    Inventor: Somasekar Seshagiri
  • Neuropilin antagonists
    Patent number: 8211429
    Abstract: Novel anti-NRP1 antibodies and variants thereof having unique structural and functional characteristics are disclosed. Also provided are uses of the antibodies in research, diagnostic and therapeutic applications.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: July 3, 2012
    Assignee: Genetech, Inc.
    Inventors: Ryan J. Watts, Yan Wu
  • Microwave assisted deglycosylation of proteins for molecular weight determination by mass spectrometry
    Patent number: 8163518
    Abstract: Methods are presented for microwave assisted, enzymatic deglycosylation of proteins. The rate at which deglycosylation is achieved and without protein degradation facilitates rapid and accurate molecular weight determination by mass spectrometry.
    Type: Grant
    Filed: April 27, 2007
    Date of Patent: April 24, 2012
    Assignee: Genetech, Inc.
    Inventors: David P. Arnott, Jennie Lill, Wendy N. Sandoval, Richard L. Vandlen
  • Purine PI3K inhibitor compounds and methods of use
    Patent number: 8158624
    Abstract: Purine compounds of Formula I, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
    Type: Grant
    Filed: May 29, 2009
    Date of Patent: April 17, 2012
    Assignee: Genetech, Inc.
    Inventors: Georgette Castanedo, Irina Chuckowree, Adrian Folkes, Daniel P. Sutherlin, Nan Chi Wan
  • Anti-CD79B antibodies and immunoconjugates and methods of use
    Patent number: 8088378
    Abstract: The present invention is directed to anti-CD79b antibody, huMA79b.v28, and compositions of matter thereof useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: July 15, 2008
    Date of Patent: January 3, 2012
    Assignee: Genetech Inc.
    Inventors: Yvonne Chen, Mark Dennis, David Dornan, Kristi Elkins, Jagath Reddy Junutula, Andrew Polson, Bing Zheng
  • Sustained release formulation
    Patent number: 8067020
    Abstract: A composition comprises a protein, a polyol, and a metal. The protein is stabilized by the polyol and the metal, and is protected from denaturing when in contact with an organic solvent. The polyol may be a hydrocarbon containing two or more hydroxyl groups (—OH) bonded to carbon. The metal may be divalent.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: November 29, 2011
    Assignee: Genetech, Inc.
    Inventors: Franklin Okumu, Jeffrey L. Cleland
  • BICYCLIC HETEROCYCLES AS MEK KINASE INHIBITORS
    Publication number: 20110190257
    Abstract: The invention relates to bicyclic heterocycles of formulae I and II with anti-cancer and/or anti-inflammatory activity and more specifically with MEK kinase inhibitory activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth, treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
    Type: Application
    Filed: July 1, 2009
    Publication date: August 4, 2011
    Applicant: Genetech, Inc.
    Inventors: Robert Andrew Heald, Philip Jackson, Joseph P. Lyssikatos, Stephen Price, Pascal Pierre Alexandre Savy