Patents Assigned to Genetech, Inc.
  • METHODS AND COMPOSITIONS FOR DIAGNOSTIC USE IN CANCER PATIENTS
    Publication number: 20110151468
    Abstract: Disclosed herein are methods and compositions useful for identifying therapies likely to confer optimal clinical benefit for patients with cancer.
    Type: Application
    Filed: November 19, 2010
    Publication date: June 23, 2011
    Applicant: Genetech, Inc.
    Inventors: Thomas D. Wu, Daniel Shin-Yu Chen, Jennifer Le Couter
  • EG-VEGF nucleic acids and polypeptides and methods of use
    Patent number: 7960531
    Abstract: The present invention is directed to novel polypeptides designated herein as EG-VEGF and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided herein are methods of screening for modulators of EG-VEGF. Furthermore, methods and related methods of treatment are described herein which pertain to regulating cellular proliferation and chemotaxis.
    Type: Grant
    Filed: April 14, 2010
    Date of Patent: June 14, 2011
    Assignee: Genetech, Inc.
    Inventors: Napoleone Ferrara, Colin Watanabe, William I. Wood
  • Compositions and methods for the diagnosis and treatment of tumor
    Patent number: 7951546
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: May 29, 2008
    Date of Patent: May 31, 2011
    Assignee: Genetech, Inc.
    Inventors: Gretchen Frantz, Kenneth J. Hillan, Heidi Phillips, Paul Polakis, Susan D. Spencer, P. Mickey Williams, Thomas D. Wu, Zemin Zhang
  • Bak binding protein, DNA encoding the protein, and methods of use thereof
    Patent number: 7888038
    Abstract: The present invention provide polynucleotide sequences encoding a Bak Binding Protein (BBP) and fragments thereof that bind to Bak. The invention also provide recombinant host cells containing polynucleotides encoding BBP. The invention further provide antibodies that specifically bind to BBP. The invention further provide methods for detecting agents such as drugs that alter the binding of a BBP with a Bak protein. The invention further provide methods for detecting the presence of Bak polynucleotides and the encoding proteins in a biological sample, and further provide methods for modulating the levels of BBP in a cell. This invention additionally encompasses novel peptides, designated the “BBP Binding Domains” and the respective nucleotides, designated “bbpbd-1” and “bbpbd-2” which are involved in the interaction between Bak and BBP.
    Type: Grant
    Filed: October 9, 2006
    Date of Patent: February 15, 2011
    Assignee: Genetech, Inc.
    Inventors: Michael C. Kiefer, Paul A. Fitzpatrick, Helen L. Gibson, Philip J. Barr
  • Treatment of Autoimmune Diseases
    Publication number: 20110008337
    Abstract: The present invention concerns treatment of autoimmune diseases with antagonists which bind to B cell surface markers, such as CD19 or CD20.
    Type: Application
    Filed: September 20, 2010
    Publication date: January 13, 2011
    Applicant: Genetech, Inc.
    Inventors: John G. Curd, Lori A. Kunkel, Antonio J. Grillo-Lopez
  • HGF beta chain variants
    Patent number: 7737115
    Abstract: The invention provides HGF/Met modulators comprising HGF having mutations in regions that affect HGF function, and antagonists that target said regions. The invention further provides methods of identifying, making and using these modulators.
    Type: Grant
    Filed: April 17, 2006
    Date of Patent: June 15, 2010
    Assignee: Genetech, Inc.
    Inventors: Daniel K. Kirchhofer, Robert A. Lazarus, Christian Wiesmann
  • PRO350 antibodies
    Patent number: 7700736
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: April 15, 2002
    Date of Patent: April 20, 2010
    Assignee: Genetech, Inc.
    Inventors: Kevin P. Baker, Maureen Beresini, Laura DeForge, Luc Desnoyers, Ellen Filvaroff, Wei-Qiang Gao, Mary E. Gerritsen, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Steven Sherwood, Victoria Smith, Timothy A. Stewart, Daniel Tumas, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Method of reducing viscosity of high concentration protein formulations
    Patent number: 7666413
    Abstract: The present application concerns concentrated protein formulations with reduced viscosity, which are particularly suitable for subcutaneous administration. The application further concerns a method for reducing the viscosity of concentrated protein formulations.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: February 23, 2010
    Assignees: Genetech, Inc., Novartis AG
    Inventors: Jun Liu, Steven J. Shire
  • IL-1 RELATED POLYPEPTIDES
    Publication number: 20090270595
    Abstract: The present invention is directed to novel polypeptides having homology to the IL-1-like family of proteins and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 1, 2009
    Publication date: October 29, 2009
    Applicant: Genetech, Inc.
    Inventors: Audrey Goddard, Guohua James Pan
  • Gene expression markers for inflammatory bowel disease
    Publication number: 20090186034
    Abstract: The present invention relates to methods of gene expression profiling for inflammatory bowel disease pathogenesis, in which the differential expression in a test sample from a mammalian subject of one or more IBD markers relative to a control is determined, wherein the differential expression in the test sample is indicative of an IBD in the mammalian subject from which the test sample was obtained.
    Type: Application
    Filed: December 19, 2007
    Publication date: July 23, 2009
    Applicant: Genetech, Inc.
    Inventors: Alexander Abbas, Hilary Clark, Lauri Diehl
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7550573
    Abstract: The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: June 23, 2009
    Assignee: Genetech, Inc.
    Inventors: Audrey Goddard, Paul Godowski, Austin Gurney, Daniel Tumas, William Wood
  • Cysteine engineered antibodies and conjugates
    Patent number: 7521541
    Abstract: Antibodies are engineered by replacing one or more amino acids of a parent antibody with non cross-linked, highly reactive cysteine amino acids. Antibody fragments may also be engineered with one or more cysteine amino acids to form cysteine engineered antibody fragments (ThioFab). Methods of design, preparation, screening, and selection of the cysteine engineered antibodies are provided. Cysteine engineered antibodies (Ab), optionally with an albumin-binding peptide (ABP) sequence, are conjugated with one or more drug moieties (D) through a linker (L) to form cysteine engineered antibody-drug conjugates having Formula I: Ab-(L-D)p??I where p is 1 to 4. Diagnostic and therapeutic uses for cysteine engineered antibody drug compounds and compositions are disclosed.
    Type: Grant
    Filed: September 22, 2005
    Date of Patent: April 21, 2009
    Assignee: Genetech Inc.
    Inventors: Charles W. Eigenbrot, Jagath Reddy Junutula, Henry Lowman, Helga E. Raab, Richard Vandlen
  • Treatment with anti-ErbB2 antibodies and anti-hormonal compounds
    Patent number: 7498030
    Abstract: The present application describes methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies, and anti-hormonal compounds, such as anti-estrogens.
    Type: Grant
    Filed: September 9, 2005
    Date of Patent: March 3, 2009
    Assignee: Genetech, Inc.
    Inventors: Camellia W. Adams, Leonard G. Presta, Mark Sliwkowski
  • Novel Gene Disruptions, Compositions and Methods Relating Thereto
    Publication number: 20080311107
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes.
    Type: Application
    Filed: February 9, 2007
    Publication date: December 18, 2008
    Applicant: Genetech, Inc.
    Inventors: Kristi Rae Bollinger, Katherin E. Combs, Jaime-Jo Cunningham, Ling Ling Culbertson, Frederic J. de Sauvage, Joel A. Edwards, Leslie Jane Green, Rosemary Girgis, Allison Anne Byers Horner, Dina Rebecca McLain, Charles Montgomery, Laurie Jeanette Minze, Bobby Joe Payne, Heidi Phillips, Trac Ellen Willis Sevaux, Zheng-Zheng Shi, Mary Jean Sparks, Joy Anne Stala, Tracy Tzu-Ling Tang, Teresa Gail Townsend, Peter Vogel
  • Anti-tumor antibody compositions and methods of use
    Patent number: 7435416
    Abstract: The invention provides antibodies targeted at a tumor antigen prevalent on prostate tumors and methods useful in alleviating cancers expressing the antigen, as well as nucleic acids and cells for expressing the antibodies.
    Type: Grant
    Filed: September 8, 2004
    Date of Patent: October 14, 2008
    Assignee: Genetech, Inc.
    Inventors: Brigitte Devaux, Gilbert-Andre Keller, Hartmut Koeppen, Lawrence A. Lasky
  • TREATMENT WITH ANTI-VEGF ANTIBODIES
    Publication number: 20080248036
    Abstract: This invention concerns in general treatment of diseases and pathological conditions with anti-VEGF antibodies. More specifically, the invention concerns the treatment of human patients susceptible to or diagnosed with cancer using an anti-VEGF antibody, preferably in combination with one or more additional anti-tumor therapeutic agents.
    Type: Application
    Filed: September 29, 2006
    Publication date: October 9, 2008
    Applicant: Genetech, Inc.
    Inventors: Gwendolyn Fyfe, Eric Holmgren, Robert D. Mass, William Novotny
  • Compositions and methods for the treatment of immune related diseases
    Patent number: 7419799
    Abstract: The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related diseases.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: September 2, 2008
    Assignee: Genetech, Inc.
    Inventors: Patricia A. Valdez, Austin L. Gurney, Iqbal Grewal
  • PRO9822 antibodies
    Patent number: 7390886
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: July 11, 2002
    Date of Patent: June 24, 2008
    Assignee: Genetech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, Colin K. Watanabe, William I. Wood
  • Antibodies against PRO4330
    Patent number: 7390887
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: May 8, 2002
    Date of Patent: June 24, 2008
    Assignee: Genetech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, William I. Wood
  • PRO357 nucleic acids
    Patent number: 7368558
    Abstract: The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: July 27, 2004
    Date of Patent: May 6, 2008
    Assignee: Genetech, Inc.
    Inventors: David Botstein, Audrey Goddard, Paul J. Godowski, Christopher Grimaldi, Austin L. Gurney, Kenneth J. Hillan, Margaret Ann Roy, William I. Wood