Abstract: The present invention is directed to topical enzymatic wound debriding compositions with enhanced enzymatic activity. These compositions comprise a dispersed phase comprising at least one proteolytic enzyme and at least one hydrophilic polyol; and a continuous phase comprising a hydrophobic base.

Abstract: A spray-on topical wound debrider spray is prepared forming a mist, spray or foam which will not drip significantly after application. The preferred wound debrider is papain. The spray contains a surfactant emulsifier admixture having a composition viscosity of from about 5000 cps to about 50,000 cps and is preferably a fatty alcohol phosphate ester emulsifier composition.

Abstract: The addition of alcohol plus acetate salts unexpectedly enhanced the tuberculocidal activity of glutaraldehyde, and decreased the fumes of glutaraldehyde from the formula of a high-level disinfectant.

Abstract: A spray-on topical wound debrider spray is prepared forming a mist, spray or foam which will not drip significantly after application. The preferred wound debrider is papain. The spray contains a surfactant emulsifier admixture having a composition viscosity of from about 5000 cps to about 50,000 cps and is preferably a fatty alcohol phosphate ester emulsifier composition.

Abstract: A liquid dispenser applicator for preoperative preparation of a target area of a patient's skin is comprised of two integrated components, a handle portion and a canister vessel. The two components are locked by a locking and sealing ring mechanism to prevent accidental rupture of the sterile antiseptic fluid in the canister vessel. When the lock is unlocked, the unit contains a perforator designed to initially slit the membrane followed by pushing it open further and thereafter venting it to provide dual-staged self-venting by the perforator for ease of flow.

Abstract: A topical composition and method for treating seborrehic dermatitis designed specifically to allow for short duration skin contact time. It is a water rinseable sulfacetamide composition free of elemental sulfur, preferably dosed in a regimen of at least two daily treatments.

Abstract: A powder composition which reacts in water to form in situ peroxycarboxylic acids at an anti-microbially effective concentration. Importantly, its utility is both for topical anti-microbial application and for effective low temperature disinfection/sterilization of instruments. It comprises the combination of a perborate, one or more novel acyl and/or aroyl donors, a buffering system which allows the pH to arise to about 9 for rapid formation of the peroxycarboxylic acids and then drop to about 7.5 for sustained stability and microbial kill. It preferably includes a surfactant facilitating antimicrobial efficacy, as well as other minors.

Abstract: An anhydrous, hydrophilic wound dressing containing a superabsorbent polymer. Its anhydrous nature allows it, when applied to a wound site, to absorb wound fluid.

Abstract: A topical delivery composition which employs a multivesicular emulsion in combination with a pharmaceutically/pharmacologically active agent is disclosed. The multivesicular emulsion is formed from a quaternary amine salt emulsifier such as behentrimonium methosulfate. The emulsion is multi-lamellar which is a series of concentric spheres or vesiculars of oil and water phase that can be seen microscopically. As a result, the active is time released over a sustained period rather than spike released as is common with most topicals.

Abstract: The present invention discloses a method, apparatus and system for electromechanical liquid dispensing. The system includes a bottle for holding liquid to be dispensed, the bottle having an inlet port and an outlet port, a one-way outlet valve on the outlet port through which liquid is dispensed from the bottle, and an electronic control system for controlling dispensement of the liquid from the outlet port such that a controlled quantity of liquid is dispensed.

Abstract: An enzymatic wound debrider which employs in combination a topical dosage form pharmaceutical carrier and a debridement agent which is thermolysin preferably in combination with an ionic co-factor of either zinc ions, or calcium ions, or both.

Abstract: An enzymatic wound debrider which employs in combination a topical dosage form pharmaceutical carrier and a debridement agent which is thermolysin preferably in combination with an ionic co-factor of either zinc ions, or calcium ions, or both.

Abstract: A powder composition which reacts in water to form in situ peroxycarboxylic acids at an anti-microbially effective concentration. Importantly, its utility is both for topical anti-microbial application and for effective low temperature disinfection/sterilization of instruments. It comprises the combination of a perborate, one or more novel acyl and/or aroyl donors, a buffering system which allows the pH to arise to about 9 for rapid formation of the peroxycarboxylic acids and then drop to about 7.5 for sustained stability and microbial kill. It preferably includes a surfactant facilitating antimicrobial efficacy, as well as other minors.

Abstract: This invention relates to an enzymatic anhydrous hydrophilic wound debrider that uses in combination a proteolytic enzyme and an anhydrous hydrophilic poloxamer carrier.

Abstract: A liquid dispenser is provided for dispensing a desired amount of liquid from a bottle, without leakage or dripping. The bottle is mounted in a fixture attached to a wall. The bottle includes an inlet and an outlet, with one-way valves operatively sealed in the inlet and outlet ports. A foam-filled foot pump is operatively connected to the inlet valve for the inlet port, such that air may be pumped into the bottle to pressurize the contents thereof. Upon pressurization, the liquid is forced through the outlet valve in the outlet port. An air filter is provided for the pump, so as to preclude contamination of liquid in the bottle. Excess pressure is released through a relief valve to preclude over-dosing of liquid from the bottle.

Abstract: A liquid dispenser applicator for preoperative preparation of a target area of a patient's skin is comprised of two integrated components, a handle portion and a canister vessel. The two components are locked by a locking and sealing ring mechanism to prevent accidental rupture of the sterile antiseptic fluid in the canister vessel. When the lock is unlocked, the unit contains a perforator designed to initially slit the membrane followed by pushing it open further and thereafter venting it to provide dual-staged self-venting by the perforator for ease of flow.

Abstract: A topical ointment pharmaceutical composition that uses a lipophilic base, a pharmaceutical active and, dispersed in the base, from about 1% to about 50% by weight of the total composition of hydrogenated non-melted castor oil in powder form. The result of using hydrogenated non-melted castor oil in powder form is a surprising pharmaceutical elegance perceived to be smoother in texture and more spreadable than an ointment made by melting the hydrogenated castor oil.

Abstract: An anhydrous, hydrophilic wound dressing containing a superabsorbent polymer and an antimicrobial agent. Its anhydrous nature allows it, when applied to a wound site, to absorb wound fluid and slowly release its water-soluble active microbial agent into the wound.

Abstract: A liquid dispenser is provided for dispensing a desired amount of liquid from a bottle, without leakage or dripping. The bottle is mounted in a fixture attached to a wall. The bottle includes an inlet and an outlet, with one-way valves operatively sealed in the inlet and outlet ports. A foot pump is operatively connected to the inlet valve for the inlet port, such that air may be pumped into the bottle to pressurize the contents thereof. Upon pressurization, the liquid is forced through the outlet valve in the outlet port. An air filter is provided for the pump, so as to preclude contamination of liquid in the bottle.

Abstract: A low odor, aqueous, quick acting cold temperature disinfectant solution primarily useful for medical instruments to disinfect within a half hour or less. The composition comprises a reacting or synergistic combination of hydrogen peroxide and from about 1% to 30% by weight of a carboxylic acid/carboxylate salt buffered solution.