Abstract: An illustrative system includes a sensor component and a controller conductively coupled by way of a first wire and a second wire in a twisted pair configuration. The controller includes a driver configured to drive the sensor component by way of the first and second wires with a drive current in accordance with a gain parameter and a control loop circuit. The control loop circuit is configured to receive a control signal representative of a target current value for the drive current, adjust the gain parameter based on a difference between the target current value and an actual current value of current that is actually being driven through the sensor component, and abstain from adjusting the gain parameter based on current capacitively coupled onto the first and second wires by an external electric field.

Abstract: A wearable module for use in an optical measurement system includes a housing including a top surface, a light guide including a distal end portion adapted to protrude from the top surface of the housing, and a spring member configured to bias the distal end portion of the light guide away from the top surface of the housing. The light guide is configured to receive, at the distal end portion, photons from a light pulse scattered by a target within a body of a user and guide the received photons toward a photodetector.

Abstract: The present disclosure provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions include a novel nucleotide sequence for regulatory elements from Lamium Leaf Distortion Associated Virus. A method for expressing a heterologous nucleotide sequence in a plant using the regulatory element sequences disclosed herein is provided. The method comprises transforming a plant or plant cell with a nucleotide sequence operably linked to one of the regulatory elements of the present disclosure.

Abstract: An optical measurement system includes a first light source configured to emit a first light pulse toward a target, a second light source configured to emit a second light pulse toward the target, a first detector, a second detector, and a processing unit. The processing unit is configured to determine a plurality of temporal distributions of photons included in the first light pulse and the second light pulse and detected by the first detector and the second detector after the photons are scattered by the target. The processing unit is further configured to determine, based on the plurality of temporal distributions, a distance between the first light source and the second detector.

Abstract: Methods and systems are provided for singulating, orienting, and delivering oriented objects (e.g., embryos) to a desired location (e.g., a plate containing a selected medium).

Abstract: An illustrative method includes accessing, by a computing device, a model simulating light scattered by a simulated target, the model comprising a plurality of parameters. The method further includes generating, by the computing device, a set of possible histogram data using the model with a plurality of values for the parameters. The method further includes determining, by the computing device, a set of components that represent the set of possible histogram data, the set of components having a reduced dimensionality from the set of possible histogram data.

Abstract: Compositions and methods are provided for stacking multiple independent transgenic loci into the genome of a plant. Compositions include plants, seeds or plant cells comprising at least one transgenic target site and at least one genomic locus of interest integrated at different genomic sites within a genomic window. Plant breeding techniques can be employed such that the transgenic target site and the genomic locus of interest can be bred together. In this way, multiple independent transgene integrations can be generated within a genomic window to create a complex trait locus. The complex trait locus is designed such that the transgenic target sites and/or genomic loci of interest can segregate independently of each other, thus providing the benefit of altering a complex trait locus by breeding-in and breeding-away specific elements. Various methods can also be employed to modify the target sites such that they contain a variety of polynucleotides of interest.

Abstract: Compositions and methods are provided for genome modification of a target sequence in the genome of a plant or plant cell, without incorporating a selectable transgene marker. The methods and compositions employ a guide polynucleotide/Cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a plant, plant cell or seed, without incorporating a selectable transgene marker. Once a genomic target site is identified, a variety of methods can be employed to further modify the target sites such that they contain a variety of polynucleotides of interest. Breeding methods and methods for selecting plants utilizing a guide polynucleotide/Cas endonuclease system are also disclosed. Compositions and methods are also provided for editing a nucleotide sequence in the genome of a cell, without incorporating a selectable transgene marker.

Abstract: A mental state awareness system comprises a non-invasive brain interface assembly configured for detecting brain activity of a user, a processor configured for determining a mental state of a user based on the detected brain activity, and a biofeedback device configured for automatically providing biofeedback to the user indicative of the determined mental state of the user.

Abstract: An illustrative optical measurement system includes a light source configured to emit light directed at a target, an array of photodetectors configured to detect photons of the light after the light is scattered by the target, and a processing unit. The processing unit is configured to measure a noise level of a photodetector included in the array of photodetectors and determine that the noise level meets a predetermined threshold. The processing unit is further configured to prevent, based on the determining that the noise level meets the predetermined threshold, an output of the photodetector from being used in generating a histogram based on a temporal distribution of photons detected by the array of photodetectors.

Abstract: An illustrative multimodal measurement system includes a wearable assembly configured to be worn by a user and comprising a plurality of light sources each configured to emit light directed at a target within the user, a plurality of detectors configured to detect arrival times for photons of the light after the light is scattered by the target, and a plurality of electrodes configured to be external to the user and detect electrical activity of the target.

Abstract: An exemplary system includes a processor, a wearable device comprising a plurality of slots, and a first module including a plurality of detectors and a module control circuit. The processor is configured to successively transmit, to each slot of the plurality of slots, a command to enable a respective module located in each slot. The processor is further configured to determine, based on an acknowledgment received from the module control circuit, that the first module is enabled and located in a first slot, and to successively transmit, based on the determining that the first module is enabled and located in the first slot, a plurality of detector address identifiers. The module control circuit is configured to successively place the plurality of detectors into an enumeration mode in which each detector of the plurality of detectors is assigned a different detector address identifier of the plurality of detector address identifiers.

Abstract: A calibration system for a magnetometer having an unknown gain is disclosed. A calibration magnetic field is generated at a calibration frequency of a known amplitude at the magnetometer. A measurement of the calibrating magnetic field is reported by the magnetometer. A ratio of an amplitude of the calibration magnetic field measurement reported by the magnetometer and the known amplitude of the calibrating magnetic field at the magnetometer is computed. The unknown gain of the magnetometer is determined at least partially based on computed ratio.

Abstract: An exemplary system includes a light source and a control circuit configured to apply voltage having a first polarity to the light source for a first time period to provide a threshold charge for the light source to start an emission of a light pulse that is directed at a target within a body. The control circuit is further configured to apply voltage having a second polarity opposite the first polarity to the light source for a second time period subsequent to the first time period to discharge the light source to stop the emission of the light pulse.

Abstract: An optical measurement system includes a wearable device configured to be worn on a body of a user and a position alignment system. The wearable device includes a support assembly and a wearable assembly supported by the support assembly. The wearable assembly includes a plurality of light sources configured to emit a plurality of light pulses toward a target within the body of the user and a plurality of detectors each configured to receive a set of photons included in a light pulse included in the plurality of light pulses after the set of photons is scattered by the target. The position alignment system is configured to facilitate positioning of the wearable assembly at a same position on the body of the user during different use sessions of the wearable device.

Abstract: An exemplary optical measurement system includes a signal generator configured to generate a signal and a processing unit configured to direct the signal generator to apply the signal to a component within the optical measurement system, generate, based on a response of the component to the signal, characterization data representative of a timing uncertainty associated with the component, and perform, based on the characterization data, an action associated with the component.

Abstract: In a non-invasive optical detection system and method, sample light is delivered into a scattering medium. A first portion of the sample light passing through a volume of interest exits the scattering medium as signal light, and a second portion of the sample light passing through a volume of non-interest exits the scattering medium as background light that is combined with the signal light to create a sample light pattern. Reference light is combined with the sample light pattern to create an interference light pattern having a holographic beat component. Ultrasound is emitted into the volume of non-interest in a manner that decorrelates the background light of the sample light pattern from the holographic beat component. The holographic beat component is detected during the measurement period. An optical parameter of the volume of interest is determined based on the detected holographic beat component.

Abstract: A neural phantom device configured and arranged to produce a magnetic field to simulate a neural signal. The neural phantom device includes a driver having a signal source configured to produce a simulated neural signal, and either i) a carrier wave source configured to produce a carrier wave having a frequency of at least 250 Hz or ii) an optical carrier wave source configured to produce an optical carrier wave, wherein the driver is configured to modulate the simulated neural signal using the carrier wave or optical carrier wave to generate a modulated signal. The neural phantom device also includes a phantom configured to receive the modulated signal, demodulate the modulated signal to recover the simulated neural signal, and generate the magnetic field in response to the simulated neural signal.

Abstract: An exemplary optical measurement system includes a light source configured to emit light directed at a target. The optical measurement system further includes a photodetector configured to detect a photon of the light after the light is scattered by the target. The optical measurement system further includes a control circuit configured to receive a first input voltage that is a temperature-dependent voltage. The control circuit is further configured to receive a second input voltage that is a temperature-invariant voltage. The control circuit is further configured to output, based on a combination of the first input voltage and the second input voltage, a bias voltage for the photodetector, wherein the combination of the first and second input voltages is configured to cause the bias voltage to vary based on temperature.

Abstract: An exemplary photodetector system includes a plurality of photodetectors connected in parallel and a processor communicatively coupled to the plurality of photodetectors. The processor is configured to receive an accumulated output from the plurality of photodetectors. The accumulated output represents an accumulation of respective outputs from each of the plurality of photodetectors detecting photons during a predetermined measurement time period that occurs in response to a light pulse being directed toward a target within a body. The processor is further configured to determine, based on the accumulated output, a temporal distribution of photons detected by the plurality of photodetectors, and generate, based on the temporal distribution of photons, a histogram representing a light pulse response of the target within the body.