Patents Assigned to Howard University
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Publication number: 20220211673Abstract: A combinatorial method for treating against, or at least inhibiting or suppressing, the proliferation of an internal ribosome entry site utilizing virus (IRES-utilizing virus) in a host in need of treatment involves administering the host a compound, a tautomer, or a pharmaceutically acceptable salt thereof, in an amount effective for inhibiting replication of the IRES-utilizing virus in cells, wherein the compound is represented by the formula: wherein each R1 is independent of the other and represents a halogen atom selected from the group consisting of bromo, chloro, fluoro and iodo; and either separately administering another anti-viral drug and/or pro-drug to the anti-viral drug or co-administering the anti-viral drug and/or the pro-drug with the compound, its tautomer, or its pharmaceutically acceptable salt.Type: ApplicationFiled: April 27, 2020Publication date: July 7, 2022Applicants: HOWARD UNIVERSITY, GEORGETOWN UNIVERSITYInventors: Hemayet ULLAH, Sivanesan DAKSHANAMURTHY
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Publication number: 20220206513Abstract: An aerial device is provided. The aerial device includes a processor and a memory that includes instructions configured to cause the processor to perform certain operations when the processor executes the instructions. The operations may include receiving a first signal indicative of a first position of the aerial device. The operations may also include generating, based on the first signal and based on a randomly or pseudo-randomly generated sequence, a second signal configured to actuate flight hardware of the aerial device to a second position.Type: ApplicationFiled: November 19, 2021Publication date: June 30, 2022Applicant: HOWARD UNIVERSITYInventor: Imani R. Oakley
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Publication number: 20220200799Abstract: A method, computer program, and computer system is provided for encrypting data or information represented by bits, numbers, used to encode images, text, or audio. For the case of an RGB image encryption applications, the data may be separated into its constituent channels before encryption. In addition to the standard encryption keys, another encryption isokey is generated based on an isounit using an algebraic isofield having a multiplicative identity value different than the number one. On the sender side, each of the channels is encrypted using the standard keys and the generated isokey. On the receiver side, each encrypted channel is decrypted before combining them to obtain the recovered RGB image. In addition to images, the cryptographic algorithm can also be used the encrypt data related to text, audio, and other file types.Type: ApplicationFiled: December 17, 2020Publication date: June 23, 2022Applicant: Howard UniversityInventors: Mamadou Ibra Wade, Tepper Gill
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Publication number: 20220168277Abstract: A method for treating against, or at least inhibiting or suppressing, the proliferation of a cancer involves administering a compound, a tautomer, or a pharmaceutically acceptable salt thereof, in an amount effective for inhibiting metastasis of cancer cells, wherein the compound is represented by the formula (1): wherein each R1 is independent of the other and represents a halogen atom selected from the group consisting of bromo, chloro, fluoro and iodo.Type: ApplicationFiled: March 25, 2020Publication date: June 2, 2022Applicants: HOWARD UNIVERSITY, GEORGETOWN UNIVERSITYInventors: Hemayet ULLAH, Sivanesan DAKSHANAMURTHY
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Patent number: 11338016Abstract: C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) provides therapeutic effects in motor impairments associated with Parkinson disease (PD), and provides long lasting antidepressant effects, thus useful in treating and mitigating depression, particularly PD-depression co-morbid condition. A method for treating or mitigating depression, including administrating an effective amount of C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) to a subject in need thereof. A method for treating or mitigating motor impairments associated with Parkinson's disease (PD), including administrating an effective amount of C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) to a subject in need thereof.Type: GrantFiled: May 20, 2020Date of Patent: May 24, 2022Assignee: HOWARD UNIVERSITYInventor: Yousef Tizabi
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Patent number: 11319273Abstract: Compounds having formulas (I) to (VIII), salts thereof, or combinations thereof and pharmaceutical compositions comprising one or more these compounds are described herein for the treatment of HIV and neurodegenerative effects caused by HIV. Also provided herein are methods and a kit for inhibiting HIV-1, treating latent HIV in the brain, and preventing HIV-mediated cognitive decline and HIV dementia comprising administering the compounds having the formulas (I) to (VIII) and pharmaceutical compositions comprising the compounds having these formulas. The compounds having formulas I through VIII are curcumin analogs which are advantageously characterized as having anti-retroviral, neuroprotective, anti-glucosidase, and anti-HIV integrase properties. In one aspect, the pharmaceutical composition is delivered intranasally.Type: GrantFiled: April 17, 2015Date of Patent: May 3, 2022Assignee: HOWARD UNIVERSITYInventors: Evaristus A. Nwulia, Amol Kulkarni
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Patent number: 11291405Abstract: A system is configured to collect information regarding a user's sleep and to graphically convey sleep factors based on the information to a user. The system can include a control circuit and a sensor that work together configured to generate a first sleep factor. The first sleep factor is associated with the user's sleep episode. A database is communicatively coupled to the control circuit and stores a graphical representation of the user and a second sleep factor, which is defined by the user. The control circuit uses the first and second sleep factors to determine a sleep episode score. Optionally, the control circuit effects conveying the determined sleep episode score to the user via the graphical representation of the user.Type: GrantFiled: September 29, 2017Date of Patent: April 5, 2022Assignee: HOWARD UNIVERSITYInventor: Tyish S. Hall Brown
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Publication number: 20220096442Abstract: A method for treating against, or at least inhibiting or suppressing, the proliferation of an internal ribosome entry site-utilizing virus (IRES-utilizing virus) involves administering a compound, a tautomer, or a pharmaceutically acceptable salt thereof, in an amount effective for inhibiting replication of the IRES-utilizing virus in cells, wherein the compound is represented by the formula: wherein each R1 is independent of the other and represents a halogen atom selected from the group consisting of bromo, chloro, fluoro and iodo.Type: ApplicationFiled: October 29, 2019Publication date: March 31, 2022Applicants: HOWARD UNIVERSITY, GEORGETOWN UNIVERSITYInventors: Hemayet ULLAH, Sivanesan DAKSHANAMURTHY
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Patent number: 11267950Abstract: A method is provided for synthesizing PLA/apatite composites with improved mechanical strength. In one aspect, a calcium-phosphate/phosphonate hybrid shell is developed to incorporate more reactive hydroxyl groups onto hydroxyapatite (HA) particles. PLA is covalently bonded to HA calcium phosphate hybrid shell, creating a strong interphase between HA and PLA, thus significantly improve the mechanical strength in comparison to that of non-modified HA.Type: GrantFiled: July 24, 2019Date of Patent: March 8, 2022Assignee: HOWARD UNIVERSITYInventors: Tongxin Wang, James W. Mitchell
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Patent number: 11236053Abstract: This disclosure relates to compounds and methods of treating or preventing a Nox related disease or condition comprising administering to a subject in need thereof a Nox inhibitor or pharmaceutical compositions comprising a Nox inhibitor disclosed herein, derivatives, or compounds disclosed herein optionally substituted with one or more substitutes including optional salt and prodrug forms. In certain embodiments, this disclosure relates to sulfonylurea compounds and uses reported herein.Type: GrantFiled: July 26, 2018Date of Patent: February 1, 2022Assignees: Emory University, Mercer University, Howard University, Union UniversityInventors: Osman Güner, Bernard Lassegue, Kathy Griendling, Qian Xu, David Brown, J. Phillip Bowen, Amol Kulkarni, E. Blake Watkins
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Publication number: 20210405105Abstract: A method, computer program, and computer system is provided for fault detection in an electrical network. An inductance between a reference point and a fault is determined at a first time based on measuring a fault current. A resistance between the reference point and the fault may be determined at a second time based on measuring a differential of the fault current as zero. A location of the fault may be identified based on the inductance and the resistance.Type: ApplicationFiled: June 30, 2021Publication date: December 30, 2021Applicant: Howard UniversityInventor: Charles J. KIM
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METHOD FOR TREATING OR MITIGATING PARKINSON'S DISEASE USING NICOTINE INHALER OR NICOTINE NASAL SPRAY
Publication number: 20210386663Abstract: A method for treating or mitigating Parkinson's disease (PD) symptoms or progression, including administering an effective amount of nicotine to a subject in need thereof, via inhalation using a nicotine inhaler or via nasal spray using a nicotine nasal spray. Significant dose-dependent improvement of all symptoms by nicotine inhaler or nicotine nasal spray is expected. A novel treatment in PD is thus provided.Type: ApplicationFiled: June 10, 2020Publication date: December 16, 2021Applicant: HOWARD UNIVERSITYInventors: Yousef TIZABI, Robert L. COPELAND -
Publication number: 20210361739Abstract: C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) provides therapeutic effects in motor impairments associated with Parkinson disease (PD), and provides long lasting antidepressant effects, thus useful in treating and mitigating depression, particularly PD-depression co-morbid condition. A method for treating or mitigating depression, including administrating an effective amount of C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) to a subject in need thereof. A method for treating or mitigating motor impairments associated with Parkinson's disease (PD), including administrating an effective amount of C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) to a subject in need thereof.Type: ApplicationFiled: May 20, 2020Publication date: November 25, 2021Applicant: Howard UniversityInventor: Yousef TIZABI
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Publication number: 20210346858Abstract: An organogel including a base fluid, cetyl alcohol, and a gelling agent provided in an amount to cause the fluid to change from a liquid state to a gelled state at temperatures below at least 25° C. A nanofluid including an organogel and a nanoparticle component which permits the nanofluid to change from a liquid state to a gelled state at temperatures below at least 25° C., the gelled state helping to maintain the nanoparticle component suspended throughout the base fluid; and a method for preparing a gelled nanofluid.Type: ApplicationFiled: May 4, 2021Publication date: November 11, 2021Applicant: HOWARD UNIVERSITYInventors: Moshen MOSLEH, Mousab AHMED, Preethi CHANDRAN, Marjan ALAGHMAND
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Publication number: 20210272656Abstract: A method, computer program, and computer system is provided for analyzing chemical mixtures. Data corresponding to a mixture comprising one or more component species is obtained. A parameter corresponding to a species having a largest parameter value within the mixture is determined from among the component species. The parameter associated with the species having the largest parameter value is subtracted from the data. One or more remaining species associated with the mixture are detected.Type: ApplicationFiled: March 1, 2021Publication date: September 2, 2021Applicant: Howard UniversityInventor: Preethi CHANDRAN
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Publication number: 20210251879Abstract: Described herein are block copolymers having hydrophobic blocks and hydrophilic blocks which are effective in binding to the surface of hard tissue; compositions comprising the same, as well as methods of making and using the same.Type: ApplicationFiled: February 12, 2021Publication date: August 19, 2021Applicants: Colgate-Palmolive Company, Howard UniversityInventors: Tongxin WANG, Yanda LEI, James W. MITCHELL, Lynette ZAIDEL, Jian-Hong QIU, Mahmoud HASSAN
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Publication number: 20210161553Abstract: In some embodiments, apparatuses and methods are provided herein useful to guide and support a medical device, such as a needle, relative to the skin of a patient. In some embodiments, the apparatus is attached to the skin of a patient through suction or adhesive materials, and allows for accurate placement of the medical instrument.Type: ApplicationFiled: April 12, 2019Publication date: June 3, 2021Applicant: HOWARD UNIVERSITYInventors: Roger C. LIN, Olmide A. OLULADE, Shannon A. SULLIVAN, Hamza HAIDER, Alexander W. SONG
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Publication number: 20210106552Abstract: The present disclosure provides methods related to treating triple-negative breast cancer (TNBC) in a mammal by administering salvianolic acid B (or a salt or solvate thereof) to promote ceramide-mediated apoptosis. In one form, the ceramide-mediated apoptosis of TNBC cells occurs by decreasing the level of one or more of glucosylceramide synthase and GM3 synthase in the subject through the use of an effective amount of salvianolic acid B. In another aspect, salvianolic acid B or its pharmaceutically acceptable salt or solvate is used as a medicament or in the manufacture of a medicament for treating TNBC.Type: ApplicationFiled: April 11, 2019Publication date: April 15, 2021Applicant: Howard UniversityInventor: Xinbin GU
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Patent number: 10948936Abstract: An apparatus, the apparatus includes a simulator, an interface, and a microgrid. The simulator includes a model of a physical electrical network. The interface is coupled to the simulator. The microgrid is coupled to the interface and includes a plurality of electrical elements that represent aspects of the physical electrical network. The simulator receives requests to analyze performance of the physical electrical network, responsively produces signals that are converted to control signals by the interface and applied to the microgrid, the microgrid providing feedback.Type: GrantFiled: November 19, 2015Date of Patent: March 16, 2021Assignee: HOWARD UNIVERSITYInventor: James Momoh
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Patent number: 10918588Abstract: Described herein are block copolymers having hydrophobic blocks and hydrophilic blocks which are effective in binding to the surface of hard tissue; compositions comprising the same, as well as methods of making and using the same.Type: GrantFiled: November 8, 2013Date of Patent: February 16, 2021Assignees: Colgate-Palmolive Company, Howard UniversityInventors: Tongxin Wang, Yanda Lei, James W. Mitchell, Lynette Zaidel, Jian-hong Qiu, Mahmoud Hassan