Patents Assigned to Howard University
  • Patent number: 10279006
    Abstract: A method, apparatus and kit have been discovered which regenerate with the use of odorants the connections of the neurons of the brain and central nervous system in the treatment of such person afflicted neuro-disorders caused by disease or trauma.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: May 7, 2019
    Assignee: Howard University
    Inventor: Evaristus A. Nwulia
  • Patent number: 10201552
    Abstract: Methods and compositions are provided for reducing transmission and/or infection of HIV in a subject by increasing the bioavailability of a drug in the subject. The methods and compositions provided herein include an efflux transporter inhibitor and a drug effective for reducing the transmission and/or infection of HIV in a subject. The efflux transporter inhibitor is effective to reduce the efflux of the drug through at least one of P-glycoprotein (Pgp), breast cancer resistant protein (BCRP), and multidrug resistant associated protein 1-9 (MRP1-9).
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: February 12, 2019
    Assignee: Howard University
    Inventor: Pradeep K. Karla
  • Publication number: 20180362186
    Abstract: An airport lighting system includes one or more lighting elements, a transient protection apparatus, and one or more electrical control cabinets. The transient protection apparatus is coupled to the one or more lighting elements. One or more electrical control cabinets are coupled to the transient protection apparatus. Each of the control cabinets produces one or more of control and power signals that are effective to operate the one or more lighting elements. The transient protection apparatus is configured to provide protection for one or more of the electrical control cabinets and the one or more lighting elements from electrical surges.
    Type: Application
    Filed: December 6, 2016
    Publication date: December 20, 2018
    Applicant: Howard University
    Inventor: James Momoh
  • Publication number: 20180325865
    Abstract: Disclosed are bruceolides for the treatment of cancer, and other diseases, selectively targeting unwanted cells. The disclosed bruceolides may include a site specific cleavable moiety inhibiting the chemotoxic activity until cleaved, i.e., removed, within and/or near a cancer to be treated. As to facilitate selective delivery to cancer tumors, the disclosed bruceolides may be loaded into, attached to or otherwise carried by nanoparticles.
    Type: Application
    Filed: November 18, 2016
    Publication date: November 15, 2018
    Applicant: Howard University
    Inventor: Simeon Kolawole Adesina
  • Publication number: 20180307841
    Abstract: A redundant and diverse secondary control system mirrors a primary control system but has some fundamental structural difference as compared to the primary control system to prevent a spread of a security breach from the primary control system to the secondary control system. The secondary control system may operate on different hardware built on different software written with different programming language as compared to the primary control system while performing the same function as that of the primary system. By hardware coding the algorithm to produce actuation signals, software based viruses and worms cannot interfere with the secondary control system's operation. A monitor device receives actuation signals from both the primary and secondary controls signals to determine whether an error occurred and to provide correct actuation signals to the controlled system.
    Type: Application
    Filed: November 23, 2015
    Publication date: October 25, 2018
    Applicant: Howard University
    Inventor: Charles J. Kim
  • Patent number: 10016473
    Abstract: A method, apparatus and kit have been discovered which utilize pulsed odorants, drugs, medicaments, and combinations thereof to treat diseases, symptoms of diseases and the like. In one form, the pulsed odorants, drugs, medicaments, and combinations thereof can be used to regenerate the connections of the neurons of the brain and central nervous system in the treatment of symptoms of such person afflicted with neuro-disorders, such as caused by disease or trauma.
    Type: Grant
    Filed: January 7, 2015
    Date of Patent: July 10, 2018
    Assignee: Howard University
    Inventor: Evaristus A. Nwulia
  • Publication number: 20180099007
    Abstract: Covalently cross-linked copolymers are described herein. More specifically, polysaccharide-polyamine copolymeric matrices or structures and cationic copolymeric matrices are described herein. The polysaccharide-polyamine copolymers, when protonated, can form cationic copolymeric matrices having exceptionally high densities of cationic sites. In one form, the covalently cross-linked copolymers provide a three-dimensional structure, especially when hydrated.
    Type: Application
    Filed: March 18, 2016
    Publication date: April 12, 2018
    Applicant: Howard University
    Inventors: James W. Mitchell, Dazhi Yang
  • Publication number: 20180094080
    Abstract: Microcarriers, matrices and scaffolds for growing mammalian cells are provided which include copolymer particles and matrices comprising of polysaccharide-polyamine copolymers. The copolymeric particles and matrices have a pore size of at least 50 microns and permit the mammalian cells to grow both on an exterior surface of the particles and matrices and within an interior of the particles and matrices. Methods for making such microcarriers, matrices and scaffolds, and compositions are also provided. Methods for growing mammalian cells utilizing such microcarriers, matrices and scaffolds and compositions are also provided.
    Type: Application
    Filed: March 18, 2016
    Publication date: April 5, 2018
    Applicant: Howard University
    Inventors: James W. Mitchell, Dazhi Yang
  • Patent number: 9900398
    Abstract: The context of a first electronic device is automatically determined, and the first electronic device has a display unit. Information is displayed at the display unit based upon the context. The context is transmitted from the first electronic device to a second electronic device, and from the first electronic device and to a third electronic device. A first consistency of information is maintained between the first electronic device and a second electronic device based at least upon the context, and a second consistency is maintained between the first electronic device and a third electronic device based at least upon the context. The first consistency is greater than the second consistency.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: February 20, 2018
    Assignee: Howard University
    Inventor: Legand L. Burge, III
  • Patent number: 9870641
    Abstract: A majorize-minimize (MM) mathematical principle is applied to least squares regularization estimation problems to effect efficient processing of image data sets to provide good quality images. In a ground penetrating radar application, these approaches can reduce processing time and memory use by accounting for a symmetric nature of a given radar pulse, accounting for similar discrete time delays between transmission of a given radar pulse and reception of reflections from the given radar pulse, and accounting for a short duration of the given radar pulse.
    Type: Grant
    Filed: February 19, 2014
    Date of Patent: January 16, 2018
    Assignee: Howard University
    Inventors: John M. M. Anderson, Mandoye Ndoye
  • Patent number: 9864046
    Abstract: The mathematical majorize-minimize principle is applied in various ways to process the image data to provide a more reliable image from the backscatter data using a reduced amount of memory and processing resources. A processing device processes the data set by creating an estimated image value for each voxel in the image by iteratively deriving the estimated image value through application of a majorize-minimize principle to solve a maximum a posteriori (MAP) estimation problem associated with a mathematical model of image data from the data. A prior probability density function for the unknown reflection coefficients is used to apply an assumption that a majority of the reflection coefficients are small. The described prior probability density functions promote sparse solutions automatically estimated from the observed data.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: January 9, 2018
    Assignee: Howard University
    Inventors: John M. M. Anderson, Mandoye Ndoye, Oludotun Ode, Henry C. Ogworonjo
  • Patent number: 9840679
    Abstract: A gelling nanofluid and methods for manufacture are provided. The composition and methods for manufacture produce nanofluid gels so that the settlement of nanoparticles in a base fluid is improved due to the inhibition of particle movement in the gel. The nanofluid gel is produced by using a gelling agent which is either coated on the nanoparticles prior to dispersion in the base fluid or directly introduced in the base fluid.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: December 12, 2017
    Assignee: Howard University
    Inventors: Mohsen Mosleh, Mohammad Ghaderi-Yeganeh
  • Publication number: 20170240698
    Abstract: The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alkylene glycol-graft-lactate) that is crosslinked by at least one hydrolysable monomer. Another embodiment of the present invention is a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent. Another embodiment of the present invention is a polymer particle comprising, a crosslinked copolymer comprising structures represented by Formulas (I), (II), and (III), where Formulas (I), (II) and (III) are defined in the specification. Yet other embodiments of the present invention include a method of preparing a methacrylate terminated macromonomer, a method of preparing a crosslinking agent, and a method of preparing a therapeutic agent loaded nanosphere by dispersion polymerization.
    Type: Application
    Filed: May 9, 2017
    Publication date: August 24, 2017
    Applicant: Howard University
    Inventors: Emmanuel Oyekanmi Akala, Simeon Kolawole Adesina
  • Patent number: 9696367
    Abstract: A distance from a measurement point to a fault in a three-phase circuit is determined. The measurement point is located at an output of a power sub-station and the three phase circuit has a loop circuit having an associated net fault line current and a ground current. A derivative of the net fault line current of the loop circuit as measured from the measurement point is calculated. An uncompensated distance to the sub-cycle fault using at least the derivative of the net fault current is determined, and configured, to compensate for the ground current of the loop circuit. The compensation is applied to the uncompensated distance to produce a compensated distance to the sub-cycle fault.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: July 4, 2017
    Assignee: Howard University
    Inventor: Charles J. Kim
  • Patent number: 9675556
    Abstract: The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alklyene glycol-graft-lactate) that is crosslinked by at least one hydrolysable monomer. Another embodiment of the present invention is a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent. Another embodiment of the present invention is a polymer particle comprising, a crosslinked copolymer comprises structures represented by Formulas (I), (II), and (III), where Formulas (I), (II) and (III) are defined in the specification. Yet other embodiments of the present invention include a method of preparing a methacrylate terminated macromonomer, a method of preparing a crosslinking agent, and a method of preparing a therapeutic agent loaded nanosphere by dispersion polymerization.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: June 13, 2017
    Assignee: Howard University
    Inventors: Emmanuel Oyekanmi Akala, Simeon Kolawole Adesina
  • Patent number: 9644166
    Abstract: A nanolubricant composition is described where the lubricant composition includes a flowable oil or grease with nanoparticles dispersed in the flowable oil or grease. The nanoparticles are configured to polish a surface of a structure slowly over a period of time. The nanoparticles a hardness of at least about 7 Mohs and a diameter that is less than one half the arithmetic average roughness of the surface or a length that is less than one half of the arithmetic average roughness of the surface.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: May 9, 2017
    Assignee: Howard University
    Inventor: Mohsen Mosleh
  • Publication number: 20170008839
    Abstract: Methods for treating retroviral infection or inhibiting HIV integrase in target cells or in a patient involve administering to target cells or to a patient in need of treatment an effective amount of at least one having a disulfonamide scaffold which is represented by the formula: wherein, independent of each other, each X independently represents hydrocarbyl, halogeno, amino, substituted amino, or alkoxy, wherein substituted amino is represented by —NR3,R4 wherein R3 and R4, are not both hydrogen and independently represent alkyl or alkenyl, n is an integer of 0, 1, 2, or 3, each Y independently represents hydrocarbyl, halogeno, amino, substituted amino or alkoxy,wherein substituted amino is represented by —NR3,R4 wherein R3 and R4, are not both hydrogen and independently represent alkyl or alkenyl, m is an integer of 0, 1, 2, or 3, and R represents di-valent hydrocarbyl, substituted or unsubstituted.
    Type: Application
    Filed: February 26, 2015
    Publication date: January 12, 2017
    Applicant: Howard University
    Inventor: Xiang Simon WANG
  • Patent number: 9511343
    Abstract: Methods and apparatus to control reaction rates of chemical reactions. Methods can include mixing chemical reactants to provide a reaction mixture, at least one chemical reactant being magnetic; and applying a magnetic field to the reaction mixture, the magnetic field being applied to effect a control of the rate of a chemical reaction between the reactants in the reaction mixture, the magnetic field being effective to change the reaction rate over a chemical reaction between the same reactants at the same pressure and temperature where the reaction mixture is not exposed to the magnetic field.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: December 6, 2016
    Assignee: Howard University
    Inventors: Reginald B. Little, James W. Mitchell
  • Publication number: 20160347739
    Abstract: A method for treating against HIV, such as by inhibiting HIV integrase, in target cells or in a patient involves administering to target cells or to a patient in need of treatment an effective amount of at least one compound having an N-indol heteroarylcarboxamide scaffold which compound is represented by the formula: wherein, independent of each other, R independently represents hydrocarbyl, halogeno, amino, substituted amino, or alkoxy, R1 represents di-valent hydrocarbyl, substituted or unsubstituted, and R2 represents an ether moiety.
    Type: Application
    Filed: July 26, 2016
    Publication date: December 1, 2016
    Applicant: Howard University
    Inventor: Xiang Simon WANG
  • Publication number: 20160308996
    Abstract: The context of a first electronic device is automatically determined, and the first electronic device has a display unit. Information is displayed at the display unit based upon the context. The context is transmitted from the first electronic device to a second electronic device, and from the first electronic device and to a third electronic device. A first consistency of information is maintained between the first electronic device and a second electronic device based at least upon the context, and a second consistency is maintained between the first electronic device and a third electronic device based at least upon the context. The first consistency is greater than the second consistency.
    Type: Application
    Filed: June 22, 2016
    Publication date: October 20, 2016
    Applicant: Howard University
    Inventor: Legand L. Burge, III