Abstract: Embodiments of the present disclosure relate to methods for ex vivo determining whether a patient with metastatic melanoma is likely to benefit from a treatment with an anti CTLA-4 molecule, preferably ipilimumab, by analyzing the gut microbiota in a fecal sample from said patient.

Abstract: This invention is related to the area of characterization of inflammation in relation with the gut microbiota, in metabolic and autoimmune disorders. In particular, it relates to the identification of gene signatures which can be used as a marker predictive of inflammation associated diseases, such as liver-related metabolic disorders, in particular to the evolution of benign steatosis towards its most severe forms (steatohepatitis and cirrhosis) or autoimmune disorders, in particular inflammatory bowel diseases (Crohn's and Ulcerative Colitis). These gene signatures can therefore be used as a means of diagnosis, prognosis, stratification for drug studies, for monitoring patient and for assigning an appropriate treatment.

Abstract: The invention relates to a method for separating, from a culture medium, an enzymatic cocktail and the fungus Trichoderma reesei, the culture medium resulting from enzyme production by the fungus, method in which: said culture medium is subjected, in a period of no longer than 30 h from the halting of production, to a separation on a filter press lined with a fabric having a porosity of 3-20 ?m, so as to obtain a filtrate having a corrected optical density OD at 600 nm of less than 2.5; and the liquid phase obtained is subjected to tangenital micro-filtration on a ceramic membrane having a cut-off limit of 0.5 to 1.4 ?m, so that the corrected OD at 600 nm does not exceed 0.1.

Abstract: Embodiments of the present disclosure relate to mutant yeast strains, in particular mutant Yarrowia strains, capable of producing medium chain fatty acids compared to the parent oleaginous yeast strain from which said mutant oleaginous yeast strain derives. Embodiments of the present disclosure also relate to means and methods for obtaining these mutant yeast strains.

Abstract: The invention relates to a process for treating a lignocellulosic biomass, with: a. Pretreatment of the biomass via at least one cooking or steam explosion operation, so as to obtain a pretreated substrate, b. Liquid/solid separation on at least a portion of the pretreated substrate, comprising two successive substeps: an upstream substep b1 of contacting the solid/liquid mixture performed with a continuous mixer (M) using a mixing fluid, a downstream sub-step b2 of extraction/washing performed with a continuous filter, using a washing fluid, to obtain a solid phase enriched in solid and a plurality of liquid phases enriched in liquid, with at least partial recycling of a liquid phase extracted from the filter at the inlet of the mixer as a mixing fluid.

Abstract: Plants of the Cucurbitaceae family and seeds of such plants with an androecious phenotype, whereas this sexual type is not natural in the plants, and the use of the plants and of the plant seeds of the invention. Moreover, the nucleic acid sequence responsible for androecy in the plants of the invention and on the polypeptide encoded by the nucleic acid sequence. Finally, methods of identifying the plants and the seeds.

Abstract: The present invention relates to a bacterial strain of the Faecalibacterium prausnitzii species selected from a bacterial strain belonging to one of the phylogroups I, II and III, for use in the treatment and/or prevention of visceral abdominal pain in an individual. The present invention also concerns compositions comprising said bacterial strains as well as specific strains as such.

Abstract: The present invention relates to novel fusion polypeptides and the uses thereof. The invention particularly relates to conjugated coat proteins derived from nepoviruses, virus-like particles made with such proteins, and the uses thereof. The particles of the invention can expose and/or encage molecules of interest and have utility in various fields such as the pharmaceutical, agro, or veterinary areas.

Abstract: Embodiments of the present disclosure relate to methods of screening and optionally designing compounds as inhibitors of Mfd (Mutation Frequency Decline), such compounds being useful for the treatment of bacterial infections. Embodiments of the methods include culturing pathogenic bacteria expressing functional Mfd with various concentrations of 1 mM or less, incubating the cultures with and without nitric oxide stress conditions, evaluating bacterial survival in each of the cultures, and calculating the concentration of the molecule required to decrease by 50% the survival rate of the bacteria (IC50) by comparing the cfu of the untreated cultures and cultures following nitric oxide stress.

Abstract: The present disclosure relates to the use of a cpcR regulator gene, which directs the expression of promoters of genes encoding Cry proteins, for reducing the sporulation of a strain of Bacillus thuringiensis, new recombinant strains of Bacillus thuringiensis and uses thereof as biopesticide.

Abstract: A sizing composition for insulating products based on mineral wool, in particular glass or rock wool, which includes at least one ammonium lignosulfonate or alkali metal or alkaline earth metal salt of lignosulfonic acid, and at least one carbonyl compound of formula: R—[C(O)R1]x??(I) in which: R represents a saturated or unsaturated and linear, branched or cyclic hydrocarbon radical, a radical including one or more aromatic nuclei which consist of 5 or 6 carbon atoms, a radical including one or more aromatic heterocycles containing 4 or 5 carbon atoms and an oxygen, nitrogen or sulfur atom, it being possible for the R radical to contain other functional groups, in particular hydroxyl or alkoxy groups, especially methoxy groups, R1 represents a hydrogen atom or a C1-C10 alkyl radical, and x varies from 1 to 10.

Abstract: The present invention relates to a method for obtaining a mutant strain of oleaginous yeast which is useful as a template strain of yeast for obtaining other mutant strains of oleaginous yeast which are capable of producing an unusual fatty acid. The present invention also relates to the mutant strains of yeast obtained by said method.

Abstract: The invention concerns a continuous method for treating a lignocellulosic biomass before enzymatic hydrolysis, said method comprising a transfer of crushed then pressed biomass to a step of impregnation by an acid liquor, the impregnated biomass dripping over the area containing the impregnation liquor, then the resulting wet biomass is pressed and sent to a steam explosion step. The impregnation liquor is prepared in a dedicated area from the used liquor from the dripping operation and/or that from the pressing operation, prior to the explosion step. The invention also concerns the facility for implementing the method.

Abstract: The present invention relates to a method of enzymatically degrading a polysaccharide, such as cellulose, comprising contacting the polysaccharide with one or more lytic polysaccharide monooxygenase (LPMO), in which the enzymatic degradation is carried out in the presence of at least one reducing agent, and hydrogen peroxide or a means which generates hydrogen peroxide in which the level of hydrogen peroxide is controlled to enhance and maintain the activity of the LPMO. The invention also extends to the additional use of hydrolytic enzymes such as hydrolases (e.g. cellulases, chitinases and/or ß-glucosidases) to increase the level or extent of degradation and to fermentation of the resulting sugars to generate an organic substance such as an alcohol, preferably ethanol, which may be used as a biofuel.

Abstract: The present invention relates to a composition exhibiting a bile-salt hydrolase activity for its use for the treatment or the prevention of giardiasis, said composition comprising a bile-salt hydrolase (BSH) enzyme, a bacterium able to secrete a BSH, a recombinant host cell able to secrete a BSH, or a combination thereof. The present invention also relates to the use of a composition exhibiting a BSH activity for the treatment or the prevention of giardiasis, and to a pharmaceutical composition or a food composition comprising, as an active principle, a BSH, a lactic acid bacterium able to secrete a BSH, or a recombinant host cell able to secrete a BSH.

Abstract: The invention relates to: —a protein having dextran-saccharase activity and the sequence SEQ ID NO: 1 for an amino acid sequence; —a protein having dextran-saccharase activity and the sequence SEQ ID NO: 2 for an amino acid sequence; —a complex containing a substrate and a protein with dextran-saccharase activity —a method for synthesizing dextrans; and —dextrans. The invention also relates to a method for synthesizing gluco-oligosaccharides and gluco-conjugates and to the resulting products.

Abstract: The invention relates to a novel olfactory/pheromonal receptor (SlitOR5) of Spodoptera littoralis (Lepidoptera, Noctuidae) and the identification of the natural ligand of Slit OR5 and uses thereof.

Abstract: The subject matter of the invention is dextrans which have between 95% and 99% of ?-1,6 glucosidic bonds, a weight-average molar mass Mw at least equal to 0.7×109 g.mol?1, and a dispersity index D of between 1.3 and 3. The invention also relates to a dextran saccharase which makes it possible to produce such dextrans, and to a method for producing said dextrans.

Abstract: A new apple tree named ‘Inobi’ notable for its attractive fruit, favorable organoleptic qualities and resistance to apple scab. Fruit of ‘Inobi’ is highly colored and has a long shelf life.

Abstract: A new apple tree named ‘Inobi’ notable for its attractive fruit, favorable organoleptic qualities and resistance to apple scab. Fruit of ‘Inobi’ is highly colored and has a long shelf life.