Abstract: The present invention relates to a new isolated polypeptide comprising an amino acid sequence having at least 94%, 95%, 99% or 100% identity to the full length amino acid sequence set forth in SEQ ID NO: 1, and having a polyester degrading activity, and uses thereof.
Type:
Grant
Filed:
October 20, 2015
Date of Patent:
May 14, 2019
Assignees:
CARBIOS, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, INSTITUE NATIONAL DES SCIENCES APPLIQUEES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Inventors:
Pablo Alvarez, Emilie Amillastre, Sophie Duquesne, Alain Marty
Abstract: Disclosed is a polypeptide including or consisting of the amino acid sequence SEQ id no:1, for use in the treatment or prevention of an inflammatory disease. It further encompasses a nucleic acid sequence encoding a polypeptide, a vector including a nucleic acid and a host cell including a nucleic acid sequence and/or a vector, for use in the treatment or prevention of an inflammatory disease. Also disclosed is a pharmaceutical composition or a food composition including a polypeptide, a nucleic acid sequence, a vector or a host cell and a pharmaceutically acceptable carrier or a dairy product, for the treatment of inflammatory disease. Additionally, a method for the screening of bacteria having immunomodulatory properties is disclosed.
Type:
Grant
Filed:
July 7, 2015
Date of Patent:
May 14, 2019
Assignees:
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), INSTITUT PASTEUR DE LILLE (IPL)
Inventors:
Gwenael Jan, Benoit Foligne, Helene Falentin, Stephanie-Marie Deutsch
Abstract: The invention relates to a lyophilized composition comprising a microbiota in its ecosystem, in particular stools, and a mixture of cryoprotectant agents comprising maltodextrin and trehalose, a capsule comprising said lyophilized composition, the use thereof, and methods for the production thereof.
Type:
Application
Filed:
December 16, 2016
Publication date:
May 9, 2019
Applicants:
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, UNIVERSITE PARIS DESCARTES, UNIVERSITE PARIS DIDEROT - PARIS 7, ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
Abstract: A nucleic acid for the controlled expression of a nucleic acid encoding a pro-apoptotic protein in an individual, including: a regulatory polynucleotide including a minimal promoter and at least one AARE (amino acid response element) nucleic acid, the regulatory polynucleotide being activated in an individual upon consumption of a diet deficient in at least one essential amino acid; and a nucleic acid encoding a pro-apoptotic protein, which is placed under the control of the regulatory polynucleotide.
Type:
Application
Filed:
June 2, 2017
Publication date:
May 9, 2019
Applicants:
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Abstract: The invention relates to a process for producing cellulolytic or hemicellulolytic enzymes comprising A growth phase a) of a cellulolytic microorganism in a closed reactor, in the presence of at least one carbonaceous growth substrate in a concentration between 10 and 90 g/L, at a temperature of 25-30° C. and a pH of 4-5.5 An enzyme production phase b) in which at least one inducer carbonaceous substrate is added, at a temperature of 25-27° C. and a pH of 4-5, process in which the said inducer substrate is a pretreated pomace obtained from a pretreatment process of lignocellulosic material that has not undergone enzymatic hydrolysis and that is added in fed-batch or continuous mode, and which has particular characteristics: a hydrolysis yield greater than 80% in a test and an apparent viscosity, measured in the test, of less than 1 Pa·s for a shear rate of 10 s?1.
Type:
Application
Filed:
March 24, 2017
Publication date:
March 21, 2019
Applicants:
IFP Energies nouvelles, AGRO INDUSTRIES RECHERCHE ET DEVELOPPEMENT, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
Inventors:
Mohamed Fadhel BEN CHAABANE, Celine COHEN
Abstract: The invention relates to a bacterial strain of species Faecalibacterium prausnitzii deposited at the CNCM under access number CNCM I-4573, for use in the treatment and/or prevention of an inflammatory gastrointestinal illness in an individual.
Type:
Application
Filed:
January 23, 2017
Publication date:
January 31, 2019
Applicants:
Institut National De La Recherche Agronomique (INRA), Sorbonne Universite, Assistance Publique - Hopitaux de Paris
Inventors:
Philippe Langella, Rebeca Martin Rosique, Luis Bermudez Humaran, Florian Chain, Harry Sokol
Abstract: A phenol polymer is obtainable by oligomerization of one or more macropolyphenols serving as monomers, wherein the oligomerization step is catalyzed by an oxidase enzyme. The bonds between the macropolyphenol fragments in the polymer are exclusively 5,5-biaryl bonds. This polymer is useful as an antioxidant, chelating agent, plasticizing agent, or antimicrobial agent.
Type:
Grant
Filed:
October 13, 2014
Date of Patent:
January 1, 2019
Assignees:
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, INST SCIENCES IND VIVANT ENVIRONNMENT
Inventors:
Florent Allais, Florian Pion, Armando Reano, Paul-Henri Ducrot, Henry Eric Spinnler
Abstract: The present disclosure relates to the use of a biopolymer as a sensitive material in a dielectric gas sensor for water vapor, carbon dioxide, and/or ethanol.
Type:
Application
Filed:
November 16, 2016
Publication date:
December 27, 2018
Applicants:
UNIVERSITE DE MONTPELLIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)
Abstract: The present invention relates to a FGF19 polypeptide for its use as an agent increasing muscle fibers size, in the prevention and/or treatment of muscle atrophy in a mammal body.
Type:
Application
Filed:
June 24, 2016
Publication date:
December 27, 2018
Applicants:
Universite Claude Bernard Lyon 1, Institut National De La Recherche Agronomique (INRA), Institut National De La Santé Et De La Recherche Médicale (INSERM), Bergen Teknologioverforing AS
Abstract: This invention relates to the use of a yeast strain overexpressing at least the following genes: the ALK3 gene, at least one of genes ADH2 and ADH5 and at least one of genes FALDH3 and FALDH4, or gene FA01, for the fermentation-based production of carboxylic diacids.
Type:
Application
Filed:
March 25, 2016
Publication date:
December 20, 2018
Applicants:
FONDS DE DEVELOPPEMENT DES FILIERES DES OLEAGINEUX ET DES PROTEAGINEUX FIDOP, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)
Inventors:
France Thevenieau, Jean-Marc Nicaud, Vincent Sauveplane, Heber Gamboa-Melendez, Nicolas Morin
Abstract: The invention concerns a process for deactivating a cellulolytic microorganism enabling the production of an enzymatic cocktail, said cocktail being used without separating the cellulolytic microorganism during the biochemical conversion of lignocellulosic materials, comprising at least one step for bringing a gaseous stream into contact with a medium containing said microorganism, said gaseous stream comprising more than 25% by weight of CO2 and comprising less than 0.5 molar % of O2.
Type:
Grant
Filed:
June 5, 2013
Date of Patent:
December 11, 2018
Assignees:
L'Institut National de la Recherche Agronomique, Agro Industrie Recherches et Developpements
Abstract: Composition for the removal of biofilms present on a substrate, characterized in that it comprises at least one detergent component comprising a sequestrant and also a wetting agent and a dispersant and at least one enzymatic component containing at least one protease, at least one laccase and at least one polysaccharidase, method of implementation thereof and uses thereof.
Type:
Application
Filed:
July 24, 2018
Publication date:
December 6, 2018
Applicants:
S.A. REALCO, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
Abstract: Alpha/alpha-prime/alkoxylated glycerol linear carbonic esters have formula (VI): where p is an integer higher than 1, x is an integer equaling 0 or 1 with x not always being zero, and M1 is hydrogen (H). Q1 can be a hydrocarbon aliphatic group, an amino hydrocarbon group or an oxygenated amino hydrocarbon group. G1 can be an ?/??-alkoxylated propyl group of general formula (II?): where R4, R5 and R6 are variously hydrogen (H), an alkyl or an amino-alkyl group having 1 to 5 carbon atoms, or general formula (VII): where R7 is a H or a hydrocarbon group having 1 to 6 carbon atoms, and m is an integer between 0 and 10 inclusive, and X is —O— or —NH—.
Type:
Grant
Filed:
February 23, 2018
Date of Patent:
September 11, 2018
Assignees:
CHRYSO, INSTITUT NATIONAL POLYTECHNIQUE DE TOULOUSE, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)
Abstract: The invention relates to yeast cells modified to express a functional type I RuBisCO enzyme, and a class II phosphoribulokinase. The expression of these enzymes recreates a Calvin cycle in said yeasts in order to enable the yeasts to use carbon dioxide.
Type:
Grant
Filed:
January 16, 2015
Date of Patent:
September 4, 2018
Assignees:
Institut National de la Recherche Agronomique, Institut National Des Sciences Appliquees De Toulouse, Centre National de la Recherche Scientifique
Abstract: The present invention relates to a method for obtaining an untransformed avian cell line enabling in vitro avian virus replication. Said method includes the following steps: a) culturing avian embryonic stem cells in the presence of a stroma for at least 3 days; b) culturing for at least 2 days in a medium having a low serum concentration; c) culturing for at least 2 days in a medium having a low serum concentration containing 1 to 10 mM of hexamethyleme bisacetamide (HMBA); d) culturing for at least 10 days in a medium having a low serum concentration; and e) culturing or freezing an avian cell line enabling avian virus replication. The invention also relates to the resulting cell line and to the use thereof in vaccine preparations.
Type:
Grant
Filed:
July 24, 2014
Date of Patent:
August 21, 2018
Assignee:
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
Abstract: The present invention relates to a novel polypeptide having the enzymatic activity of reduction of NADP+ using electrons from reduced ferredoxin (Ferredoxin-NADP+ reductase activity), a polynucleotide having a nucleotide sequence encoding such polypeptide and uses thereof. The invention relates to the modulation of the Ferredoxin NADP+ reductase activity in a microorganism by varying the expression level of the polynucleotide coding for such polypeptide. The invention also relates to the production of commodity chemicals, especially ethanol, n-butanol, 1,3-propanediol, 1,2-propanediol, isopropanol and acetone by fermenting microorganisms wherein their Ferredoxin NADP+ reductase activity is modulated.
Type:
Application
Filed:
July 22, 2016
Publication date:
August 2, 2018
Applicants:
Institut National des Sciences Appliquees, Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique
Inventors:
Philippe Soucaille, Isabelle Meynial-Salles, Céline Foulquier, Antoine Riviere
Abstract: A process for the production of an enzymatic cocktail with a cellulolytic microorganism comprises two phases: a phase a) for growth of said microorganism in a closed reactor in the presence of a carbonaceous growth solution; a phase b) for the production of said enzymatic cocktail carried out with a supply of carbonaceous production solution the concentration of carbonaceous substrate of which is in the range 150 to 400 g/L, said carbonaceous production solution comprising a carbonaceous inducer substrate; characterized in that said carbonaceous inducer substrate is a liquid residue obtained from a step for pre-treatment of lignocellulosic materials, the C5 sugar oligomers of which represent at least 1% by weight of the total sugars present in said liquid residue, and at least 0.3% by weight of the total sugars present in said carbonaceous production solution.
Type:
Grant
Filed:
June 10, 2013
Date of Patent:
July 24, 2018
Assignees:
L'INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, AGRO INDUSTRIE RECHERCHES ET DEVELOPPEMENTS
Abstract: A compound of general formula (I) in which R1, R2, R3 and R5, identical or different, each represent a hydrogen atom or a hydroxyl group, optionally protected by a protecting group. R4 represents a hydrogen atom or an —OR7 group, in which R7 represents a hydrogen atom, a protecting group or a gallate group. R6 represents a hydroxyl group, optionally protected by a protecting group. R?1, R?2, R?3 and R?4, identical or different, each represent a hydrogen atom or a substituent not comprising a mesomeric electron withdrawing group conjugated with the furan ring. A substituent from R?1, R?2, R?3 and R?4 representing the covalent bond with the pyran ring or one of the salts of same. A method for obtaining such a compound includes a step of depolymerization of condensed tannins in the presence of an acid by means of a nucleophile derived from furan.
Type:
Grant
Filed:
August 3, 2015
Date of Patent:
July 24, 2018
Assignees:
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, CENTRE INTERNATIONAL D'ETUDES SUPERIEURES EN SCIENCES AGRONOMIQUES, UNIVERSITE DE MONTPELLIER 1
Inventors:
Laurent Roumeas, Hélène Fulcrand, Chahinez Aouf, Eric Dubreucq
Abstract: The invention relates to novel entomotoxic polypeptides of the family of albumins 1b in legumes. Said polypeptides can be especially used as insecticides.
Type:
Grant
Filed:
December 9, 2014
Date of Patent:
June 12, 2018
Assignees:
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON
Inventors:
Corinne Royer, Pedro Da Silva, Frédéric Gressent, Lamis Karaki, Yvan Rahbe
Abstract: Disclosed is a method for producing nanocelluloses from a cellulose substrate including cellulose fibers, the method including the following sequence of steps: a step of enzymatic treatment of the cellulose substrate, by bringing same into contact with at least one cleaving enzyme, then a step of mechanical treatment of the cellulose substrate subjected to the step of enzymatic treatment, in order to delaminate the cellulose fibres and obtain the nanocelluloses. The at least one cleaving enzyme is chosen from the enzymes belonging to the family of lytic polysaccharide monooxygenases (LPMOs) capable of achieving cleavage in the presence of an electron donor. Also disclosed are the nanocelluloses obtained according to the method.
Type:
Application
Filed:
June 1, 2016
Publication date:
May 24, 2018
Applicant:
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE-INRA
Inventors:
Bernard CATHALA, Ana VILLARES, Jean-Guy BERRIN, Celine MOREAU