Abstract: Techniques for processing images to be used for more accurate measurement of biological processes such as cell migration, as well as techniques for measuring cell migration. A method for processing microscopic images includes generating a smoothed image for a raw image by applying a smoothing filter to the raw image, wherein the raw image shows a plurality of cells and a background; generating a high pass filter image by dividing the raw image by the smoothed image; and transforming the high pass filter image into a transformed image by augmenting the spatial frequency of the plurality of cells shown in the high pass filter image with respect to the background.

Abstract: The present invention relates to a method for manufacturing a monocrystalline metal foil and a monocrystalline metal foil manufactured thereby, the method comprising the steps of: fixing each of the ends of a polycrystalline metal foil to electrodes; and heat-treating the fixed polycrystalline metal foil to manufacture a monocrystalline metal foil.

Abstract: Prodigiosin analogs which reactivate the p53 pathway are provided, as well as compositions of these compounds, and methods for reactivation of the p53 pathway using these compounds are provided. The prodigiosin analogs may be used to treat cancer in which p53 mutation plays a role, including prostate cancer, breast cancer, kidney cancer, ovarian cancer, lymphoma, leukemia, and glioblastoma, among others.

Abstract: A micropore ultrasonic disintegration device for sludge cell disintegration is provided, including an ultrasonic treatment chamber. The ultrasonic treatment chamber is internally provided with a first stirring mechanism which includes a reciprocating lead screw. One end of the reciprocating lead screw penetrates through a top surface of the ultrasonic treatment chamber, and the other end of the reciprocating lead screw is provided with stirring blades. The ultrasonic treatment chamber is internally provided with a second stirring mechanism, a side wall of the ultrasonic treatment chamber is provided with a first opening, and an inner wall of the ultrasonic treatment chamber is provided with a switch mechanism. The switch mechanism includes a baffle plate and a second connecting rod. The side wall of the ultrasonic treatment chamber is provided with an ultrasonic generator, and the top surface of the ultrasonic treatment chamber is provided with a liquid inlet pipe.

Abstract: Structures and sensor assemblies having engagement structures for securing a compliant substrate assembly are disclosed. In one embodiment, a sensor assembly includes a compliant substrate assembly having a base layer, and a deformable layer heat-sealed to the base layer such that the base layer and the deformable layer define at least one inflatable chamber. The sensor assembly further includes a first member proximate to a first edge of the compliant substrate assembly, a second member proximate to a second edge of the compliant substrate assembly, wherein the second edge is opposite the first edge, and at least one pressure sensor fluidly coupled to the at least one inflatable chamber and operable to produce a signal indicative of a pressure within the at least one inflatable chamber.

Abstract: A functional resin material is manufactured by the following reagents including a polyol, a polyamine, a first cross-linking agent, a second cross-linking agent, and a nanocellulose. Each of the first cross-linking agent and the second cross-linking agent includes an isocyanate block.

Abstract: Preparation of phosphorus fine chemicals from phosphate sources is described.

Abstract: Embodiments of the invention include methods of identifying microorganisms and/or diagnosing infections in subjects cause by microorganisms. Embodiments of the invention may also include further characterizing (e.g., determining the presence of one or more antibiotic resistance markers) the microorganisms and determining a strain identity of the microorganisms.

Abstract: A medicament with excellent JAK kinase (Janus Kinase) inhibitory activity can be used to prevent, treat and/or improve an autoimmune disease (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus and the like). The present invention also provides a pharmaceutically acceptable composition containing the compound and a method for preparing these compounds.

Abstract: Knit textile structures are formed of a yarn made of composite fibers, which is an active material within the knit structure that transforms in response to a change in temperature. In combination with non-active fibers and performative knit structure, this contraction can enable changes in the fabric that are adaptive to changes in environmental conditions during wear.

Abstract: Provided are antibodies that specifically bind to CTLA-4 and/or PD-1 and antagonize CTLA-4 and/or PD-1 function. Also provided are pharmaceutical compositions and kits comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies either alone or in combination.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for determining a velocity model for a geological region. In one aspect, a method comprises: obtaining a current velocity model for the geological region; obtaining pre-stack and post-stack seismic data characterizing the geological region; and for each of a plurality of iterations: identifying a plurality of reflection events from the post-stack seismic data and the current velocity model; determining a respective observed travel time for each of the plurality of reflection events, comprising, for each reflection event, determining the respective observed travel time for the reflection event based at least in part on kinematic features derived from a respective seismic trace included in the pre-stack seismic data; and updating the current velocity model based at least in part on the observed travel times of the plurality of reflection events.

Abstract: A marine climate environment-bending load collaborative acceleration test method is provided, including conducting a static bending load loading test in an outdoor marine climate environment, conducting an alternate cycle of a dynamic bending load loading test in the outdoor marine climate environment and a test in the outdoor marine climate environment, and conducting an alternate cycle of the dynamic bending load loading test and the static bending load loading test in the outdoor marine climate environment. In the present disclosure, an acceleration rate of the marine climate environment-bending load collaborative acceleration test reaches over 8 times that of the test in the outdoor marine climate environment by taking the maximum bending force as an evaluation index, which may achieve a change from a static test to a static and dynamic combined test for examining and evaluating the environmental adaptability of the metal material.

Abstract: In an approach to active engine idle control, an apparatus comprises: an accelerator module interface; an engine control module (ECM) interface; a computer readable storage media; and a controller. The controller is configured to: determine an engine speed target for a vehicle engine in revolutions per minute (RPM) based on an electrical load on the vehicle; determine a voltage curve for one or more position sensors of an accelerator module in the vehicle; determine a voltage target for the ECM for each position sensor of the one or more position sensors; and responsive to a first signal that the apparatus is engaged and a second signal that the vehicle is stopped, set an input voltage to the ECM at the voltage target for each of the one or more position sensors.

Abstract: A floating-oil recovery device includes: a bubble-curtain generation mechanism configured to discharge air into water to generate a bubble curtain in the water so as to increase a thickness of a film of floating oil while regulating spread of the floating oil; and an ejector configured to recover an oil-water mixed fluid having the floating oil and the water mixed with each other by jetting high-velocity water toward the film of floating oil enclosed with the bubble curtain to destroy the film of floating oil.

Abstract: The present invention discloses a dendritic reverse underground mining method for a thin coal seam at an end slope of a strip mine. The method includes the following steps: step S1: using a continuous coal mining machine to excavate a main adit toward a boundary of the strip mine along a seam floor; step S2: excavating secondary adits on two sides of the main adit obliquely in a forward direction of the main adit; step S3: transporting the excavated coal out of the main adit by the self-moving belt conveyors; step S4: after the excavating of a secondary adit of the secondary adits is ended, withdrawing the continuous coal mining machine and the self-moving belt conveyor from the secondary adit, and then excavating subsequent secondary adits of the secondary adits in a similar way; step S5: filling the secondary adits, and filling a goaf of the main adit.

Abstract: A method for localization performed by an agent includes receiving a query image of a current environment of the agent captured by a sensor integrated with the agent. The method also includes receiving a target image comprising a first set of keypoints matching a second set of keypoints of the query image. The first set of keypoints may be generated based on a task specified for the agent. The method still further includes determining a current location based on the target image.

Abstract: A subpixel structure includes a substrate and a light emitting diode chip. The light emitting diode chip is disposed on the substrate. The light emitting diode chip has a chip area and a light emitting area, and the light emitting area is less than or equal to one tenth of the chip area.

Abstract: An adversarial image generation method, a computer device, and a computer-readable storage medium are provided. The method includes the following. A reference model classification-equivalent with a target classification model is generated according to the target classification model. A target image is obtained and an original noise for the target image is generated according to the reference model. A first noise and the original noise are input into an adversarial model and a second noise corresponding to the first noise is output when the adversarial model meets a convergence condition, where the second noise enhances an information entropy of the original noise. An enhanced noise image corresponding to the target image is generated according to the second noise and the target image, where a classification accuracy of the enhanced noise image in the target classification model is less than a classification accuracy of the target image in the target classification model.

Abstract: A focusing device includes a substrate and a plurality of scatterers provided at both sides of the substrate. The scatterers on the both sides of the focusing device may correct geometric aberration, and thus, a field of view (FOV) of the focusing device may be widened.