Patents Assigned to Katholieke Universiteit Leuven
  • Patent number: 11618966
    Abstract: Porous solid materials are provided. The porous solid materials include a plurality of interconnected wires forming an ordered network. The porous solid materials may have a predetermined volumetric surface area ranging between 2 m2/cm3 and 90 m2/cm3, a predetermined porosity ranging between 3% and 90% and an electrical conductivity higher than 100 S/cm. The porous solid materials may have a predetermined volumetric surface area ranging between 3 m2/cm3 and 72 m2/cm3, a predetermined porosity ranging between 80% and 95% and an electrical conductivity higher than 100 S/cm. The porous solid materials (100) may have a predetermined volumetric surface area ranging between 3 m2/cm3 and 85 m2/cm3, a predetermined porosity ranging between 65% and 90% and an electrical conductivity higher than 2000 S/cm. Methods for the fabrication of such porous solid materials and devices including such porous solid material are also disclosed.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: April 4, 2023
    Assignees: IMEC VZW, Katholieke Universiteit Leuven, KU Leuven R&D
    Inventors: Stanislaw Piotr Zankowski, Philippe M. Vereecken
  • Patent number: 11615288
    Abstract: The present disclosure relates to secure broker-mediated data analysis and prediction. One example embodiment includes a method. The method includes receiving, by a managing computing device, a plurality of datasets from client computing devices. The method also includes computing, by the managing computing device, a shared representation based on a shared function having one or more shared parameters. Further, the method includes transmitting, by the managing computing device, the shared representation and other data to the client computing devices. In addition, the method includes, based on the shared representation and the other data, the client computing devices update partial representations and individual functions with one or more individual parameters. Still further, the method includes determining, by the client computing devices, feedback values to provide to the managing computing device.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: March 28, 2023
    Assignees: IMEC VZW, JANSSEN PHARMACEUTICA NV, KATHOLIEKE UNIVERSITEIT LEUVEN
    Inventors: Hugo Ceulemans, Roel Wuyts, Wilfried Verachtert, Jaak Simm, Adam Arany, Yves Moreau, Charlotte Herzeel
  • Patent number: 11599138
    Abstract: An arrangement for use in a matrix-vector-multiplier, comprising a stack of material layers arranged on a substrate, and a waveguide element formed in at least one material layer in the stack is disclosed. In one aspect, the arrangement further comprises a transducer arrangement which is coupled to the waveguide element. The transducer arrangement is configured to generate and detect spin wave(s) in the waveguide element, and wherein the waveguide element is configured to confine and to provide interference of the at spin wave(s) propagating therein. The arrangement further comprises a control mechanism comprising at least one control element coupled to the waveguide element, and a direct current electric source coupled to the at least one control element. The control mechanism, via the at least one control element, is configured to modify the phase velocity of the spin wave(s) propagating in the waveguide element.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: March 7, 2023
    Assignees: IMEC VZW, KATHOLIEKE UNIVERSITEIT LEUVEN
    Inventors: Hanns Christoph Adelmann, Jose Diogo Costa, Florin Ciubotaru
  • Patent number: 11587708
    Abstract: In one aspect, the disclosed technology relates to a magnetic device, which may be a magnetic memory and/or logic device. The magnetic device can comprise a seed layer; a first free magnetic layer provided on the seed layer; an interlayer provided on the first free magnetic layer; a second free magnetic layer provided on the interlayer; a tunnel barrier provided on the second free magnetic layer; and a fixed magnetic layer. The first free magnetic layer and the second free magnetic layer can be ferromagnetically coupled across the interlayer through exchange interaction.
    Type: Grant
    Filed: September 30, 2020
    Date of Patent: February 21, 2023
    Assignees: IMEC vzw, Katholieke Universiteit Leuven
    Inventors: Van Dai Nguyen, Sebastien Couet, Olivier Bultynck, Danny Wan, Eline Raymenants
  • Publication number: 20230042743
    Abstract: According to example embodiments, there is provided a photoresist inspection method. The photoresist inspection method includes: providing a photoresist on a substrate; irradiating the photoresist with an electron beam and an excitation beam; detecting fluorescent light generated by the photoresist in response to the excitation beam; and evaluating the photoresist based on the fluorescent light.
    Type: Application
    Filed: February 24, 2022
    Publication date: February 9, 2023
    Applicant: Katholieke Universiteit Leuven
    Inventors: Sukjong Bae, Johan Hofkens, Haifeng Yuan, Flip de Jong
  • Patent number: 11566025
    Abstract: The present invention relates to a series of novel compounds, methods to prevent or treat viral infections in animals by using the novel compounds and to said novel compounds for use as a medicine, more preferably for use as a medicine to treat or prevent viral infections, particularly infections with RNA viruses, more particularly infections with viruses belonging to the family of the Flaviviridae, and yet more particularly infections with the Dengue virus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the novel compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: January 31, 2023
    Assignee: Katholieke Universiteit Leuven
    Inventors: Dorothée Bardiot, Gunter Carlens, Kai Dallmeier, Suzanne Kaptein, Mohamed Koukni, Arnaud Marchand, Johan Neyts, Wim Smets
  • Patent number: 11554346
    Abstract: The invention relates to the use of an uncoated cross-linked non-pyrolysed selective vinyl based halopolymer-membrane with a mwco of between 100 and 1000 Da, in the filtration of compounds from liquids comprising organic solvents and/or from liquids with a pH below 2 or above 12.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: January 17, 2023
    Assignee: KATHOLIEKE UNIVERSITEIT LEUVEN
    Inventors: Ivo Vankelecom, Cédric Van Goethem, Matthias Mertens
  • Patent number: 11555745
    Abstract: Example embodiments relate to methods and devices for generating (quasi-) periodic interference patterns. One embodiment includes a method for generating an interference pattern using multi-beam interference of electromagnetic radiation. The method includes computing a set of grid points in a complex plane representing a grid with a desired symmetry. The method also includes selecting a radius of a virtual circle. Additionally, the method includes selecting a set of grid points in the complex plane that lies on the virtual circle centered around a virtual center point. Further, the method includes associating an argument of each grid point of the selected set of grid points in the complex plane with a propagation direction of plane waves or quasi plane waves or parallel wave fronts. In addition, the method includes obtaining the interference pattern that is a superposition of the plane waves or quasi plane waves or parallel wave fronts.
    Type: Grant
    Filed: April 7, 2021
    Date of Patent: January 17, 2023
    Assignees: IMEC VZW, Katholieke Universiteit Leuven, KU Leuven R&D
    Inventors: Niels Verellen, Dmitry Kouznetsov, Pol Van Dorpe
  • Patent number: 11548881
    Abstract: The present invention relates to a compound of formula (I) or a tautomer thereof, wherein R1, R2, R3, R4 and R5, have the same meaning as that defined in the claims and the description. The present invention also relates to compositions, in particular pharmaceuticals, comprising such compounds, and to uses of such compounds and compositions for the prevention and/or treatment of epilepsy and/or neurodegenerative diseases.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: January 10, 2023
    Assignees: reMYND N.V., Katholieke Universiteit Leuven
    Inventors: Johan Gerard Griffioen, Katrien Princen, Tom Francois L. Van Dooren, Arnaud Didier Marie Marchand, Amuri Kilonda, Sara Allasia, Patrick Chaltin
  • Patent number: 11549963
    Abstract: Example embodiments relate to methods and apparatuses for aligning a probe for scanning probe microscopy (SPM) to the tip of a pointed sample. One embodiments includes a method for aligning an SPM probe to an apex area of a free-standing tip of a pointed sample. The method includes providing an SPM apparatus that includes the SPM probe; a sample holder; a drive mechanism; and detection, control, and representation tools for acquiring and representing an image of a surface scanned by the SPM probe. The method also includes mounting the sample on the sample holder. Further, the method includes positioning the probe tip of the SPM, determining a 2-dimensional area that includes the pointed sample, performing an SPM acquisition scan, evaluating and acquired image, and placing the SPM probe in a position where it is aligned with an apex area of the free-standing tip of the pointed sample.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: January 10, 2023
    Assignees: IMEC VZW, Katholieke Universiteit Leuven, KU Leuven R&D
    Inventors: Kristof Paredis, Jonathan Op de Beeck, Claudia Fleischmann, Wilfried Vandervorst
  • Publication number: 20220409583
    Abstract: The present invention relates to the use of substituted indole derivatives and substituted indoline derivatives in the manufacture of a medicament for the treatment of dengue disease in an individual infected by dengue virus or the prevention of dengue disease in an individual at risk of being infected by Dengue virus. The invention further provides a method for the treatment or the prevention of dengue in an individual at risk of being infected by Dengue virus.
    Type: Application
    Filed: November 13, 2020
    Publication date: December 29, 2022
    Applicants: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Olivia Gabriella M. GOETHALS, Bart Rudolf Romanie KESTELEYN, Bart Henri Theresia STOOPS, Jean-François BONFANTI, Tim Hugo Maria JONCKERS, Marnix VAN LOOCK, Suzanne KAPTEIN, Johan NEYTS
  • Patent number: 11535896
    Abstract: The present invention concerns the analysis of cell-free nucleic acids to determine the contribution of cell-free nucleic acids from specific tissues. In addition, the invention provides methods for diagnosing diseases based on cell-free nucleic acid analysis. The methods of the invention are also useful to detect quality defects in samples containing cell-free nucleic acids.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: December 27, 2022
    Assignee: Katholieke Universiteit Leuven
    Inventors: Luc Dehaspe, Joris Vermeesch
  • Patent number: 11530383
    Abstract: The present invention provides methods to improve the health and vigor, including enhancement of the growth of plants, including important crop plants. In particular, the present invention provides methods of treating or preventing a rhizogenic or tumorigenic plant disease caused by bacteria, comprising administering to the plant an effective amount of at least one isolated Paenibacillus strain or of an extract of at least one isolated Paenibacillus strain, wherein said at least one Paenibacillus strain comprises a 16S rRNA sequence with at least 93% sequence identity to the sequence of SEQ ID NO: 1.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: December 20, 2022
    Assignees: KATHOLIEKE UNIVERSITEIT LEUVEN, NEDERLANDS INSTITUTE OF ECOLOGY (NIOO-KNAW), SCIENTIA TERRAE VZW, PROEFSTATION GROENTETEELT, PROEFCENTRUM HOOGSTRATEN
    Inventors: Lien Bosmans, Bart Lievens, Hans Rediers, Jos Raaijmakers, Irene De Bruijn
  • Patent number: 11527709
    Abstract: The disclosed technology relates to a multibit memory cell. In one aspect, the multibit memory cell includes a plurality of spin-orbit torque (SOT) tracks, plurality of magnetic tunnel junctions (MTJs), an electrically conductive path connecting a first MTJ and a second MTJ together, and a plurality of terminals. The plurality of terminals can be configured to provide a first SOT write current to the first MTJ, a second SOT write current to the second MTJ, and at least one of: the second SOT write current to a third MTJ, a third SOT write current to the third MTJ, and a spin transfer torque (STT) write current through the third MTJ. The junction resistances of the various MTJs are such that a combined multibit memory state of the MTJs is readable by a read current through all the MTJs in series.
    Type: Grant
    Filed: September 21, 2020
    Date of Patent: December 13, 2022
    Assignees: IMEC vzw, Katholieke Universiteit Leuven
    Inventors: Mohit Gupta, Trong Huynh Bao
  • Patent number: 11524637
    Abstract: A vibration reduction device having an acoustic meta structure mounted to a vehicle body and configured to block a structure-borne noise transmitted through the vehicle body may include a plurality of unit structures arranged at a predetermined interval therebetween, wherein each of the unit structures includes frame mounted to the vehicle body and configured to separate a predetermined space into a predetermined number of separate sections formed by walls of the frame; and a vibrator formed at a corner portion of each of the separate sections and each of which has a natural frequency to block a vibration transmitted from the vehicle body through the frame.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: December 13, 2022
    Assignees: Hyundai Motor Company, Kia Motors Gorporation, Katholieke Universiteit Leuven of KU Leuven Research & Development
    Inventors: Kyoung Jin Chang, Claus Claeys, Wim Desmet, Bert Pluymers, Elke Deckers, Lucas Van Belle, Noé Geraldo Rocha De Melo Filho
  • Patent number: 11513089
    Abstract: A system for measuring electrical characteristics of bioparticles is described. The system comprises an incubator for performing electrochemical measurements in a defined environment and a substrate holder positioned in said incubator for holding a substrate comprising a plurality of wells. The system is furthermore configured for continuously or regularly measuring electrochemical data. The system also comprises a processing means for comparing the continuously or regularly measured electrochemical data with reference data and for determining a moment for adding an active compound based on said comparison.
    Type: Grant
    Filed: December 18, 2016
    Date of Patent: November 29, 2022
    Assignees: VRIJE UNIVERSITEIT BRUSSEL, KATHOLIEKE UNIVERSITEIT LEUVEN
    Inventors: Yves Van Ingelgem, Bart Landuyt, Sven Verguts
  • Patent number: 11492596
    Abstract: The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express a hepatic stellate phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other applications, for treatment of liver deficiencies, liver metabolism studies, and liver toxicity studies, fibrogenic studies, or to support hepatocyte function in co-culture setting.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: November 8, 2022
    Assignees: Katholieke Universiteit Leuven, Institut D'Investigacions Biomediques August PI | Sunyer (IDIBAPS)
    Inventors: Catherine Verfaillie, Ruben Boon, Pau Sancho Bru, Mar Col Loperena, Luis Perea Sanchez
  • Publication number: 20220340522
    Abstract: The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Application
    Filed: June 16, 2022
    Publication date: October 27, 2022
    Applicants: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Jean-François Bonfanti, Bart Rudolf Romanie Kesteleyn, Dorothée Alice Marie-Eve Bardiot, Arnaud Didier M Marchand, Erwin Coesemans, Jérôme Michel Claude Fortin, Guillaume Jean Maurice Mercey, Pierre Jean-Marie Bernard Raboisson
  • Patent number: 11480569
    Abstract: Mucosal healing is an indication to the disease activity level in patients affected by inflammatory bowel diseases, and it is thus far mainly monitored by endoscopy. Instead or in addition to endoscopy, the invention provides blood test using biomarkers and an index that allows a practitioner to assess the status of mucosal healing, to change or adapt dosage of treatment and to predict which patient will become responder versus non-responder to treatment as assessed by endoscopy. While none of neutrophils cell count, c-reactive protein (CRP), Human type of Cathelicidin (LL-37), or Chitinase 3-like 1 (CHI3L1) alone is able to provide an assessment means of mucosal healing, the invention provides a novel combination of the levels of these biomarkers to assess the level of mucosal healing in relation to endoscopic healing.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: October 25, 2022
    Assignees: Glycominds, LLC, Katholieke Universiteit Leuven
    Inventors: Avinoam Dukler, Randy Ringold, Severine Vermeire, Magali De Bruyn, Ghislain Opdenakker
  • Patent number: 11471492
    Abstract: The application provides biocompatible carriers comprising bone forming and/or cartilage forming cells and methods for making them. The application further provides pharmaceutical compositions comprising said ATMPs and method of treatments using said ATMPs. The application further relates to said ATMPS for use in the treatment of bone disorders, cartilage disorders and joint disorders. The current invention further relates to method of treatments of bone disorders, cartilage disorders and joint disorders.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: October 18, 2022
    Assignee: KATHOLIEKE UNIVERSITEIT LEUVEN
    Inventors: Veerle Bloemen, Johanna Bolander, Frank Luyten