Patents Assigned to Lonza, Ltd.
  • Method for preparation of alkylated or fluoro, chloro and fluorochloro alkylated compounds by heterogeneous catalysis
    Patent number: 9771367
    Abstract: The invention discloses a method for preparation of alkylated or fluoro, chloro and fluorochloro alkylated compounds by a heterogeneous Pt/C-catalyzed alkylation or fluoro, chloro and fluorochloro alkylation with alkyl halides or with fluoro, chloro and fluorochloro alkyl halides in the presence of Cs2C03 or CsHC03.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: September 26, 2017
    Assignee: LONZA LTD
    Inventors: Christoph Taeschler, Matthias Beller, Helfried Neumann, Lin He, Kishore Natte, Stefan Ellinger, Florencio Zaragoza Doerwald
  • Process for the synthesis of 3-methyl-pyridine
    Patent number: 9701634
    Abstract: The present invention discloses a process for the synthesis of 3-methyl-pyridine from formaldehyde, paracetaldehyde, ammonia and acetic acid, whereby said compounds are reacted and said process comprises the following parameters: a) a reaction temperature of 260-300° C.; b) a molar ratio of formaldehyde and paraldehyde (calculated as acetaldehyde) of 0.7-1.4 mol/mol: c) an ammonia concentration of 10-20 weight-% d) an acetic acid concentration of 4-20 weight-% e) a paraldehyde (calculated as acetaldehyde) concentration of 0.4-1.6 Mol/kg f) a retention time of 10-30 minutes in case of a continuous reaction and 10-90 minutes in case of a discontinuous reaction; and g) a reaction pressure of 30-130 bar.
    Type: Grant
    Filed: June 24, 2010
    Date of Patent: July 11, 2017
    Assignee: LONZA LTD
    Inventors: Detlef Roederer, Daniel Zollinger, Jean-Yves De Riedmatten
  • Method for preparation of 4-alkoxy-1,1,1-trifluorobut-3-en-2-ones from 1,1,1-trifluoroacetone
    Patent number: 9663436
    Abstract: The invention discloses a method for the preparation of 4-alkoxy-1,1,1-trifluorobut-3-en-2-ones from 1,1,1-trifluoroacetone.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: May 30, 2017
    Assignee: Lonza Ltd
    Inventors: Florencio Zaragoza Doerwald, Christoph Taeschler
  • REGULATABLE PROMOTER
    Publication number: 20170037418
    Abstract: A method of producing a protein of interest (POI) by culturing a recombinant eukaryotic cell line comprising an expression construct comprising a regulatable promoter and a nucleic acid molecule encoding a POI under the transcriptional control of said promoter, comprising the steps a) cultivating the cell line with a basal carbon source repressing the promoter, b) cultivating the cell line with a limited amount of a supplemental carbon source de-repressing the promoter to induce production of the POI at a transcription rate or at least 15% as compared to the native pGAP promoter, and c) producing and recovering the POI; and further an isolated regulatable promoter and a respective expression system.
    Type: Application
    Filed: October 26, 2016
    Publication date: February 9, 2017
    Applicant: LONZA LTD.
    Inventors: DIETHARD MATTANOVICH, BRIGITTE GASSER, MICHAEL MAURER, ROLAND PRIELHOFER, JOACHIM KLEIN, JANA WENGER
  • Arabinogalactan for enhancing the adaptive immune response
    Patent number: 9549979
    Abstract: The present invention discloses a composition containing Arabinogalactan for enhancing the adaptive immune response in subjects to foreign antigen(s) by administering said composition prior, during and after the phase of exposure to said foreign antigen(s). Furthermore, the present invention relates to a vaccination kit comprising a composition comprising Arabinogalactan and a vaccine.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: January 24, 2017
    Assignee: Lonza Ltd.
    Inventors: Bryan Rodriguez, Kevin Q. Owen, Ulla Freitas, Jay Udani
  • Methods for decolorizing compositions comprising betaines
    Patent number: 9550726
    Abstract: The invention relates to a process for decolorizing a composition comprising a betaine comprising the steps of (a) providing a solution of the composition in an organic solvent, (b) contacting the solution with a decolorant, wherein the decolorant is a polar solid decolorant. The invention also relates to uses of ion exchange materials and decolorized solutions and compositions obtainable by the inventive process.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: January 24, 2017
    Assignee: LONZA LTD.
    Inventors: Thomas Büchner, Gesa Paradies, Justin Yang
  • Method for preparation of imidodisulfuryl compounds
    Patent number: 9546136
    Abstract: The invention relates to a method for the preparation of imidodisulfuryl compounds in a continuous reaction at elevated temperatures.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: January 17, 2017
    Assignee: Lonza Ltd
    Inventors: Christian Schnider, Dominique Roberge, Michael Gottsponer, Andreas Klein, Thomas Gruetzner, Michael Bittel, Stefan Tille, Anna-Christina Hormes, Janine Leiggener
  • Method for preparation of 6-trifluoromethylpyridine-3-carboxylic acid derivatives from trifluoroacetylacetic acid
    Patent number: 9522885
    Abstract: The invention discloses a method for the preparation of 6-trifluoromethylpyridine-3-carboxylic acid derivatives (I) from trifluoroacetylacetic acid (II) and orthoesters (III), and their use for the preparation of pharmaceutical, chemical or agro-chemical products.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: December 20, 2016
    Assignee: Lonza Ltd
    Inventors: Florencio Zaragoza Doerwald, Michael Bersier, Christoph Taeschler
  • Process for the enzymatic production of carnitine from beta-lactones
    Patent number: 9523106
    Abstract: Subject of the invention is a process for the production of L-carnitine, wherein a ?-lactone, which is a 4-(halomethyl)oxetane-2-one, is converted into L-carnitine, wherein the process comprises an enzymatic conversion of the ?-lactone into (R)-4-halo-3-hydroxybutyric acid or (R)-4-halo-3-hydroxybutyric acid ester.
    Type: Grant
    Filed: July 25, 2012
    Date of Patent: December 20, 2016
    Assignee: LONZA LTD.
    Inventors: Ellen Klegraf, Manuela Avi
  • LIQUID LAUNDRY DETERGENT COMPOSITION FOR CLOTHING
    Publication number: 20160355761
    Abstract: [Problem to be Solved] To provide a liquid laundry detergent composition for clothing which can remove bacteria from the clothing effectively during washing and also impart an excellent antibacterial effect to the clothing after washing.
    Type: Application
    Filed: February 6, 2015
    Publication date: December 8, 2016
    Applicant: Lonza Ltd.
    Inventors: Mutsumi NAKANISHI, Kazuhiko SAKATA
  • Regulatable promoter
    Patent number: 9512432
    Abstract: A method of producing a protein of interest (POI) by culturing a recombinant eukaryotic cell line comprising an expression construct comprising a regulatable promoter and a nucleic acid molecule encoding a POI under the transcriptional control of said promoter, comprising the steps a) cultivating the cell line with a basal carbon source repressing the promoter, b) cultivating the cell line with a limited amount of a supplemental carbon source de-repressing the promoter to induce production of the POI at a transcription rate of at least 15% as compared to the native pGAP promoter, and c) producing and recovering the POI; and further an isolated regulatable promoter and a respective expression system.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: December 6, 2016
    Assignee: Lonza Ltd.
    Inventors: Diethard Mattanovich, Brigitte Gasser, Michael Maurer, Roland Prielhofer, Joachim Klein, Jana Wenger
  • Method for preparation of cyano compounds of the 13th group with a lewis acid
    Patent number: 9458180
    Abstract: The invention discloses a method for preparation of cyano compounds of the 13th group of the periodic table with 1, 2, 3 or 4 cyano residues, represented by formula (I): [Catn+][Z1F4-m(CN)m)?]n by a reaction of [(Z1F4)?] with trimethylsilylcyanide in the presence of a Lewis acid and in the presence of the cation Catn+; Cat2+ is a cation, Z1 is B, Al, Ga, In or Tl, m is 1, 2, 3 or 4 and n is 1, 2, 3 or 4.
    Type: Grant
    Filed: September 23, 2014
    Date of Patent: October 4, 2016
    Assignee: Lonza Ltd.
    Inventors: Katharina Sievert, Axel Schulz, Jorg Harloff, Stefan Ellinger, Christoph Taeschler, Cornelia Zur Taeschler
  • Method for preparation of medetomidine with chloroacetone
    Patent number: 9434694
    Abstract: The invention discloses a method for the preparation of medetomidine starting from 1-bromo 2,3-dimethylbenzene and chloroacetone.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: September 6, 2016
    Assignee: Lonza Ltd.
    Inventors: Florencio Zaragoza Doerwald, Anna Kulesza, Stephan Elzner, Robert Bujok, Zbigniew Wrobel, Krzysztof Wojciechowski
  • Process for the recovery of betaines from electrodialysis waste stream
    Patent number: 9415346
    Abstract: The present invention discloses a process for the recovery of betaines from electrodialysis (ED) waste streams, whereby said waste streams are treated with a pressure driven membrane process.
    Type: Grant
    Filed: February 3, 2010
    Date of Patent: August 16, 2016
    Assignee: Lonza Ltd.
    Inventors: Markus Bicker, Miguel Angel Caraucán Dávila
  • Process for the production of carnitine from ?-lactones
    Patent number: 9394238
    Abstract: The invention relates to a method for the production of L-carnitine, wherein a ?-lactone, which is a 4-(halomethyl)oxetane-2-one, is converted into carnitine with trimethylamine (TMA), wherein the ?-lactone is not subjected to a basic hydrolysis step before being contacted with the trimethylamine. The invention also relates to a carnitine having a unique impurity profile.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: July 19, 2016
    Assignee: LONZA LTD.
    Inventors: Paul Hanselmann, Ellen Klegraf
  • Composition comprising arabinogalactan and polyphenols from larch trees
    Patent number: 9393259
    Abstract: The present invention includes a composition and method of treatment having arabinogalactan and polyphenols from larch trees for the use in prophylactic treatment of upper respiratory tract infections. The invention also includes treatment using such composition.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: July 19, 2016
    Assignee: Lonza Ltd.
    Inventors: Ulla Freitas, Bryan Rodriguez
  • Halogenated diethyltoluenediamines
    Patent number: 9340487
    Abstract: Disclosed are halogenated diethyltoluenediamines of formula wherein either R1 is an amino group and R2 is chlorine or bromine, or R2 is an amino group and R1 is chlorine or bromine, and isomeric mixtures thereof. The halogenated diethyltoluenediamines of formula I are useful as chain extenders for polyurethanes and hardeners for epoxy resins having a relatively long gel time.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: May 17, 2016
    Assignee: LONZA LTD.
    Inventors: Stefan Ellinger, Gaetano La Delfa, Constanze Franzke
  • Preparation of 3,5-dioxo hexanoate ester in two steps
    Patent number: 9296718
    Abstract: The invention discloses a method for the preparation of tert-butyl 6-chloro-3,5-dioxohexanoate from Meldrum's acid derivative and its use for the preparation of tert-butyl (4R,6S)-(6-hydroxymethyl-2,2-dimethyl-1,3-dioxan-4-yl)acetate (BHA), Rosuvastatin and Atorvastatin.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: March 29, 2016
    Assignee: Lonza Ltd
    Inventors: Christian Noti, Guixian Hu, Barry Jackson
  • Process for the production of methylbutynol
    Patent number: 9284243
    Abstract: Subject of the invention is a process for the production of methylbutynol, wherein the process comprises at least one pervaporation step. In a preferred embodiment, the process comprises the steps of (a) providing a feed composition comprising methylbutynol and water, (b) subjecting the feed composition to distillation in a distillation device, (c) removing a sidestream from the distillation device, the sidestream having a higher water content than the feed composition, and (d) subjecting said sidestream to pervaporation, thereby reducing the water content. The invention also relates to uses and devices relating to the inventive process.
    Type: Grant
    Filed: July 11, 2013
    Date of Patent: March 15, 2016
    Assignee: LONZA LTD
    Inventors: Stefan Ottiger, Thomas Scholl, Stefan Stoffel, Klaus Kalbermatter, Andreas Klein, Kishore Nedungadi
  • Process for the production of 4-chloroacetoacetyl chloride, 4-chloroacetoacetic acid esters, amides and imides
    Patent number: 9227905
    Abstract: The invention relates to process for the continuous production of 4-chloroacetoacetyl chloride, comprising the steps of (a) feeding diketene and chlorine into a thin film reactor and (b) reacting the diketene and chlorine to obtain 4-chloroacetoacetyl chloride. The invention also relates to a process for the production of 4-chloroacetoaceticacid ester, 4-chloroacetoaceticacid amide or 4-chloroacetoaceticacid imide from 4-chloroacetoacetyl chloride obtained according to the inventive process.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: January 5, 2016
    Assignee: LONZA LTD.
    Inventors: Ellen Klegraf, Miguel Angel Caraucan Davila