Patents Assigned to Mallinckrodt Inc.
  • Crystalline forms of Fentanyl Alkaloid
    Publication number: 20100076198
    Abstract: The present invention provides crystalline forms of fentanyl alkaloid and methods for preparing crystalline forms of fentanyl alkaloid.
    Type: Application
    Filed: September 16, 2009
    Publication date: March 25, 2010
    Applicant: Mallinckrodt Inc.
    Inventor: Gary A. Nichols
  • Polymorphs of 6-Beta-Naltrexol
    Publication number: 20100076007
    Abstract: The present invention provides polymorphs of 6-beta-naltrexol and process for their preparation. In particular, the present invention provides crystalline forms of the free base of 6-beta-naltrexol and processes for their preparation. The present invention also provides crystalline and amorphous forms of the hydrochloride salt of 6-beta-naltrexol and processes for their preparation.
    Type: Application
    Filed: September 21, 2009
    Publication date: March 25, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Jian Bao, Gary A. Nichols
  • Bifunctional tridentate pyrazolyl containing ligands for re and tc tricarbonyl complexes
    Patent number: 7682601
    Abstract: The present invention relates to a chelating agent of the general formula: (I), wherein m is 0 or 1; X is NR4 or S; Y is SR5, NHR5 or P(R5)2; R1 and R3 are the same or different and are selected from H, alkyl or aryl; R2 is H, COOH, NHR6 or (CH2)nCOOR6; R4 is H, alkyl, aryl, (CH2)nCOOR6 or (CH2)nOR6; R5 is H, alkyl, aryl, (CH2)nCOOR6 or (CH2)nOR6, R6 is H, alkyl or aryl; n is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10; and when R1?R3?CH3, R2, R4 and R5 are not all three H. The invention further relates to a method and kit for the preparation of radiolabeled biomolecules while using the chelating agent.
    Type: Grant
    Filed: April 15, 2004
    Date of Patent: March 23, 2010
    Assignee: Mallinckrodt Inc.
    Inventors: Isabel Rego Santos, Joao Domingos Galamba Correia, Antonio Manuel Rocha Paulo, Susana Alves, Rute Vitor
  • Multiple cannula systems and methods
    Patent number: 7681576
    Abstract: The preferred embodiments provide, e.g., a high quality flexible tracheostomy tube assembly including an outer tracheostomy cannula and a disposable, flexible inner cannula. In preferred embodiments, the product provides a single patient use, sterile device.
    Type: Grant
    Filed: May 6, 2003
    Date of Patent: March 23, 2010
    Assignee: Mallinckrodt Inc.
    Inventors: Ralph Thomas, Luigi Tateo, Duane L. Horton, Steven M. Brackney
  • Processes for the Synthesis of Five and Six Membered Heterocyclic Rings
    Publication number: 20100069639
    Abstract: The present invention provides processes for the synthesis of five and six membered rings. In particular, the present invention provides processes for the synthesis of five and six membered rings in alkaloids.
    Type: Application
    Filed: September 14, 2009
    Publication date: March 18, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Peter X. Wang, Tao Jiang, David W. Berberich
  • Luminescent metal complexes for monitoring renal function
    Patent number: 7674902
    Abstract: Some embodiments of the present invention may be said to be directed to metal complexes of Formula I, wherein at least one of X1, X2, X3, R1, R2, R3, R4 and R5 is what may be characterized as an antenna capable of providing (e.g., absorbing and/or emitting) an appropriate electromagnetic signal. Some embodiments of the present invention are directed to ligands corresponding to metal complexes of Formula I. Some embodiments of the invention are directed to methods of determining renal function using at least one metal complex of Formula I.
    Type: Grant
    Filed: August 3, 2005
    Date of Patent: March 9, 2010
    Assignee: Mallinckrodt Inc.
    Inventors: Raghavan Rajagopalan, Richard B. Dorshow, Dennis A. Moore
  • Composition of and Method for Preparing Orally Disintegrating Tablets Containing a High Dose of Pharmaceutically Active Ingredients
    Publication number: 20100055179
    Abstract: The present invention is directed to improved compositions and methods for preparing orally disintegrating tablets (ODTs). In one aspect of the present invention, the ODT further contains at least one active pharmaceutical ingredient (API). In another aspect of the present invention, the ODT contains a high load of at least one API. Specifically, the ODTs described in this invention containing a high load of API can accommodate up to about 70% w/w of active pharmaceutical ingredient in a unit dosage, while exhibiting the desirable attributes of fast disintegration time, acceptable hardness and friability for push through blister and bottle packages, and acceptable mouth feel.
    Type: Application
    Filed: December 20, 2007
    Publication date: March 4, 2010
    Applicant: MALLINCKRODT INC.
    Inventors: Jae Han Park, Stephen H. Wu, Kevin M. Holman, Glenn A. Bish, Donald G. Krieger, Daniel S. Ramlose
  • Substituted Berbines and Processes for their Synthesis
    Publication number: 20100056789
    Abstract: The present invention provides processes for the synthesis of substituted berbine compounds. Also provided are intermediates used in the synthesis of substituted berbine compounds.
    Type: Application
    Filed: September 2, 2009
    Publication date: March 4, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Peter X. Wang, Frank W. Moser, Gary L. Cantrell, Christopher W. Grote
  • Methods for Controlling Medical Fluid Injections
    Publication number: 20100056909
    Abstract: The present invention is directed to control of medical fluid injection systems. For instance, in some embodiments, an injection protocol may be initiated, and an actual flow rate of the medical fluid utilized in the injection protocol may be adjusted based, at least in part, on an inherent system elasticity of the injection system.
    Type: Application
    Filed: November 10, 2009
    Publication date: March 4, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Frank M. Fago, James E. Knipfer
  • CONTRAST CONTAINER HOLDER AND METHOD TO FILL SYRINGES
    Publication number: 20100051135
    Abstract: The filling of a syringe can be performed at a faster rate using a filling sequence which expels air from the fill tube before filling the syringe. A similar method is used when changing contrast containers during a filling sequence to ensure that all the air is expelled from the fill tube before filling resumes with the new contrast container. Additionally, by including a contrast container holder that is affixed to an injector head and holds the container near the syringe tip, the filling sequence can be accomplished without requiring the operator to hold the contrast container during the sequence.
    Type: Application
    Filed: November 12, 2009
    Publication date: March 4, 2010
    Applicant: MALLINCKRODT INC.
    Inventors: Frank M. Fago, Robert G. Bergen, James F. Farmer
  • Crystalline Forms of Sufentanil
    Publication number: 20100056574
    Abstract: The present invention provides crystalline forms of sufentanil citrate and methods for preparing crystalline forms of sufentanil citrate.
    Type: Application
    Filed: August 25, 2009
    Publication date: March 4, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Brian K. Cheng, Gary A. Nichols
  • Method and system for separation and purification of at least one narcotic alkaloid using reverse phase preparative chromatography
    Patent number: 7671203
    Abstract: An apparatus and method for separating at least one narcotic alkaloid that includes loading a stationary phase media into a high performance preparative liquid chromatography column, feeding a crude narcotic alkaloid solution into the chromatographic column, applying a mobile phase to the chromatographic column, and recovering a narcotic alkaloid eluate from the chromatographic column. The narcotic eluates arc collected and treated separately from each other. Each separated alkaloid, however, has sufficient recovery and purity.
    Type: Grant
    Filed: February 18, 2003
    Date of Patent: March 2, 2010
    Assignee: Mallinckrodt Inc.
    Inventor: Enrico Anthony Antonini
  • N-demethylation of N-methyl morphinans
    Patent number: 7671204
    Abstract: The present invention provides a synthetic process for the N-demethylation of N-methyl morphinans. In particular, the invention provides improved synthetic methods for the preparation of N-demethylated morphinan compounds that may be employed as starting materials, for example, commonly available N-methyl opiates such as oripavine and thebaine, and C(3)-protected hydroxy derivatives of oripavine.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: March 2, 2010
    Assignee: Mallinckrodt Inc.
    Inventors: Peter X. Wang, Tao Jiang, Gary L. Cantrell, David W. Berberich
  • MULTICOMPONENT ASSEMBLIES HAVING ENHANCED BINDING PROPERTIES FOR DIAGNOSIS AND THERAPY
    Publication number: 20100041827
    Abstract: An organized mobile multicomponent conjugate (OMMC) and method of using to enhance binding of weakly binding compounds to a target. A lamellar structure containing at least two binding compounds is assembled under conditions in which the binding compounds self-regulate in or on the lamellar structure, forming a cooperative ensemble that is capable of binding with enhanced affinity to a complementary affinity site on a target. Each binding compound is bound to the lamellar surface, and may be connected by a linker. The OMMC may contain an effector molecule, such as a diagnostic or therapeutic agent, for administration to a patent who is then diagnosed or treated using the effector molecule.
    Type: Application
    Filed: October 23, 2009
    Publication date: February 18, 2010
    Applicant: Mallinckrodt, Inc.
    Inventors: Gary L. Cantrell, B. Daniel Burleigh
  • MULTICOMPONENT ASSEMBLIES HAVING ENHANCED BINDING PROPERTIES FOR DIAGNOSIS AND THERAPY
    Publication number: 20100041826
    Abstract: An organized mobile multicomponent conjugate (OMMC) and method of using to enhance binding of weakly binding compounds to a target. A lamellar structure containing at least two binding compounds is assembled under conditions in which the binding compounds self-regulate in or on the lamellar structure, forming a cooperative ensemble that is capable of binding with enhanced affinity to a complementary affinity site on a target. Each binding compound is bound to the lamellar surface, and may be connected by a linker. The OMMC may contain an effector molecule, such as a diagnostic or therapeutic agent, for administration to a patent who is then diagnosed or treated using the effector molecule.
    Type: Application
    Filed: October 23, 2009
    Publication date: February 18, 2010
    Applicant: MALLINCKRODT INC.
    Inventors: Gary L. Cantrell, B. Daniel Burleigh
  • Process for the Preparation of Quaternary N-Alkyl Morphinan Alkaloid Salts
    Publication number: 20100035910
    Abstract: An improved process for the N-alkylation of tertiary morphinan alkaloid bases to form the corresponding quaternary morphinan alkaloid derivatives.
    Type: Application
    Filed: September 3, 2009
    Publication date: February 11, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Peter X. Wang, Gary L. Cantrell, Robert E. Halvachs, Kevin R. Roesch, Henry J. Buehler, Joseph P. Haar
  • Injector Having Low Input Power
    Publication number: 20100030153
    Abstract: A powered injector that stores energy at a low rate when not in use and delivers energy at a high rate during injection. Energy may be stored in a highly responsive energy storage device, such as a capacitor, for rapid delivery of power to the injector motor. In certain embodiments, wires connecting the powered injector to a power supply may be relatively small and inexpensive because the current and voltage loads placed on the wires are relatively low.
    Type: Application
    Filed: September 25, 2007
    Publication date: February 4, 2010
    Applicant: MALLINCKRODT INC.
    Inventor: Charles S. Neer
  • RECEPTOR-AVID EXOGENOUS OPTICAL CONTRAST AND THERAPEUTIC AGENTS
    Publication number: 20100022449
    Abstract: Cyanine and indocyanine dye compounds and bioconjugates are disclosed. The present invention includes several cyanine and indocyanine dyes, including bioconjugates of the same, with a variety of bis- and tetrakis (carboxylic acid) homologues. The compounds of the invention may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of compounds of the invention allows favorable delivery to tumor cells as compared to larger molecular weight imaging agents. Further, use of a biocompatible organic solvent such as dimethylsulfoxide may be said to assist in maintaining the fluorescence of compounds of the invention.
    Type: Application
    Filed: May 21, 2009
    Publication date: January 28, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Samuel I. Achilefu, Raghavan Rajagopalan, Richard B. Dorshow, Joseph E. Bugaj
  • Pyrazine Derivatives and Uses Thereof
    Publication number: 20100021382
    Abstract: Disclosed herein are pyrazine derivatives and methods of using the same.
    Type: Application
    Filed: January 12, 2009
    Publication date: January 28, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Richard B. Dorshow, John Freskos, William L. Neumann, Amruta Reddy Poreddy, Raghavan Rajagopalan
  • Pyrazine derivatives, Methods of use, and methods for preparing same
    Publication number: 20100010223
    Abstract: The present invention relates to methods for producing N,N?-alkylated diaminopyrazines.
    Type: Application
    Filed: January 7, 2009
    Publication date: January 14, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Richard B. Dorshow, John Freskos, William L. Neumann, Amruta Reddy Poreddy, Raghavan Rajagopalan