Abstract: A method for determining the risk of acute kidney injury (AKI) in a mammal following cardiac surgery is provided. The method comprises determining the sample value of IL-6 or hFABP concentration, or the ratio of IL-6 to IL-10, in a biological sample from the mammal, either prior to cardiac surgery or within 6 hours following surgery; comparing the sample value to a corresponding reference value; and determining that the mammal is at risk of acute kidney injury following cardiac surgery if the sample value is greater than the corresponding reference value.
Type:
Grant
Filed:
March 15, 2017
Date of Patent:
October 17, 2023
Assignee:
MCMASTER UNIVERSITY
Inventors:
Peter Kavsak, Richard Whitlock, John Eikelboom, Chirag R. Parikh
Abstract: A novel macroscale, contactless, label-free method to print in situ three-dimensional (3D) particle assemblies of different morphologies and sizes is demonstrated using non-adherent (blood) and adherent (MCF-7 and HUVEC) cells. This method of manipulating particles such as cells or biological moleules does not necessarily require the use of nozzles that can contaminate the cell suspension, or to which cells can adhere. Instead, the intrinsic diamagnetic properties of particles such as cells are used to magnetically manipulate them in situ in a nontoxic paramagnetic medium, creating various shapes such as (a) rectangular bar, (b) three-pointed star, and (c) spheroids of varying sizes. A normal distribution of 3D cell structures is produced when formed through magnetic assembly. The use of this method in co-culturing of different cell lines is also demonstrated.
Type:
Grant
Filed:
November 1, 2018
Date of Patent:
October 17, 2023
Assignee:
McMaster University
Inventors:
Abdel Rahman Abdel Fattah, Rakesh Prasad Sahu, Fei Geng, Sarah Mishriki, Elvira Meleca, Ishwar K. Puri, Suvojit Ghosh
Abstract: An improved system for assessing cognitive function is described that uses tracked electrical activity of the brain of the individuals in response to a specific sequence of stimuli in generating data sets, which, for example, can be encapsulated as a data structure. The data sets can include tracked specific response types, at different times and amplitudes, including, but not limited to, event related potential signal components. Brainwave features including, event related potentials, are tracked in relation to both pre-attentive brain responses and consciously controlled attention responses.
Type:
Application
Filed:
June 9, 2023
Publication date:
October 12, 2023
Applicant:
McMaster University
Inventors:
John Francis Connolly, Kyle Ingram Ruiter, Rober Boshra
Abstract: Provided herein are methods and compositions for modulating a microorganism's response to an antimicrobial agent. In one embodiment, the method comprises contacting the microorganism with an antimicrobial agent and bicarbonate. In one embodiment, provided herein are methods for treating a microbial infection comprising administering to a subject in need an effective amount of (i) bicarbonate and (ii) an antimicrobial agent. Also provided herein are methods of screening for antimicrobial compounds.
Type:
Grant
Filed:
January 25, 2021
Date of Patent:
October 10, 2023
Assignee:
McMaster University
Inventors:
Eric Brown, Maya Farha, Craig MacNair, Jonathan Stokes
Abstract: Described herein is a hybrid biological membrane comprising an endogenous bilayer doped with one or more synthetic lipid molecules. Also described herein is a method of preparing a hybrid biological membrane, the method comprising doping an endogenous bilayer with one or more synthetic lipid molecules.
Type:
Grant
Filed:
December 18, 2020
Date of Patent:
October 3, 2023
Assignee:
McMaster University
Inventors:
Maikel C. Rheinstädter, Sebastian Himbert, Matthew Blacker
Abstract: The present invention relates to methods of detecting CD200L in a female subject from a secretory phase biological sample. Increased levels of CD200L have been determined to be associated with endometriosis. CD200L is therefore a useful biomarker for the diagnosis of endometriosis and a useful target for therapeutic intervention.
Type:
Grant
Filed:
April 30, 2020
Date of Patent:
August 8, 2023
Assignee:
McMaster University
Inventors:
David Alexander Clark, Warren George Foster
Abstract: This disclosure relates to biosensors, and in particular, biosensors based on nucleic acid cleaving enzymes such as ribonucleotide-cleaving DNAzymes for the detection of analytes, and methods of use.
Type:
Grant
Filed:
February 19, 2021
Date of Patent:
July 4, 2023
Assignee:
McMaster University
Inventors:
Carlos Filipe, Yingfu Li, Sahar Esmaeili Samani, Dingran Chang, Erin M. McConnell, Meghan Rothenbroker
Abstract: The present application describes a two-step drug delivery formulation comprising a high affinity interaction between a drug conjugate and a compound, followed by introduction of a second compound with higher affinity to the drug conjugate to facilitate drug release. Delivery methods and specific interactions are also described.
Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y182T mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
Type:
Grant
Filed:
October 12, 2018
Date of Patent:
May 9, 2023
Assignee:
McMaster University
Inventors:
Christopher W. Helsen, Jonathan Bramson, Anna Dvorkin-Gheva, Galina F. Denisova, Ksenia Bezverbnaya, Kenneth Anthony Mwawasi
Abstract: An aluminum alloy for near net shaped casting of structural components is disclosed. The alloy contains 2 to 10 wt. % Zn, 0.5 to 5 wt. % Mg, 0.5 to 5 wt. %) Fe, optionally Cu, Ti, Sr, Be, Zr, V, Cr, Sc, Na, Si, Mn, Mo, B, and Ni, with balance aluminum. The alloy may be subjected to heat treatment selected from the group consisting of solutionizing, incubation, aging, and two or more heat treatment steps.
Abstract: An approach to control or monitoring of battery operation makes use of an artificial neural network (ANN), which receives one or more battery attributes for a Lithium ion (Li-ion) battery, and determines, based on the received one or more battery attributes, a state-of-charge (SOC) and/or a state-of-health (SOH) estimate for the Li-ion battery. The ANN includes at least one of a recurrent neural network (RNN) and a convolutional neural network (CNN), and the series of values of the battery attributes includes at one of battery voltage values, battery current values, and battery temperature values.
Type:
Grant
Filed:
November 19, 2019
Date of Patent:
April 25, 2023
Assignees:
The Trustees of Columbia University in the City of New York, McMaster University
Abstract: An improved system for assessing cognitive function is described that uses tracked electrical activity of the brain of the individuals in response to a specific sequence of stimuli in generating data sets, which, for example, can be encapsulated as a data structure. The data sets can include tracked specific response types, at different times and amplitudes, including, but not limited to, event related potential signal components. Brainwave features including, event related potentials, are tracked in relation to both pre-attentive brain responses and consciously controlled attention responses.
Type:
Application
Filed:
October 28, 2022
Publication date:
February 16, 2023
Applicant:
McMaster University
Inventors:
John Francis CONNOLLY, Kyle Ingram Ruiter, Rober Boshra
Abstract: A biosensor detector device is disclosed suitable for use in measuring membrane fluidity or membrane permeability. The biosensor detector device is formed of a solid substrate having a lipid bilayer compatible surface, a multi-lamellar lipid membrane structure derived from a biological cell and localized on the lipid bilayer compatible surface, an aqueous layer interposed between each lipid bilayer of the multi-lamellar lipid membrane structure. The biological membrane is derived from human red blood cells and localized on the lipid bilayer compatible surface. An electrode forming all or part of the lipid bilayer compatible surface may be used to detect disruptions in the multi-lamellar lipid membrane structure and hemolytic activity in a test sample.
Type:
Grant
Filed:
December 21, 2018
Date of Patent:
February 14, 2023
Assignee:
McMaster University
Inventors:
Maikel Rheinstadter, Sebastian Himbert, Richard Alsop, Jose Moran-Mirabal, Sokunthearath Saem, Dawn Bowdish
Abstract: Provided herein are nucleic acid-cleaving catalytic nucleic acid probes, biosensors and lateral flow biosensor devices and methods and kits of using the probes, biosensors and lateral flow biosensor devices for detecting an analyte present on or generated from a microorganism in a test sample, including Helicobacter pylori and methods for determining whether a subject has a Helicobacter pylori infection.
Type:
Grant
Filed:
May 15, 2020
Date of Patent:
January 10, 2023
Assignee:
McMaster University
Inventors:
John D. Brennan, Yingfu Li, Monsur Ali, Carlos Filipe, Michael Gregory Wolfe
Abstract: The present application relates to a method for improving analytical efficiency and cost effectiveness of oxygen isotope analysis of an aqueous sample. In particular, the present application relates to a method of determining an oxygen isotope composition of an aqueous sample by (a) equilibrating the aqueous sample with CO2 gas wherein the aqueous sample comprises an effective amount of carbonic anhydrase (CA) enzyme; and (b) measuring the oxygen isotope composition of the CO2 at equilibrium, wherein the oxygen isotope composition of the CO2 corresponds to the oxygen isotope composition of the aqueous sample.
Type:
Grant
Filed:
October 29, 2019
Date of Patent:
January 3, 2023
Assignee:
McMaster University
Inventors:
Sang-Tae Kim, Nicolas Randazzo, Martin Knyf
Abstract: The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (I) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted. The present application also includes compounds of Formula (I).
Type:
Grant
Filed:
May 28, 2021
Date of Patent:
November 29, 2022
Assignee:
McMaster University
Inventors:
Jakob Magolan, Nicholas Jentsch, Xiong Zhang, Mathew Piotrowski
Abstract: The present application is in the field of imaging reagents. In particular, the present application relates to labelled fluorocarbon imaging reagents, the preparation of the reagents, and their uses for imaging such as PET scanning.
Type:
Grant
Filed:
June 4, 2018
Date of Patent:
November 8, 2022
Assignees:
Sunnybrook Research Institute, McMaster University
Abstract: The present application relates to a biosensor for detecting an analyte comprising a first and second working electrode; a detection probe functionalized on the first working electrode, the detection probe comprising a reporter moiety and a recognition moiety for an analyte; a capture probe functionalized on the second working electrode; and a counter electrode. Each working electrode is configured to provide a change in signal if the analyte is present. The biosensor can be used to detect an analyte in a sample.
Type:
Application
Filed:
March 20, 2020
Publication date:
October 6, 2022
Applicant:
MCMASTER UNIVERSITY
Inventors:
Leyla SOLEYMANI, Richa PANDEY, Yingfu LI, Todd HOARE, Dingran CHANG, Yang LU
Abstract: A method for autonomous path planning triggered by freeway rubbernecking includes obtaining gaze directions of drivers of a plurality of connected vehicles in a region of a road. The method also includes determining whether an average speed of the plurality of connected vehicles in the region is less than a predetermined speed. The method further includes controlling mobility of one or more of the plurality of connected vehicles in response to determining that the gaze directions of one or more drivers of the plurality of connected vehicles deviate from the moving direction of the connected vehicles and determining that the average speed of the connected vehicles is less than the predetermined speed.
Type:
Application
Filed:
March 24, 2021
Publication date:
September 29, 2022
Applicants:
Toyota Motor Engineering & Manufacturing North America, Inc., McMaster University
Inventors:
Baik Hoh, Seyhan Ucar, Kentaro Oguchi, Hao Yang
Abstract: A method of operating a traffic management system may comprise identifying a vehicle queue in a first lane of a road based on sensor data from one or more connected vehicles traveling along the road, determining driving instructions for a connected vehicle within a queue management region in a second lane, adjacent to the first lane, to create a gap in front of the connected vehicle for a vehicle in the vehicle queue to change lanes into the gap, and transmitting the driving instructions to the connected vehicle.
Type:
Application
Filed:
March 24, 2021
Publication date:
September 29, 2022
Applicants:
Toyota Motor Engineering & Manufacturing North America, Inc., McMaster University
Inventors:
Baik Hoh, Hao Yang, Seyhan Ucar, Kentaro Oguchi