Abstract: A switched reluctance machine has a stator core salient with stator poles disposed concentrically with a rotor that is salient with rotor poles. A plurality of coil windings are wound about the stator core so that a pair of windings are adjacent each of the stator poles. The pair of coil windings induces magnetic flux in the adjacent stator poles and the rotor rotates to align the rotor poles with the stator poles having the induced magnetic flux. The rotor is rotatable at high speeds of up to 50,000 RPM and the coil windings can be directly cooled.

Abstract: A method of image projection including selecting a set of desired chromaticity coordinates of a projection system, the projection system including a plurality of laser sources; determining a set of parameters of an expected operational environment; and configuring each laser source to have a power ratio and a power spectrum density function generating a normalized power spectrum density function of the projection system having the set of desired chromaticity coordinates and a wavelength diversity factor of at least 2 in the expected operational environment. A projection system including an input device configured to receive a set of desired chromaticity coordinates and a set of operational parameters; a plurality of laser sources each having a power ratio and a power spectrum density function configured to generate a normalized power spectrum density function producing the set of desired chromaticity coordinates and a wavelength diversity factor of at least 2.

Abstract: This disclosure relates to the field of energy recovery systems, and more particularly to exhaust heat recovery devices and exhaust flow control devices.

Abstract: The present application describes a two-step drug delivery formulation comprising a high affinity interaction between a drug conjugate and a compound, followed by introduction of a second compound with higher affinity to the drug conjugate to facilitate drug release. Delivery methods and specific interactions are also described.

Abstract: The present application relates to methods of using compounds of Formulae (I) and (II): for treatment of various cancers. The application further relates to pharmaceutical compositions and uses comprising the compounds of the application.

Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.

Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.

Abstract: This application provides constructs for use as complex cell systems of a desired shape and methods of preparing thereof. The constructs comprise cells contained within a biocompatible gel matrix deposited on a scaffold material optionally cut into defined patterns and impregnated with a crosslinking agent, wherein the biocompatible gel matrix crosslinks upon contact with the crosslinking agent on the scaffold. By stacking multiple alternating layers of the scaffold material cut into defined patterns and the biocompatible gel matrix deposited on the scaffold in defined patterns, complex 3D structures with features like embedded channels are be formed. These complex cell system constructs can be used as in vitro models of biological processes.

Abstract: The present application relates to a method for improving analytical efficiency and cost effectiveness of oxygen isotope analysis of an aqueous sample. In particular, the present application relates to a method of determining an oxygen isotope composition of an aqueous sample by (a) equilibrating the aqueous sample with CO2 gas wherein the aqueous sample comprises an effective amount of carbonic anhydrase (CA) enzyme; and (b) measuring the oxygen isotope composition of the CO2 at equilibrium, wherein the oxygen isotope composition of the CO2 corresponds to the oxygen isotope composition of the aqueous sample.

Abstract: Biocompatible block copolymer micelles for use in mucoadhesive drug delivery are provided. The micelles comprise a degradable hydrophobic polymer, a degradable synthetic hydrophilic polymer and a mucoadhesive polymer. The micelles are particularly useful for ophthalmic uses.

Abstract: Provided herein are aptamers, aptamer probes and biosensor systems that detect C. difficile glutamate dehydrogenase (GDH). Also provided are methods of detecting C. difficile GDH using the aptamers, probes and biosensors and methods of determining whether a subject has a C. difficile infection.

Abstract: The present application describes a two-step drug delivery formulation comprising a high affinity interaction between a drug conjugate and a compound, followed by introduction of a second compound with higher affinity to the drug conjugate to facilitate drug release. Delivery methods and specific interactions are also described.

Abstract: Two isoforms of thyroid receptor alpha (THR?1 and THR?2) have been found to be associated with the growth of cancer. Use of inhibitors of THR?1 (Formula I) and/or agonists of THR?2 (Formula II) in the treatment of such cancers is disclosed. Treatment of other disorders associated with such receptors is also contemplated, as is the use of diagnostic methods for predicting therapeutic outcomes based on the levels of expression of THR?1 and THRa?2 in a tissue sample.

Abstract: The present application relates to sensors and methods for detecting and/or quantifying an oxidant such as free chlorine in a liquid sample such as drinking water. The sensors comprise a first electrode, a second electrode and a composite material between and connecting the first electrode and the second electrode, the composite material comprising a semiconductor and a redox-switchable organic compound associated therewith. The methods comprise exposing the liquid sample to the sensor under conditions to oxide the redox-switchable organic compound and analyzing a resulting change in current.

Abstract: A method of image projection including selecting a set of desired chromaticity coordinates of a projection system, the projection system including a plurality of laser sources; determining a set of parameters of an expected operational environment; and configuring each laser source to have a power ratio and a power spectrum density function generating a normalized power spectrum density function of the projection system having the set of desired chromaticity coordinates and a wavelength diversity factor of at least 2 in the expected operational environment. A projection system including an input device configured to receive a set of desired chromaticity coordinates and a set of operational parameters; a plurality of laser sources each having a power ratio and a power spectrum density function configured to generate a normalized power spectrum density function producing the set of desired chromaticity coordinates and a wavelength diversity factor of at least 2.

Abstract: A device for manipulating magnetic particles, and the method of fabricating and use thereof. The device includes a substrate; a conductive element formed onto the substrate in a pattern shaped to enhance a magnetic field generated in response to an applied current; an insulating layer to isolate the conductive element from a magnetic element; and a magnetic element formed onto the insulating layer to enhance a magnetic force resulting from the magnetic field generated by the conductive element. The magnetic element can be shaped similarly to the conductive element, and edges of the magnetic element are substantially aligned with edges of the conductive element. During fabrication, the substrate and the conductive element can be heated to cause the substrate to shrink thereby resulting in a wrinkled structure at the conductive element. The device can be used to manipulate the magnetic particles within a biological sample, such as cells and/or biomolecules.

Abstract: The present disclosure claims an apparatus, a method and a system for the calibration of a streak camera. A plurality of fiber optic cables is bundled together such that the input ends and the output ends of the fibers are grouped together. Each fiber in the bundle has a distinct and characteristic time taken for light to traverse from the input end to the output end known by the observer. This characteristic time depends on the physical and optical properties of the fibers selected. Calibration light is collected by the fiber input face and travels through the individual fibers in a characteristic time. Individual light pulses will subsequently be detected by the streak camera which converts the time profile of the incoming light pulses into a spatial profile. An observer can compare the observed spatial separation profile to an expected spatial separation profile for calibration.

Abstract: In various example embodiments, hybrid waveguide devices are disclosed based on a silicon nitride waveguide conformally coated with a tellurium oxide layer. A tellurium oxide layer is deposited over a silicon nitride waveguide such that the tellurium oxide layer forms a conformal layer that inherits the underlying shape of the silicon nitride waveguide, thereby forming a conformal raised region above the silicon nitride waveguide, while also forming planar regions that extend laterally from the silicon nitride waveguide. The present example hybrid waveguide structures enable the formation of a guided single mode that extends from the raised region of the tellurium oxide layer that resides above the silicon nitride waveguide into the silicon nitride waveguide, and the dimensions of the structure may be selected such that a majority of the optical mode is confined within the tellurium oxide layer, at least over a portion of the infrared region.

Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

Abstract: A method of restoring activity in phenylalanine hydroxylase is provided. The method comprises exposing the phenylalanine hydroxylase to shikimic acid, a functionally equivalent analog thereof, a pharmaceutically acceptable salt of shikimic acid or analog thereof, or combinations thereof.