Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Type:
Application
Filed:
March 15, 2013
Publication date:
April 23, 2015
Applicant:
Moderna Therapeutics, Inc.
Inventors:
Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Sayda M. Elbashir, Matthias John, Atanu Roy, Susan Whoriskey, Kristy M. Wood, Paul Hatala, Jason P. Schrum, Kenechi Ejebe, Jeff Lynn Ellsworth, Justin Guild
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Type:
Grant
Filed:
March 9, 2013
Date of Patent:
April 7, 2015
Assignee:
Moderna Therapeutics, Inc.
Inventors:
Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Sayda M. Elbashir, Matthias John, Atanu Roy, Susan Whoriskey, Kristy M. Wood, Paul Hatala, Jason P. Schrum, Kenechi Ejebe, Jeff Lynn Ellsworth, Justin Guild
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Type:
Application
Filed:
March 9, 2013
Publication date:
March 26, 2015
Applicant:
Moderna Therapeutics, Inc.
Inventors:
Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Sayda M. Elbashir, Matthias John, Atanu Roy, Susan Whoriskey, Kristy M. Wood, Paul Hatala, Jason P. Schrum, Kenechi Ejebe, Jeff Lynn Ellsworth, Justin Guild
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Type:
Application
Filed:
May 19, 2014
Publication date:
September 18, 2014
Applicant:
Moderna Therapeutics, Inc.
Inventors:
Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Type:
Application
Filed:
December 13, 2013
Publication date:
September 11, 2014
Applicant:
MODERNA THERAPEUTICS, INC.
Inventors:
Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey, Ron Weiss
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Type:
Application
Filed:
December 13, 2013
Publication date:
September 11, 2014
Applicant:
MODERNA THERAPEUTICS, INC.
Inventors:
Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey, Ron Weiss
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Type:
Application
Filed:
February 3, 2014
Publication date:
September 4, 2014
Applicant:
MODERNA THERAPEUTICS, INC.
Inventors:
Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey
Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent diseases, disorders or conditions, or to improve a subject's heath or wellbeing.
Type:
Grant
Filed:
August 5, 2011
Date of Patent:
September 2, 2014
Assignee:
Moderna Therapeutics, Inc.
Inventors:
Jason P. Schrum, Stéphane Bancel, Noubar B. Afeyan
Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent diseases, disorders or conditions, or to improve a subject's heath or wellbeing.
Type:
Application
Filed:
May 6, 2014
Publication date:
August 28, 2014
Applicant:
Moderna Therapeutics, Inc.
Inventors:
Jason P. Schrum, Stephane Bancel, Noubar B. Afeyan
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Type:
Application
Filed:
February 3, 2014
Publication date:
August 7, 2014
Applicant:
Moderna Therapeutics, Inc.
Inventors:
Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of signal-sensor polynucleotides, primary transcripts and mmRNA molecules.
Type:
Application
Filed:
December 20, 2013
Publication date:
July 24, 2014
Applicant:
MODERNA THERAPEUTICS, INC.
Inventors:
Stephen G. Hoge, Antonin de Fougerolles, Tirtha Chakraborty
Abstract: Provided are formulations, compositions, kits and methods for delivering biological moieties such as modified nucleic acids into cells to induce, reduce or modulate protein expression in non-human vertebrates.
Type:
Application
Filed:
May 16, 2012
Publication date:
July 24, 2014
Applicant:
MODERNA THERAPEUTICS, INC.
Inventors:
Noubar B. Afeyan, Gregory Sieczkiewicz, Stephane Bancel
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Type:
Application
Filed:
February 3, 2014
Publication date:
July 24, 2014
Applicant:
MODERNA THERAPEUTICS, INC.
Inventors:
Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Type:
Application
Filed:
February 3, 2014
Publication date:
July 17, 2014
Applicant:
MODERNA THERAPEUTICS, INC.
Inventors:
Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of signal-sensor polynucleotides, primary transcripts and mmRNA molecules.
Type:
Application
Filed:
September 30, 2013
Publication date:
July 17, 2014
Applicant:
MODERNA THERAPEUTICS, INC.
Inventors:
Stephen G. Hoge, Tirtha Chakraborty, Joshua P. Frederick, Matthias John, Antonin de Fougerolles
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Type:
Application
Filed:
December 12, 2013
Publication date:
July 17, 2014
Applicant:
MODERNA THERAPEUTICS, INC.
Inventors:
Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey, Sayda M. Elbashir
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Type:
Application
Filed:
February 3, 2014
Publication date:
July 17, 2014
Applicant:
MODERNA THERAPEUTICS, INC.
Inventors:
Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Type:
Application
Filed:
December 12, 2013
Publication date:
July 17, 2014
Applicant:
MODERNA THERAPEUTICS, INC.
Inventors:
Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey, Ron Weiss