Patents Assigned to modeRNA Therapeutics
  • MODIFIED POLYNUCLEOTIDES FOR TREATING PROTEIN DEFICIENCY
    Publication number: 20140194494
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: February 3, 2014
    Publication date: July 10, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey
  • MODIFIED POLYNUCLEOTIDES ENCODING V-MYC AVIAN MYELOCYTOMATOSIS VIRAL ONCOGENE HOMOLOG
    Publication number: 20140193482
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: December 12, 2013
    Publication date: July 10, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey, Ron Weiss
  • MODIFIED POLYNUCLEOTIDES ENCODING CITED4
    Publication number: 20140186432
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: December 12, 2013
    Publication date: July 3, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey, Ron Weiss
  • MODIFIED POLYNUCLEOTIDES FOR TREATING DOLICHYL-PHOSPHATE (UDP-N-ACETYLGLUCOSAMINE) N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE 1 (GLCNAC-1-P TRANSFERASE) PROTEIN DEFICIENCY
    Publication number: 20140179771
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: February 3, 2014
    Publication date: June 26, 2014
    Applicant: Moderna Therapeutics, Inc.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey
  • MODIFIED POLYNUCLEOTIDES ENCODING CD28 MOLECULE
    Publication number: 20140171485
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: December 13, 2013
    Publication date: June 19, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey, Ron Weiss
  • DLIN-KC2-DMA lipid nanoparticle delivery of modified polynucleotides
    Patent number: 8754062
    Abstract: The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: June 17, 2014
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Antonin de Fougerolles, Kristy M. Wood, Sayda M. Elbashir, Jason P. Schrum
  • MODIFIED POLYNUCLEOTIDES ENCODING ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR
    Publication number: 20140161873
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: December 16, 2013
    Publication date: June 12, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey, Ron Weiss
  • MODIFIED POLYNUCLEOTIDES FOR TREATING ARGININOSUCCINATE SYNTHASE 1 PROTEIN DEFICIENCY
    Publication number: 20140155472
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: February 3, 2014
    Publication date: June 5, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey
  • MODIFIED POLYNUCLEOTIDES FOR TREATING LIPASE A, LYSOSOMAL ACID, CHOLESTEROL ESTERASE PROTEIN DEFICIENCY
    Publication number: 20140155475
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: February 3, 2014
    Publication date: June 5, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey
  • MODIFIED POLYNUCLEOTIDES FOR TREATING CYSTIC FIBROSIS
    Publication number: 20140155474
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: February 3, 2014
    Publication date: June 5, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey
  • TERMINALLY MODIFIED RNA
    Publication number: 20140147454
    Abstract: The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules via optimization of their terminal architecture.
    Type: Application
    Filed: October 2, 2013
    Publication date: May 29, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Tirtha Chakraborty, Stephane Bancel, Stephen G. Hoge, Atanu Roy, Antonin de Fougerolles, Noubar B. Afeyan
  • MODIFIED POLYNUCLEOTIDES FOR TREATING PROTEIN DEFICIENCY
    Publication number: 20140148502
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: February 3, 2014
    Publication date: May 29, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey
  • MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS ASSOCIATED WITH BLOOD AND LYMPHATIC DISORDERS
    Publication number: 20140147432
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: December 13, 2013
    Publication date: May 29, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey, Sayda M. Elbashir
  • MODIFIED POLYNUCLEOTIDES ENCODING SIAH E3 UBIQUITIN PROTEIN LIGASE 1
    Publication number: 20140141068
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.
    Type: Application
    Filed: December 16, 2013
    Publication date: May 22, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey, Ron Weiss
  • MODIFIED POLYNUCLEOTIDES ENCODING SEPTIN-4
    Publication number: 20140141067
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.
    Type: Application
    Filed: December 16, 2013
    Publication date: May 22, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey, Ron Weiss
  • Engineered nucleic acids encoding a modified erythropoietin and their expression
    Patent number: 8710200
    Abstract: Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the delivery of biological moieties, and are useful for production of proteins.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: April 29, 2014
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Jason P. Schrum, Noubar B. Afeyan, Gregory J. Sieczkiewicz, Stephane Bancel, Antonin de Fougerolles, Sayda M. Elbashir
  • MODIFIED POLYNUCLEOTIDES ENCODING CASPASE 6
    Publication number: 20140113959
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.
    Type: Application
    Filed: December 16, 2013
    Publication date: April 24, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey, Ron Weiss
  • MODIFIED POLYNUCLEOTIDES ENCODING GRANULYSIN
    Publication number: 20140113960
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.
    Type: Application
    Filed: December 16, 2013
    Publication date: April 24, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey, Ron Weiss
  • MODIFIED POLYNUCLEOTIDES ENCODING HEPATITIS A VIRUS CELLULAR RECEPTOR 2
    Publication number: 20140105966
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: December 13, 2013
    Publication date: April 17, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey, Ron Weiss
  • MODIFIED POLYNUCLEOTIDES ENCODING AQUAPORIN-5
    Publication number: 20140105964
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: December 11, 2013
    Publication date: April 17, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey, Ron Weiss