Patents Assigned to Musculoskeletal Transplant Foundation
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Patent number: 10813743Abstract: Soft tissue repair grafts are provided for supporting, covering, and/or retaining an implant positioned in the body of a subject. The grafts are particularly suitable for use for pre-pectoral breast reconstruction with a breast implant or tissue expander. The grafts include positional notches for more accurate positioning in a subject. The grafts also include at least one cuff element which is folded to form a reinforced folded edge for suturing the graft more securely to adjacent tissues than previously known grafts. The grafts also include a plurality of arcuate slots which form a plurality of circular patterns arranged concentrically about a focal point, thereby enabling the grafts to expand without tearing and to conform more closely to the implant and/or adjacent body tissues such as the breast pocket, than previously known grafts. Acellular dermal matrices are particularly suitable for making the soft tissue repair grafts.Type: GrantFiled: September 7, 2018Date of Patent: October 27, 2020Assignee: Musculoskeletal Transplant FoundationInventors: Aldona Jedrysiak Spiegel, Kai-Roy Wang
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Patent number: 10695157Abstract: A tissue graft packaging system having a retainer including first and second members with respective first and second pluralities of channel sidewalls that define first and second pluralities of channels, and first and second engagement means configured to removeably interconnect the first and second members. The first and second pluralities of channel sidewalls are configured to create a continuous interior space between the first and second members. A tissue graft, such as a cryopreserved viable tissue graft, is contained within the continuous interior space of the retainer. Processes for packaging, thawing and rinsing the tissue graft using the tissue graft packaging system and its retainer are also disclosed.Type: GrantFiled: January 10, 2017Date of Patent: June 30, 2020Assignee: Musculoskeletal Transplant FoundationInventors: Elizabeth Ann Poyss, Todd J. Nilsen, Alison Ling, Kevin Wu
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Patent number: 10596201Abstract: An acellular soft tissue-derived matrix includes a collagenous tissue that has been delipidated and decellularized. Adipose tissue is among the soft tissues suitable for manufacturing an acellular soft tissue-derived matrix. Exogenous tissuegenic cells and other biologically-active factors may be added to the acellular matrix. The acellular matrix may be provided as particles, a slurry, a paste, a gel, or in some other form. The acellular matrix may be provided as a three-dimensional scaffold that has been reconstituted from particles of the three-dimensional tissue. The three-dimensional scaffold may have the shape of an anatomical feature and serve as a template for tissue repair or replacement. A method of making an acellular soft tissue-derived matrix includes steps of removing lipid from the soft tissue by solvent extraction and chemical decellularization of the soft tissue.Type: GrantFiled: September 5, 2018Date of Patent: March 24, 2020Assignee: Musculoskeletal Transplant FoundationInventors: Yen-Chen Huang, Asia Ivery, Bryan Choi, Benjamin Schilling, Manh-Dan Ngo
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Patent number: 10582994Abstract: A medical implant packaging assembly having an outer tray, an inner tray and a retainer The implant may include a tissue graft. The inner tray is formed from a moisture barrier material whereby the implant may be maintained in a hydrated state, thereby avoiding need for rehydrating steps that are required for dehydrated or cryopreserved implants. The outer tray and inner tray and a retainer are also made of transparent materials, enabling medical personnel to view the implant through these packaging components prior to and during surgery.Type: GrantFiled: March 6, 2018Date of Patent: March 10, 2020Assignee: Musculoskeletal Transplant FoundationInventors: Jeffrey Kapec, Jacob Turetsky, Yukiko Naoi, Alison Ling, German Eduardo Jurado Rivera, Darrin Friend, Morris Jacobs
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Patent number: 10531957Abstract: Surgical implants (or grafts) for the repair of bone defects, more particularly, surgical implants that include demineralized bone fibers, are disclosed. The surgical implants have a wettability time of less than 5 minutes and a residual moisture content of less than 6% by weight, and they remain cohesive and retain their shape upon complete rehydration. Methods for making such implants and for increasing their wettability and ensuring uniform density are also disclosed.Type: GrantFiled: May 19, 2016Date of Patent: January 14, 2020Assignee: Musculoskeletal Transplant FoundationInventors: Michele McAllister, David Wang, Michelle Bubear, Joed Canales, Amy Chang, Roman Shikhanovich, Mark Spilker, Eric Semler
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Patent number: 10238485Abstract: Allografts for soft tissue repair, including breast reconstruction and other plastic surgery procedures, are disclosed. One allograft is made from decellularized dermal tissue and constitutes a collagen matrix having substantially uniform density and porosity. Another allograft is a hybrid bilayer tissue form that is made from decellularized dermal and adipose tissues. Methods for making both allografts are also disclosed.Type: GrantFiled: June 13, 2017Date of Patent: March 26, 2019Assignee: Musculoskeletal Transplant FoundationInventors: Michael Locarno, Bryan J. Choi, Manh-Dan Ngo
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Patent number: 10130736Abstract: The disclosure provides implants containing a plurality of particles containing at least one population of viable osteogenic cells adherent to and resident in an osteoconductive matrix or at least one viable population of osteogenic cells caused to be in contact with the osteoconductive matrix; methods of fabricating the implants; and use of the implants in bone repair. The implant further contains an osteoinductive component. An example of an osteoinductive component is a demineralized bone matrix in the form of particles or fibers.Type: GrantFiled: November 5, 2015Date of Patent: November 20, 2018Assignee: Musculoskeletal Transplant FoundationInventors: Eric Semler, Alex Callahan, Joed Canales, Katrina Carroll, Anouska Dasgupta, Roman Shikhanovich
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Patent number: 10092600Abstract: An acellular soft tissue-derived matrix includes a collagenous tissue that has been delipidated and decellularized. Adipose tissue is among the soft tissues suitable for manufacturing an acellular soft tissue-derived matrix. Exogenous tissuegenic cells and other biologically-active factors may be added to the acellular matrix. The acellular matrix may be provided as particles, a slurry, a paste, a gel, or in some other form. The acellular matrix may be provided as a three-dimensional scaffold that has been reconstituted from particles of the three-dimensional tissue. The three-dimensional scaffold may have the shape of an anatomical feature and serve as a template for tissue repair or replacement. A method of making an acellular soft tissue-derived matrix includes steps of removing lipid from the soft tissue by solvent extraction and chemical decellularization of the soft tissue.Type: GrantFiled: December 22, 2016Date of Patent: October 9, 2018Assignee: Musculoskeletal Transplant FoundationInventors: Yen-Chen Huang, Asia Ivery, Bryan Choi, Benjamin Schilling, Manh-Dan Ngo
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Publication number: 20170348088Abstract: A dermal tissue allograft includes a dermal matrix having a profile including first and second vertices, a first imaginary axis extending between the first and second vertices, a first peripheral edge extending along a continuous path from the first vertex to the second vertex on a first side of the first imaginary axis, and a second peripheral edge extending along a continuous path from the first vertex to the second vertex on a second side of the first imaginary axis. The first peripheral edge includes an apogee, a convex portion, and a concave portion. The convex and concave portions meet at a transition point located on the first peripheral edge between its apogee and the second vertex. The second peripheral edge includes an apogee and is convex. The second perpendicular distance is greater than the first perpendicular distance. The dermal matrix has a substantially uniform thickness across its profile.Type: ApplicationFiled: June 3, 2016Publication date: December 7, 2017Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATIONInventors: Antonio M. Bunce, Todd J. Nilsen, Evangelia Chnari, Aldona J. Spiegel, Michael Locarno, Gregory P. Adams
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Publication number: 20170281333Abstract: Allografts for soft tissue repair, including breast reconstruction and other plastic surgery procedures, are disclosed. One allograft is made from decellularized dermal tissue and constitutes a collagen matrix having substantially uniform density and porosity. Another allograft is a hybrid bilayer tissue form that is made from decellularized dermal and adipose tissues. Methods for making both allografts are also disclosed.Type: ApplicationFiled: June 13, 2017Publication date: October 5, 2017Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATIONInventors: Michael Locarno, Bryan J. Choi, Manh-Dan Ngo
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Publication number: 20170119826Abstract: An acellular soft tissue-derived matrix includes a collagenous tissue that has been delipidated and decellularized. Adipose tissue is among the soft tissues suitable for manufacturing an acellular soft tissue-derived matrix. Exogenous tissuegenic cells and other biologically-active factors may be added to the acellular matrix. The acellular matrix may be provided as particles, a slurry, a paste, a gel, or in some other form. The acellular matrix may be provided as a three-dimensional scaffold that has been reconstituted from particles of the three-dimensional tissue. The three-dimensional scaffold may have the shape of an anatomical feature and serve as a template for tissue repair or replacement. A method of making an acellular soft tissue-derived matrix includes steps of removing lipid from the soft tissue by solvent extraction and chemical decellularization of the soft tissue.Type: ApplicationFiled: December 22, 2016Publication date: May 4, 2017Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATIONInventors: Yen-Chen Huang, Asia Ivery, Bryan Choi, Benjamin Schilling, Manh-Dan Ngo
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Publication number: 20170049930Abstract: Cartilage fibers and implants made therefrom are disclosed, with and without cartilage particles. Methods for making the cartilage fibers and the implants containing them are also disclosed. The implants may be pre-shaped and may be reshapable and provide good shape retention and little swelling when placed into a cartilage defect.Type: ApplicationFiled: August 15, 2016Publication date: February 23, 2017Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATIONInventors: Michael A. Nasert, Florence Stoffel, Paul R. Williams, Alex Callahan
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Publication number: 20170021058Abstract: A composition including delipidated, decellularized adipose tissue and delipidated, decellularized fascial tissue is provided. The composition may further include exogenous tissuegenic cells, an exogenous growth-inductive substance, and/or a carrier. The composition is suitable for implantation into a living body in plastic surgery procedures, including reconstructive or cosmetic surgery procedures, wound care procedures or other procedures of regenerative medicine. A method of preparing an acellular soft tissue-derived matrix from adipose tissue and fascial tissue is also provided.Type: ApplicationFiled: July 22, 2016Publication date: January 26, 2017Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATIONInventors: Yen-Chen Huang, Asia Ivery, Bryan Choi, Benjamin Schilling, Manh-Dan Ngo, Evangelia Chnari, Todd Nilsen
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Publication number: 20160361171Abstract: Surgical grafts for the repair of bone defects, more particularly, surgical grafts that include demineralized bone fibers, are disclosed. Methods for making such grafts and for increasing their wettability and ensuring uniform density are also disclosed.Type: ApplicationFiled: May 19, 2016Publication date: December 15, 2016Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATIONInventors: David Wang, Michele McAllister, Michelle Bubear, Joed Canales, Amy Chang, Roman Shikhanovich, Mark Spilker, Eric Semler
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Patent number: 9352003Abstract: The disclosure provides implants containing a plurality of particles containing at least one population of viable osteogenic cells adherent to and resident in an osteoconductive matrix or at least one viable population of osteogenic cells caused to be in contact with the osteoconductive matrix; methods of fabricating the implants; and use of the implants in bone repair. The implant further contains an osteoinductive component. An example of an osteoinductive component is a demineralized bone matrix in the form of particles or fibers.Type: GrantFiled: November 30, 2012Date of Patent: May 31, 2016Assignee: MUSCULOSKELETAL TRANSPLANT FOUNDATIONInventors: Eric Semler, Alex Callahan, Joed Canales, Katrina Carroll, Anouska Dasgupta, Roman Shikanovich
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Patent number: 9138509Abstract: The invention is directed toward an improved formable bone composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing compound of demineralized lyophilized allograft bone particles ranging from about 100 to 850 microns. The bone particles are mixed in an excipient carrier combination containing carboxymethylcellulose, sodium hyaluronate, and a sodium phosphate saline buffer, the carboxymethylcellulose component of the carrier ranging from about 5.0 to about 11.0% of the composition and the sodium hyaluronate component of the carrier ranging from about 0.3 to about 0.7% of the composition, the composition having a pH between 6.5-7.5.Type: GrantFiled: September 14, 2007Date of Patent: September 22, 2015Assignee: MUSCULOSKELETAL TRANSPLANT FOUNDATIONInventors: Moon Hae Sunwoo, Victor A. Lizano, Arthur A. Gertzman
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Patent number: D832457Type: GrantFiled: January 10, 2017Date of Patent: October 30, 2018Assignee: Musculoskeletal Transplant FoundationInventors: Elizabeth Ann Poyss, Todd J. Nilsen, Alison Ling, Kevin Wu
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Patent number: D856517Type: GrantFiled: June 3, 2016Date of Patent: August 13, 2019Assignee: Musculoskeletal Transplant FoundationInventors: Aldona J. Spiegel, Michael Locarno, Gregory P. Adams
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Patent number: D864414Type: GrantFiled: October 3, 2017Date of Patent: October 22, 2019Assignee: Musculoskeletal Transplant FoundationInventors: Elizabeth Ann Poyss, Todd J. Nilsen, Alison Ling, Kevin Wu
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Patent number: D895812Type: GrantFiled: September 7, 2018Date of Patent: September 8, 2020Assignee: Musculoskeletal Transplant FoundationInventors: Aldona Jedrysiak Spiegel, Kai-Roy Wang