Patents Assigned to Musculoskeletal Transplant Foundation
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Publication number: 20150037436Abstract: An acellular soft tissue-derived matrix includes a collagenous tissue that has been delipidated and decellularized. Adipose tissue is among the soft tissues suitable for manufacturing an acellular soft tissue-derived matrix. Exogenous tissuegenic cells and other biologically-active factors may be added to the acellular matrix. The acellular matrix may be provided as particles, a slurry, a paste, a gel, or in some other form. The acellular matrix may be provided as a three-dimensional scaffold that has been reconstituted from particles of the three-dimensional tissue. The three-dimensional scaffold may have the shape of an anatomical feature and serve as a template for tissue repair or replacement. A method of making an acellular soft tissue-derived matrix includes steps of removing lipid from the soft tissue by solvent extraction and chemical decellularization of the soft tissue.Type: ApplicationFiled: July 30, 2014Publication date: February 5, 2015Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATIONInventors: Yen-Chen Huang, Asia Ivery, Bryan Choi, Benjamin Schilling, Manh-Dan Ngo
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Patent number: 8926701Abstract: The present invention is directed to an allograft intervertebral implant sized and configured for insertion between adjacent vertebral bodies in a spinal fusion surgery. The implant is preferably manufactured from two or more pieces of allograft bone joined together by a joint, more preferably a dovetail joint. The dovetail joint being sized and configured to substantially follow the exterior shape or surface of the intervertebral implant.Type: GrantFiled: October 9, 2013Date of Patent: January 6, 2015Assignees: DePuy Synthes Products, LLC, Musculoskeletal Transplant FoundationInventors: Robert J. De Lurio, Ryan Walsh, Joshua McManus, Bradford Robert Bowman, Sr.
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Patent number: 8906110Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped allograft two piece construct with a demineralized cancellous cap and a mineralized cylindrical base member defining a blind bore with a through-going transverse bore intersecting the blind bore. The demineralized cancellous cap has a cylindrical top portion and a smaller diameter cylindrical stem extending away from the top portion which fits into the blind bore of the mineralized base member. The cap stem defines a transverse through-going bore which is aligned with the through-going bore of the base member to receive a cylindrical cortical pin holding the cap within the base member. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that the assembly engages the side wall of the drilled bore in an interference fit.Type: GrantFiled: September 14, 2010Date of Patent: December 9, 2014Assignee: Musculoskeletal Transplant FoundationInventors: Eric J. Semler, Katherine G. Truncale, Alex B. Callahan, Judith I. Yannariello-Brown
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Patent number: 8883210Abstract: The disclosure provides implants containing a plurality of particles containing at least one population of viable tissuegenic cells adherent to and resident in the growth-conductive matrix or at least viable population of tissuegenic cells caused to be in contact with the growth-conductive matrix; methods to fabricate implants; methods of fabricating the implants; and use of the implants in tissue repair.Type: GrantFiled: May 16, 2011Date of Patent: November 11, 2014Assignee: Musculoskeletal Transplant FoundationInventors: Katherine Gomes Truncale, Arthur A. Gertzman, Yen-Chen Huang, Eric Semler, Evangelia Chnari, Anouska Dasgupta, Judith Yannariello-Brown, Terri Riley
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Publication number: 20140276957Abstract: Allografts for soft tissue repair, including breast reconstruction and other plastic surgery procedures, are disclosed. One allograft is made from decellularized dermal tissue and constitutes a collagen matrix having substantially uniform density and porosity. Another allograft is a hybrid bilayer tissue form that is made from decellularized dermal and adipose tissues. Methods for making both allografts are also disclosed.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATIONInventors: Michael Locarno, Bryan J. Choi, Mahn-Dan Ngo
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Patent number: 8834928Abstract: The disclosure provides implants containing a plurality of particles containing at least one population of viable tissuegenic cells adherent to and resident in the growth-conductive matrix or at least viable population of tissuegenic cells caused to be in contact with the growth-conductive matrix; methods to fabricate implants; methods of fabricating the implants; and use of the implants in tissue repair.Type: GrantFiled: July 23, 2013Date of Patent: September 16, 2014Assignee: Musculoskeletal Transplant FoundationInventors: Katherine Gomes Truncale, Arthur A. Gertzman, Yen-Chen Huang, Eric Semler, Evangelia Chnari, Anouska Dasgupta, Judith Yannariello-Brown, Terri Riley
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Patent number: 8795284Abstract: The invention is directed toward an instrumentation kit used to replace a damaged human knee joint meniscus with an allograft meniscus implant. The kit includes a workstation having a base and upright end sections with a clamping assembly is mounted on the end sections and a movable cutting guide mounted to a side wall of each end section. The tibia is then drilled with a drill to a desired depth and length and a groove is formed in the tibia with an osteotome so that the width is the same as the width of the bone base of the meniscus implant which has been trimmed in the workstation.Type: GrantFiled: October 13, 2011Date of Patent: August 5, 2014Assignee: Musculoskeletal Transplant FoundationInventors: Helio M. Ribeiro, Joed Canales, Cesar Chavista, Gregory C. Fanelli, John E. Barker
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Publication number: 20140058527Abstract: The invention is directed toward a sterile cartilage defect implant material comprising milled lyophilized allograft cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or mixed polymers with allograft chondrocytes added in an amount ranging from 2.5×105 to 2.5×107.Type: ApplicationFiled: October 31, 2013Publication date: February 27, 2014Applicant: Musculoskeletal Transplant FoundationInventors: Katherine Gomes Truncale, Arthur A. Gertzman, Moon Hae Sunwoo, William W. Tomford
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Publication number: 20140039628Abstract: The present invention is directed to an allograft intervertebral implant sized and configured for insertion between adjacent vertebral bodies in a spinal fusion surgery. The implant is preferably manufactured from two or more pieces of allograft bone joined together by a joint, more preferably a dovetail joint. The dovetail joint being sized and configured to substantially follow the exterior shape or surface of the intervertebral implant.Type: ApplicationFiled: October 9, 2013Publication date: February 6, 2014Applicants: Musculoskeletal Transplant Foundation, DePuy Synthes Products, LLCInventors: Robert J. DeLurio, Ryan Walsh, Joshua McManus, Bradford Robert Bowman, SR.
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Patent number: 8579980Abstract: The present invention is directed to an allograft intervertebral implant sized and configured for insertion between adjacent vertebral bodies in a spinal fusion surgery. The implant is preferably manufactured from two or more pieces of allograft bone joined together by a joint, more preferably a dovetail joint. The dovetail joint being sized and configured to substantially follow the exterior shape or surface of the intervertebral implant.Type: GrantFiled: October 2, 2012Date of Patent: November 12, 2013Assignees: DePuy Synthes Products, LLC, Musculoskeletal Transplant Foundation, Inc.Inventors: Robert J. DeLurio, Ryan Walsh, Joshua McManus, Bradford Robert Bowman
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Patent number: 8562613Abstract: The present invention is a kit and a method of using a kit for treating bone including a fill material mixture made of osteoconductive material, osteoinductive material and a lubricating carrier, a porous container to receive the fill material mixture and a tool that flowably introduces the fill material mixture into the porous container.Type: GrantFiled: April 5, 2010Date of Patent: October 22, 2013Assignees: Spineology Inc., Musculoskeletal Transplant FoundationInventors: James W. Ahern, Arthur Gertzman, Karen Roche, Moon Hae Sunwoo, Steven Wolfe, John E. Kuslich
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Patent number: 8557581Abstract: The present invention is a process for preparing soft tissue such as tendons, ligaments, cartilage, fascia, dermis, human valves and human veins for implant in a human and removes cellular components and forms an decellular matrix having as major components collagens and elastins while sterilizing the tissue. The process comprises the following steps: (1) isolating from a suitable donor a desired soft tissue sample of the biological material; (2) processing and decellularizing the soft tissue including inspection for visual defects, trimming and soaking the tissue in a detergent depending on whether the tissue is fascia or dermis and rinsing same with sterile water; (3) sterilizing the soft tissue in a vacuum and soaking the tissue in an antibiotic composition or peracetic acid depending on whether the soft tissue is fascia or dermis and rinsing same; (4) processing the tissue by cutting the tissue to size and perforating the tissue; and (5) dipping the tissue in 70% ethanol and packaging the tissue.Type: GrantFiled: May 3, 2010Date of Patent: October 15, 2013Assignee: Musculoskeletal Transplant FoundationInventors: Manh-Dan Ngo, Katherine Gomes Truncale, Jeffrey S. Cartmell, Carina Syring, Rudiger Von Versen
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Patent number: 8486074Abstract: The invention is directed toward a surgical kit having component parts capable of use to prepare a cartilage implant plug from allograft condyle. The kit comprises a sizing gauge used to measure surface of the allograft condyle so that a cartilage implant plug can be removed that corresponds to the contours of the defect site excised on a patient. An adjustable guide member is mounted in a fixed orientation over the allograft condyle in which a cylindrical graft cutter for cutting a cylindrical allograft bone plug having a cartilage cap and a bone end portion. A chamfering tool is used for chamfering the bone end of the allograft bone plug.Type: GrantFiled: June 1, 2009Date of Patent: July 16, 2013Assignee: Musculoskeletal Transplant FoundationInventors: Anton J. Steiner, David I. Knight, Paul J. Mulhauser, Karl D. Kirk, III, Richard J. Cosenza, Gregory C. Fanelli
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Patent number: 8435551Abstract: The invention is directed toward an osteochondral repair assembly comprising a shaped allograft construct comprising an unbalanced barbell-shaped cylindrical cancellous bone primary member formed with a mineralized cylindrical base section having a smaller diameter cylindrical stem leading to a second cylindrical section which is demineralized. A mineralized ring-shaped support member is forced over the compressed demineralized second demineralized the aperture of the ring-shaped member to fit around the stem with one ring surface being adjacent the bottom surface to the second cylindrical section and the opposite ring surface being adjacent the upper surface of the mineralized cylindrical base section.Type: GrantFiled: July 24, 2009Date of Patent: May 7, 2013Assignee: Musculoskeletal Transplant FoundationInventors: Eric J. Semler, Roman Shikhanovich, Alex B. Callahan, Katherine Gomes Truncale, Judith I. Yannariello-Brown, Yen-Chen Huang
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Publication number: 20130030534Abstract: The present invention is directed to an allograft intervertebral implant sized and configured for insertion between adjacent vertebral bodies in a spinal fusion surgery. The implant is preferably manufactured from two or more pieces of allograft bone joined together by a joint, more preferably a dovetail joint. The dovetail joint being sized and configured to substantially follow the exterior shape or surface of the intervertebral implant.Type: ApplicationFiled: October 2, 2012Publication date: January 31, 2013Applicants: Musculoskeletal Transplant Foundation, Synthes USA, LLCInventors: Synthes USA, LLC, Musculoskeletal Transplant Foundation
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Publication number: 20120297550Abstract: The present invention relates to a process for preparing skin removed from a human donor, removal of cellular components and sterilizing the decellularized skin. The process comprises the following steps: (1) decellularizing the skin including soaking the tissue in a detergent and rinsing same with sterile water; (2) sterilizing the skin with electronic beam irradiation, gamma irradiation or ultraviolet light for a time period to achieve a concentration to maximize sterilization; and (3) processing the tissue by cutting the tissue to a designated size.Type: ApplicationFiled: July 31, 2012Publication date: November 29, 2012Applicant: Musculoskeletal Transplant FoundationInventors: Manh-Dan Ngo, Jeffrey S. Cartmell
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Patent number: 8292968Abstract: A construct for repairing articular cartilage defects includes a cap member and a base member. The cap member has an upper section and a stem depending from a central region thereof. The upper section includes a peripheral region. The stem includes a cavity. The base member has first and second ends, the first end including an annular recess dimensioned such that the stem is receivable therein. The first end also includes an annular edge positioned laterally outwardly from the annular recess, for abutting and supporting the peripheral region of the upper section when the stem is received in the annular recess. The base member further includes an island which is surrounded by the annular recess and receivable in the cavity of the stem, such that the island is abuttable with and may thereby support the central region of the upper section when the stem is received in the annular recess.Type: GrantFiled: February 1, 2011Date of Patent: October 23, 2012Assignee: Musculoskeletal Transplant FoundationInventors: Katherine G. Truncale, Eric J. Semler, Arthur A. Gertzman, Moon Hae Sunwoo, William W. Tomford, Roman Shikhanovich
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Patent number: 8288344Abstract: The invention is directed toward a sterile formable implant composition for application to a bone defect site comprising bioactive glass particles in an aqueous carrier solution, the bioactive glass particles being added to a viscous carrier at a concentration ranging from about 68% to about 76% (w/w), the carrier comprising a mixture of glycerol and polyethylene glycol ranging from 24% to 32% (w/w) with the ratio of glycerol to polyethylene glycol ranging from about 45:55 to about 65:35.Type: GrantFiled: March 15, 2007Date of Patent: October 16, 2012Assignee: Musculoskeletal Transplant FoundationInventor: Carl Alexander DePaula
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Patent number: 8221500Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped allograft structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled allograft cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that either the shaped bone or the cartilage cap engage the side wall of the drilled bore in an interference fit and is in contact with a milled cartilage and biocompatible carrier mixture allowing cell transfer throughout the defect area. A method for inserting the shaped allograft structure into a cartilage defect area is also disclosed.Type: GrantFiled: July 24, 2008Date of Patent: July 17, 2012Assignee: Musculoskeletal Transplant FoundationInventors: Katherine Gomes Truncale, Arthur A. Gertzman, Moon Hae Sunwoo, William W Tomford
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Patent number: 8152808Abstract: The invention is directed toward a surgical kit having component parts capable of use in excising a cartilage defect site on a patient to prepare the same for receipt of an implant plug, the kit comprising a cylindrical gauge with a central bore used to measure the defect area, a guide rod adapted to be driven through the gauge tube into the center of said defect area and a cartilage cutting assembly adapted to be mounted over the guide rod and used for excising the defect area and cutting a cylindrical bore into the defect area. The method for use of the kit comprises the steps of: marking the defect area to be cut; placing a guide rod into the center defect area and driving the same to a predetermined distance to secure the same in the defect area and placing a drill bit over the guide rod and rotating the drill bit to cut a cylindrical blind bore removing the cartilage defect.Type: GrantFiled: May 28, 2009Date of Patent: April 10, 2012Assignee: Musculoskeletal Transplant FoundationInventors: Anton J. Steiner, David I. Knight, Paul J. Mulhauser, Karl D. Kirk, III, Richard J. Cosenza, Gregory C. Fanelli