Patents Assigned to National University Corporation Nagoya University
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Patent number: 10828377Abstract: An object of the present invention is to provide a method for determining whether a subject suffers from malignant lymphoma or leukemia and an agent for treating and/or preventing the disease. The present invention relates to a method for assisting in determining whether a subject suffers from, or is likely to suffer from malignant lymphoma or leukemia, comprising: a detection step of detecting at least one of a fusion mutation of a DUX4 gene, an overexpression of a DUX4 gene, and a fusion mutation of an MEF2D gene; and a determination step of determining that the subject suffers from or is likely to suffer from the disease when at least one of the fusion mutations or the overexpression is detected. Moreover, the present invention relates to a pharmaceutical composition comprising a DUX4 inhibitor as an active ingredient, for treating and/or preventing malignant lymphoma or leukemia in a subject having a fusion mutation of a DUX4 gene and an IGH or IGL gene and/or overexpression of a DUX4 gene.Type: GrantFiled: October 26, 2016Date of Patent: November 10, 2020Assignees: THE UNIVERSITY OF TOKYO, NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY, AICHI PREFECTURE, NATIONAL HOSPITAL ORGANIZATIONInventors: Hiroyuki Mano, Toshihide Ueno, Takahiko Yasuda, Masahito Kawazu, Fumihiko Hayakawa, Hitoshi Kiyoi, Shinobu Tsuzuki, Tomoki Naoe
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Patent number: 10830685Abstract: Provided is a device for electrical measurement designed to be able to perform high sensitivity detection by reading not only changes in steady-state current, but also the occurrence of transient current, and an electrical measurement apparatus including the device for electrical measurement. The device for electrical measurement includes a substrate on which are formed at least a sample separation channel and a sample migration channel, as well as a sample measuring unit, with one end of the sample separation channel formed to connect to one end of the sample migration channel, and the sample measuring unit including a first measuring unit connected to the sample migration channel, and a second measuring unit connected to the sample migration channel from the reverse side to the first measuring unit.Type: GrantFiled: April 6, 2016Date of Patent: November 10, 2020Assignee: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITYInventors: Yoshinobu Baba, Noritada Kaji, Takao Yasui, Tomoji Kawai, Takeshi Yanagida
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Publication number: 20200333764Abstract: A numerical control system according to the present invention controls machine drive systems included in a machine tool that performs machining using a tool, according to a numerical control program, and includes a coordinate transformation unit that acquires a disturbance force or a disturbance torque applied to each machine drive system, and coordinate-transforms the disturbance force or the disturbance torque into a tool reference coordinate system for output, and an identification unit that calculates cutting process parameters that determine characteristics of a cutting process model and dynamic characteristic parameters that determine characteristics of a dynamics model of the machine tool, using the disturbance force or the disturbance torque output from the coordinate transformation unit, states of the machine drive systems, predetermined equation models, and cutting conditions.Type: ApplicationFiled: August 30, 2017Publication date: October 22, 2020Applicants: Mitsubishi Electric Corporation, NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITYInventors: Kazuki TAKAHEI, Ryosuke IKEDA, Norikazu SUZUKI, Shoya OHNO
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Patent number: 10804004Abstract: A conducting film of the present invention includes (A) graphene and/or graphene oxide, and/or derivatives thereof, and (B) a compound having a sulfonic acid group, and/or derivatives thereof, and has a volume resistivity of 1×104 ?·cm or less. A method for producing the conducting film of the present invention includes preparing a dispersion by dispersing a component including (A) graphene and/or graphene oxide, and/or derivatives thereof, and (B) a compound having a sulfonic acid group, and/or derivatives thereof in a dispersion medium, applying the dispersion on a substrate and drying it, and performing heat treatment at a temperature of 100° C. or more. Thereby, the present invention provides a conducting film that has high conductivity and can be applied to a wide range of composites including graphenes, and a method for producing the same.Type: GrantFiled: July 11, 2016Date of Patent: October 13, 2020Assignees: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY, FUJI POLYMER INDUSTRIES CO., LTD.Inventors: Shigeji Konagaya, Toshio Saruyama, Hitoshi Shibuya
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Publication number: 20200308483Abstract: A method of producing semiconductor nanoparticles is provided. The method includes heating primary semiconductor nanoparticles and a salt of an element M1 in a solvent at a temperature set in a range of 100° C. to 300° C. The primary semiconductor nanoparticles contain the element M1, an element M2, optionally an element M3, and an element Z, and have an average particle size of 50 nm or less. The element M1 is at least one element selected from the group consisting of Ag, Cu, and Au. The element M2 is at least one element selected from the group consisting of Al, Ga, In, and Tl. The element M3 is at least one element selected from the group consisting of Zn and Cd. The element Z is at least one element selected from the group consisting of S, Se, and Te.Type: ApplicationFiled: June 14, 2020Publication date: October 1, 2020Applicants: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY, NICHIA CORPORATIONInventors: Tsukasa TORIMOTO, Tatsuya KAMEYAMA, Akihiro FUKATSU, Daisuke OYAMATSU
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Publication number: 20200300788Abstract: A method for measuring a fiber orientation degree includes: irradiating a sample formed of a composite material containing discontinuous carbon fibers with an X-ray to acquire an X-ray diffraction image; calculating an angle (2?)A of a peak originating from a crystal face of graphite; calculating a correction coefficient ? of a thickness of the sample; calculating an upper limit (2?)B of the peak of the crystal face of graphite; calculating a diffraction sensitivity IC(?) of the peak originating from the crystal face of graphite by correcting an integrating range with the correction coefficient ? and integrating the X-ray diffraction image with respect to a diffraction angle (2?); and calculating a fiber orientation degree Sd(?) by the method of Hermans from the diffraction sensitivity IC(?).Type: ApplicationFiled: October 2, 2018Publication date: September 24, 2020Applicants: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY, TORAY INDUSTRIES, INC., KYOWA INDUSTRIAL CO., LTD.Inventors: Atsuhiko YAMANAKA, Mariko TERADA, Yukitane KIMOTO, Koji SHIRAKI, Yuji HOTTA, Daisuke SHIMAMOTO
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Publication number: 20200295227Abstract: Provided is a method for manufacturing a semiconductor nanoparticle, the method includes performing a heat treatment of a first mixture containing a silver (Ag) salt, an alkali metal salt, a salt containing at least one of indium (In) and gallium (Ga), a sulfur source, and an organic solvent. A ratio of the number of atoms of an alkali metal to the total number of atoms of Ag and the alkali metal in the first mixture is greater than 0 and less than 1.Type: ApplicationFiled: March 11, 2020Publication date: September 17, 2020Applicants: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY, OSAKA UNIVERSITY, NICHIA CORPORATIONInventors: Tsukasa TORIMOTO, Tatsuya KAMEYAMA, Yuki MORI, Hiroki YAMAUCHI, Susumu KUWABATA, Taro UEMATSU, Daisuke OYAMATSU
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Patent number: 10749200Abstract: A non-humidified proton-conductive membrane according to the present invention includes a polymer and a proton-conductive substance. The polymer includes a glassy or crystalline first site having a glass-transition temperature or melting temperature higher than the service temperature of the proton-conductive membrane and a second site capable of forming a noncovalent bond. The proton-conductive substance includes a proton-releasing/binding site capable of noncovalently binding to the second site of the polymer and a proton coordination site capable of coordinating to protons, the proton-releasing/binding site and the proton coordination site being included in different molecules that interact with each other or being included in the same molecule. A proton-conductive mixed phase that includes the second site to which the proton-releasing/binding site of the proton-conductive substance is bound and the proton-conductive substance is lower than the service temperature of the proton-conductive membrane.Type: GrantFiled: March 27, 2017Date of Patent: August 18, 2020Assignee: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITYInventors: Atsushi Noro, Takato Kajita, Takahiro Mori, Yushu Matsushita
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Publication number: 20200255607Abstract: A main purpose of the present invention is to provide a multi-block copolymer composition having good elasticity and excellent stress relaxation properties, as well as small tension set. The present invention achieves the purpose by providing a multi-block copolymer composition obtained by a modification treatment, the composition including a block copolymer B formed by introducing a functional group capable of forming a non-covalent bond to a block copolymer A; wherein the block copolymer A includes a block copolymer A1 having a specific primary structure and a block copolymer A2 having a specific primary structure, and the mass ratio (A1/A2) of the block copolymer A1 and the block copolymer A2 is 100/0 to 50/50.Type: ApplicationFiled: August 23, 2018Publication date: August 13, 2020Applicants: ZEON CORPORATION, NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITYInventors: Kousuke ISOBE, Sadaharu HASHIMOTO, Atsushi NOZAWA, Atsushi NORO, Takato KAJITA, Yushu MATSUSHITA
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Patent number: 10739360Abstract: Disclosed is an analyzing method, for analyzing a blood specimen, which includes: mixing a blood specimen and a thrombin-containing reagent to coagulate the blood specimen, and obtaining a coagulation waveform; obtaining a value of a parameter concerning differentiation of the coagulation waveform, based on the coagulation waveform; and obtaining information concerning an amount of antigen of fibrinogen based on the obtained value of the parameter.Type: GrantFiled: April 19, 2018Date of Patent: August 11, 2020Assignees: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY, SYSMEX CORPORATIONInventors: Atsuo Suzuki, Tadashi Matsushita, Sho Shinohara, Nobuo Arai
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Patent number: 10717925Abstract: A method of producing semiconductor nanoparticles is provided. The method includes heating primary semiconductor nanoparticles and a salt of an element M1 in a solvent at a temperature set in a range of 100° C. to 300° C. The primary semiconductor nanoparticles contain the element M1, an element M2, optionally an element M3, and an element Z, and have an average particle size of 50 nm or less. The element M1 is at least one element selected from the group consisting of Ag, Cu, and Au. The element M2 is at least one element selected from the group consisting of Al, Ga, In, and Tl. The element M3 is at least one element selected from the group consisting of Zn and Cd. The element Z is at least one element selected from the group consisting of S, Se, and Te.Type: GrantFiled: January 29, 2019Date of Patent: July 21, 2020Assignees: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY, NICHIA CORPORATIONInventors: Tsukasa Torimoto, Tatsuya Kameyama, Akihiro Fukatsu, Daisuke Oyamatsu
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Patent number: 10712716Abstract: A control device according to the present invention includes a plurality of arithmetic units that operate in parallel. A sensor value of the control amount is input to the first arithmetic unit in a signal transmission sequence, and a correction amount for the manipulation amount is output from the last arithmetic unit in the signal transmission sequence. The first arithmetic unit has a controller that produces an output by processing the input sensor value, and the arithmetic units other than the first arithmetic unit has a delay element that delays an input by a predetermined number of steps and a controller that produces an output by processing the delayed input.Type: GrantFiled: February 12, 2014Date of Patent: July 14, 2020Assignees: TOYOTA JIDOSHA KABUSHIKI KAISHA, NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITYInventors: Kota Sata, Junichi Kako, Satoru Watanabe, Yuta Suzuki, Masato Edahiro
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Patent number: 10709741Abstract: A composition for preventing or treating inflammatory disease and that is effective for inflammatory disease such as fulminant hepatitis and interstitial pneumonia. For such an objective, the present uses a culture supernatant obtained by culturing dental pulp stem cells as the active ingredient of the composition for preventing or treating inflammatory disease.Type: GrantFiled: February 13, 2014Date of Patent: July 14, 2020Assignee: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITYInventors: Akihito Yamamoto, Minoru Ueda, Hidemi Goto, Masatoshi Ishigami, Yoshihiro Matsushita, Yoshinori Hasegawa, Naozumi Hashimoto, Hirotaka Wakayama
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Patent number: 10699106Abstract: A direction discrimination device includes: an extraction unit configured to extract pieces of feature information from an image of a person, each of the pieces of feature information representing a feature of corresponding one of portions of the person; and a discrimination unit configured to discriminate a direction of the person based on the pieces of feature information. The discrimination unit is configured to weight first feature information which is feature information of a portion that is likely to have a difference in the feature between a first direction and a second direction range, more than second feature information which is feature information of a portion that is less likely to have a difference, in determination of the direction of the person. The second direction range not includes the first direction and includes a second direction opposite to the first direction.Type: GrantFiled: August 1, 2017Date of Patent: June 30, 2020Assignees: Toyota Jidosha Kabushiki Kaisha, National University Corporation Nagoya UniversityInventors: Yasutomo Kawanishi, Fumito Shimmura, Daisuke Deguchi, Ichiro Ide, Hiroshi Murase
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Publication number: 20200203916Abstract: Provided is a carbon isotope analysis device including a carbon dioxide isotope generator provided with a combustion unit that generates gas containing carbon dioxide isotope from carbon isotope, and a carbon dioxide isotope purifying unit; a spectrometer including optical resonators having a pair of mirrors, and a photodetector that determines intensity of light transmitted from the optical resonators; and a light generator including a single light source, a first optical fiber that transmits first light from the light source, a second optical fiber that generates second light of a longer wavelength than the first light, the second optical fiber splitting from the first optical fiber and coupling therewith downstream, a first amplifier on the first optical fiber, a second amplifier on the second optical fiber, different in band from the first amplifier, and a nonlinear optical crystal.Type: ApplicationFiled: August 24, 2018Publication date: June 25, 2020Applicants: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY, SEKISUI MEDICAL CO., LTD.Inventors: Tetsuo IGUCHI, Hideki TOMITA, Norihiko NISHIZAWA, Volker SONNENSCHEIN, Ryohei TERABAYASHI, Atsushi SATOU
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Publication number: 20200197446Abstract: The purpose of the present invention is to provide a novel medical application of pluripotent stem cells (muse cells) in regeneration medicine. The present invention provides a cell preparation and a pharmaceutical composition which are for amelioration and treatment of brain disorders resulting from fetal growth retardation, such as abnormal motor quality or abnormal neurological development, and which contain SSEA-3 positive pluripotent stem cells isolated from a mesenchymal tissue from a live body or cultured mesenchymal cells. It is assumed that this cell preparation is based on a mechanism where muse cells that are administered to objects having the disorders are engrafted on an impaired brain tissue, thereby ameliorating or treating the disorders.Type: ApplicationFiled: June 20, 2018Publication date: June 25, 2020Applicants: National University Corporation Nagoya University, TOHOKU UNIVERSITY, NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, Life Science Institute, Inc.Inventors: Yoshiaki SATO, Yuma KITASE, Shinobu SHIMIZU, Masaaki MIZUNO, Masahiro HAYAKAWA, Mari DEZAWA, Masahiro TSUJI
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Publication number: 20200179918Abstract: A dispensing apparatus, a liquid dispensing method, and a cell dispensing method which can dispense liquid with very high accuracy. A dispensing apparatus includes a glass pipette, a tubular elastic member, a rod-shaped member, and a piezoelectric element actuator. A portion of the tubular elastic member located adjacent to a first open end thereof covers a portion of the glass pipette located adjacent to an opening portion thereof. A portion of the tubular elastic member located adjacent to a second open end thereof covers at least a forward end portion of the rod-shaped member. When the piezoelectric element actuator pushes the rod-shaped member toward the opening portion of the glass pipette, the tubular elastic member deforms such that the volume of the internal space of the tubular elastic member decreases.Type: ApplicationFiled: June 19, 2018Publication date: June 11, 2020Applicant: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITYInventors: Shinya SAKUMA, Yusuke KASAI, Fumihito ARAI
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Patent number: 10676371Abstract: A ruthenium compound exhibits large negative thermal expansion. The ruthenium oxide is represented by the formula (1) Ca2?xRxRu1?yMyO4+z (wherein R represents at least one element selected from among alkaline earth metals and rare earth elements; M represents at least one element selected from among Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, and Ga; and the following relations are satisfied: 0?x<0.2, 0?y<0.3, and ?1<z<?0.02).Type: GrantFiled: February 10, 2017Date of Patent: June 9, 2020Assignee: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITYInventors: Koshi Takenaka, Yoshihiko Okamoto, Tsubasa Shinoda, Naruhiro Inoue
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Patent number: 10669525Abstract: Means which enables preparation of a thick cell aggregate by a simple process without an operation of detaching and stacking of cells is disclosed. The method for preparing a three-dimensional cell aggregate by the present invention comprises: a cell encasing step of placing a cell suspension in a cell container; and a pressure application step of applying pressure to cells in the container. The cell encasing step and the pressure application step may be carried out a plurality of times. By the present invention, a thick, robust cell aggregate can be obtained by a simple operation of applying pressure to a cell suspension or a medium containing cells. Since the method does not require an operation of stacking a plurality of cell sheets, the cells are hardly damaged, and the conditions of the cells can be favorably maintained, so that the cells can be advantageously used as a tissue piece for transplantation.Type: GrantFiled: September 29, 2015Date of Patent: June 2, 2020Assignees: PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY, OSAKA UNIVERSITY, NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITYInventors: Utako Yokoyama, Yoshihiro Ishikawa, Makoto Kaneko, Shinya Sakuma, Fumihito Arai
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Patent number: 10669624Abstract: In an amorphous carbon film of a sliding member, provided that a number of nitrogen atoms each singly bonded to three carbon atoms is A, and a number of nitrogen atoms each singly and doubly bonded to two carbon atoms, respectively, is B, a value A/B of the amorphous carbon film obtained through X-ray photoelectron spectroscopy analysis is 10 to 18. The method includes irradiating the surface of the substrate with nitrogen ion beams and irradiating a carbon target with electron beams, thereby forming an amorphous carbon film on the surface of the substrate while vapor-depositing a part of the carbon target onto the surface of the substrate. The output of the electron beams that irradiate the carbon target is 30 to 50 W.Type: GrantFiled: September 26, 2017Date of Patent: June 2, 2020Assignees: TOYOTA JIDOSHA KABUSHIKI KAISHA, NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITYInventors: Kazuyoshi Manabe, Noritsugu Umehara, Hiroyuki Kousaka, Kazuyuki Ichimura