Patents Assigned to Nisshin Flour Milling Co., Ltd.
  • Patent number: 6048882
    Abstract: Hepatic diseases can be prevented or treated by administering an isoprenylamine derivative represented by the general formula (II) ##STR1## [wherein n represents an integer of 4-12, m represents an integer of 0-3, Ar represents a phenyl group, a furyl group, a thienyl group or a pyridyl group, said group being optionally substituted with one or more of an alkyl group of 1-4 carbon atoms, and alkoxy group of 1-4 carbon atoms, a methylenedioxy group, a hydroxy group or a halogen atom, and R represents a hydrogen atom or an alkyl group of 1-4 carbon atoms] or a pharmacologically acceptable salt thereof at a daily dose of 0.01-500 .mu.g/kg.A lipid emulsion of the compound (II) is particularly useful and can be administered at a remarkably lowered dose as compared with other pharmaceutical preparations.
    Type: Grant
    Filed: August 8, 1997
    Date of Patent: April 11, 2000
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Tatsuya Ohwaki, Masako Yamada, Hiroyuki Yamazaki, Hitoshi Inoue, Yoshiyuki Tahara, Shigeo Kawase
  • Patent number: 6046201
    Abstract: N-(12-Nitroxydodecyl)-6-(4-ethyl or isopropyl-1-piperazinyl)pyridine-3-carboxamide or physiologically acceptable salts thereof. The said compounds have excellent inhibiting activity of cerebral edema, especially ischemic cerebral edema, and inhibiting activity of delayed neuronal death (an inhibiting activity of Ca-influx in neuronal cells). Cerebral edema is a pathologic condition accompanying cerebrovascular disorders, especially the acute stage cerebrovascular disorders and then the compounds are useful as an inhibiting agent for cerebral edema or a therapeutic agent for cerebrovascular disorders. Moreover, because the compounds do hardly show a behavior suppressing action, which is considered to be side effect in treating cerebrovascular disorders at the acute stage, they are an excellent therapeutic agent for, in particular, the acute stage cerebrovascular disorders.
    Type: Grant
    Filed: July 15, 1998
    Date of Patent: April 4, 2000
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Norio Oshida, Yoji Mimaki, Hiroaki Satoh, Shinji Yokoyama, Yukiko Muraki, Kazumi Nishimura, Tamiko Hamada, Einosuke Sakurai, Hiroshi Sakai, Toshiji Sugai, Tomomi Tonoike, Koichi Itoh
  • Patent number: 6042867
    Abstract: Flour blends are described containing waxy wheat flour and are suitable for the preparation of breads, cakes, or noodles. These flour blends make it possible to obtain foods which do not show degraded texture after prolonged storage, and which particularly provide an excellent texture when consumed after being frozen and thawed.
    Type: Grant
    Filed: January 14, 1997
    Date of Patent: March 28, 2000
    Assignees: Ministry of Agriculture, Forestry and Fisheries Tohoku National Agricultrual Experiment Station, Nisshin Flour Milling Co., Ltd.
    Inventors: Tsuguhiro Hoshino, Ryo Yoshikawa, Seiji Ito, Koichi Hatta, Toshiki Nakamura, Makoto Yamamori, Katsuyuki Hayakawa, Keiko Tanaka, Hajime Akashi, Shigeru Endo, Seiji Tago, Shinji Ishigami
  • Patent number: 6040495
    Abstract: A hairless mouse designated NS:Hr/ICR is sensitive to H. pylori. This NS:Hr/ICR hairless mouse can be easily infected with H. pylori in its alimentary canal, and is therefore useful as an experimental animal model for H. pylori infection.
    Type: Grant
    Filed: March 25, 1998
    Date of Patent: March 21, 2000
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Nobutake Kimura, Masato Ariga, Hirohito Yamakawa, Yoshio Nakagawa, Akio Shimizu
  • Patent number: 6024915
    Abstract: A process for producing a metal-base sinter, comprising sintering coated metal particles wherein the particles are prepared for sintering by the steps of: dispersing a powder of metal core particles in a gaseous atmosphere to form a mixture of a gas and particles in a powder of highly dispersed core particles; charging a precursor for the coat forming substance that has been formed via the vapor phase and/or a precursor for the coat forming substance in a vapor-phase state and the mixture of the gas and the powder of highly dispersed core particles that have a predetermined dispersity according to the average diameter of the core particles in a coating start region of a coating space; coating the surfaces of the core particles with the coat forming substance by allowing the precursor to contact and/or impinge against the core particles; shaping and sintering the thus coated metal core particles or a mixture containing them under appropriate sintering conditions.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: February 15, 2000
    Assignees: Agency of Industrial Science & Technology, Nisshin Flour Milling Co., Ltd.
    Inventors: Shoichi Kume, Haruo Yoshida, Yukiyoshi Yamada, Tadashi Fuyuki, Satoshi Akiyama, Yoshiaki Hamada, Eisuke Kuroda
  • Patent number: 6024909
    Abstract: A process for producing a ceramic-base sinter, comprising sintering coated ceramic particles wherein the particles are prepared for sintering by the steps of: dispersing a powder of ceramic core particles in a gaseous atmosphere to form a mixture of a gas and particles in a powder of highly dispersed core particles; charging a precursor for the coat forming substance that has been formed via the vapor phase and/or a precursor for the coat forming substance in a vapor-phase state and the mixture of the gas and the powder of highly dispersed core particles that have a predetermined dispersity according to the average diameter of the core particles in a coating start region of a coating space; coating the surfaces of the core particles with the coat forming substance by allowing the precursor to contact and/or impinge against the core particles; shaping and sintering the thus coated ceramic core particles or a mixture containing them under appropriate sintering conditions.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: February 15, 2000
    Assignees: Agency of Industrial Science & Technology, Nisshin Flour Milling Co., Ltd.
    Inventors: Haruo Yoshida, Shoichi Kume, Yukiyoshi Yamada, Tadashi Fuyuki, Satoshi Akiyama, Yoshiaki Hamada, Eisuke Kuroda
  • Patent number: 6011069
    Abstract: There is disclosed a multidrug resistance inhibitor for overcoming a multidrug resistance of cancer, or an agent for enhancing the activity of anti-cancer agents, which comprises as an active ingredient a compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein n is an integer of 5 to 12,R.sub.1 and R.sub.2 are each independently benzyl, of which a phenyl ring may be substituted by 1 to 5 substituents selected from hydroxy, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy and halogen, and/or by methylenedioxy, with the proviso that R.sub.1 and R.sub.
    Type: Grant
    Filed: December 17, 1996
    Date of Patent: January 4, 2000
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Kohei Inomata, Toshihiro Takahashi, Hitoshi Inoue, Makoto Yanai, Hiroyuki Yamazaki, Masashi Suzuki, Tsutomu Takasawa, Kouji Kawamura, Norio Oshida, Hiroyuki Ikemoto, Takao Kishiye
  • Patent number: 6010736
    Abstract: There is disclosed a steamed durum wheat flour having a gluten vitality of 0.70-0.95 based on that of untreated durum wheat flour and a gluten swelling power of 1.05-1.30 based on that of untreated durum wheat flour. The steamed durum wheat flour is suitable for the manufacture of cakes and doughnuts and for a coating material for fried foods including tempura and fried chicken.
    Type: Grant
    Filed: December 11, 1996
    Date of Patent: January 4, 2000
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Hirofumi Motoi, Kazuhiro Omata, Futoshi Hirasawa, Masaru Kyugo
  • Patent number: 6001815
    Abstract: A depsipeptide containing N-substituted glycine residue having the formula (1) or (2): ##STR1## (wherein R.sub.1 is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15 carbon atoms; R.sub.2 is a group of the formula --A--B--W--(D).sub.m --(E).sub.n, --A--B--W--(D).sub.m --(E).sub.n --F or --A--B--W--(D).sub.m --(E).sub.n --F--Z; R.sub.3 is a hydroxyl group, a lower alkoxy group, a benzyloxy group, or a group of the formula --Z, --Z--G or --Z--G--J; A, B, D, E, F, G and J independently are an N-substituted glycine residue or a residue of an amino acid selected from the group consisting of alanine, valine, leucine, serine, etc.; W and Z independently are a residue of an amino acid selected from the group consisting of an aspartic acid, a glutamic acid, etc.; at least one of A, B, D, E, F, G and J is an N-substituted glycine residue) or a pharmacologically acceptable salt thereof.
    Type: Grant
    Filed: December 21, 1998
    Date of Patent: December 14, 1999
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Makoto Yanai, Masashi Suzuki, Norio Oshida, Koji Kawamura, Shigeru Hiramoto, Orie Yasuda, Nobuhiro Kinoshita, Akiko Shingai, Masako Takasu
  • Patent number: 5989617
    Abstract: The present invention is directed to a method of assessing suitability of wheat or wheat flour for producing noodles, wherein starch contained in the wheat or wheat flour is analyzed by differential scanning calorimetry for its thermal characteristics and assessment is carried out based on the results of the analysis; wheat flour which is suitable for preparing noodles, wherein the wheat flour is prepared from wheat containing starch having an endothermic enthalpy (.DELTA.H) of 0.3 J/g of dry matter or less at a thermal change onset temperature (To) of 80.degree. C. or higher when the starch is analyzed by differential scanning calorimetry in the presence of added water; and use of the wheat or wheat flour for preparing noodles.
    Type: Grant
    Filed: July 6, 1998
    Date of Patent: November 23, 1999
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Hajime Akashi, Miwa Takahashi, Yasuhiro Tanaka, Masakazu Mizukami, Masahiko Kamada
  • Patent number: 5972391
    Abstract: A swine feed containing as additives a spice and 50-500 ppm of vitamin E. A method for producing pork with improved quality by raising swine with such a feed is also disclosed. When swine are raised with the feed of the present invention, it is possible to produce pork which gives less smell, maintains freshness and quality for prolonged periods, generates less drip, and exhibits good moisture retainability. Moreover, the growth rate of the swine is excellent.
    Type: Grant
    Filed: July 11, 1997
    Date of Patent: October 26, 1999
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Hiroyuki Suzuki, Hiroyuki Nakao, Jino Kikuchi
  • Patent number: 5972943
    Abstract: Pyridinecarboxamide derivatives of the formula ##STR1## (wherein n represents an integer of 14-18, and R represents a hydrogen atom or a straight or branched C.sub.1 -C.sub.4 alkyl group) or physiologically acceptable salts thereof. The compounds have excellent inhibiting activity of cerebral edema, especially ischemic cerebral edema, and inhibiting activity of delayed death of neuronal cells (an inhibiting activity of Ca-influx in neuronal cells). Cerebral edema is a pathologic condition accompanying cerebrovascular disorders, especially the acute stage of cerebrovascular disorders and then the compounds are useful as an agent for inhibiting cerebral edema or a therapeutic agent for cerebrovascular disorders. Moreover, the compounds have no hypotensive action which is considered to be side-effect in treating the acute stage cerebrovascular disorders and hardly show a behavior suppressing action so that they are an excellent therapeutic agent for, in particular, the acute stage cerebrovascular disorders.
    Type: Grant
    Filed: July 20, 1998
    Date of Patent: October 26, 1999
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Norio Oshida, Yoji Mimaki, Hiroaki Satoh, Shinji Yokoyama, Yukiko Muraki, Kazumi Nishimura, Tamiko Hamada, Einosuke Sakurai, Hiroshi Sakai, Toshiji Sugai, Tomomi Tonoike, Koichi Itoh
  • Patent number: 5945434
    Abstract: An indazole compound having the formula (I): wherein:R.sub.1 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl or C.sub.3 -C.sub.6 cycloalkyl;Q is carbonyl, thiocarbonyl or methylene; andR.sub.2 is a group of the formula (II) or (IV); ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl or benzyl, of which a phenyl group thereof is optionally mono- or di-substituted by the same or different halogen or methoxy; m is 0 to 2; n and o is 1 or 2. The compound exhibits 5-HT.sub.4 receptor agonist activity.
    Type: Grant
    Filed: November 28, 1997
    Date of Patent: August 31, 1999
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Masashi Suzuki, Masahiro Ueno, Ryuta Fukutomi, Hiroaki Satoh, Haruhiko Kikuchi, Koichiro Hagihara, Takeo Arai, Sugure Taniguchi, Setsuko Mino, Yumiko Noguchi
  • Patent number: 5931305
    Abstract: The present invention provides a powder classifier using a classification rotor capable of classifying powder with high efficiency and high accuracy. The classification rotor is attached to a rotating shaft as a body and rotatably supported in a casing. Within the classification rotor, a cavity is formed from the outer edge to the center and classifying vanes are provided around the circumference. The cavity is bent downwardly near the center with the lower end connected through a fine powder passage to a fine powder outlet. The outer edge of the classification rotor is connected to a coarse powder outlet. After feeding powder from a powder supply port, the powder is rotated by the classifying vanes such that coarse powder particles are taken out from the rough outlet by centrifugal force and fine powder particles are taken out by airflow from the fine powder outlet.
    Type: Grant
    Filed: May 1, 1997
    Date of Patent: August 3, 1999
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Satoshi Akiyama, Takahiro Ichikawa, Naoto Tonoike, Hideo Okabe, Taisuke Tanaka, Hiromi Omura, Eisuke Kuroda, Yukiyoshi Yamada
  • Patent number: 5929057
    Abstract: 9-Cis-retinoic acid-.alpha.-tocopherol esters, pharmaceutical compositions containing the same and use of the same as a medicine for the treatment of leukemia, in particular, the remission of leukemia are provided and a combined use of a 9-cis-retinoic acid-.alpha.-tocopherol ester and either 1.alpha.,25-dihydroxyvitamin D.sub.3 or 9-cis-retinoic acid exhibits a synergistic effect in the treatment of leukemia without any side effects caused by 1.alpha.,25-dihydroxyvitamin D.sub.3 or 9-cis-retinoic acid.
    Type: Grant
    Filed: June 5, 1998
    Date of Patent: July 27, 1999
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Makoto Makishima, Yasuhiro Kanatani, Yoshio Honma, Kohei Inomata, Takao Kishiye
  • Patent number: 5916619
    Abstract: A method for manufacturing a fried instant noodle wherein noodle strings comprising cereal flours, a chemical leavening agent and at least one enzyme selected from the group consisting of amylase and protease are steamed and then fried. The fried instant noodles exhibit a low oil absorption, a low calorie content, no oily odor or flavor and superior gastronomical taste and texture. The noodles can be reconstituted to a ready to eat state in a short time.
    Type: Grant
    Filed: February 28, 1996
    Date of Patent: June 29, 1999
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Eiji Miyazaki, Hajime Akashi, Miwa Takahashi, Yasuhiro Tanaka, Shoji Yokozuka
  • Patent number: 5882701
    Abstract: In a method for producing eggs with improved flavor, hen poultry are fed a feed containing nutmeg and/or cinnamon. Eggs obtained from the poultry and foods produced from the eggs have an improved taste.
    Type: Grant
    Filed: August 1, 1996
    Date of Patent: March 16, 1999
    Assignees: Nisshin Flour Milling Co., Ltd., Kaneka Corporation
    Inventors: Yukihiro Motozono, Shuging Li, Noboru Ishihara, Nobuyuki Arai, Ryozo Nakahara, Yoshihiro Kochi, Sachiko Tanaka, Akiko Kami
  • Patent number: 5874122
    Abstract: A steamed wheat flour for use in the fried good to be reheated in an microwave oven contains starch not substantially converted into alpha starch, and has a gluten vitality of 0.80 to 0.92 based on that of untreated wheat flour and a gluten swelling power of 1.05 to 1.55 based on that of untreated wheat flour. A process for producing steamed wheat flour for fry-cooking, which comprises steaming wheat flour in a closed type high-speed agitator under pressure with saturated steam and under conditions of a residence time of 2-20 sec and a product temperature higher than 80.degree. C. but not higher than 92.degree. C.
    Type: Grant
    Filed: January 16, 1997
    Date of Patent: February 23, 1999
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Yoshihito Ueki, Hirofumi Motoi, Hideyuki Miyamura, Hirofumi Sori, Futoshi Hirasawa
  • Patent number: 5846600
    Abstract: The process for producing coated particles of the present invention is applicable to a process of producing coated particles by charging powder of core particles into the coating space and permitting a coat forming substance generated via a vapor phase or being in a vapor-phase state to contact against particles of the powder, and the process is characterized by dispersing powder of core particles having an average particle diameter of not more than 10 .mu.m and a particle size distribution of ((D.sub.M /5, 5D.sub.M), .gtoreq.90%) to adjust a dispersity .beta. to at least 70%, and contacting the dispersed powder of the core particles with the coat forming substance.
    Type: Grant
    Filed: April 11, 1995
    Date of Patent: December 8, 1998
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Yukiyoshi Yamada, Tadashi Fuyuki, Satoshi Akiyama, Yoshiaki Hamada, Eisuke Kuroda
  • Patent number: 5847123
    Abstract: Imide compounds having a propioloyl group or pharmaceutically acceptable salts thereof which exhibit potent activities to inhibit the production of Interleukin 1-.beta. and also the production of Tumor Necrosis Factor .alpha.. These imide compounds are useful as a prophylactic or therapeutic agent for inhibiting the production of Interleukin 1-.beta. and the production of Tumor Necrosis Factor .alpha., typically for such diseases as chronic rheumatism, sepsis, ulcerative colitis, Crohn's disease and many other related diseases in which Interleukin 1-.beta. and/or Tumor Necrosis Factor .alpha. would participate.
    Type: Grant
    Filed: July 1, 1997
    Date of Patent: December 8, 1998
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Shinji Yokoyama, Noriyoshi Sueda, Hiroaki Yamada, Ryotaro Kojima, Koichi Katsuyama